Mechanism of Action of Acetazolamide - a Carbonic Anhydrase Inhibitor 

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Video Summary:
Acetazolamide inhibits carbonic anhydrase in the proximal tubule. This results in decreased absorption of bicarbonate and sodium in the proximal tubule. yet, the diuretic action of acetazolamide is mild because most of the Na is reabsorbed in the later portion of the tubule. On the other hand, the excretion of K is markedly increased.
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