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MHC class I assembly and presentation 

Immunology Toronto
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This short video describes how MHC class I molecules are assembled and delivered on the surface of cells to present petides to T cells. This allows T-cells to determine whether the cell is iinfected with a virus by allowing a T cell to essentially look inside the cell. The immune sytem, T cells and MHC class I molecules play a vital role in protecting our bodies from infection.
Video by Diego Accorsi. Brought to you by the Departments of Immunology and Biochemistry and Biomedical Communications at the University of Toronto.

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13 сен 2012

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Комментарии : 78   
@RYung31
@RYung31 10 лет назад
This is a very well organized and descriptive presentation of a seemingly complex process. It can help all levels of education learning Immunology i.e. undegrad, grad, and medical students. Definitely helped me as a grad student! Once again, GREAT JOB!
@brcarter1111
@brcarter1111 5 лет назад
The MHC I pathway is also essential to antitumor immunity. Just as the immune system views viral proteins as "non-self", peptides derived from mutated genes are also presented on MHC I and will also be viewed as foreign by T cells.
@danielmaringellipasqui1593
@danielmaringellipasqui1593 3 года назад
Amazing videos like this help us to hav a better notion of how beautiful our Immune System is! Thank you very much for the content!
@user-vu9st6fd7v
@user-vu9st6fd7v Год назад
This is incredibly comprehensive. I got goosebumps after watching it!
@tlskillman
@tlskillman 8 лет назад
Nice work. I understand the MHC process much better now. Thanks.
@noorclark2226
@noorclark2226 7 лет назад
best video about MHC I have ever seen , very helpful
@drmavs
@drmavs 11 лет назад
The best medical animation I've ever seen
@internettee
@internettee 10 лет назад
Best Animation+best narrator, good job!
@jessicachen
@jessicachen 8 лет назад
Thank you so much for the excellent video!!
@zeeshanmansuri3714
@zeeshanmansuri3714 10 лет назад
Brilliant explanation...Hats off!
@Candyvan87
@Candyvan87 10 лет назад
Excellent video, thank you so much!
@theowalcott829
@theowalcott829 6 лет назад
Absolutely fantastic video!
@ansai.2451
@ansai.2451 5 лет назад
This was amazing. Thank you!
@samionita2008
@samionita2008 10 месяцев назад
I wish I could give this video a thousand likes.
@alexanderstrau4135
@alexanderstrau4135 10 лет назад
Absolutely amazing video!
@bryannsalamida680
@bryannsalamida680 11 лет назад
Well presented and helped a lot.
@caenteclaer3177
@caenteclaer3177 Год назад
stunning!
@DrSoda.
@DrSoda. 4 месяца назад
Brilliant. With God, anything is possible. Jesus loves you!
@prathibapremchandhar2747
@prathibapremchandhar2747 3 года назад
Mind blowing work.
@Olgaumed
@Olgaumed 11 лет назад
Very helpful animation!
@deepaksahani2408
@deepaksahani2408 5 лет назад
Presented it very nicely
@torpedomagnet
@torpedomagnet 11 лет назад
Wonderful video, thank you!
@songbird7450
@songbird7450 Год назад
Beautiful animation! Would have loved a mention of ERAAP, but aside from that still a 10/10.
@venkatanarayanaare4386
@venkatanarayanaare4386 4 года назад
Thanks a lot, nice Video
@angelicashalfanitanudireja7142
@angelicashalfanitanudireja7142 3 года назад
thank you so much for this amazing video.. 👍
@poojashinde2563
@poojashinde2563 5 лет назад
Excellent animation
@saivarun7412
@saivarun7412 7 лет назад
great video ,presentation of antigen by mhc1 tomorrow begin cell mediated immunity
@pinkcloud17
@pinkcloud17 11 лет назад
I LEARNED SO MUCH... YOU TOOK ME VERY VERY DEEP
@kanayanfantv
@kanayanfantv 3 года назад
Into the human cell... 😅
@gurralajasmini2139
@gurralajasmini2139 3 года назад
Tq soo much sir.... For this wonderful animation concept
@abrilrestrepolopez250
@abrilrestrepolopez250 9 лет назад
Excelent video! Thank you so much
@cicerochen313
@cicerochen313 Год назад
Awesome.
@Whiteamy
@Whiteamy 9 лет назад
Just perfect . Thanks a lot
@esssssssssssssra
@esssssssssssssra 11 лет назад
very clear explanation, thanks a lot :)
@johnbates2709
@johnbates2709 6 лет назад
This is excellent.
@T-She-Go
@T-She-Go 5 лет назад
That was really good. Thanks
@ybbed019
@ybbed019 10 лет назад
Amazing, thank you!
@dominicduncombe4692
@dominicduncombe4692 10 лет назад
Loved this !
@Saed7630
@Saed7630 6 лет назад
Excellent!
@pfeliciano4062
@pfeliciano4062 4 года назад
WOW! THE WONDERS OF GOD!!!! HE SURELY IS EVEN IN THE SMALLEST OF ALL DETAILS! PERFECTION IS NOT A MISTAKE, IT IS THE PRODUCT OF GODS HAND AND INTELLIGENT MIND.
@wgoulding
@wgoulding 2 года назад
If he's so good then why the f*** are autoimmune diseases and cancer things that exist.
@benardw.wanyonyi5586
@benardw.wanyonyi5586 5 лет назад
Great. nice and price explanation
@kanviaery2542
@kanviaery2542 3 года назад
superb!!
@elissataylor7884
@elissataylor7884 2 года назад
I wish there was the same video for MHC class II assembly and presentation.
@cmslitd10
@cmslitd10 11 лет назад
Three clearly defined loci are recognized within the HLA complex for classⅠHLA antigens. The principal role of the CD4 molecule is to promote interaction of T cells with class ⅡHLA molecules on antigen-presenting cells. The MHC genes expressed in the thymus play crucial role in the selection of the T cell receptor repertoire during maturation ?
@sanchez1508
@sanchez1508 4 года назад
Thanx You saved my ass 👍🏾👍🏾😍😍
@eliselardo1624
@eliselardo1624 4 года назад
thank you!
@joetokki
@joetokki 3 года назад
this is so great
@yazir123
@yazir123 11 лет назад
made so much more sense
@houssambensaad9819
@houssambensaad9819 5 лет назад
Great presentation , thank you . Though I wish to ask why would the peptide loading groove have more affinity to the viral peptide than that of a self-peptide ?
@ivysmoments5262
@ivysmoments5262 5 лет назад
i believe because self peptides do not have the correct conformation and also sometimes the self peptide do not have a chance to be loaded
@mrniceguy4277
@mrniceguy4277 4 года назад
I think they don't have a higher affinity per se because self peptides are loaded as well. Therefore we have the negative selection of CD8 cells in the thymus so we don't have self-reactive CTLs...
@vintusokonkwo5211
@vintusokonkwo5211 8 лет назад
Great video... What software did you use in making it?
@akshatsahai3551
@akshatsahai3551 5 лет назад
How was all this discovered? Anyone who can give a link leading to the answer would be of a great help ! :)
@abdulchakladar3402
@abdulchakladar3402 9 лет назад
NICE VIDEO, THANKS
@stephenleyva9672
@stephenleyva9672 4 года назад
I need these for every concept in immunology these diagrams are exhausting lol
@TheManOfRash
@TheManOfRash 10 лет назад
Great video, found the music made it so dramatic (ha made the revision a bit more exciting)
@joaofred-art
@joaofred-art 11 лет назад
Beautiful. Thanks a lot! :D
@brendanwhite1830
@brendanwhite1830 3 года назад
How are viral peptides different than regular peptides? And also the viral peptide has to have a high affinity?
@nisroonaali5133
@nisroonaali5133 Месяц назад
@immadisarojini2775
@immadisarojini2775 3 года назад
Super
@Daechav
@Daechav 10 лет назад
KEEP MAKIN MORE OF THOSE!!! :P
@spypipi2714
@spypipi2714 3 года назад
@BlackHat0100
@BlackHat0100 8 лет назад
Excelente vídeo! :D
@rmurphy440m
@rmurphy440m 2 года назад
the immune system is some impressive shit!
@benzer2709
@benzer2709 9 лет назад
Thank you
@RehanKhanNISER
@RehanKhanNISER 8 лет назад
We want more such video's. ....Plzzzzzzzzzzzzzzzzzz
@stephaniea1221
@stephaniea1221 4 года назад
love it really helpfulllll!!
@germ2germ
@germ2germ 11 лет назад
beautiful :)
@zoraiaaureadesouzaaraujo8245
@zoraiaaureadesouzaaraujo8245 10 лет назад
Perfeito!!!
@saurabhrkox
@saurabhrkox 9 лет назад
thx all
@Yudin_
@Yudin_ 9 лет назад
ty. nice;)
@COO113
@COO113 9 лет назад
no ERAAP or did i miss that?
@abdallakhabazeh8538
@abdallakhabazeh8538 4 года назад
تم
@amiermunasser3736
@amiermunasser3736 2 года назад
Watching the cytotoxic T cell releasing perforin and killing the cell makes me feel sad for the poor cell
@annapaula3070
@annapaula3070 3 года назад
I´d like to see this video in portuguese :(
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