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I’ve been taking it every day for several years and I feel better now than before I started taking it. When I run out, my energy levels go down so I’ll take the risk.
Good to know...saves me a lot of money. Wouldn't nmn have the same effect?...yeah...I'll run right out to ask my doc if I should be taking nr or nmn as an Nad booster....and watch while his mouth drops open and he looks at me with total incomprehension. The last time docs thought about glycolosis, the Krebs cycle, and the electron transport chain was in college biology...unless they be mitochondrial experts and they don't hang out a shingle. They are buried in research labs far from the light of day. Ask your doctor...what a ridiculous disclaimer.
Smoking increases cancer risk exponentially and people still smoke and smoking has no benefit to humans what so ever. Not to mention many other health ailments from smoking like COPD. Here we have a molecule that has many benefits and 1 study says it may increase 1 particular type of cancer risk in 1 subset of the population. In the end with anything in life one has to weigh the risks and benefits and make a decision. Just my 2 cents.
NR and NMN make NAD+ which is the cell's energy source, Cancer is at its core a cell, it makes sense then that more energy to those cancer cells would benefit the cancer cells. The real question is does it have a more positive effect or negative effect on all cells
Ohh Really Like to know🤯 Cause scary news. Stopped this am after Listening to Vince of course, I'm not that much brave to continue but maybe 3 days a week 200 mg continue to take. So unhappy with this news around and went viral now. Came to me a couple of times as well and was not easy to absorb quickly. But I was just going to take my NMN when saw Vince's video. Coming from him made me think twice. Cause I trust him, Looking forward to hearing more & see, What Dr Sinclair will say about all these investments of Missouri University 😔 Then give our final decision 🫠 But I'm afraid seriously😰 Thank you all for trying to help us and Vince 's videos are informative and useful As always🙏💟💊😔😔😔
exactly... it sounds like garbage. my suspicion is its just like the study that shows vitamin c causes cancer in test tubes.. lol... I smell a certain degree of BS.
Thanks for the video. It's important to know what is the risk - both relative and absolute risk. You may want to provide this information instead of just saying there is an increased risk. There is an increased risk of getting hit by a lightning if I walk outside. Does that mean I should stop walking outside?
@@mattsmith1440 that's why I say you do research and you do your homework because this information out there that you don't have any need to get it one way or another so you can make an informed decision. At least that's what I do.
I remember reading a study a long time ago that reducing NAD levels could be used to treat / slow down cancer. And that you should definitely not use NMN etc. if you have cancer.
Cancer was injected into the mice. NR didn’t create cancer. The cancer was spread faster with NR but not statistically significant data. Author of study said it’s bait click news distortion. Pls correct this !
@@andresfs4090 "both normal and cancer cells share the same NAD biosynthetic and metabolic pathways, selectively lowering levels of NAD(H) and NADPH would be a promising strategy for cancer treatment." I was talking about this, not nad causing cancer.
One study is not going to change my mind about NMN or NR, I will continue to take them. I have heard so many times such and such is bad for you then years down the road you get a "opps sorry!" we were wrong. As long as you are reasonable about the intake of a supplement or certain foods you should be good. IF I am wrong and I get cancer from taking NR so be it. At this point in my life the benefits far outweigh the dangers.
curious you didnt link the article. Even one of the authors reported the hysteria around this that you are an example of is clearly unwarranted. There were 19 mice in the study. They were injected in the heart w a highly aggressive breast tumor. The study group had an accelerated rate of brain mets but it did not reach clinical significance. So what this study actually says is, if you PLAN TO INJECT A HIGHLY AGGRESSIVE BREAST CANCER INTO YOUR HEART u may want to avoid NAD supplementation, but we need A LOT MORE RESEARCH to actually make this claim.
Cancer is more or less developing in our bodies every day, but it is detected and destroyed by a healthy immune system. The issue is that NR and NMR are obviously enhancing the human growth hormone. For me it seems that the conditioning and controlling of the HGH are key for extension of a healthy lifetime.
It’s not. What accelerates the cancer is the radiation from cell phones and computers, also all the sugar we consume. Sugar is added to almost everything.
This study would also apply to NMN in my view, which is exactly the same reason that cancers in children are known to be ‘much more aggressive’ and rapidly spreading than in older people. Raised NAD+ has a variety of major health benefits, but IF a cancer occurs, it also spreads more rapidly in such circumstances too. I might be wrong of course, but generally I see this as not a concern for healthy people, and not a reason to not use NR or NMN. Of more concern to me is finding out if Sinclair really is chasing money to have NMN removed as a supplement so he can make money off a slightly modified form. Disgusting if that proves to be the case, and currently his radio silence on Twitter is deafening.
I agree but we need to be patient on the whole banning of nmn, companies like DONOTAGE are saying business as usual and so far no NMN products that are being sold from America have stopped if the FDA had contacted these companies then they would either be trying to offload there stock or they wouldn't be permitted to sell. Also if it does transpire that David Sinclairs company is trying to monopolise the NMN market then his entire reputation would be flushed down the toilet overnight in the longevity community, I don't believe this is the case and his silence is just that nothing will come of all this will be a non event in a couple of weeks when everything settles, there are alot of Sinclair haters out there that are jumping on this with no actual evidence of anything changing.
@@MyLongevityExperiment Im in my early sixties,.and presumeably my NAD+ levels are lower than lets say a decade ago. If I take an NAD precursor Im attempting to raise my NAD levels to a more youthful state, I would guess Im not increasing my risk of cancer. Also, if you are raising your NAD levels. what does it matter if its through NR, NMN, or Niacin? Yes, No, Maybe? Is it even possible for the average person to the adequate dosage of NAD precusors, throughout our lifespan without testing that is not availble to us?
The clear is answer is we don't know if this is a concern for the average person. To imply it's of little or no concern may be throwing caution into the wind. At some point, as people age, everyone likely becomes more susceptible to cancer. This is likely the case for all or most seniors, whether they're considered to be healthy or not. For the most part, it's older people that are taking NAD supplements, not younger people. It could be that NAD overstimulation (through NMN, NR, Niacin etc..) could cause an increase in risk for certain cancers for older people in general. Likewise, it may cause a decrease in risk in certain cancers. Perhaps the one thing that supplement/ risk takers have going for them is that Niacin is more well studied, Niacin appears to reduce cancer risk in some cases, so to the extent that there is a lowering of risk in certain cases with Niacin, that may port over to NMN, NR, Niacinamide etc . . . However, right now NMN/ NR supplementation is pretty much a roll of the dice. In my view, Exercise is perhaps a less risky and more effective way to boost NAD compared to supplements.
At the moment I cannot take NMN as it causes migraines to me, even 0.05 gr. I was thinking to try NR. Anyway what I have noticed is that usually people take too much NMN, in my opinion. I have seen a study that proves 0.5 is better than 0.9 gr. I think 1 gr is the maximum, I would take 0.5 gr and I am 61yi. This is also because these vitamins are not fully tested. About the problem of NR and the cancer, I think it is important not to take too much NR or NMN, but stay under 1 gr. Waiting for more studies
Chromadex did ask that other companies not be allowed to sell NR, but that request failed. NR is still classed as a supplement, and if they tried to test it as a drug now, after it has been commercially available for years as a supplement they request would also fail.
Healthy cells regulate the amount of intracellular NAD+. Cancer cells increase the enzyme NAMPT which in turn increases the production of NAD+. The study shows that cancer cell growth accelerates with large doses of NR (and I assume NMN). It seems reasonable to conclude that taking large amounts of NMN or NR in healthy people will not be useful after the minimum is reached. It also seems reasonable that if you have any kind of cancer, taking these kinds of supplements is a bad idea.
The problem is that all people tend to deteriorate as they age and become more susceptible to cancer. Throw NMN or NR into a deteriorating body and who knows what will happen. It might be a positive effect, it might be a negative effect. Compared to supplements, exercise, is probably a safer solution (and perhaps a more effective solution) for boosting NAD
I am following this; so far I am finding a great deal of push back from other researchers- 'the conclusion reached is not supported by the research'. See Dr. Brad for a summary.
I don't think k nicotinamide is an NAD precursor, Major NAD+ precursors are nicotinamide riboside (NR), nicotinamide mononucleotide (NMN), and the new discovered dihydronicotinamide riboside (NRH)
This doesn’t change my view that NMN is a beneficial, cellular level energy booster. Agree that if you are diagnosed with cancer, likely a good idea to stop taking either NR or NMN. I’ll continue taking NMN. Important to note that theses molecules are not “causative” for a cancer, but potentially an accelerator if one has cancer.
I think you're correct on that. Because I think it accelerates things in your body to work more efficiently that would speed I guess the cancer cells to grow faster. I'm not a scientist but I would definitely go along with that hypothesis to be true or accurate.
Yes I already knew that. I was concerned because I had a history of malt lymphoma. I would want to check myself to be sure I don't have it anymore cuz lately my stomach has been bothering me so I'm concerned that I may have it again. But not going to take NMN until I'm sure I don't have cancer anymore.
The way my comment had nothing to do with anyone else taking or not taking NMN. I was just voicing my point of view not judging anyone else's activity regarding. People get so defensive when somebody points out something in their own life or their own thoughts and then somebody feels attacked. Of course you go ahead and do whatever you want with your own body I was talking about my body.
If modern medicine was based ob physiology, then we would have massive RCTs to investigate the true RDAs of every known vitamin,mineral and other compounds such as ginseng, NAC etc. Every trial on these essential nutrients made by a lab in anyway associated with the Allostatic School of Medicine invariably comes up with a scare. When the mRNA booster vaccines are tested we only need 8 mice to quickly establish that they are perfectly safe… As were the opioids for pain treatment. Vioxx.. Etc, etc..
This study is narrowed in on NR, but I’m not sure how any other NAD precursors including NMN and niacin wouldn’t also have a similar effect. If it boosts your body’s NAD levels, it’ll boost a cancer in your body’s NAD levels.
To say that you have to take a healthy person and see if any cancer develops and how fast by high dose NR........all i am hearing sounds like fairy tails...as other have said follow the money
I would like to know the actual risk factor associated with NR, and how much was given. Currently taking 300mg NR a day. I haven't yet decided whether or not I'll stop. I still have a month's supply left, so I'll finish that off first.
Hi, for a complete doof like me, are you able to actually pull out any data in the study or press release that expresses any actual stats? Like the difference in rate of cancer spread between the non NAD boosted cells vs the NAD boosted cells? It's hard to take any medical type research seriously with the way they express opinions based on what other scientific disciplines would consider statistically insignificant data.
Sorry Jay, no I can't, I am not a scientist, I just review the articles, I think it would be reckless for me to try and extrapolate data or make assumptions, that is down to PhDs; not even MDs are trained to do that, although some do have a stab at it on RU-vid.
That was quite the title to your video! First, who doesn't have some cancer somewhere in their family? My mother had breast cancer for instance. I take Niagen NR daily, and I look forward to more research on the side effects, both good and bad. I would not have known of this research if you had not presented it here. Please continue your work. Thank you.
Vince I have seen this all before with studies which were conducted with NR and then NMN and it turns out this is all BS. I'll tell you why I looked into this, I was diagnosed with a tennis ball sized brain tumor 12 years ago and given 3 months to live and NO conventional treatment as a terminal patient as any treatment would offer no benefit. That's my background and I'm still here because even while being severely effected by my cancer I learned everything there is to know about cancer and how to conquer it. What the failing in this studies is is that they are not identifying an observation or interaction in the metabolic process, yes there colored molecule is insitu but no metabolic change is observed in CD (cluster of differentiation) 24 or CD72 or any of the relevant transmembrane proteins and no cellular activation has been observed. Just because you are standing outside the house does not mean you are invited in. What fuels cancer is far more important than what triggers it. Cholesterol and sugar in conjunction with insulin are the fuel and Angiogenesis sustains growth above one cell size. So the way I conquered cancer was to eat a no oil low sugar Vegan diet high in anti Angiogenic foods - search methionine restriction as it works. I'm still here and can show you all the medical evidence to prove that I'm exactly what I claim to be if you doubt. NR and NMN only help in the creation of NAD and we all create NAD during our lifetime regardless of supplementation and we would die without NAD, taking the precursors to NAD does not raise the level beyond what should and can be sustained by our bodies. As a side note did you know that the MAJOR CAUSE of BREAST CANCER is Bovine Leukemia virus so why would you ever want to drink cows milk. Human stupidity is outstanding.
Hi Michael and thanks for you very comprehensive answer. There are many medical practitioners that show a zero sugar diet whether that be vegan or carnivore has positive outcomes when it comes to cancer, but that doesn't make money for big Pharma or Big Sugar, so they get labelled as Quacks. I very rarely drink milk these days, occasionally heavy cream in coffee.
@@MyLongevityExperiment Try New Zealand cream (if you can get it) as New Zealand is the only western country trying to eliminate bovine leukemia virus from their herds. while there is a definite link between bovine leukemia virus and breast cancer there is a suspected link with prostate cancer as well.
@@MyLongevityExperiment It's been proven that metastasis of cancer is fueled by Cholesterol so being vegan is better for you than carnivore, sad but true and no you can't separate the cholesterol by removing the skin as the fat is integrated into the muscle tissue. David Sinclair says he is trying to be as vegan as possible but he does love his chicken and of course his morning yogurt (coconut yogurt would work).
Thank you for posting! This was very useful information, as I have health issues that I'm consistently trying to find ways to reverse. I'm looking into the "methionine restriction" studies and hoping to figure out a good diet plan to heal. Did you take any supplements on your journey to healing your cancer or was it strictly the change in diet?
@@ivyfeenix Not so much supplements although I do take some regularly. I do take herbs which I try to take as fresh food and in pill form if I can't get the fresh. I consider food as the greatest healing influence. We as humans eat a lot of crap and think of ourselves as omnivores., that is cultural BS, we are herbivores, rear end digestors, not ruminates like cows but microbiome digestors, we digest the organisms that digest our food as well as the food, that's why we don't need to eat fat, we literally get all the short chain fatty acids we need from digesting dead microbiome. If you have cancer try to starve it without staving yourself. Eat lots of cooked and raw vegetables, absolutely no dairy at all ever, cut out fruit juices, eat whole fruit with very little citrus as citrus is mostly juice sugar. Honey is just sugar which is bad. Any vegetable that made you go "yuk" as a kid is probably good for you as an adult. Eat lots of nuts of all types, do not eat any vegetable oils and only extra virgin olive oil if you have to use any oil but keep it to a minimum, avoid pre-prepared foods even if they are vegan foods as you can't tell what they put in it as the ingredients are mostly oil and sugar. Rice and Beans are a main stay food and if cooked right very satisfying. I will eat anything plant or fungus variety is the key. I eat food in the style of a Japanese Bento box but with western food making sure I eat fresh salad everyday. I eat as much as I like. I only eat one meal a day. I am not fat or skinny if I am either then I am not balanced correctly. The herbs I take for cancer but also for anti-aging (same thing really) - Quercetin, Fierstein, Turmeric, Garlic, Broccoli, Brazil nuts ( only 6 to 8 nut segments a month as they are toxic). Fenugreek (good for men, really good for lactating women only). Vitamin Supplements - Calcium ascorbate, vitamin D, K2 MK7, Nicotinamide ( it is the same thing and does them same thing as NR and NMN at 1/10 the cost) B12, Zinc (good for covid immunity and for prostate). You must have a good relationship with food, if you have issues with food which are generating your health issues find out what ales you and treat that as a priority. If you tell me what your health issue is I can be a lot more specific.
Thank for the links. I find the data to be somewhat squishy & suspect. Much more is needed to actually support valid parameters. All good to keep abreast of what is out there as we venture forth in biologicals. Happy you’re out there reviewing data!!!
I'm a 15 yr old male and I take a vitamin supplement for a bunch of stuff including 50 mg of nicotinamide (b3). Do you think that I should stop or keep taking them?
You’re our a kid with all of natures goodness working or you. Very little need to supplement anything if you are eating well and sleeping. If you are an elite athlete then talk to a coach or nutritionist. Otherwise, doubt you need anything. Cheers.
It's so why you so called professors and PhD holder kept quite about pesticides used in natural nmn content vegetables and fruits, pesticides are more dangerous than NMN NR OR NIACIN synthetic supplements, you know you people should search some other house nursing job, untill unless that is permanent after AI introduced to world 🤣🤣🤣
