Dr. David Sinclair: The Biology of Slowing & Reversing Aging

Подписаться 5 млн

Просмотров 3,3 млн

50% 1

In this episode, I am joined by Dr. David Sinclair, tenured Professor of Genetics at Harvard Medical School and an expert researcher in the field of longevity. Dr. Sinclair is also the author of the book Lifespan: Why We Age & Why We Don't Have To, and the host of the Lifespan Podcast, which launches January 5, 2022.
In this interview, we discuss the cellular and molecular mechanisms of aging and what we all can do to slow or reverse the aging process. We discuss fasting and supplementation with resveratrol, NAD, metformin, and NMN. We also discuss the use of caffeine, exercise, cold exposure, and why excessive iron load is bad for us. We discuss food choices for offsetting aging and promoting autophagy (clearance of dead cells). And we discuss the key blood markers everyone should monitor to determine your biological versus chronological age. We also discuss the future of longevity research and technology. This episode includes lots of basic science and specific, actionable protocols, right down to the details of what to do and when. By the end, you will have in-depth knowledge of the biology of aging and how to offset it.
#HubermanLab #DavidSinclair #Longevity
Thank you to our sponsors:
ROKA - www.roka.com/huberman
InsideTracker - www.insidetracker.com/huberman
Magic Spoon - www.magicspoon.com/huberman
Dr. David Sinclair Links:
Lifespan Podcast: lifespanpodcast.com
Twitter: / davidasinclair
Instagram: / davidsinclairphd
RU-vid: / davidsinclairpodcast
Lifespan (book): amzn.to/47MLimC
Aging Test Waitlist: www.tallyhealth.com
Harvard Lab Website: sinclair.hms.harvard.edu
Our Patreon page:
/ andrewhuberman
Supplements from Thorne:
www.thorne.com/u/huberman
Social:
Instagram - / hubermanlab
Twitter - / hubermanlab
Facebook - / hubermanlab
Website - hubermanlab.com
Newsletter - hubermanlab.com/neural-network
Timestamps:
00:00:00 Dr. David Sinclair, Harvard Medical School
00:03:30 ROKA, InsideTracker, Magic Spoon
00:07:45 “Aging as a Disease” vs. Longevity & Anti-Aging
00:10:23 What Causes Aging? The Epigenome
00:15:53 Cosmetic Aging
00:17:15 Development Never Stops, Horvath Clock
00:20:12 Puberty Rate as a Determinant of Aging Rate
00:23:00 Fasting, Hunger & Food Choices
00:32:44 Fasting Schedules, Long Fasts, (Macro)Autophagy
00:34:50 Caffeine, Electrolytes
00:35:56 Blood Glucose & the Sirtuins; mTOR
00:37:55 Amino Acids: Leucine, “Pulsing”
00:44:35 Metformin, Berberine
00:50:29 Resveratrol, Wine
00:53:20 What Breaks a Fast?
00:56:45 Resveratrol, NAD, NMN, NR; Dosage, Timing
01:09:10 Are Artificial Sweeteners Bad for Us?
01:12:04 Iron Load & Aging
01:15:05 Blood Work Analysis
01:19:37 C-Reactive Protein, Cholesterol: Serum & Dietary
01:26:02 Amino Acids, Plants, Antioxidants
01:33:45 Behaviors That Extend Lifespan, Testosterone, Estrogen
01:40:35 Neuroplasticity & Neural Repair
01:46:19 Ice Baths, Cold Showers, “Metabolic Winter”
01:48:07 Obesity & How It Accelerates Aging, GnRH
01:52:10 Methylation, Methylene Blue, Cigarettes
01:56:17 X-Rays
01:59:00 Public Science Education, Personal Health
02:05:40 The Sinclair Test You Can Take: www.doctorsinclair.com
02:08:13 Zero-Cost Support & Resources, Sponsors, Patreon, Supplements, Instagram
The Huberman Lab Podcast is for general informational purposes only and does not constitute the practice of medicine, nursing or other professional health care services, including the giving of medical advice, and no doctor/patient relationship is formed. The use of information on this podcast or materials linked from this podcast is at the user’s own risk. The content of this podcast is not intended to be a substitute for professional medical advice, diagnosis, or treatment. Users should not disregard or delay in obtaining medical advice for any medical condition they may have and should seek the assistance of their health care professionals for any such conditions.
Title Card Photo Credit: Mike Blabac - www.blabacphoto.com
Audio Engineering: Joel Hatstat at High Jump Media

Наука

Опубликовано:

30 апр 2024

Ссылка:

Скачать:

Готовим ссылку...

Добавить в:

Мой плейлист

Посмотреть позже

Комментарии : 4,8 тыс.

@hubermanlab 2 года назад

The first episode of Dr. David Sinclair's new podcast launches Wednesday, January 5, 2022. You can subscribe now to that podcast, "Lifespan with Dr. David Sinclair", on all podcast platforms ( lifespanpodcast.com ) and here on RU-vid: ru-vid.com. Thank you for your interest in science!

@memastarful 2 года назад

What a beneficial opportunity to learn and grow more. Thank you for this

@memastarful 2 года назад

P.S.= Oh and happy almost New Year

@BS-lc5cd 2 года назад

Type 1 diabetic here. Lots of Type 2 talk regarding longevity. I have no insulin in me, does that help me? How screwed am I

@memastarful 2 года назад

@@BS-lc5cd my 12 year old daughter has type 1 diabetes. 8m so grateful for your question.

@rubyblu21 2 года назад

Great interview Andrew! Thank you so much for bringing David on and asking the questions that you did, you've out done yourself yet again.

@kcmaxwell1509 2 года назад

My father is 97 years old. He is a WWII vet and has survived double pneumonia, sepsis and Covid in the last two years. And he rides his recumbent bicycle 30 minutes daily. His longevity, in my opinion, is directly related to his low caloric intake (and great caretaking). He’s eaten once or twice per day for his entire life. Super interesting science. Thank you.

@sarahscottageholidaylet.5071 2 года назад

Wow! Your Dad sounds awesome! Good for him!

@big_chungus73 2 года назад

When someone tells a story like this, a lot of people will say or think, "That's just anecdotal." But when there are so many anecdotes pointing one direction... where there's smoke, there's fire. Love hearing stories like your Dad's, and it's inspiring for those of us half his age to continue to prioritize health and self improvement, and maybe even help others on that journey.

@luciozanela7069 2 года назад

Dr Sinclair is an absolute genius and I am great full for his amazing work to change mankind mindset regarding aging

@gabrielkvarnberg8656 2 года назад

low caloric intake = looking like a emaciated soyboy with no muscles.

@Zoltar1811 2 года назад

Legend

@AboodCohen 2 года назад

Welcome to the Future everyone, where golden information like this is free and available instantly.

@sauravsingh8534 2 года назад

We are the Future

@JC_inc 2 года назад

. . RU-vid is more than 15 yrs old.

@RichieIsRight 2 года назад

The future is getting this info directly chipped into your brain and available immediately

@ronnieradke9240 2 года назад

@Brett M I think you missed the point

@ronnieradke9240 2 года назад

@@JC_inc Jesus Christ zero common sense

@mss_tanja 8 месяцев назад

Dr. Huberman is really creating an amazing legacy of information. The only problem I have with him is that I get lost in those eyes and forget to listen.

@sfardales 7 месяцев назад

I so AGREE!

@tadasturonis 6 месяцев назад

i am a man, but i totally agree, lol

@drironmom6815 5 месяцев назад

Definitely! 😅

@squamish4244 5 месяцев назад

I think he's spreading himself too thin, though. He's been firing off these podcasts so rapidly, and I just want to say, dude, slooooow down. You're going to burn through all your best potential guests quickly, and it's too much for a lot of us to absorb anyway.

@555SwissMiss 3 месяца назад

😂❤

@Niceonthefrenchriviera Год назад

The video starts at 8:00 (for those who want to avoid the advertising and marketing) 😉

@jeanettewight6365 4 месяца назад

I skipped it too!

@akashprathod 2 года назад

Two scientists that I follow all the time, now on one podcast. This is a Christmas gift.

@ballapalleballe 2 года назад

Yeah! By Far the best Christmas Gift!

@paulaneves2548 2 года назад

So true!! Same feeling here!

@newpixelsapp 2 года назад

same here!

@lynnnestor7985 2 года назад

Yep top Christmas inspiration from my two fav scientists. Very proud of our Aussie Sinclair🙏👌

@alok3129 2 года назад

Bhai very nicely put!

@Livingwithadog 2 года назад

Imagine how the internet has changed the world. You can now easily prolong your life for free because of technology and intelligent people like Andrew

@andybaldman 2 года назад

Live-longer fads (and people making money off of them) have existed for decades.

@shealdedmon7027 2 года назад

Just think of all the people that will live an extra week or two because of this video.

@AstroMartine 2 года назад

resveratrol and nmn are not free though :>

@phoenixjoe5520 2 года назад

People are gullible nowadays, a sad fact...

@orbifold4387 2 года назад

Unfortunately it only works if you are not worried or thinking about living longer.

@peterellis4262 4 месяца назад

I have to say that the obvious enthusiasm and excitement you both show as you discuss these topics is absolutely wonderful.

@germandaria Год назад

The best what I like about how Andrew is handling an interview is that he really does not interrupt. In this case its even more important than saying things.

@vickihughes9476 Год назад

I am a practicing physician assistant and went into medicine because my family has always been on the wholistic/ natural path. We grew our own veggies, bought farm fresh eggs and grass fed local beef, had fruit trees and grape arbors. We ate fruits and veggies all day. We were physically active all day. My father is 93 and not on any meds. My mom is 89. They do not smoke and rarely drink alcohol. They have never had cancer, diabetes, dementia, heart disease. I have been telling patients for years that it is not rocket science and the best treatment I can give them is to eat only to live and keep moving. I could talk for hours about this! Our food production and lifestyles are killing us. It is that simple!! I would love to help get more of this information out there! And I would love to meet you both! Thank you and Keep up the great work!

@healingjourneys4241 Год назад

Where do you practice?

@vickihughes926 Год назад

@@healingjourneys4241 Illinois

@healingjourneys4241 Год назад

@@vickihughes926 wish I was closer because you sound like a perfect physician for me.

@CollegeWebMag Год назад

Hi Vicki, I couldn't agree with you more. I once had an older bodybuilder (72 yrs old) tell me to stay away from processed food, and you will be ok, Rudy. Thanks for your reply. Cheers! Rudy

@ey8648 Год назад

Have fun making no cash. All the money is in the meds.

@jaynanewbold8263 Год назад

In addition to the generosity and vast knowledge provided, can we all agree that this podcast is most enjoyable due to the fact that these two gentlemen utilize the art of conversation very well? No interrupting, grandstanding, one upmanship, talking over one another. A lost art, indeed. Well-directed by Dr .Huberman and cooperative responses by Dr. Sinclair. Riveting!! Thank you both!

@cindysmallwood2695 Год назад

Except that Huberman really likes to hear himself talk. Questions could be summed up in half the time.

@alsin1597 Год назад

@@cindysmallwood2695 he obviously wants to make questions as clear as possible and, in my opinion, very much succeeds. You mam, I assume, just jealous.

@thomasbeaumont8884 Год назад

@@cindysmallwood2695 He knows he's a specimen

@thomasbeaumont8884 Год назад

@@alsin1597 you offended on his behalf. He's a lecturer. It's undeniable he talks a lot

@alsin1597 Год назад

@@thomasbeaumont8884 what... I am actually stand for him

@KipIngram Год назад

Absolutely LOVE how Dr. Huberman handles this - he carefully brings out all the right things. Fantastic interview!

@Jbsa1998 Год назад

I felt like I was sitting in on a lecture and I was engaged the whole time! Super informative and insightful! Thank you so much!

@TheInterwebzMan 2 года назад

I’m 35 now and starting to see and feel it. I swear I was 22 just yesterday. Time flies!

@54Rockit 2 года назад

Funny, I'm 68 and 22 lives on inside, believe me and hope it never fades. Music is a great way of hold on to that time of your life.

@clarisaojedaleon3653 2 года назад

same here bro but I look amazing xd

@skdjirrrdjdm3926 2 года назад

Tell me about it...not only did I just turn 34 but now I look just like my mom.

@christianzwaga9434 2 года назад

@chevalier577 tell us more

@templeray5692 2 года назад

I'll be 37 next month time does go way to fast but at the same time I believe aging will be cured by 2035.

@Kitten_Stomper 2 года назад

For someone who's 52 yrs old and looking like that, Dr. Sinclair's an excellent ambassador for anti-aging science.

@jonluis2647 2 года назад

He's done botox tho

@lionemporor 2 года назад

@@jonluis2647 are you sure?

@joelcruz811 2 года назад

@@jonluis2647 He said on Joe Rogan that he hasn’t done Botox

@TheSweetvyc 2 года назад

He looks every bit of 52.. However, maybe if he wasn't taking all of his anti-aging supplements and taking care of himself, he would look older than that

@amoghdurgam5621 2 года назад

@@TheSweetvyc bruh have u seen most 50 year olds?

@hobbyfarmer1452 4 месяца назад

When I first listened to this podcast, it was about one year ago. Since then, I had listened to many other similar podcasts. I learned so much from all of them. This time listening to this one, I understood the subject so much better.

@wasimkmob1586 4 месяца назад

Dear Andrew, I want to give you a huge shoutout and express my gratitude for all the awesome info you're putting out there hosting such great minds and the incredible work you're doing to make education accessible. On top of all the cool science stuff, your subtle sense of humor really adds to the experience. Watching your videos is a blast! Thanks a ton!

@katewenzell 2 года назад

One thing I question is the exposure to cold. I was homeless for 6 years and it wrecked my health. I have to say right here that I don't do drugs, that was never my problem, because a lot of people on the streets self-medicate, but I never liked drugs, not even pot. The main contributing factors for my health deterioration were were chronic stress (bordering on PTSD), especially due to constant police and societal harassment, and poor diet, due to being poor, eating old, cold and cheap foods. However, one other thing started really messing my hormones up, and that was living through winters and snow without heating. I lived in my van, so I would get under the feather comforter and sleeping bag at night and shiver for about an hour until my own body heat would heat up the space. I was able to get warm during the days at a cafe or library, but there was no refuge at night from the cold. The last couple winters, my body started having trouble self-regulating its heat. I would be so cold, and then I would suddenly overheat and be sweating. I have gone into early menopause in my early 40's. I am totally traumatized by the cold now. I feel like Scarlet O'Hara in "Gone With the Wind," except I would say, "As God is my witness, I will never go cold again!" Dr. Sinclair saying he wears a T-shirt in winter gives me shivers. So I respect deprivation of our ancestors (and the current indigent) as something that can be absolutely damaging. The homeless have a much lower lifespan than the rest of society. Controlled deprivation is still privileged deprivation. That being said, we do live in a society of sickening over-abundance. And I do notice that wealthier people often seem less happy than the homeless, where the smallest thing is appreciated. I watched your video on dopamine, and it finally made sense to me why that is. Now that I am housed, I am able to rest and heal and have some peace, but I'm also in a slump. Being alive in this world is a difficult balance between security and thrill.

@sarabutt3428 2 года назад

Thank you for sharing your incredible story of resilience with us. I am so sorry for the trauma that you experienced and very grateful that you are housed and recovering now. My best wishes and prayers for you.

@katewenzell 2 года назад

@@sarabutt3428 Thank you for your kind wishes

@anagroszek7743 2 года назад

thank you for sharing your story .

@EmiKimura88 2 года назад

I've just had an urgent desire to help homeless people

@katewenzell 2 года назад

@@EmiKimura88 The homeless survive with the help of kind strangers, but the best way to help in the long-run is supporting the push for democratic socialism, for much stronger social safety nets, and social investment in mental health, addiction support and housing, instead of policing and criminalization of the homeless. The phenomenon of homelessness is absolutely connected to society at large and politics.

@Darnabymom 2 года назад

I just turned 60 and am the caregiver for my mom who this week turns 100!!!! For her age she is doing amazingly well. As I see her quality of health, it spurs me on to increase my health span not just my life span.

@jelizabethpetrie6656 2 года назад

Same here, 60 with 92 yo mom & 14 yo border collie. Learned applicable lessons for us all! Most appreciative 🧘‍♀️🚴‍♀️🧗‍♀️🚣‍♂️

@nebber1234 2 года назад

Your mom had you at 40? That's amazing by itself.

@CB-ln2eb 2 года назад

Could you share with us what they say their "secrets" are to living a long life? 🙏

@randdiamond8090 2 года назад

@@nebber1234 In the first place, the “infertile by 36” data comes from a really high-mortality time and place 😂

@Darnabymom 2 года назад

@@nebber1234 Actually my grandmother, who was born in 1884, had my aunt at 36 and my mom at 38. I had my daughter at 40 and our son at 43.

@carolfairfieldmua9040 Год назад

Currently watching this. Only recently discovered Dr David Sincalir and Huberman this morning. An absolute pleasure to listen to these 2 gentlemen. I'm defo going down this rabbit hole lol

@brandonbarnes6493 7 месяцев назад

Why I love Dr. Sinclair. He always answers so honestly. “We don’t know, but I’ll give you my best answer.” I appreciate you both for taking the time to educate us!

@TatooedDoc 7 месяцев назад

LMAO!

@rubyblu21 2 года назад

I knew it was only a matter of time until Dr David Sinclair made his way onto your show. Thank you Andrew!

@AgendaInMind 2 года назад

Most of the more severe illnesses happen to people because an upsetting event occurs in their lives taking them by surprise, unexpectedly, impacting first in the brain, then in the corresponding organ which that part of the brain controls. The end of WWI had absolutely everything to do with the Flu and lung TB outbreak that occurred killing millions. In nature, the biological conflict linked with a territorial fear (just what it means-a fear in your territory, your home, your community, etc.) is a widening of the bronchia (tissue loss). Your body attempts to widen your bronchia in order to allow more air into your lungs to give you more strength and energy to fight to keep your territory safe. Stay with me.......The biological conflict linked with a death fright impacts the lungs. The lungs attempt to grow larger in order to allow more air in because breath equals life, as we all know. No breath equals death. While you are in the fear or death fright conflict, you notice no symptoms of “disease”, except you have cold hands, cold feet, you can’t sleep, you awaken at 3 AM every night, you have little appetite. During the war, millions of people were in fear of the bombing of their homes and cities where the war was most active. Fearing for their lives, their loved ones in the war, their ability to survive. The food in the stores was sparse due to shortages. This lasted for 4 long years! The longer the conflict, the worse the healing phase. Within 2 weeks of the German Chancellor announcing the end of WWI, these millions of people ALL went into the healing phase all at the same time. It is during the healing phase that you experience symptoms of illness! What is the healing phase of the bronchia widening? Severe bronchitis, pneumonia. The body attempts to refill this lost tissue and you experience inflammation, fever, coughing, body aches, fatigue, etc. What is the healing phase of the extra lung tissue that grew? Decomposing of the tissue by TB bacteria and fungi. The symptoms of this healing phase are: severe coughing up of blood and tissue, fever, inflammation, severe mucous, body aches, fatigue. During this decomposing of the extra tissue (tumor), the body expels a lot of protein, and without replenishment, severe protein loss can result in death. Antibiotics did not exist yet. If TB bacteria does not exist in a person or they have been vaccinated against TB (big mistake), then the tumor will simply encapsulate and become dormant and not harm you. Who died during the Spanish Flu? Mainly the poor who could not afford to buy meat and proper nourishment, and the people who were directly impacted by the bombings and destruction of their homes. Millions of people suffered fear and death frights during the fighting of WWI, and millions of people all went into healing at the end of it. Not everyone was affected because not everyone suffered the same way. It’s not a “flu”, it’s not something you “catch”. It’s biological, meaningful, and unavoidable. One hundred years later, a Fear Campaign begins, using the media to spread it......

@StoicAurelius1 2 года назад

Me too, I knew it was gonna happen before the end of 2021

@RoscoeDaMule 2 года назад

it was recorded in mid summer so it already happend a while ago

@ronandheather3079 2 года назад

2 humble geniuses genuinely appreciating each other’s genius. No competition. No agenda. (Except to share) wow! What a gift indeed. Everybody loves this

@szymonbaranowski8184 2 года назад

Sinclair promotes the greatest global experiment on human beings... so not so much agendaless... not mentioning nr of pharma businesses involved...

@Michael-gi5th 2 года назад

@@szymonbaranowski8184 yeah I'm not so sure about NMN cause there's so much contradiction involved, some say no it doesn't get into the mitochondria of the cell so can't increase lifespan as it does in mice

@alisontomsett5248 5 месяцев назад

Angina completely gone since taking reservatrol and NMN. Also doing intermittent fasting. Amazing info thank you. Life changing literally.

@BloomByCC 8 месяцев назад

Menopause is brutal. It led me to David Sinclair and life changes... i feel so much better but still not the same as before. We desperately need more research to address this bro real issue affecting over half the population.

@oliround 2 года назад

This channel/show is a gift to mankind and we should be forever grateful to this man

@sovereign775 2 года назад

100% feel you. I am blown away when I share this podcast with others and they don't tune in

@markkash Год назад

Thanking you very much for your brilliant work on genetic influences attaining fountain back to youth so to speak .people close to me are astonished at the bullet proof genetics I was blessed with I just turned,60 don't look day over 40 literally lived the life of a rockstar rarely ate and when I wasn't obliterated it was all about adrenaline surf snow skydiving racing motorcycles cars . never seen a depressed person dropping into 20ft wave wondering if adrenaline has benefits slowing deterioration of are meat suites

@jessikalove4788 2 года назад

I feel like Professor Huberman is my friend on the inside at this point, lol. I look forward to these weekly podcasts. Such a wealth of information. Also, he seems to have such a positive aura. Keep up the great work, Professor! ♥️

@walkerusmc07 2 года назад

I couldnt agree more!

@CertainExposures 2 года назад

Lol, it really does feel that way. Tossing my multivitamin today. Too much iron!

@jessikalove4788 2 года назад

@@CertainExposures Me too!

@funtimes8296 2 года назад

Oh girl don't lie, you wish he was more than just a friend.

@keng7758 2 года назад

Hey Jessika, I gotta say…you are simply gorgeous! Nothing creepy…just a compliment!

@supremecanine6848 Год назад

Dr. Huberman, thanks for making the world a better and healthier place.

@deniseunknown4576 Год назад

I could listen to Dr. Sinclair for eternity. Great interview. I rarely stick around for 30 minutes much less 2 hours. So great job Andrew & David. Thank you for such amazing information. Enlightening to those of us that aren’t on that biological level of information. Eye opening. Truly appreciated.

@marywakely5550 5 месяцев назад

Great info Tks So much

@marywakely5550 5 месяцев назад

@Nightowl1947 2 года назад

What a gift for us, your audience. I do the fasting at 74 and feel great. Implementing new ways to maintain good health, never felt so good! Thank you both for you kindness and willingness to share .

@susanwoodward7485 2 года назад

I do the same at 70, convinced I can beat the chronic kidney disease I have had since 2005, for which modern medicine offers nothing but ineffective drugs with powerful negative side effects. Never once has the concept of fasting, sirtuin pathway activation, mTOR inhibition, autophagy, NMN supplementation to increase NAD+, or stem cell regeneration crossed any of my MD's lips - criminal.

@jackparker6472 Месяц назад

Fasting is easy if you place yourself in a location where there is no food and you don't leave that location. Drink some water and get over it. It's not like being cold and getting colder. When you are hungry, you don't get more hungry. You're just hungry, and if you eat, you'll probably be hungry again in a few hours. So cowboy up.

@laurenwinters6897 2 года назад

What a difference it makes to have well practiced professors explain these ideas! This is such a gift.

@susanhenley8844 Год назад

I am so happy to have stumbled upon this podcast and will be listening to more. Thank you!

@bio_vet 6 месяцев назад

That was a mindblow. What a conversation to shake everything we heard before about diets and health. Thank you for doing this podcast!

@xxlegitfailxx 2 года назад

Was on the borderline of checking myself into drug treatment this month until i started reading Why We Sleep by Matthew Walker, watched a few of the podcasts in this series followed by a responsible psychedelic experience...can't explain how grateful I am for resources like yours, Dr Wakers, Dr Sinclairs etc. People don't talk enough about how diet, exercise and proper rest enable making the right decisions in other areas of your life so much easier. Normally i shitpost and troll in the comments but with 100% of my sincere-ness thank you.

@nikos4641 2 года назад

You should probably look at "Why We Sleep" by Alexey Guzey. RU-vid doesn't allow links but he implicates that the book is riddled with errors.

@sweetsue4204 2 года назад

It’s always nice to come across someone else that this podcast is helping. Thanks for sharing, and good luck going forward. I feel pretty certain stories like yours are what they hoped to create when they kicked the podcast off. 👍🏻

@burnttoast6397 2 года назад

@@nikos4641 what’re alexey’s certifications? Is he even qualified to try and discredit Dr. Walkers book? I highly doubt it

@nikos4641 2 года назад

Burnt Toast I’m confused why qualifications matter; he just cites the relevant literature that goes against his claims.

@ES-ex5it 2 года назад

Congratulations on your progress. Two books that I'd recommend: Spark by John J. Ratey, MD and Dopamine Nation by Dr. Anna Lembke. Godspeed!

@lauralockie 2 года назад

After viewing this podcast, I grabbed a copy of "Lifespan" by David Sinclair, and I was completely unprepared for what a well written, intriguing theory of life itself on our planet it would contain. Everyone should read this book to gain an understanding of the science of themselves and how to live a better life. Thank you so much for introducing us to his work!

@breadinthesesticks 2 года назад

Just ordered mine now!

@joeanna1100 2 года назад

are you going to take metaformin

@THEWIZARDDK2 2 года назад

nice advertisement. did they pay you to write it ? because that also just happens to be a fact in commment with this type of weird doctors

@xxcorrosive 2 года назад

Is it a tough read? And how long did it take you to finish it?

@lauralockie 2 года назад

@@xxcorrosive Not a tough read, in fact there are illustrations and Dr. Sinclair isn't pompous or evangelical, in fact he's pretty humorous at times. I'm still reading it, because I skip around a lot of books at once, and even within the book.

@kathy8389 9 месяцев назад

Wow, even from the first question posed by Huberman and then Sinclair's answer to that, it's a paradigm shift. Now, will continue listening to the rest of the podcast.

@jonahalldors5488 7 месяцев назад

Thank you both for a fantastic podcast, I can’t thank you enough for your great work and for sharing this with us ❤

@AB-zq4fw 2 года назад

Thank you Dr. Sinclair and Dr. Huberman for all you've done and do! We appreciate you 🙏

@stevegreen65 Год назад

I love Dave. He is such a smart guy, has a great sense of humor and he is able to break down complicated subjects in easy to understand pieces.

@Susan-L193 8 месяцев назад

I freaking love this conversation! Wow, the iron levels. When I was pregnant with my first child I was advised strongly by my doctor to take iron. I did so, and when my daughter was born, I could smell the iron in her/our blood! That frightened me and have only ever taken it in moderation and rarely since then. Fast forward two years, the same daughter was pale in skin tone as she inherited her father's celtic skin, and a different doctor was concerned but at least didn't go hard on advising supplements and I knew her diet was good. Fast forward a few decades and when I started donating blood, noticed my iron level was lower each time I donated, so I limited my donations to annually despite being told that it is 'safe' to do this every 6 weeks. It is so refreshing to hear the science with acknowledgements that everyone is different, as is our upbringing.

@shaktirising3854 4 месяца назад

Only trust yourself... YOU are the expert on your body, if it feels off, it is.

@gabrielledavis7491 Год назад

Thank you SO MUCH to both of you for allowing us to listen to this spectacularly insightful conversation. Us viewers are sincerely appreciative.

@lotfibouhedjeur 2 года назад

Both of my favorite professors get together! This was so exciting I could listen to them all day. I love how they treat anyone who gets close enough as a potential science experiment 😂 Thank you both for making this happen.

@motherofcrows5911 2 года назад

Every time I hear Sinclair talk I learn something new. Your interview here was just perfect and covered a wide range of actionable longevity strategies.

@franciscochacon5542 5 месяцев назад

Thank Andrew and David. This is the best video I've ever seen about aging so far. Thank you for sharing all the good knowledge 💯

@lisabrown3015 4 месяца назад

This is gold… I am 48 and started taking AG1 and NMN and I got pregnant…. Nothing else had changed except those two things! … I did lose the baby at 3 months but I understand the body will do what the body wants… the key is consistency!

@roxypedro100 4 месяца назад

Awesome!!! Gives me hope, I'm all about supplementation, may I please ask- What BRAND/TYPE of NMN??

@lisabrown3015 3 месяца назад

@@roxypedro100 Renue By Science

@roxypedro100 3 месяца назад

@@lisabrown3015 THANK YOU LISA 🥰 i'm going to try that one!!

@hariprasanth2727 2 года назад

This was the collab I was eagerly waiting for. I am a researcher in robotics and I am very excited to learn about a topic that is completely out of my research interest all because of you how interesting you guys made this. Thanks for all this work

@1234highman Год назад

I'm extremely impressed with Dr. Sinclair's insights on aging - it's incredible how much progress is being made in understanding our biology! I recently heard about a study that showed certain dietary modifications could extend lifespan and I'm excited to see what other discoveries we uncover on this fascinating topic!

@rarebird_82 Год назад

Me too, stop shouting! 😘

@mermaid5948 9 месяцев назад

What were the dietary modifications? Thanks 😊

@chuckleezodiac24 5 месяцев назад

@@mermaid5948 according to Sinclair: Metformin, Botox, Spermidine, yogurt & plants.

@ifnotnowthenwhen9063 4 месяца назад

We Are being lied for many years.He actually pointed it out that living longer is connected to eating less which was ignored by the medic world no wonder why

@filomelavarisco8183 Год назад

So interesting! I could listen to David Sinclair all day long

@JesseStevenPollom 3 месяца назад

I can’t believe this content is free. Thanks docs!

@paduraruovidiu201 Год назад

I believe this is the 7th episode I'm listening to, in the past 4 days. Thank you again, Mr Huberman!

@allangraham3649 2 года назад

Thank you to yourself and David for your time and to everyone involved in making these happen as ever !

@nancyreilly1873 7 месяцев назад

Please accept an infinite Thank you Dr. David Sinclair and the one and only Huberman.

@MB-my5kc 10 месяцев назад

Thank you both for this most informative share. Health is wealth and knowing how to achieve that is key. Thank you for your transparency, so very refreshing!

@dannypiper383 2 года назад

Time flew by while I watched this 2 hours and 10-minute video; it was equivalent to watching a great movie. It's refreshing to see the dialog and hear unfiltered information directly from the source instead of through an intermediator. A wide array of subject matter was extrapolated from this podcast. Well done!

@ssiddarth 2 года назад

This conversation is like one of the best Christmas gifts ever, thanks Dr Huberman for having Dr Sinclair on the podcast and asking such great questions

@Mohammadali_9999 Год назад

I love you Mr.Huberman, I've said it before and say it again, you are my hero. Wish you the best,from Iran.

@adrianbalteanu6095 5 месяцев назад

Andrew, fantastic job! You've placed all the right questions in order to complete the image of what Dr. David's explained, great work!

@digitaldeepak21 2 года назад

Going to buy the book. Insane podcast. I didn't take him seriously until I knew he was 52.

@RunOfTheTrill 2 года назад

Botox tends to have that effect.

@saurabhchaudhary7342 2 года назад

Wow kinda surprised to see you here. Make a post on FB about this too and even this might trigger a few lol.

@diamoo8021 2 года назад

Keep in mind that he has access to high level professional tests any time he wants to optimize how he interacts the world. This is not available to most.

@aaronsilva5784 2 года назад

@@RunOfTheTrill what makes you think he's had injections?

@michelles2299 2 года назад

Really I think he looks in his 50s

@treyd3433 2 года назад

Stuff like this is a representation of some of best attributes of our species. Thank you doctors for sharing your knowledge!!

@roljicb Год назад

Thank you Andrew for all informations! I will try to do so as much as posible. I wish to look young as Dr.Sinclair who is 52!!! Awesome!

@scotchbarrel4429 2 месяца назад

Your line of questioning, and thought process is on another level here. It maybe the dynamic between the two of you, or maybe the time period. A solid four days of intermittent listening/digesting, thanks Docs 👊😎

@ES-ex5it 2 года назад

I have watched many hours of David Sinclair interviews and I was able to gain new insight thanks to your interviewing skills. You posed certain questions with a clinical edge that other interviewers lacked, and you also relayed questions that "lay people"/non-scientists asked you. It was very well rounded and accesible. The timing of the podcast is great too. As we approach the new year it is refreshing to have scientifically proven ways to improve one's life paired with actionable steps. Thank you for this interview.

@abdulsattarali8220 Год назад

Truly what these incredible human beings are doing is amazing. People should follow their findings and listen to their advise and try to live healthy life and keep helping others. Together we need to spread this information as much as possible.

@mayday24916 4 месяца назад

Sinclair, Huberman, Patrick.... all 3 of you have changed my life.

@tonyz7216 2 месяца назад

Who's Patrick?

@feelingoffbalance Месяц назад

Rhonda Patrick

@jonathandaniels5825 2 года назад

This was the best interview of Dr. Sinclair and I've seen a lot of these interviews over the years. Too many times interviewers ask Dr. Sinclair questions that his book or prior podcasts answer. You asked some to unassumingly baseline an understanding and go further to ask questions I would have asked (e.g., dietary cholesterol, iron, finer protocol practices, etc). We got answers we hadn't heard before. Nicely done!

@anonona1 Год назад

I just watched the "best gratitude practices" episode, where he shows one of the best ways to practice gratitude is to replay a story of someone being genuinely grateful to someone else, and here Andrew himself provides us with that story, such a heartfelt moment. Thank you both for all you've done.

@andreaslynen6113 Год назад

So great. Dr. Sinclair and you changed my live. I read his book. Great interview. Thanks so much🙏🙏🙏

@tijen_ Год назад

My father lived to be 90 years old; my mother is a healthy 93 year old. In my opinion, their longevity is based on good genes, a healthy vegetable heavy; meat light diet and, a physically active and social life style. We have a citrus orchard & they ate a lot of citrus fruits. Perhaps, vitamin C can take some credit too. Most of their senior years they lived in a Blue Zone, south-western corner of Turkiye where the seas Aegean and Mediterranean meet. There are four seasons and only summers are hot. I have been told by a doctor that continuously living in a hot climate tends to result in shorter life spans.

@potbellygoblin2495 Год назад

thanks for putting education stuff out there for everyone. I never adapted well to the standard educational system and didn't do well at college, but I still love learning. Thanks to this kind of content I can still feel like I am learning and broadening my horizons.

@raquelvidales7568 Год назад

Thank you Andrew for this awesome podcast! I’ve read Dr Sinclair’s book, and I’m so grateful that you have covered a lot of open questions that are not so easy to Digest, specially for the non-scientific people (like me). It really helped me and clarified a lot of the Q’s I had myself, and that you have covered them in a very easy going chat with him, by sharing, discussing and doing a deep dive on how the ageing can be reversed and so forth… it was such a great idea on inviting him to your show! I’m looking forward for your next updates and shows!

@annap214 8 месяцев назад

People really thirst for this type of information!~ thank you for sharing all the amazing and extremely useful information in this channel ❤

@mohamadhasanansarizadeh7420 6 месяцев назад

Super informative, I really enjoyed it as a researcher in the biotech field. this is perfect to share such videos and making them viral instead of superficial medical suggestion on social media

@Borromeo377 2 года назад

My two favourite scientists who I deeply admire 🙌🏼 Thank you Andrew for bringing David to your podcast 🙏🏼 I am grateful to both of you for sharing your precious knowledge and experience with us ❤️❤️❤️

@susanstultzhauss132 2 года назад

Dr Huberman and Dr Sinclair. Thank you so much for sharing your passion and knowledge, for free, with us!! It is very frustrating that a lot of sources want you to buy their book first or pay for the "secrets". I loved this podcast!!

@chrissienewtosupps7733 8 месяцев назад

Again another information packed interesting interview.. both you Andrew And David are incredibly knowledgeable... extremely enjoy listening to the depth you went to... thankyou for sharing your incredible work :)

@avinashrockstar 9 месяцев назад

Great job Huber🎉 All your videos should get language subtitles for most of the used languages so that it reaches all over the world.

@JeffNixonComedy 2 года назад

Just finished reading Lifespan last night and now waking up to this podcast. Pretty sure this means I’ll never die. Hell ya, time to get into hobbyist sky-diving!

@MMyL7 2 года назад

😂 😂 😂

@avaidn7451 2 года назад

🤔🤔🤔

@zorabw8948 2 года назад

You should really do a parachute tandem jump. It is an unforgettable experience.

@billkemp9315 2 года назад

Great podcast! I always love to hear what David has to say and you Andrew ask all the right questions.

@angelamontes9571 Год назад

Love you guys , congratulations on this amazing program ! ❤

@tylerjcranford Год назад

The problem with meat and eggs isn't the cholesterol, it's the saturated fat (among other things - heme iron, neu5gc, TMAO, et cetera). Eating saturated fat raises LDL cholesterol, not eating cholesterol.

@JoyOnTheDaily Год назад

What a gift! Thank you to both of these brilliant scientists, Sinclair & Huberman, for being not only articulate in their thoughts & data, but also entertaining! I’m on my second listen & have shared with many friends & family. Great takeaways for living an optimally healthy, long life! 🤓♥️✨

@bernardradcliffe6240 2 года назад

One of the all time greatest podcasts in relation to health and longevity. Thank you guys.

@luiscrespo9902 9 месяцев назад

Awesome interview, Andrew! Your detailed questioning was superb!

@BloomByCC 8 месяцев назад

100% into following Sinclair's guidance on health. Brilliant.

@nomsaledwaba8931 2 года назад

My first time on this Andrew Huberman channel. I am so impressed by the simple way this interview is conducted by scientists.

@poshpasha 2 года назад

The internet creates a spawn of information, but information isn't intelligence. Thank you for continually putting out a sense of logical thought and allowing the public to sit in on conversational engagements between intellectuals like this. Excellent work.

@vka82055 Год назад

Very excited about these facts we can apply to our lives instantly with amazing results❣ Many thanks to you and David Sinclair!

@michaelwellner8151 Год назад

Thank you, gentlemen for such forward thinking about humanity moving forward in being healthy

@caliskanutkan 2 года назад

I can't even dare to explain how valuable this podcast was. Thank you very much! I would also LOVE to listen to your philosophical conservation. Please consider that. The youth/future needs real influencers like you guys!

@meimei2630 2 года назад

what a time to access knowledge, narration as easy as it gets and being accessible to those who seek!! thank you.

@anyaturker412 Год назад

Brilliant ! ❤❤❤ so very impressive to hear about your great grand parents winning the NOBEL PRIZE with critical periods (The apple does not fall far from the tree). Can you PLEASE do a podcast specifically how to reopen critical periods even if briefly due to infants getting ill during a critical period and having long term developmental issues ? PLEASE? This would be incredibly helpful. THANK YOU SO MUCH for sharing all this information with the public, truly brilliant !

@karenvantuyl901 8 месяцев назад

What an Amazing pod cast 🎉 Im grateful for the information from scholars in the fields.

@sharonp.6505 2 года назад

What an amazing podcast! I've watched dozens of interviews with David Sinclair. Dr. Huberman asked different and intriguing questions that no one else has asked before. Two brilliant and forward thinking scientists together, sharing provocative ideas and insights. This podcast gets my vote for "best of 2021". Thank you!!!!i

@juicebox86 2 года назад

Huberman Team; You're truly making a positive impact in my life. The information and the way in which it is presented leaves me feeling empowered. Finally caught up to your most recent podcasts after binging all last year to catch up. I look forward to being hooked to the Lifespan Podcast as well!

@alisonmcintosh937 6 месяцев назад

This was one of the most exciting things I've listened to in a long time. So interesting. Thank you both!

@m.talmagemoorehead Год назад

Andrew, Thanks for interviewing David Sinclair. Respectfully, I wish you wouldn't interrupt him so often during the interview. Thanks. You're doing great work. Keep it going, Andrew.

@DrPeacockOfficial 2 месяца назад

He barely did… 😅

@Professional-ki2uk 2 года назад

This is what every Science fan would love to attend. Thank you so very much Dr. Huberman for your extraordinary efforts. Keep going

@mashantha Год назад

What a brilliant podcast! In absolute awe - extremely grateful to you both for your service to humanity and your commitment to educating the public! loved this.

@y7ti3ug9t Год назад

Quite the opposite. Filling your silly brain with nonsense and bro-science

@alritchie25 Год назад

This was a fabulous interview! I learned so much ❤

@georgeyung6185 Год назад

Thank you for reminding us simplicity and paying attention to our nutrition, body changes, and supplementing. Also changing our habits. i like using these tools to gauge my aging and my husband’s.

@thomasbeaumont8884 Год назад

Ironic name