Better than NMN & NR: Future of NAD+ Boosters for Longevity | Dr. Nichola Conlon & Beyond Sapiens 

Excellent synopsis

Good sommaty of NAD etc video

thanks, and may I add that her products price is in the very high end.

Nice chat AI generated summary.

Ive now ordered 3 times..... no reply. , M.W.

That’s actually insane if it lowered your age 20 years lol

keep us posted

you want to mess up their business? 😅

@@cryptobiose4809 No, I'm giving people the truth. It's a rip off.

At first glance, I see the supplement is in a capsule. I like that NMN comes as a sublingual powder where it’s not destroyed by digestive acids or dependent on an aging digestive system to get absorbed.

Thanks for your input! In the trial they measured NAD+ in the blood, because to measure it in the muscle or the brain they would have needed to collect biopsies, which as you can imagine is quite invasive and challenging to do. Taking blood samples is common practice for trials measuring NAD+ changes. You will be able to read more about it once the trial get published in a scientific journal in the upcoming future. Thanks and best wishes on your longevity journey! 🌱✨

Why not take both? Niacin and Niacinamide?

@@narenmenon6906 The non flush kind can be hard on the liver.

¹

Yes, B3 is probably the best bang per buck NAD+ booster around! Pair it with some bulk Apigenin supplement and you've got a very convincing NAD therapy for super cheap.

Actually Niacin is one of the ingredients in the supplement they sell, if you look at the label.

@@thx1136 It's not Niacin, it's Nicotinamide. However, again, everybody talks about NR and NMN, but very few about these other 2. $$$$$

the high dose of Nicotinamide in this sup is likely to impede Sirtuin 1 activation and the amount of dried parsley provided is unlikely to provide much Apigenin to reduce CD38

@@chuclkles58 Yes, bur according to Dr Conlon that ony happens in vitro, not in humans.

I need a cheaper version 😢

You're very welcome, Karen! Thanks for your support, and if you need any help for your health & longevity, please feel free to reach out or book a call with us (calendly.com/beyond-sapiens/30min), we're always happy to help! 😊

Did it ever get published?

What about these precursors potentially causing an existing cancer to spread dangerous

Glad to hear that is working for you, and of course, we're all free to choose what works best for us 🌱✨ As mentioned in the video, boosting NAD+ through NMN/NR isn't necessarily a bad thing - and indeed, many are benefitting from it. But it's important to remember that boosting NAD+ with just a precursor is a one-sided approach that isn't taking into account the much more complex processes involved. So, that's why there's a price difference. Hope this helps, and best wishes on your longevity journey!

@@beyondsapiens I wan't thinking so much about choice but about risk. I'm 61 and my skin is absolutely amazing since starting NMN several years back. My walking speed is amazing, my angina is manageable even without isosorbide mononitrate. I get an almost instant boost to skin look and feel, just 20 minutes after taking NMN. So if I was to switch to yours, at greater cost then find I'm not getting the same results, it's been a waste of money. I understand the pathways that lead up to NMN and have tried addressing those myself in the past, but without much success. I noticed several companies claiming to have their own unique formula, but wonder if it's just them trying to cash in by claiming to be able to do things better. I think that if it's not broken don't try to fix it. Think I'll stick with what I know!

@@catman4471 Because everyone are unique, it's depend if taking Time+ can help, right now, I have RP eyes disease with moderate condition. I assume our eyes need significant energy that NMN I took from AliveByNature seems for 30 days only help in the beginning, better energy, I have no idea if it worth long-term. But Nuchido seems to focus multi-target could be my answer I need. I'm a web developer and a cofounder, and I dislike tech debt. In the same analogy to supplements that only focus on one target is not effective.

I agree. NMN has worked absolute wonders for my elderly father. Not sure why I would want to mess with success. Also, if boosting NAD+ isn't necessary, then why are they ALSO including an NAD+ booster, niacinamide, in this formula? Also, why not just include NMN then instead if niacinamide?

@@CyrilAndPriscilla Hi, I feel that this is just another 'I'm a scientist, buy my product' type of thing. I do understand the reasoning behind it..there are different pathways to creating NAD and the idea behind their supplement is to ensure the de novo pathway is working as it should, rather than relying on the salvage pathway (Niacin, NR, NMN). But all you have to do is get a good nights sleep to create NAD+ through the Kynurenine/de novo pathway. I've noticed that a number of doctors are too engrossed in stats and reports rather than practical experiences of those who take NAD pre-cursors, and I don't think they can really appreciate the benefits we get from NMN. You do not get the same physical or visual benefits by increasing Tryptophan or B6 etc, and you're right, it doesn't make sense according to their approach, to include Niacin.

micromol is not a concentration but an amount, so you can not convert it directly to ng/ml, unless you are talking about micromolar? if that is the case I get 33ng in 1ml of 50 micromolar

@@besanit How about this? 660 grams/mole for NAD+ 50 micromolar is 0.00005 mole/L 0.00005 mole/L x 660 gms/mole = 0.033 gm/L 1,000,000,000 ng/gm x 0.033 gm/L = 33,000,000 ng/L 1000 ml/L 33,000,000 ng/L x 1L/1000ml = 33,000 ng/ml

It's about $2 per day, which is 3 servings per day. 1000 mg NMN is about $1.8 per day. But if you look at the ingredients in TIME+, it's mostly just nicotinomide (250 per serving x 3 servings per day = 750 mg), plus some vitamin c, zinc, and some herbal ingredients. If you already take a multivitamin with vitamin C and zinc, then you could just buy nicotinamide, which is about $0.06 per 250 mg , $0.18 per day if you took it 3 times a day.

Why not just take NAD?

@@HH-gv8mx Great question. NAD is not absorbed well if taken and so you must take a precursor molecule instead. There are three chemical pathways for NAD synthesis: the tryptophan path (not very responsive to supplementation); the niacin path (effective, but getting the dose right is challenging as too much increases inflammation); and, then there's the NR path. NR is turned into NMN so, recently, people have been augmenting NR with NMN or just taking NMN. I've just switched to taking NMN sublingually. The NMN by Renue by Science is what I'm trying. By the way, Nicatonamide is on the same pathway (the Salvage pathway) as NR/NMN, and NMN is also after it in the pathway. If you've heard of people taking Resveratrol or proanthocyanins, too, it's partly to grease the enzymatic wheels for that conversion to NMN. I hope this little ramble expresses well enough my limited understanding.

Thank you for the breakdown . So I guess the NAD I’ve been taking is just a waste of money. Dr. Drew swears by NAD. So I ponied up the money for tru NIAGEN NAD. But haven’t really felt a difference in energy levels. @@cravarc

🤣 Keep researching Sunshine.

Thanks for your feedback, Charles! Our goal here is simply to talk about science, share knowledge, and help others. 🌱✨ We didn't mention it in the video, but the clinical trial is currently being peer-reviewed and will be published in an important journal, so you will be able to go deeper into the topic. Overall, the goal of this episode was to go deeper into the processes around NAD+, while also understanding more of Dr. Nichola's innovative product. It's not that often that supplements are tested with a randomized, double-blinded, placebo-controlled crossover clinical trial, and we believe this says a lot about Dr. Nichola's approach. P.S. DoNotAge is also one of our partners, and we're glad to hear that combo works for you. Let's just remember that it's a different approach where, for example, NAMPT (the NAD+ salvage pathway enzyme) is not being activated, as well as AMPK.

I've heard recently NMN amongst others on donotage is questionable. I'm in Ontario Canada and wondered why some are so expensive and renue by science was a different price. Looking for good quality for decent price.

@@freespiritwithnature4384 Where exactly are you hearing that "NMN on donotage is questionable"? This has not been my experience. I started giving DNA NMN to my elderly father and it has made a huge difference in his health.

Hi Dove! You will find the field where to insert the discount code during the checkout process 😊 (starting from here nuchido.com/pages/choose-your-supply) So, you would first need to add the product (30 days or 180 days supply) to the cart, create your account, and then on the shipping address page you will also see the field you're looking for. We hope this helps! Here for you if you need anything else. Thanks and have a great weekend! 🌱✨

Hi Peter, the clinical trial mentioned is currently being peer-reviewed, so that's why it's not accessible. It will be published in a prestigious scientific journal, and we'll update the description with the link once available. We'll get back to you about the additional query 😊

@@beyondsapiensThanks. My point was that their web site shows the data without the baseline values for context. If an NAD+ increase is measured, which they claim and show, it's significance can only be judged by comparing against the background (normal) values. Just asking that those values be put up as well. They can still note that the data is undergoing to peer review.

Thank you for exposing their junk science. She should have told us during the interview those crucial parameters. Clearly she. is obfuscating.

Hi Brant, that's a great question, and it's spot on! In fact, by taking Nuchido TIME+ before and after your NAD+ infusion you can ensure your cells are primed for the sudden influx of NAD+. This extends and enhances the benefits. For more info about it, here's a useful blogpost for you → nuchido.com/blogs/news/enhance-the-effect-of-nad-ivs We hope this helps! 🙌✨

@@beyondsapiens Thanks for the quick response. I already ordered the three month supply using your coupon code. Thanks!

Taking NAD+ directly is not very effective (except for neurons), as the molecule is too large to enter cells. That's why the focus is on NAD+ precursors that *do* enter cells.

Can you just take NAD supplements ? @@beyondsapiens

Why not just take NAD supplements ?

@@HH-gv8mx So Many - Nicotinamide Riboside (NR): Nicotinamide riboside is a precursor to NAD and is often used in NAD-boosting supplements. Nicotinamide Mononucleotide (NMN): NMN is another precursor to NAD and is commonly used in NAD supplements. Nicotinamide (Niacinamide): Nicotinamide is a form of vitamin B3 and is involved in NAD production. It is available as a dietary supplement. Niacin (Nicotinic Acid): Niacin is another form of vitamin B3 that can support NAD production when converted in the body. It is available in various supplement forms. NADH (Nicotinamide Adenine Dinucleotide Hydride): NADH is a coenzyme form of NAD and is available as a dietary supplement. NAD+ Precursors: Some supplements contain a combination of NAD+ precursors, such as NR and NMN, to support NAD+ levels. NAD+ Boosting Blends: These supplements often contain a combination of NAD precursors, antioxidants, and other compounds aimed at promoting NAD+ levels and overall cellular health. NAD+ IV Therapy: In some cases, NAD+ is administered intravenously under medical supervision.

That’s only if you get to extreme levels and in older people they’re so low it’s not going to raise it to super high levels, but just to get it to a normal range again

Hi Mike, thanks for your comment! The best option is to take the first 3 pills before your breakfast. While the second dose of 3 capsules should be taken at least 6 hours apart. What I, Alessandro, do, is to take the first dose just a bit before my 1st meal at around 8.30AM, and then last 3 pills with my 3rd meal at around 4PM. Overall, the directions are to take 3 capsules with water twice daily, at least 6 hours apart. It's recommended taking them with food as for some people taking any supplements on an empty stomach can make them nauseous. Depending with how strict you are with your fasting (in case you do it), it should be noted that TIME+ does break the fast. If you take the 1st dose to break your fast, then you extend some benefits, such as AMPK activation. If you need anything, we're always here to help. Thanks and best wishes on your longevity journey 🌱✨

The Nuchido team is excellent at answering any questions you throw at them. I have been taking NMN (1000mg) with TMG and Apigenin for 6 months with great effect. Nuchido has everything in their TIME+ that controls methylation and CD38 levels (although they said you can keep taking TMG if you want, but it's not necessary) so I'm looking forward to starting my TIME+ after finishing my NMN supply in about 7 days time.

Hi Craig, great question, and thanks for the comment! Generally, TMG is taken alongside NMN and NR to counteract the methyl group depletion that they cause. TMG is not needed alongside Nuchido TIME+ because rather than simply trying to fix falling NAD+ levels by putting more raw material into the cell (using precursors like NR and NMN) it is designed to fix the underlying reasons why NAD+ is actually declining, namely the failing salvage pathway. As the cell can recycle the NAM back into NAD+ it avoids the methylation problem. TMG though, can still provide additional benefits such as improved muscle performance (when combined with high-intensity training) and reduced homocysteine levels. So, you can continue taking it to get those additional benefits :) Hope this helps!

I have now been taking Nuchido Time+ for 8 weeks at the dose you recommended (2x3 capsules daily with meals, with at least 6 hours between each dose). It makes no sense to take an additional NMN product.. I would like to take you on a short journey to see how the product works for me: - After 7 days: I have a deeper sleep. Although I still wake up 1-2 times during the night, I am much better rested in the morning! - After 14 days: In addition, I no longer have chronically cold hands and have not been so sensitive to cold for a long time before taking Nuchido Time+. Maybe Nuchido Time+ even has a positive influence on the blood circulation! Best regards from Germany and thank you for the really great product. I am curious to see what effect the consistent use of the product will have on me. Before I started taking Nuchido Time+, I had my biological age tested via GlycanAge. I will have the results in 2-3 weeks. After one year of taking the product, I will repeat the test and then compare how my biological age has developed. A very exciting story 😊 But if you look into the science behind the product, you can certainly hope for further very positive effects, here I am thinking especially of the preventive prevention of serious diseases. The system pharmacological approach of Nuchido convinces me very much. - After 21 days: I have been doing fitness sports for many years and therefore probably have a relatively high NAD level in relation to my age. So far, I have not been able to directly feel an increase in energy. But now I have done a test. So far, and for years, I have not managed to do more than 154 pull-ups in 5 sets. I usually managed between 148 and 152 pull-ups. Now I did the test after 3 weeks and I am positively surprised. I now managed to do 165 repetitions in 5 pull-up sets. This might not sound like a big increase (between 7-11%), but for me personally this is a very positive surprise after years of stagnation. Since I haven't changed any other dietary or training habits, the increase in strength endurance can be chalked up to Nuchido Time+. Overall, I recover faster between sets and I am also ready to go again faster after the training sessions. On 23.09.2023 (i.e. before taking Nuchido Time+) I had my biological age tested by GlycanAge for the first time. On 09.10.2023 I received my result. I would have to lie if I said I wasn't a bit excited.  My expectation was already tending towards the positive, which means I was already expecting my biological age to be slightly lower than my chronological age. However, the actual result surprised me very positively. My biological age is 23 years lower than my chronological age. It felt like a birthday ;-) But the result is not set in stone and motivates me to continue to lead as healthy a lifestyle as possible, to make sure I get enough exercise, fitness training and sleep. I will also continue to take the dietary supplements I have been taking so far, such as curcumin, astaxanthin, resveratol, etc. I am very excited about the results. For me, it will be very exciting when I do the test again in just under a year's time to see if I can go one step further with Nuchido Time+. In any case, my anecdotal experiences in the first 3 weeks of taking it are extremely positive. - After 28 days: A further increase in strength endurance has been recorded. In addition to 170 pull-ups (back) in 5 sets, increases of between 3-10% have also been recorded in all other muscle groups. For the first time in the 4th week of taking Nuchido Time+, an improved metabolism is also noticeable, which enables me to maintain my weight more easily. The ratio of muscle to fat should therefore also improve. All other already existing positive effects of the first weeks continue undiminished. - After 5 weeks: Visible reduction in belly and hip fat. Overall, my skin is becoming softer and the first very slight improvements in the appearance of my skin can be seen. In the meantime, I have increased the number of pull-ups to an incredible 180 repetitions in 5 sets. All other exercises have also improved by between 5-20% since I started taking Nuchido Time +! The muscle pain after the training sessions is reduced and also gone much faster. More by accident, I have discovered that I have become faster when walking. Overall, I feel an energy boost that I had not thought possible. The already mentioned benefits from the first 4 weeks all remain (deeper sleep, reduced sensitivity to cold, longer endurance, faster regeneration, improved metabolism, improved weight control). - Continued after 6 weeks of use: All the previous benefits of the first 5 weeks are retained, and in some cases even enhanced. The complexion is noticeably better, finer-pored and fresher. I was able to increase the number of pull-ups in 5 sets to 187! There has also been steady progress with other exercises (legs, shoulders, etc.). - Continuation of my experience with Nuchido Time+ after 7 weeks: There are still slight performance boosts in terms of strength - and endurance. This applies to all muscle groups. I have now completed 192 pull-ups in 5 sets. That's about 28% more than I was able to do before taking Nuchido Time+. In the meantime, I can also feel and see that my skin is becoming more elastic. Apart from that, all the positive experiences of the past weeks remain. It's remarkable how much energy Nuchido Time+ gives me after just 7 weeks. I am curious to see whether there will be further improvements. Perhaps my NAD+ level is now slowly being topped up to such an extent that in future even more resources can be used for secondary tasks in the cells, such as for skin and hair. So far, I am completely thrilled. - Ongoing experience with Nuchido Time+ after 8 weeks: Further improvements in the appearance of the skin are recognisable, smaller wrinkles are slowly disappearing. There has already been an improvement in the overall contours of my face. I wouldn't have thought it possible, but my hair is slowly starting to darken (white hair is turning light grey and light grey is turning dark grey). I have no idea whether this will continue and whether I will even get my natural dark brown hair colour back. However, I am realising one thing more and more. Among other things, Nuchido Time+ improves my metabolism considerably. Nutrients that I take with my meals and food supplements that I have been taking for years (curcumin, astaxanthin, resveratol, OPC, hyaluronic acid capsules) seem to have considerable positive synergistic effects when I also take Nuchido Time+! I am convinced that the food supplements I have already been taking can be processed much better in the cells. For some time now, I have been following Dr Nichola Conlon's numerous and very informative presentations very closely. Among other things, I learnt that the body cannot distinguish the source of the nutrients it receives (food, food supplements or medication). Incidentally, my strength is still increasing, for example I can now do 197 pull-ups in 5 sets. Am I enthusiastic about Nuchido Time+? Yes, I am 😇

29:40

31:23

Good question! I wish a doctor would answer.

@@HH-gv8mx ​@HH-gv8mx well if we can get a definitive answer supplementation becomes null/void where hard core fasters are concerned. At least until my diet is normal again. ❤

Hi Cyril & Priscilla, very good question! The reason why TIME+ uses nicotinamide is because nicotinamide is actually the best precursor in terms of bioavailability, and it's the precursor that our bodies naturally use to make the largest amount of the largest proportion of NAD+. It doesn't require any transporters to get in the cells, and it freely diffuses across membranes. Unlike NR and NMN that do require transport. So, the whole argument is that precursors alone don't address the root cause of the problem, and a whole-system approach is needed to boost NAD+ in the best way. Hope this helps!

@@beyondsapiens Thank you for the comprehensive reply! Can you please refer me to some scientific references that show that nicotinamide is the most bioavailable precursor to NAD? I've read some papers that show that supplementing NMN will raise intercellular NAD, but I have not found any papers that show that supplemental nicotinamide does that. Are there any research papers that, first, show that nicotinamide actually raises intercellular NAD and, second, that it does this BETTER than supplemental NMN? Thanks again!

@@beyondsapiens I did find some papers that show that nicotinamide raises intercellular NAD, so please ignore part of my last question. However, I still haven't found a paper that shows that it's more bioavailable than NMN. For example, while NAM doesn't need a transporter to get into a cell, it is still TWO biochemical steps away from NAD while NMN is only ONE biochemical step away from NAD. That is, it is not at all obvious to me which would produce more NAD in the cell-- NAM or NMN. It is completely possible that that, because it takes an EXTRA STEP to make NMN from NAM that that might trump the fact that it doesn't require a transporter. What I'm saying is, I have found no research that proves that supplemental NAM does a BETTER JOB than supplemental NMN at raising intercellular NAD. I mean, it MIGHT--- but is there actual research on that?

Hi Edmund, thanks for your question! In the trial they measured NAD+ in the blood, because to measure it in the muscle or the brain they would have needed to collect biopsies, which as you can imagine is quite invasive and challenging to do. Taking blood samples is common practice for trials measuring NAD+ changes. You will be able to read more about it once the trial get published in a scientific journal in the upcoming future. Thanks and best wishes on your longevity journey! 🌱✨

Hi Steven, glad to hear you've been able to increase your NAD+ in that way! It's important to remember, though, that in that way, you're still not having a whole-system approach to boosting NAD+. For example, NAMPT (the NAD+ salvage pathway enzyme) is not being activated, as well as AMPK. To learn more about the formulation and how the ingredients work collectively, you can take a look here nuchido.com/pages/nad-supplement-ingredient We hope this is helpful, and best wishes on your longevity journey! 🌱✨

I would also consider taking Apigenin, I take that and Fisetin. I also take quercetin, ECGC and ALA that are mentioned in the video.

Fisetin has great research behind it.

⁠​⁠@@CyrilAndPriscillaI’ve being seeing quite a number of video with doctors with research that I trust on the subject of Fisetin.. I’m confident enough to give it a try and have bought & taking 50mg Niacin & 100mg Fisetin..

Hi there, thanks for your comment :) To give you more context about the use & quantity of sunflower oil, please see the comment below from the Nuchido team. We hope it helps! ✨ Sunflower Oil is not ‘added’ to our product as an ingredient in its own right. It is present as an ingredient contained within the Rice Extract Blend we use in Time+, and allows us to avoid the use of other less natural ingredients, such as magnesium stearate, to help the flow of ingredients into the capsule shell. Sunflower oil is present only in a tiny amount. In 6 capsules (daily dose) the sunflower oil provides only 1.7mg linolenic acid (omega 6). As a comparison a 5ml spoon of sunflower oil contains roughly 3250-3500mg linoleic acid (Omega 6). • The sunflower oil is Non GMO verified. In fact, Nuchido Time+ does not use any GMO materials. • The sunflower oil is not heat treated. The oil is expeller pressed. • The sunflower oil is not processed using additives or hexane chemicals. • The sunflower contains no trans fats.

thanks@@beyondsapiens

if that company provides a product and does not accept worldwide credit cards then they are just TOTAL JERKS !!!\

Will become cheaper soon - as with all inventions . . .

Thanks for playing.

Thanks

Hi Daniel, thanks for your input! We want to provide a comprehensive reply, so please find below the reply directly from the Nuchido team. We hope it helps! "NAM is our chosen precursor in Nuchido TIME+ because it has increased bioavailability over NMN. NAM is an uncharged molecule that can rapidly diffuse across the membrane of any cell and mitochondrial membranes. On the other hand, NR and NMN depend on specific transporters to allow them to cross the cell membrane (ENTs and SLC12A8 respectively). This means bioavailability of these precursors is dependent on whether the cell type has the transporter or not (and many do not). Additionally, with NMN some studies have suggested that the majority of NMN is metabolised into NR before it is taken up by the cells. NAM is also the bodies preferred precursors as it is the breakdown product of NAD+ consumption. Nuchido TIME+ increases activity of NAMPT which is the enzyme that converts NAM to NMN, therefore this conversion process does not limit the production of NAD+. As you mention there are very promising studies with fisetin, however it has limited bioavailability in humans. Further human clinical trials are needed to consolidate the pre-clinical benefits of fisetin and work is needed to improve its bioavailability. Nuchido TIME+ contains saphora japonica because it contains rutin a glycoside of quercetin, this greatly increases the bioavailability of the quercetin in the body. We also know from our human clinical trials that Nuchido significantly increases the activity of NAMPT to restore NAD+ recycling. When designing the formulation for Nuchido TIME+ we used a systems Pharmacology approach to identify active ingredients against specific targets. Each ingredient was included and formulated to ensure maximum bioavailability and our approach is supported by evidence from our human clinical trials. Our lead scientist Dr Conlon has published several papers about this -> Conlon, N., & Ford, D. (2022). A systems-approach to NAD+ restoration. Biochemical pharmacology, 198, 114946."

According to the latest studies from Google Scholar, both NAD+ precursors NR (nicotinamide riboside) and NAM (nicotinamide) have beneficial effects against aging and aging-related diseases in animal models. However, some studies suggest that NR may be superior to NAM in terms of efficacy and safety. For example, one study compared the effects of NR and NAM in mice with Alzheimer's disease and showed that NR significantly increased NAD+ levels in the brain and blood, while NAM had no effect. Moreover, NR improved cognitive function, reduced inflammation, and protected mitochondria in mice, while NAM had no such benefits. Another study compared the effects of NR and NAM in healthy humans and showed that NR was well tolerated and increased NAD+ levels in the blood by up to 2.7 times, while NAM caused side effects such as nausea, fatigue, and headache and did not increase NAD+ levels. Therefore, based on this evidence, NR seems to be a more effective and safe NAD+ precursor than NAM. However, more studies are needed to confirm these findings and explore the molecular mechanisms involved. References: (1) NAD+ Precursors Nicotinamide Mononucleotide (NMN) and ... - Springer. link.springer.com/article/10.1007/s13668-023-00475-y (2) Frontiers | NAD+ in Alzheimer’s Disease: Molecular Mechanisms and .... www.frontiersin.org/articles/10.3389/fcell.2021.668491/full (3) Frontiers | Oral Administration of Nicotinamide Mononucleotide Is Safe .... www.frontiersin.org/articles/10.3389/fnut.2022.868640/full (4) Recent research into nicotinamide mononucleotide and aging - Nature. www.nature.com/articles/d42473-022-00002-7 (5) NAD+ in Alzheimer’s Disease: Molecular Mechanisms and Systematic Therapeutic Evidence Obtained in vivo doi.org/10.3389/fcell.2021.668491@@beyondsapiens

@@danielalbuquerque3909 do you prefer to take NR vs NMN supplements ?

Yes, I have been taking it, it is good for those who have more inflammation in the body or autoimmune diseases, according to the most current science. It is recommended to take it together with resveratrol 1000mg and quercitin, for better effects, as they complement each other and enhance the effects.@@aneva2464

Really ? What poor outlook you have ! I know many people in their 80s that still work and are very active all day. I'm 59 and more athletic than most 30 year olds.

@@beardumaw24 , Their old.

First of all you start aging the minute you're born not at 40 and I don't know in whose book your old at 50 except yours. And as long as I'm not in a diaper and no one has to feed me I want to live to be 100

@@christinamerklin2166 , You do understand you will be decaying beyond belief till 100? That's no quality of life.

Nasty arthritis, decaying of joints, nasty skin aging, arthritis. It's all very horrible to look at. Nobody in their right mind would think aging is good. You'd have to be very naive to think loss of mobility, stamina, and just feeling alive loss is good. If you didn't, you wouldn't be on longevity sights. There is no longevity, lol. It's just decaying, and die by 70. It's terrible