Neurologist reviews St John's Wort TOP BRANDS and EVIDENCE

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This video is NOT SPONSORED, and I have NO affiliate relationships with any brands mentioned. My goal is to offer you a free, unbiased informational resource to aid your understanding of supplements in the often complex and potentially misleading nutraceutical industry.
In this video, I discuss whether there is enough clinical evidence to support St Johns Wort’s effectiveness in the management of depression, anxiety, menopausal symptoms, Obsessive Compulsive Disorder (OCD) (OCD), Attention Deficit Hyperactivity Disorder (ADHD), Somatoform Disorder, and Premenstrual Syndrome/Premenstrual Dysphoric Disorder (PMS/PMDD). I also talk about adverse effects and drug interactions, some of which can be life-threatening. Additionally, I’ll discuss what to look for when researching St John’s Wort brands, and I’ll provide you with a list of several high quality brands that have passed safety and quality testing. Finally, I’ll discuss my own recent experience with St John’s Wort and also discuss the brand that I personally use.
Disclaimer:
This video is provided as an informational resource only, and does not create a patient-physician relationship. This video does not constitute medical advice and is not an alternative to medical advice from your physician. Please speak with your physician before starting any supplement.
This video does NOT represent a recommendation for any products. The brand info in this video is up to date as of December, 2023 (any data beyond this date is not reflected in this video).
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References:
pubmed.ncbi.nlm.nih.gov/9342774/
www.jillcarnahan.com/2018/02/...
pubmed.ncbi.nlm.nih.gov/15492...
pubmed.ncbi.nlm.nih.gov/17704...
pubmed.ncbi.nlm.nih.gov/12808...
www.ncbi.nlm.nih.gov/pmc/arti...
pubmed.ncbi.nlm.nih.gov/15846...
pubmed.ncbi.nlm.nih.gov/9878826/
www.thieme-connect.com/produc...
pubmed.ncbi.nlm.nih.gov/12053...
Depression:
www.bmj.com/content/330/7490/...
pubmed.ncbi.nlm.nih.gov/18843...
www.ncbi.nlm.nih.gov/pmc/arti...
pubmed.ncbi.nlm.nih.gov/28064...
pubmed.ncbi.nlm.nih.gov/36226...
systematicreviewsjournal.biom...
Anxiety:
www.medigraphic.com/cgi-bin/n...
journals.sagepub.com/doi/10.1...
onlinelibrary.wiley.com/doi/e...
www.ncbi.nlm.nih.gov/pmc/arti...
Menopausal symptoms
pubmed.ncbi.nlm.nih.gov/16449... (menopausal symptoms + depression)
ncbi.nlm.nih.gov/pmc/articles...
pubmed.ncbi.nlm.nih.gov/31331...
pubmed.ncbi.nlm.nih.gov/17630...
pubmed.ncbi.nlm.nih.gov/10623...
pubmed.ncbi.nlm.nih.gov/24188...
pubmed.ncbi.nlm.nih.gov/19194...
pubmed.ncbi.nlm.nih.gov/20216...
ADHD
pubmed.ncbi.nlm.nih.gov/18544...
Somatiform disorder
pubmed.ncbi.nlm.nih.gov/12424...
pubmed.ncbi.nlm.nih.gov/15272...
OCD
pubmed.ncbi.nlm.nih.gov/10982...
pubmed.ncbi.nlm.nih.gov/16192...
PMS/PMDD
www.ncbi.nlm.nih.gov/pmc/arti...
pubmed.ncbi.nlm.nih.gov/21315...
journals.lww.com/adhb/fulltex...
Photo references:
Serotonin syndrome - commons.wikimedia.org/wiki/Fi...
Luteal Phase - commons.wikimedia.org/wiki/Fi...

Опубликовано:

21 дек 2023

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Комментарии : 65

@rossb4802 5 месяцев назад

We found that St Johns Wort had a profoundly postive effect on my 86 year old father's Sundowner symptom. When we stopped giving it to him, he suddenly developed severe Sundowners. We started it again and they disappeared. We stopped once more and the Sundowners returned and cleared up when added back in. It could not have been a placebo effect because he did not know it had been removed or added.

@marybusch6182 4 месяца назад

Thank you so much for that comment! I have decided to use it for interrupted sleep. I had purchased melatonin with hops and something else at the pharmacy in Vienna, but it didn't help at all. Also I previous used it when taking tamoxifen and my radiologist thought my affect was great as opposed to others..

@rossb4802 3 месяца назад

I would add that it is very potent and the interactions are real. @marybusch6182

@ja5304 6 месяцев назад

I love this series and the information you provide. Looking forward to seeing more, especially on supplements: choline inositol, pregnenolone, DHEA, L-tyrosine, 5-htp & CoQ10.

@dianatobarlozano 8 дней назад

Wow! Thanks for all your hard work on this research and for sharing it with us!

@janetpage246 5 месяцев назад

Very helpful to be able to get this information in a well presented format. Thank you, and pls keep up the good work!

@mrsmc2612 6 месяцев назад

Great video! Best one I have seen on the subject!

@davidchase5345 3 месяца назад

Well made and researched, thank you for such an informative video!

@onyekaabasiri5100 6 месяцев назад

I loved this video. I just finished my first semester of medical school and we talked about St. John’s wort and it’s effect on the CYP450 system! It was so cool to actually understand and follow that part of the video!

@theresaprior993 5 месяцев назад

Super helpful and well researched. Thank you!

@sixthmanU 6 месяцев назад

Very informative, thank you for this!

@sheylabvlima 2 месяца назад

Thank you for the valuable video. I am taking St. John's Wort prescribed by my Naturopathic Doctor. At the beginning, she asked me to take it twice a day; however, two days later, I had the worst headache ever. So I went to the pharmacist, and she asked me to stop the medication. I felt better after... BUT I didn't give up yet. Now, instead of taking it twice a day, I take it once during the night, but not every day.

@ahmedalfi8487 Месяц назад

Very inormative, organized and well presented ... Thank you

@marksanders8095 6 месяцев назад

Wonderful information good job!!!

@michaelsharpe4217 6 месяцев назад

St. John's wort can also make the skin overly sensitive to sunlight. If you take St. John's wort , use sunscreen.

@g54b95 6 месяцев назад

I was going to mention this as I have heard this many times before.

@marybusch6182 4 месяца назад

Thank you! excellent information!

@TimeStampHero 3 месяца назад

Don't ever use sunscreen. You're fixing one issue and creating another

@loveleenmeyers6437 2 месяца назад

Very informative and helpful video

@uhhohstinkyy_ 5 месяцев назад

Thank you for covering this topic. Would you be able to make a video on how pairing St Johns Wort with other supplements would affect the brain? For example, pairing it with something like L-theanine?

@DaDansinBear 6 месяцев назад

Excellent video with great information. Thank you for sharing this information. There’s far too many people on RU-vid, recommending drugs that have no background in medicine. Those are some scary videos on RU-vid.

@pianomusic5283 6 месяцев назад

I love your Reviews, can you review Rhodiola please thank you.

@toddwilliams4493 14 дней назад

Thank you for so graciously sharing your knowledge! ... how is St. John's as opposed to Sam E?

@maxnine57 6 месяцев назад

Merry Christmas 🎄

@rossb4802 5 месяцев назад

Is there a pdf to download with the lists you gave? I appreciate the thorough reference list.

@aestheticnursingservices3514 3 месяца назад

Vey good summary

@tuanvicta 3 месяца назад

Hi love ur content.. i just use st john worth, when is the best to reduce the dosage or stop use it ?

@genevievehawkins9856 27 дней назад

1:22 it was amazing for me for postpartum. I don't still take it.

@ourdaysgoby 4 месяца назад

Tks for great info. But i cant decide st John or ashwagandha is better for me. Can you do a video compare those 2? A lot of misleading info on the internet on those 2

@whatszup1206 6 месяцев назад

@Anna - what do you think about Psychedelics as a treatment for depression and anxiety etc? This seems to be the next revolution in psychiatric treatment. what are your thoughts on this? The results and trials seem to be promising.

@marybusch6182 4 месяца назад

Well let me tell you my experience with hallucinogens, and I don't like it... until the processing is formulated to be something safe, I wouldn't touch psychedelics with a 10 foot pole... I think I took LSD and saw the gable on the house across the street spinning and when I had dilaudid, I saw three of everything. I did take St Johns Wort when I was taking Tamoxifen for LCIS. Im pretty sure it was sporadic and it moves a mood disfunction from a 3 to a 2... it never made me energetic like a good cup of coffee does..

@kenhaze5230 Месяц назад

Wikipedia cites a journal article giving the IC50 of hyperforin for the GABA transporter as 184 nm, as an inhibitor, so St. John's wort apparently has equivocal effects on GABAergic transmission.

@user-vc5wl7uq2x 5 месяцев назад

Is it possible to take Saint John’s Wort + GABA before bed time?

@annmarieoliverie7526 5 месяцев назад

What’s best time to take for depression

@Khai-Tri 6 месяцев назад

Please do a video on iodine and a video on boron.

@inatorquoisemood93 6 месяцев назад

A lot of people report a positive experience after using it, but it's not for everyone. I wonder can it be combined with another herb to reduce anxiety... I heard it combines well with Valerian but I would need to research that. I ordered a 3 month supply of Natures Way (premium extract) Thank you for your review.

@marybusch6182 4 месяца назад

I have had valerian a few times to assist with my sleep and have not been aware of any mood impact. I am planning on taking St Johns for my sleep disorder, (interrupted sleep) that is why I watched this video and am reading the comments..

@hollywoodwear123 3 месяца назад

Is it ok to take long term? Thanks

@kareemahmed7028 6 месяцев назад

Hello, Doctor.. When encountering people or standing on stage, I feel anxiety, trembling, increased heart rate, excessive sweating.. When I use propanol, tremors disappear and I feel much better, but I suffer from asthma, and propanol has negatively affected the health of my lungs.. Is there an alternative treatment for beta-blockers?Is St. John's wort considered an alternative to beta-blockers if it has the same effect as beta-blockers

@marybusch6182 4 месяца назад

are you taking a therapeutic dose of Vitamin D and by that I mean enough to get your level to 75? My husband and I both take that amount and I believe it helps with the Seasonal Affective Disorder (we all know we are supposed to hibernate, but most of us dont even get enough sleep anyway)..

@-7070 5 месяцев назад

Unfortunately for me, I was drinking Saint johns wort in the form of tea (not in supplemental form, raw whole herb) and it gave me headaches and my eyes became very sensitive for light adding to the headaches, tho no changes in mood I also noticed the day after it would cause a teenage level increase in appetite 😅 but I haven't heard anyone else have that

@billr8829 3 месяца назад

I need a neurologist so badly. My life has stoped. I’ve spent all my money and now I have to wait for Ontario drs to speed up.

@Paul-hu1ht 2 дня назад

Yeah I think a lack of studies does not = not effective (for things like OCD/ADHD etc) - these are disorders with quite specific neurotransmitter deficiencies/problems and we know why there are a lack of studies in this area (because the industry has monopoly on medications for these disorders). We know that Dopamine/Norepinephrine/Epinephrine issues are especially linked in ADHD along with COMT, MAO's, receptors and reuptake transporters. St Johns Wort is known to act as a reuptake inhibitor for all neurotransmitters, once you realise that, you can start to address the fundamental issues behind ADHD, for example dopamine > norepinephrine > epinephrine conversion issues. (TH > DDC > DBH > PNMT).

@28bull 6 месяцев назад

It grows on my farm. If I dry the aerial plant and powder it how much is a good dose for a 60 yo 250# man?

@lauramcknight2321 6 месяцев назад

You can't control the dose of the active ingredient of herbal medicine as different plant contain different amounts. That's why typical drugs are easier because they can control the dose.

@TelevisionJohnson 5 месяцев назад

300 mg three times per day for mild depression and five times per day for moderate depression. It is about 50% effective for moderate depression, but 50% is a lot better than zero.

@marybusch6182 4 месяца назад

You can always titrate it in tea... by that I mean in the morning before anything else, take a cup of tea with a.teeny teeny bit.... or just lick a teeny bit off a finger.. I just dont know how strong it will be... I have a kitchen scale that measures grams which is one fifth of a teaspoon, but think about it, drugs and spices are powerful, so by making tea you are making a dilution, so that would be an even smaller dose... So lets say you put a gram in a cuppa 10 ounces, then 1 oz of tea is 1/10 of that gram.... Heck, I dont think I would do it because it might be too risky. First thing I would do is purchase a supplement and try that out for impact on your body... If you have any kind of adverse reaction, then you are not going to pursue this further... Interesting thought...

@hungryplant3849 6 месяцев назад

I love the science of it, but I also like to think of it as liquid sunshine, as if those golden petals have somehow captured a bit of the suns essence. Its funny but the science kind of agrees with this.

@Fred-zt5ky 3 месяца назад

I used it for six months straight trying to cure my mild depression but it did nothing. I really didn’t notice any difference, whether positive or negative. No side effects either. Very unfortunate as I was really hoping it would help me.

@neurogalmd 3 месяца назад

Thank you for sharing your experience with SJW! I'm sorry to hear that it didn't provide the relief you were hoping for. Everyone's journey with managing depression is unique, and it can take time to find the right approach that works for you. I hope you find something that works for you.

@jagodagrabowska6540 5 месяцев назад

Wielka szkoda że nie ma chociażby napisów w języku polskim. Na pewno wartościowy film, zorientowałam się po ilustracjach. Gratuluję

@BM-hb2mr 6 месяцев назад

I love your videos Could ypu possibly do a video on Kratom? It does something to the brain and with physical help with pain. For me i want to let everyone know this is just from my perspective. It seems to work for my back pain and it stimulates my mind for energy Ive been on ot for quite some time now and it seems to work and ota much much better than being on some pharmaceutical Ita not fda approved but we all know why anyway ive done as much research as i could and of course tested it for many years thanks , Have an awesome Christmas happy birthday Jesus

@marybusch6182 4 месяца назад

that is so interesting because we have back issues sometimes... I just want to say that if you can purchase it from the EU, I think they actually monitor the supplements better than we do, at least in France and probably /germany etc...

@KaizerRemix Месяц назад

St Johns Wort: just fucking don't if you're on other medications. It interacts with near damn everything.

@BossInVegas 6 месяцев назад

i have anxiety, which is mostly financially driven, but you can take all the supplements you want in the world but it really comes down to staying busy and having a hopeful future and not a fearful future, when you start thinking about the good things to come, and eating healthy (carnivore based diet with minimal carbs) - so alot of it is mindset & diet. That has worked the best with my symptoms (gut inflamation, etc). All the gabapentin, dicyclomine, hydroxyzine, and all the other meds the doc throws at me i fully believe are destroying my brain - and i only take them when i have bad flareups and have no other option because YES they do make you feel like a Zombie.

@michaelsharpe4217 6 месяцев назад

I tried St John's Wort for 30 days - no effect,.Nothing! - Later I got a prescription for paroxitine 40 mg, which I have been on for 15 years.

@MrsBalfour2U 6 месяцев назад

You probably needed a higher dose. It takes the edge off for sure

@TelevisionJohnson 5 месяцев назад

Some brands have zero effect, others a lot more. It is pretty weak overall. I'm guessing about 50% effective for moderate depression. It's a good starting point to add 5-HTP, methylfolate, methylcobalamin, NAC, and tyrosine, etc.