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Neuromuscular blocking agents are among the most commonly used drugs during general anaesthesia. They compete with acetylcholine and interfere with the transmission of nerve impulses resulting in skeletal muscle relaxation. Based on their mechanism of action, neuromuscular blocking agents are classified as either depolarizing or nondepolarizing. Succinylcholine is a short-acting depolarizing agent. Commonly used nondepolarizing agents are curare (long-acting), pancuronium (long-acting), atracurium (intermediate-acting), and vecuronium (intermediate-acting). Neuromuscular blocking agents are used clinically to facilitate endotracheal intubation and to provide skeletal muscle relaxation during surgery.
Classification- Non-depolarizing blocking agents: These agents constitute the majority of the clinically relevant neuromuscular blockers.
Depolarizing blocking agents: These agents act by depolarizing the sarcolemma of the skeletal muscle fibre. This persistent depolarization makes the muscle fibre resistant to further stimulation by ACh.
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21 апр 2019
