My Vitamin B3 MEGADOSE Experiment: Health Benefits & Research 

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Started taking 1000mg 3x a day for the last couple weeks. Usually get the flush whenever taken on an empty stomach but oddly really enjoy the flush. The warm and tingling feeling along with a very relaxed state I find satisfying. The biggest benefit I found is the elimination of a mild brain fog I’ve seemed to have for at least several years also a good increase in energy throughout the day. Hopefully the benefits continue over the weeks and months. By far currently my favourite vitamin/supplement.

I take 1000mg of Niacin every night before bed along with Nattokinase and its beyond relaxing the hot tingle feels like a massages and I wake up every morning with a refreshing burst of energy. Plus the combo of the taking the two has my cholesterol levels amazing. #EmbraceTheFlush

I started taking just 100 mg. a day. And I noticed a big difference in my digestion (MUCH BETTER) and I feel better. My mood is enhanced, I sleep better... Man, I wish I knew about this a long 30 years ago. I was just googling " Does vitamin B help with digestion" yesterday and nothing came up. And today I randomly saw this video on RU-vid. THANK YOU THANK YOU THANK YOU!!😃

Great for hair . Blood to the scalp . Builds capillaries. I’ve used it on and off for years. Full stack 63 .

I’ve megadosed NIACIN for years conjunction with sauna use .. I was a gym owner and at the time subscribed to Dirk Pearson and Sandy Shaw’s Life Extension book/course. There was very little information about supplements and the body at the time. It seemed logical to me to use sauna while experiencing the flushing effect from B3. I will now start Using activated charcoal after my B3/sauna sessions..

I've been taking 500 mg of Niacin once a day for 25 years - my doctor recommended it when my cholesterol was over 200. Since taking Niacin my cholesterol has been 175 to 185. I do a low carb diet, so I'm sure that helps too.

It may be a good idea to supplement both glycine and TMG in equal dosages alongside high dose niacin supplementation. Niacin can eventually deplete methyl groups in the liver which 'may' lead to liver issues and feeling more tired and rundown. TMG will replete those methyl groups. I've also heard people like Chris Masterjohn talk about timing the dose of niacin to be taken with meals due to the FFA lowering qualities since you don't want to be eating large carb heavy meals when the FFA rebound takes place. Eating during the FFA rebound may increase blood glucose levels much higher than normal which is where certain high dose niacin users eventually developed diabetes.

I was fatigued during a year. After starting with B3 I got my energy back. I have been taking Niacin with flush 1000mg 3 times a day for 4 years now. My uric acid slowly increase and was elevated. Now I take life extension uric acid control, tart sherry and apple cider vinagre and my uric acid level has a massive dropp and is now in the middle of the good range. I also take B50 metyl and TMG. The uric acid increase is the only side affect I have notice. But now it is no problem.

I was diagnosed with schizophrenia when I was 33, and wanted desperately to come off the antipsychotics. I read some books by Dr Abram Hoffer and started taking 2g of niacin daily. I eventually came off meds but have them on hand in case I feel a psychosis coming on. Though the niacin doesn't prevent or get rid of a psychosis like the meds, it does have a stabilifying effect that would have made my last psychosis much worse if I hadn't been taking my niacin.

I started took niacin because I saw it as one of the ingredients in many energy drinks. But when I got the "flush," I thought it was an allergic reaction (I thought it was a mix of niacin and something like black pepper or chili pepper). So I laid off it for years. I came back to niacin after a bit more research and understanding that the flushing effect was "normal". I've been at 300mg every other day for a few weeks and now at every day. Flushing was pretty strong initially, but now it's completely gone. Also, I was taking "Dual Action Pepcid Complete" with some regularity (3 to 5 times a week), only when acid reflux had occurred. I've noticed I don't need as much when I'm on niacin.

I am here because I got wrongly sent a parcel full of Niacinamide (B3) supplements instead of Pantothenic acid (B5). 2 months ago I was megadosing on B5 as it helped me tremendously with controlling my moderately severe acne. However, this time when I ordered my new batch, I did not read the label properly and continued megadosing on Niacinamide (the packaging was the exact same colour and even the pills looked the same). A week later I started to feel my body was floating, like I was so dizzy all the time. The same night I started to experience symptoms, my blood sugar dropped so low that I couldn't even get up. I was sent to the A&E and was immediately hospitalised. Doctors warned of possible organ failure as my blood count was way too low. They suspect it was caused by a toxic medication and when I got home after being discharged, I saw to my horror what I had been unknowingly taking. So please do your proper research before self supplementing! B3 is poisonous in high levels and I do not recommend taking more than 500mg a day to be safe.

I have taken high dose Niacin, 500 mgs on and off for maybe 17 years, but I generally take it with Magnesium and sometimes NAC w/selenium/molybdenum or some sort of fermented postbiotic/probiotic food formula. I actually enjoy the flush, but I notice it seems to positively impact hair growth/appearance.

I took 1500-2000 mg of B3 daily for at least five years and my HDL was 98, LDL was 73, triglycerides 49 and total cholesterol 181. Doctors have commented that mine was among the highest HDL they’d seen. I stopped taking niacin for a couple of years just out of convenience but I’m starting back up again now.

I have been using 5 g of niacin nightly for cholesterol. My cholesterol is just about perfect. I reduced the overall cholesterol level by 100 points. I cut my triglycerides in half. Elevated my HDL and lowered my LDL. The one effect that has been negative is the bile production caused. I had my gallbladder removed and there are mornings when I wake up and vomit bile in copious amounts. Not the way to start your day! I'm doing some research now to see if it would be better for me to take the niacin during the day with meals versus taking 5 g at once. I don't really have a problem with the flushing because I have trained myself by taking it at night before bed. And over a long period of time several months I increased the dose. I would go for blood work every 3 months and would increase by about a gram each time. The magic number for me is 5 g. I tried backing off to 4 g and my cholesterol numbers were not to my satisfaction. I'd be interested to hear what you have to say.

Niacin clears my brain fog, I consider a nootropic too.

Yup, taking 1500 Mg a day all in one fell swoop. Take Apple juice with it to minimize the “blazing skin”I get. But it is getting better to which I am grateful for I feel better generally when taking it. My last bloodwork was perfect according to Doc. I am hoping it will blow out my circulatory system!

I'm FLOOOSHING!

I like niacin. For sure, i would say it gives me better memory and focus. Overall I feel better as well. Better blood circulation. The only side effect I've had is sometimes I get a sharp pain for about 2 seconds in the stomach region, and then I feel absolutely great with the flush. It's something to try I guess! My dose is 250 mg Niacin when I do take it.

Niacin has helped with my circulation and my gerd. It works (for me) better than any other supplement when it comes to energy. I just finished my 2nd pack of it and will order more. Addicted to the flush at this point

see the recearch of Dr Abraham Hoffer

i find that higher doses of niacinamide (500-1000 mg) work as an insulin memetic, lowering my blood sugar rapidly. great to use right before big sugary meals.

I use it often but not daily, 500mg to 2grams. Have been for past 15 years. It’s good feeling relaxed, it does affect appetite but I use it before a workout or cardio and naturally feel hungry afterwards. It helps the skin aswell. I mainly use it for the relaxing effect on the brain.

Please I need The Flush Niacin and My Local Stores do not Stock this ! What Brand Do You Recomend?! The Flus One Is My Favorite by Far! The Ones With No Flushing Has No Effect on Me ! Please keep sharing spreading love Truth Each New Day Never The Less. 🕊❤️🙏🏻

I eatva ton of niacin rich foods daily, have done for years, along with a generally well balanced ( mostly plant based) diet, but also high fat foods like eggs, cheese and nuts/ seeds etc. At 58 i feel amazing, super fit, strong, healthy, youthful, lean, muscular, have great skin, and look 20 years younger than my actual age.

I think I remember reading that the niacin flush is great for cholesterol but not great for blood glucose. Is this true?

It inhibits nitric oxide? Nitric Oxide is a good thing to have

Last year I had covid and I was taking niacin along with other supplements like, zinc, magnesium, selenium, D3 multi vitamins and minerals. I barely had any symptoms. This year taking the same supplements except niacin and I was sick with covid for a month. Maybe coincidence I don't know but I'm not going to stop taking niacin again 🤔

Isn’t ray peat more of a proponent of Niacinamide not niacin? Give it elevates prostaglandins and serotonin?

due to the flushing effect, I started with a low 50mg dose. I did get the flush, it was very noticeable and I can see why some do not like it. I actually like it. If you take it with a high protein meal, the flushing effect is significantly stronger. For me the dosing effect with a 50mg dose went away after about 45 minutes, so I took another 50mg. Right now I'm to the point where, on an empty stomach I can take 200mg with little to no flushing effect.

I took Niacin which caused a flushing effect for 3 to 4 weeks. As a type 2 diabetic, it increased my sugar levels considerably. I took B3 to manage my cholesterol, however it played havoc with my sugar levels. I don't take insulin so what I consume is how I control it naturally. It took months for my body to re-adjust my sugar levels after years of natural control.

Thanks for the great video. I have read that Niacin blocks DHT. Is this true?

I am experimenting with using the niacin flush as a way to build a tolerance to histamine, stress, and auto-immune related issues. Since there's a short term spike in histamine, adrenaline, cortisol my theory is that the body should learn how to better manage these things and over time learn not to respond with an autoimmune reaction since the body returns back to baseline relatively quickly and realizes everything is fine. I also find it helpful as a way to train how to remain mentally calm during the flush as a way to get better at managing stress, similar to taking cold showers.

Maybe I missed it, but for the sauna protocol do you just take it like 30 minutes before the sauna?

Excellent video I'm looking in to taking b3 to reduce my high cholesterol and found this very informative

I wouldn't recommend mega dosing. It can negatively affect liver function and increase SHBG, which, reduces free testosterone.

What time of the day do you recommend taking Niacin 500mg? Is it better to take it closer to bedtime, or before noon, or early morning?

Inhibits nitric oxide in that list!!!....not raking that!

I have a question: Listed as one of the Biological Actions (3:17) is "inhibits Nitric Oxide". It seems to me that that is not a positive from the stand point of sexual performance. Is this correct? Thanks ahead of time.

I have been on 3 grams per day for several years. My triglyceride/HDL ratio dropped to 0.4. Less than 2.0 is healthy cvd risk. My glucose/ketone ratio also drops to about 0.4 by the 3rd day of fasting (great anti cancer results).

3:18 "inhibits nitric oxide" why would you want to inhibit nitric oxide?

Reduces Serotonin Formation and/or Accelerates it's Elimination ????? Really 👀 I read it can make it ???👀 (Niacin is part of the metabolizing process of forming serotonin from tryptophan)

Nice one, need to keep this favourited to come back to. Guess the noradrenaline doesn't affect me much. I find a niacin flush to be one of the most consistent sleep hacks I've found!

When i started with b3. My stomach started working

I might try it for my brain fog and overall mental health. Il try 500mg to begin with

I have tried on the advice of my Eye Specialist 500mg B3 for a few days. I have now reduced the dose to 1/3rd of the 500mg tablet. With 500mg intake of B3 my blood pressure increased. Now it appears okay. Is this intake (1/3 of 500MG tablet twice daily) any useful?

My friend mega dosed it at lunch and then stood up and fainted cracked his face on the floor first and only time it’s ever happened think that could have caused it ?

yes at 500 mg per day my wives arthritis pain in her knees has disappeared and she is much more mobile

Nothing to add except I have been taking niacin for the flush since 1970 and today, at 84, I am in excellent health except for the arthritis I have developed in all my broken bones

Take 500 mg time release before bed every night.

3:15 - inhibits NO would that contribute to ED ?

Oddly the Niacin I take states 500 mg is the average recommended dose. I take it at bedtime so I sleep through the flush.

I take 2500 every morning, love it! You get used to flush, I enjoy the flush, especially when its cold out.

Please Share all Niacin non Flush Too God Bless You Proverbs 3:5-6 🎉❤️🙏🏻🎉

I'm at 500 mg's of Niacin 3 times per day and I have noticed a reduced appetite. I've started taking it for NAD production and brain health so the appetite reduction and weight loss has been a nice "side effect."

500mg every day for years - I flush maybe only once a week now

I can not use over 10 Mg Niacin.....with 100 Mg i would burn myself to Hell....the Flush comes to my Feets...so i use just 5-10 Mg what is really enough for my red Face🙃

Please Real Facts Solution Feet Calluses! No one Has Real Answers! And True Healthy Water!

I megadosed niacin awhile back and stopped because each time I did it for longer than a week, I developed plantar fasciitis. That was without tmg and I do intend to try again with a source of methyl groups

Nicotinic acid is the best

1000mg dose makes me look 15 years older. It's pretty messed up what it does to my face. I get burning and itching, :(

I have been taking 500mg of niacin a day for the past 4 days , the first flush was alarming , like i had walked through a field of nettles . I was ready for it day 2 and actual quite enjoyed it , day 3 not so much of a flush and today i could barely feel it . I intend to get some activated charcoal to help eliminate the toxins ,

Niacin Vs Niacinimide?

I saw somewhere that for certain things Niacin would be helpful. So. For the first night(last night), Ivwent mad dog max and took the 1.5 g of flush rated. Is in. Now, let me just tell you that in addition to Restless Leg Syndrome my wife was greatly worried because in addition to thrashing about, I was a light sheen of fire engine red. And gadctremendoussskin itching and burning. I looked both sunburned and enraged all at once. Then Handy, great wife looked up that if you drink appke juice and get a 325 g aspirin with it it helps. Plus, I took it on an empty stomach. Tonight not so. Drinking apple juice and took an aspirin, just “wait in’ for the root to kick in”.

I started taking 90mg and worked my way up to 500mg in the morning. I can’t say my mood has improved but it wakes me up. I take it for the NAD precursor benefits. Although NMN may be better according to Dr Sinclair.

I'm looking into b vitamins, and the set where I usually order has b3 500mg, and a vt-b complex where all of 'm have 25mg and some extra added stuff like a bit of choline. Which one would you recommend?

What is the ideal then, add to your daily supp intake by using it after a meal as per your usual multi and minerals... Or at a certain time away from food or under certain specific conditions?

So weird this was posted today. I was not aware of the flushing effects and had 2 episodes of strong flushing. I found that Gingko Biloba enhances the flushing effects.

taking 200mg got a bad flush, now two weeks in same dose low flush, not sure to increase dosage, fasting during day hunger gone as I take niacin in morning

Inhibits nitric oxide? Is this a benefit?

i take 1milligram of niacin every second tuesday

Niacin. Rebound. Sauna. Is the protocol.

Please share I can’t find in local stores pharmacy the flushing niacin? Where to get this Niacin by Name ! What is the Correct Flushing kind Niacin?

1000mg of B3 before a workout is THE BEST! (After a tiny bit of food to line your stomach)

Niacin strips methyl groups so using it supplementally should always be combined with TMG ideally in a 1:1 ratio. High homocysteine among other things can occur from undermethylation.

Sauna? I am thinking about boosting cold showers by going there with a flush :D

I ended up getting a peptic ulcer from taking niacin. I had high hopes for it until I developed the severe pain from it.

Love this thank you for blessing us with knowledge

Would you recommend niacin for pellagra?

It's unfortunate there was no warning that although rare some people may have a prolonged and severe reaction to niacin in a large single dose such as 500 mg. It might be a good idea for those people to have antihistamines on hand

What about nicotinamid instead of niacin? It was said that it helps against the development of glaucoma or, rather, against losing vision field.

I love niacin flush. All the benefits are true except appetite suppression, I experienced increased hunger and extreme need for carbs..

I took 500mg extended release 4 times a day and it did help my cholesterol levels but was starting to hurt my AST/ ALT liver numbers, so I dropped it to 3 times a day and that seems to work ok for me.

500 mg of niacinamide...is that the same as niacin?

Can you get same results whit no flush niacine or do it need to specific that flush?do your blood vessels dilate whit no flush too🤔Thank you.

500mg turns me into a spicy pepper

What could be causing abdominal pain when taking 500mg niacin on empty stomach?

Started yesterday with 100 mg dose out of abundance of caution. No noticeable effects.

Please Share Does it cause Die area?

Hey Lucas, any truth that you need to be careful with niacin dosage if you are also taking black seed oil? Something do do with liver or kidney damage or no? Can you clarify this for me and others

It should be noted that there is a difference between FLUSH and NOT FLUSH Niacin. I used to be able to buy 100mg of Flush Niacin but not it's capped at 35mgand am not sure if it's flush or non flush. What I noticed after the flush was that there was something in my eyes that felt like tiny grains of sand and was told that it was excess cholesterol in my system. Maybe I should try a binder like activated charcoal after flushing like you suggested.

I am currently taking 1500 mg per day, divide that in 3 doses but, I have anxiety issues and would like to up my dose to 3000 mg. A few here and there talk about liver damage which I think is a tactic used by pharma companies to steer people away from using it. Andre Saul talks about treatments with people with severe mental issues and higher doses, I believe from the book of Dr. Hoffer. I just want to be sure that it does not cause any issues to the liver.

First time I took niacin, I mixed it with some other stuff and had an allergic reaction. My skin got hot and red. I just tried it alone after watching this and I got a full body sensation but nothing like last time. Wait a min.. Im heating up. Oh shi

Most of it mouse data - not gospel exactly

Thanks for the great content on an important topic. It would be great if you could go deeper in depth into the protocols for how to take high dose Niacin. Like, what time of day to take, the minimum quantity of carbs needed to take with dose, to reduce liver toxicity, etc. I've been experimenting on myself trying different protocols and getting blood tests to see the results with some mixed success. There is very little info out there on how to structure and time and type of macro nutrient intake. Chris Masterjohn PhD has covered the topic well, but I still think there;s room to distill this down for regular folks like myself, so we can really grasp the concept. Breakdown of what Chris Masterjohhn PhD stated on high hose Niacin: The body is really good at using carbohydrates in the 2 hrs after taking Niacin. (Suppresses Free Fatty Acids > Surpasses release & use of FAT for fuel, it preferentially burns Carbohydrates) The body is really Terrible at using carbohydrates in the 3-6 hours after taking Niacin. After 3 hours there's a huge release of Free fatty acids Huge rebound in Fatty Acids- higher than they would usually be. So... Eat a high carbohydrate (LOW FAT) Meal when you take Niacin, within 1-2 hours. Eating carbs also buffers impact on Liver AND THEN FAST AFTER!!! AVOID Carbohydrates in 3-6 hour window AFTER taking Niacin. AVOID FATs during the 6 hours after taking Niacin. To help support Liver methylation and to reduce risk of harm to liver, take Niacin with: Equal dose TMG (Betaine) 1/2 to 1 equal dose Glycine

I only took about 250 mg’s of niacin, not as much as most people take… My body started to convulse a little bit I thought i was having a heart attack… I’m wondering if this is healthy for everyone… Am I just very deficient?

b6 made me moody lol i know this is b3

Wow if I do 50-100 MG I'm burning up! _ I do 500MG once and hed to get into a cold bath - and I've generally got a high pain threshold (MMA and Stunts)

the flushing effect is HISTAMIN being released from your body. reference- Niacin: "The Real Story: Learn about the Wonderful Healing Properties of Niacin Paperback" i read the whole book. ive taken 1000mg a few days a week for years now and i don't have any problems with cholesterols. and i enjoy the flushing effect its also gotten rid of headaches for me at times. and i feel relaxed and take a nap sometimes when i flush. WARNING when taking 1000mg of niacin on a completely empty stomach you must drink a minimum or 32 oz of water. if you dont you will experience intense pain in your stomach because it also increases the acid level in your stomach acid

Took 500 mg once a day w food, definitely helped with stressor and brought on positive mood, I have irregular heartb n indigestion, after day three it has been pretty smooth, besides occasionally therapy trigger things I've felt immediately better interestingly enough even after first dose ✌️💛