My Repeat Pregnancy Loss Test Results - part 1

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My abnormal results so far:
🧪Protein S deficiency
🧪Plasminogen activator inhibitor-1 4g/5g polymorphism
🧪MTHFR Heterozygous for C677T
🧪Elevated IgA and No IgE
⁉️ PAI-1 can cause implantation Failure:
📚 Association between plasminogen activator inhibitor 1 gene mutation and different subgroups of recurrent miscarriage and implantation failure
🖋️ Khosravi et al., 2014
🔗 www.ncbi.nlm.nih.gov/pmc/arti...
⁉️ 92% without physical, hormonal or chromosomal cause for miscarriage have thrombophilia:
📚 Recurrent miscarriage syndrome and infertility due to blood coagulation protein/platelet defects: a review and update.
🖋️ Bick et al., 2005
🔗 www.ncbi.nlm.nih.gov/pubmed/15...
⁉️ 78% of women with repeat miscarriage suffer from acquired and/or inherited thrombophilia
📚 Etiology of hypercoagulable state in women with recurrent fetal loss without other causes of miscarriage from Southern Italy: new clinical target for antithrombotic therapy.
🖋️ D'Uva et al., 2008
🔗 www.ncbi.nlm.nih.gov/pubmed/19...
⁉️ Only homozygous and multiple gene mutations are associated with recurrent miscarriage
📚 Multiple thrombophilic gene mutations rather than specific gene mutations are risk factors for recurrent miscarriage.
🖋️ Coulam et al., 2006
🔗 www.ncbi.nlm.nih.gov/pubmed/16...
More about MTHFR:
⁉️ MTHFR C677T mutation causes a 6.3 fold increase in early miscarriage risk
📚 MTHFR C677T and factor V Leiden in recurrent pregnancy loss: a study among an endogamous group in North India.
🖋️ Mukhopadhyay et al., 2009
🔗 www.ncbi.nlm.nih.gov/pubmed/19...
More about PAI-1:
"In summary, this meta-analysis found a positive association between the 4G/5G PAI-1 polymorphism and the increased risk of recurrent miscarriage in Caucasian, African and Asian populations. In addition, effective therapeutic prevention can theoretically be developed by focusing on anticoagulation and improving genetic polymorphism studies in recurrent miscarriages."
📚 PAI-1 and Recurrent Abortion
🖋️ Lara et al., 2018
🔗 pdfs.semanticscholar.org/4d3d...
#RepeatPregnancyLoss

Опубликовано:

22 ноя 2019

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Комментарии : 20

@gillianescudero5292 3 года назад

Thank you for posting this. Knowing that other women are going through this helps me get through this.

@catwmn14 2 года назад

This is absolutely incredible, I think I found my cause! 😭

@brendabenitez7359 2 года назад

You have some will power which is really impressive. You didn’t give up on your miracle. Funny you had all these tests and none worked. What worked for you was when you relaxed and let it be. The mind is a powerful thing!!

@ghaydakh 3 года назад

Thank you so much for this video, I had 2 miscarriage and I'm 24 years old, found out yesterday my PAI-1 is 216 so must start with aspirin and Clexane during pregnancy... so shattered

@laurawilliams1508 3 года назад

I had a number of tests and have been diagnosed with protein S deficiency as well. I now have a virtual appointment with a high risk ob to come up with a plan and my husband will be getting tested soon since I have a live child and he does not.

@KelliMiguez 4 года назад

💖 Thanks so much for watching! Have you had any testing done? Please share if RPL testing gave you any answers.

@cshortee2002 3 года назад

I have had 4 miscarriages and have an appointment with my ob in a week so I can have as many tests as possible. I am asking for all these that you have mentioned. Thank you so much for this information, I hope it helps me get answers. Also have you ever been tested for celiac?

@prince32410 11 месяцев назад

Hoping and wishing it turns well for you. My wife had 4 miscarriages and we did a lot of tests and learnt it’s genetic high lipo protein a that was causing it

@duasohail2015 4 месяца назад

Can your wife concive healty baby ?? And what treatment option for this??

@laurawilliams1508 3 года назад

Ahhhh, we have soo much in common....my doctor told me my protein s deficiency numbers are not too bad so he's not sure that it's the only issue!!!

@laurawilliams1508 3 года назад

I'm sure there's lots that are unknown!!! I've been repeatedly told I'm fine!!!!

@mineidysmancebo1839 Год назад

Hey Kelli, I just happened to be diagnosed with PAI-1 4G/4G homozygous after 2 very early miscarriages. I have been on baby aspirin for a month now. I also have had a hematology consult when I got my results back and to my surprise he said that he doesn’t know what it means besides the description given by the lab. He also said that he can definitely prescribe Lovenox as soon as a get pregnant again. Do you happen to have more information about this gene mutation?

@palacsaigal3233 9 месяцев назад

My results came today and show 4G /4 G as well. Do you have more information on this?

@junesnow4760 2 года назад

I had my first testing done and I had PAI-1 5G/5G homozygous, but that's all they tested me for. I'm getting a full panel on Friday. I've had multiple chemical pregnancies. Is there a way to treat it to help implantation & prevent chemical loss??

@KelliMiguez 2 года назад

From what I understand, if you start the baby aspirin and lovenox earlier (prior to implantation) it is supposed to help.

@junesnow4760 2 года назад

@@KelliMiguez Thank you. I think today is implantation day. I started taking it 3 days ago. Might not be soon enough. But I'm praying!