Neurotransmitters of the human body

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This is a overview of some common neurotransmitters found in the human body.
I created this presentation with Google Slides.
Image were created or taken from Wikimedia Commons
I created this video with the RU-vid Video Editor.
ADDITIONAL TAGS:
Neurotransmitters
An introduction to chemicals that transmit information across the body, their functions, and their receptors
Acetylcholine
Serotonin
Dopamine
Norepinephrine
Glutamate
GABA
Glycine
Amino acids
Monoamines
Catecholamines
Acetylcholine (ACh)
Acetylcholine
Serotonin
Dopamine
Norepinephrine
Glutamate
GABA
Glycine
Found in:
Motor neurons
Brain: basal ganglia and nucleus basalis of Meynert
Autonomic nervous system (ANS)
Sympathetic (ganglion neurotransmitter)
Parasympathetic (both ganglion and final product)
Used in treatment of:
Alzheimerâ€™s disease
Dementia
Receptors:
Ionotropic â†’ nicotinic receptors, excitatory
Metabotropic â†’ muscarinic receptors, excitatory or inhibitory
Serotonin (5-HT)
Acetylcholine
Serotonin
Dopamine
Norepinephrine
Glutamate
GABA
Glycine
Found in:
Brain and brainstem
Pineal gland
Raphe nuclei in the pons
Limbic function (emotions/mood, hunger, sex, instincts, temperature) sleep
Used in treatment of:
Depression
Sleep regulation
Receptors:
Ionotropic â†’ 5-HT3 receptor, excitatory
Metabotropic â†’ 5-HT1-7 receptors, excitatory or inhibitory
Dopamine
Acetylcholine
Serotonin
Dopamine
Norepinephrine
Glutamate
GABA
Glycine
Found in:
Brain and brainstem
Substantia nigra (reward, addiction, movement)
Hypothalamus (inhibits prolactin release)
Used in treatment of:
Schizophrenia, psychosis
Parkinsonâ€™s disease
Receptors:
Ionotropic â†’ none
Metabotropic
D1 â†’ excitatory (K+/Ca2+)
D2 â†’ inhibitory (K+/Ca2+)
Norepinephrine
Acetylcholine
Serotonin
Dopamine
Norepinephrine
Glutamate
GABA
Glycine
Found in:
Brain: Locus ceruleus, projecting to cortex, for arousal, attention, and anxiety
ANS: sympathetic neurons (final product, postganglionic neurons)
Used in treatment of:
ADHD
Anxiety
Cardiac failure
Receptors:
Ionotropic â†’ none
Metabotropic
Î±1 and Î²1 are excitatory
Î±2 and Î²2 are inhibitory
Glutamate
Acetylcholine
Serotonin
Dopamine
Norepinephrine
Glutamate
GABA
Glycine
Found everywhere in CNS:
Excites the cerebral cortex, spinal cord, brainstem, hippocampus, cerebellum
Used in treatment of:
Amyotrophic lateral sclerosis (ALS), Lou Gehrig's disease
Excites motor, sensory, and cognitive neurons
Receptors (all excitatory):
Ionotropic
NMDA receptor
AMPA receptor
Kainate receptor
Metabotropic
gamma-Aminobutyric acid
Acetylcholine
Serotonin
Dopamine
Norepinephrine
Glutamate
GABA
Glycine
Found everywhere in CNS:
Inhibits the cerebral cortex, spinal cord, brainstem, hippocampus, cerebellum, basal ganglia
Predominately found in interneurons
Used in treatment of:
Anxiety and rehab for drug abuse
Inhibits motor, sensory, and cognitive neurons â†’ sedation, muscular/cardiorespiratory relaxation, inhibits pain/reflexes
Receptors (all inhibitory):
Ionotropic
GABAA receptor â†’ Cl- channel (ligand-gated)
Metabotropic
GABAB receptor â†’ decrease cAMP and increase K channels
Glycine
Acetylcholine
Serotonin
Dopamine
Norepinephrine
Glutamate
GABA
Glycine
Found in the spinal cord:
Inhibits spinal cord interneurons
Used in treatment of:
Spasticity
Receptors (all inhibitory):
Ionotropic
Cl- channel

Опубликовано:

12 ноя 2015

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Комментарии : 101

@TinaWu 3 года назад

Awesome video. Very informative and helpful. Thank you for making it easy to understand

@gayathrishylesh4471 6 лет назад

The lecture omits to inform how these NTs work in the NE cells of the Gut and its effect or relationship on the brain.This is an important factor.

@essewaxegard9423 2 года назад

Psychology test on the biological approach later today and this is exactly what I needed

@natnaelmerk8445 5 лет назад

FYI Cl is chlorine. If it was calcium, it would have been excitatory not inhibitory

@jenny.8915 4 года назад

If its Cl then it means its inhibitory and if its Ca it means its excitatory . Am i right??

@xxaidanxxsniperz6404 4 года назад

@@jenny.8915 no those have different functions. Calcium is used to bind the synaptic vesicles to the pre synaptic neurons membrane. This releases neurotransmitters that could either be excitatory or inhibitory depending on the part of the brain it is released. Chlorines function is less clear but it does have an affect on the excitation of a neuron. Chlorine is most likely inhibitory alongside potassium. Calcium has less of a function on the action potential and more on the neurotransmission of signals across neurons. Sodium is excitatory.

@joecaz Год назад

He just misread his Cl- as Calcium in the last 2 slides. It's Chloride. Great summary!

@sparklelight 5 лет назад

Thanks for this informative sharing

@spidey5281 4 месяца назад

beautiful video so informative and well paced

@faithnduta866 2 года назад

You have a beautiful voice!

@300Moritz 6 лет назад

thank you

@julesjgreig 3 года назад

Very good, thank you

@Mr.Sp0cK 4 года назад

What do you know about the impact of the neurotransmitters on an HSP ?

@mercurious6699 Год назад

fascinating, thank you

@pennwoman Год назад

Very very good.

@Mjayy_onyekwere 10 месяцев назад

Thank you

@edmarlabor4087 3 года назад

I learned a lot more reading the comments. HAHAHA

@user-rp2ui8ro4r 7 месяцев назад

Same…

@chienn77 8 лет назад

For the GABA and glycine you say Calcium channels, but use the abbreviation Cl-. Do you mean Chloride channels?

@twofingersmakes71 8 лет назад

+chienn77 That would make sense, because Chloride would cause hyper-polarization and decrease the likelihood of an action-potential (resulting, I would assume, in less neural activity and, hence, sedation.) Calcium would do the opposite.

@ProfShibe Год назад

Yeah he meant Chloride. If GABA released Calcium we’d all seize up and die lmao

@aurora09baby Год назад

@@ProfShibe lol

@Tvtcrvtvgcrvrvrv-ce5lx 4 месяца назад

Very important topics

@HitmanR97 5 месяцев назад

Nice video brother

@seyoumalemu357 4 года назад

B2 is stimulatory (Gs)

@thegloryumoh 2 года назад

It was really helpful

@medexams1463 2 года назад

Hi if you're a medical student how can I contact you??I'm releasing USMLE question and answer books in amazon tomorrow for every part of medicine and I need some reviews and some help

@Voyager602 3 года назад

that is what ı was searching for

@rishabhvaishnav5109 6 лет назад

That was chloride channel.. If calcium channel opens than it will show excitatory effect

@muskduh 3 года назад

thanks

@Nickael7 7 лет назад

What about the peptides like vasopressin, somatostatin...

@p1kto 6 лет назад

hormones not NTs

@dalalm1821 6 лет назад

10:36-10:45 absence seizure

@pginaeemidris2069 4 года назад

lol?

@francoisr4036 3 года назад

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@santicruz4012 3 года назад

Doesn't the D2 receptor causes Chloride ion channels to open to make the cell more negative, thus inhibitting it?

@iQmliAwyrMRyPWfV 4 месяца назад

Can u elab?

@blueshade26 8 лет назад

Wait wait so at 4:00 you are saying depression is treated with serotonin? I.e. you administer serotonin? I'm pretty the standard treatment is with SSRIs, which inhibit the reuptake of serotonin, not direct administration of the serotonin itself.

@OwenWithAHammer 8 лет назад

I think he meant that drugs that affect 5-HT are used to treat depression. Inhibiting the reuptake of 5-HT allows for more to be in the synaptic cleft at all times, meaning that in a way the depression is being treated with more serotonin.

@blueshade26 8 лет назад

thanks!

@RebelRager88 6 лет назад

Tyler Schmidt these psych meds do jack shit and actually screw u up more. Notice what you’re saying, THEY INHIBIT THE REUPTAKE PROCESS. It’s hypothesis is this will make more serotonin roam in the brain which is false. It kills off neurotransmitters because it no longer has anything to transmit at the synapse. This is why they say there’s a need to increase the dosage. That’s because the body and brain no longer supplement it and the medicine is. What happens then? You poop out. You end up destroying neurotransmitters and reducing the amount you originally had. These meds are evil and they’re being taught from big pharma they’re not doing these functions which is outrageous.

@KiloTray 6 лет назад

Serotonin really makes my depression an anxiety worst don't believe the hype

@Byrial 6 лет назад

How do you know its high serotonin that causes your depression?

@Byrial 6 лет назад

By supplemental dopamin you mean the amino acid L-dopa?

@Byrial 6 лет назад

refering to treatment of Parkinsons

@nickjohn2051 5 лет назад

@@Byrial Yes.

@jenny.8915 4 года назад

Calcium is Ca why its written as Cl ??

@jailenebaby 4 года назад

Because Cl- is chlorine

@Bender2045 3 года назад

Glycine, did the sound just go out?

@l9878 6 лет назад

Norepinephrine worsens anxiety. One medication bupropion that works on NE and Dopamine for depression can worsen anxiety.

@KiloTray 6 лет назад

Kay true I think norepinephrine is actually the cause of anxiety

@daltonboehm9539 5 лет назад

It dependent on the type of anxiety. Rarely social anxiety has a small benifet

@ShardulIyer 4 года назад

Irregularities in norepinephrine levels or a quick raise will induce anxiety but not cause it. Anxiety is a stress response & norepinephrine alone, isn't responsible for it. As for bupropion/wellbutrin - that's an NMDA, which simply means that it not only affects dopamine, norepinephrine but acetylcholine & some other neurotransmitters based off regions being targeted. Lastly, irregularities in levels of one or more neurotransmitters will cause anxiety/depression symptoms as a response by brain trying to balance itself.

@MetatroN197924 4 года назад

@@ShardulIyer I read your comments and i find your knowledge about brain chemistry amazing,when you say the brain trying to balance it self but the impact will be the individual to feel the side effects of homeostasis like depression and anxiety.I wondered if the brain try to rebalance it self why some many people cannot feel happy after quiting drugs,how many years need it for brain to work again as it should be.Could be other factors play role on mental illness like neurosteroids.I bring the neurosteroids on the spot cause in the past i had a terrible experience with a 5a reductase inhibitor that altered my production of neurosteroids like pregnenolone

@ShardulIyer 4 года назад

@@MetatroN197924 it largely differs from person to person due to individual neurology thus hard to predict, especially over such comments. Again, i am not a medical professional but a research scientist so it will be reckless to suggest something that I am not familiar with. As much as I know, while the brain strives for homeostasis much like the body - the brain has regenerative limitations despite the fascinating nature of neuroplasticity which again is very much dependent upon site. Regarding the reaction you mentioned - it might have a link since compounds interacting with hormones can leave a lasting effect on production & thus cause variety of effects including desirable ones & side-effects as well. I can't say much & maybe an endocrinologist, neurology specialist might assist better.

@lanajovic6259 4 года назад

Hey, im really scared that my neurons are damaged, can anxiety cause long term damaged neurons? Or they can recover?

@elijahgesu1145 4 года назад

ru-vid.com

@elijahgesu1145 4 года назад

maybe this channel wil help

@ethankrown 2 года назад

You forgot about the opioid receptors

@melanieg.9283 3 года назад

How can Glutamate be reduced?

@texaspatriot9159 2 года назад

Taking l glutamine,zinc,tuarine and p5p together

@user-lh1yr7rc7n Год назад

Awesome video! However I heard Ca channel in the glycine receptor, but in the presentation, it was shown as Cl channel. what does it mean?

@arturomauriciobautistaroma5694 11 месяцев назад

I guess is Cl channel, because is inhibitory

@shrutisingh9932 4 года назад

1k likes reached

@manivannankannaiyan5420 2 года назад

Which is responsible for pain

@muhammadsulaiman6023 5 лет назад

What are Neuromodulator??????

@johndoeble 6 месяцев назад

My brain is lacking all of these

@KeepPrayingCA 8 лет назад

thought serotonin receptors were recently found in the digestive tract?

@nickjohn2051 7 лет назад

Haley Andreotti Yes that correct

@kaustubhsangale9027 3 года назад

@arron frederick hey brother in how many months sero and dopa balance naturally

@Joeythegoats Год назад

Damnnn

@lightbeingpontifex 2 года назад

How can I give myself schizophrenia,,, and how can I inhibit norepinephrine,,,

@carmen_13 2 года назад

Schizophrenia is hereditary. You can't get it unless your parents carry the genes.

@almaalvarado9606 2 года назад

Why would u want that for yourself like so curious 😂🤨

@lightbeingpontifex 2 года назад

@@almaalvarado9606 to boost perception,,, can you see or talk to ghosts gods or demons in normal perception? no you can't,,,

@libertarianact7655 2 года назад

Norepinephrine is not used for adhd, dopamine reuptake inhibitors are tho

@kenhaze5230 Год назад

So are NRIs, like atomoxetine.

@everythingissalad2969 Месяц назад

Snris

@Byrial 6 лет назад

K= potassium?

@Danheim641 5 лет назад

No K = kalium Kalium = pottasium

@sathidevi6657 3 года назад

Yes,K is pottasium

@bradanderson7978 Год назад

I think you messed up right at the end of this video

@jainendracheema9029 3 года назад

not clear

@jainendracheema9029 3 года назад

stephen stahl

@KiloTray 6 лет назад

This guy don't know what his teaching norepinephrine don't help anxiety it actually causes anxiety

@ShardulIyer 4 года назад

No, it doesn't. Norepinephrine may influence cortisol but there are plenty of other factors associated with norepinephrine-seratonin interactions or even dopamine-norepinephrine interactions, which is why atomoxetine fails as an NRI antidepressant but excels as adhd medication. However, it's so complex to simply state that whether norepinephrine, seratonin, dopamine, acetylcholine, gaba irregularities are causing anxiety which itself varies over a spectrum. Not to mention, norepinephrine helps in extreme cases where someone with chronic anxiety, will exhibit excess norepinephrine thus an overactive sympathic nervous system that is interestingly calmed down by low uptake of norepinephrine & regulation of it, instead of irregularities of levels which is what gives that feeling of anxiety and not the other way around.

@xxaidanxxsniperz6404 4 года назад

@@ShardulIyer that is because of homeostasis, works in some case and in others makes anxiety worse. The excess norepinephrine inhibits further release of norepinephrine preventing an emotional cascade. Not all norepinephrine increasing drugs work the same way, some modulate how norepinephrine works in the brain, reducing symptoms.

@ShardulIyer 4 года назад

@@xxaidanxxsniperz6404 isn't that why I mentioned to the original commenter that we can't simply assume that norepinephrine drugs work at same level & each patient also exhibit different results though atleast a baseline can be maintained for some, allowing for treatment options. Plus the modulating ones are the ones we call RUI/re-uptake inhibitiors as you correctly mentioned that not all create new norepinephrine but help regulate the compromised flow as with chronic conditions and homeostasis factors. Even partial agonist & complete agnoist behaviour have varying results leading me to state how you can't generically state that norepinephrine causes anxiety without knowing a person's history.

@xxaidanxxsniperz6404 4 года назад

@@ShardulIyer you seem to know a lot about about neurochemistry, mind if I ask you how mirtazapine affects the metabolism of vyvanse? I have ADHD and barely used stimulants, in the past 20 mg of vyvanse would last 7-8 hours but with mirtazapine the effects only last 4 hours. My theory is that the rise in serum triglycerides adds to the metabolization of LDX, alongside its effects on some enzymes mechanics. It seems contradictory as mirtazapine increases norepinephrine and serotonin by binding to A2 receptors. I'm going to see if there is a difference if I take my mirtazapine after the effects of the vyvanse fully wear off instead of in the morning at 30 mg. 15 mg at night.

@ShardulIyer 4 года назад

@@xxaidanxxsniperz6404 Hi, i am a research scientist by profession so will be reckless on my part to comment on your case. Having said that, I also strongly suggest not to share your dosage online - either on comments like these or even social media forums - this is bcoz you just dunno who you are talking to & any advice may result in personal damage. Now, without getting into complex interactions or neuro chemistry - i can however comment on how these two are cross-reacting with each-other. Vyvanse uses your metabolic rate which again depends upon your circardian rhythm, norepinephrine levels, etc. Now, once you do take mirtazapane - it starts to mess around these factors so while you still have Vyvanse compounds within you, they start to compete with mirtazapane compounds which each individually have respective affinity - the part where I mentioned agnoist behaviour. Due to this, mirtazapane might start slowing your metabolic rate, much like how melatonin at night - will potentially numb the impact of norepinephrine dependent medication & even substances like nicotine, caffeine. Therefore, I highly suggest to consult with your doctor about timing of these medication, to avoid such cross-reactions. Rest, i can't comment much as i am not qualified to medical diagnose/counslt as such. Hope this helped.