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Here is a summary of the key points from the video: - NAD+ is a critical molecule for cellular energy production and repair that declines with age. Boosting NAD+ may promote longevity. - Popular NAD+ precursors like NMN and NR may provide some benefit but don't address the root causes of NAD+ decline. - The root causes are declining NAD+ recycling enzymes and increased inflammation. NMN and NR simply provide more raw material. - Dr. Nichola Conlon created Nuchido TIME+ to target the root causes. It contains nicotinamide plus ingredients to boost NAD+ recycling and reduce inflammation. - A placebo-controlled, double-blind crossover study on TIME+ showed it significantly increased NAD+ levels, NAD+ recycling enzymes, sirtuins, and reduced biological age in 28 days. - Future Nuchido products will likely target cellular senescence. - Dr. Conlon believes future anti-aging treatments will make age-related decline seem inhumane, much like current views on allowing cancer. In summary, the video explains how Nuchido TIME+ targets root causes of NAD+ decline and showed significant anti-aging effects in a robust clinical trial. Future longevity treatments may make aging as we know it obsolete.
I have been on NMN now for two years. I am 91 and my Bio Age is 73. I have done a number of things to keep my Bio Age down. I am highly impressed with the data in the video. Good job of presentation. I have purchased a three-month supply of NMN Time and am willing to give it a try. Hopefully my trust will be backed up by the integrity of your presentation. Thank you.
Can you please tell me what is the brand of NMN that you use? And if you tried Nuchido did you see any improvement? Can you take both together NMN and Nuchido Time? Thank you!
As a medical person myself, i appreciate the time and commitment required to collate and concisely present such a broad and complex subject. Every bit of research and provocation of thought will lead us closer to enlightenment. Thank you for the informative video 🙏
I'd advice an alternative, one brand I have the best experiences with is: Greenfood. They have Vitamin B3 (Niacin) high dose. And yes, it causes the flush, but you can limit that with some tricks. The other ingredients of the rather expensive Nuchido time stuff are easily available from nature. I mean, just take the parsely and green tea fresh! Grow your own if you can.
I’m so happy with my 76 year old energy level. A young lady I talk with said, you have the energy of someone 30 years younger, maybe I have more work to do. I MB routinely don’t eat sugar or processed food ect. Thanks for the video.
Wonderful for you! I am 65 and I eat a whole-food plant-based diet and I exercise. I am more fit than the 40 year olds which I work with. I have so much energy others can be annoyed with me….
I remember when NAD supplements hit the market around a decade ago. But I didn’t really start to understand it’s precursors and pathways until I started a keto diet with IF. I am currently supplementing with niacinamide and niacin as I’m only a few months in to my new life style but plan on dropping them as I’m taking in much higher levels of these nutrients through a high fat & protein diet. I feel sooo much better!
Niacin (B3) and niacinimide (nicotinamide) both enter cells through passive transport. No ATP is required. NMN must be converted into NR and then can be absorbed through ACTIVE transport. Niacine and niacinamide are less expensive, can be taken in higher molar concentration, and are likely to be more quickly absorbed. Niacinimide is the primary and limiting storage substrate of the salvage pathway to make NAD. Ribose is present in abundance.
At first glance, I see the supplement is in a capsule. I like that NMN comes as a sublingual powder where it’s not destroyed by digestive acids or dependent on an aging digestive system to get absorbed.
One of the issues with NMN and NR is that it only affects blood levels of NAD. These have not been shown to increase the levels of NAD in the bone or muscle tissue. Has anyone heard anything else about how this product is different?
Thanks for your input! In the trial they measured NAD+ in the blood, because to measure it in the muscle or the brain they would have needed to collect biopsies, which as you can imagine is quite invasive and challenging to do. Taking blood samples is common practice for trials measuring NAD+ changes. You will be able to read more about it once the trial get published in a scientific journal in the upcoming future. Thanks and best wishes on your longevity journey! 🌱✨
The clinical trial mentioned in the video is currently being peer-reviewed. It will be published in a prestigious scientific journal, and we'll update the description with the link once available. Thanks for your views and support!😊
Yes, B3 is probably the best bang per buck NAD+ booster around! Pair it with some bulk Apigenin supplement and you've got a very convincing NAD therapy for super cheap.
the high dose of Nicotinamide in this sup is likely to impede Sirtuin 1 activation and the amount of dried parsley provided is unlikely to provide much Apigenin to reduce CD38
I would prefer regular niacin over the non-flushing kind, as the flush has some benifits and is more gentle on the liver. It is good that there are more options out there becoming available. We are still in the early days of this research.
£60.00 for a months supply or £165.00 for 3 months as opposed to £99.00 for 100 days NMN from donotage. I'm getting great results from NMN, not sure why I should change to something more expensive.
Glad to hear that is working for you, and of course, we're all free to choose what works best for us 🌱✨ As mentioned in the video, boosting NAD+ through NMN/NR isn't necessarily a bad thing - and indeed, many are benefitting from it. But it's important to remember that boosting NAD+ with just a precursor is a one-sided approach that isn't taking into account the much more complex processes involved. So, that's why there's a price difference. Hope this helps, and best wishes on your longevity journey!
@@beyondsapiens I wan't thinking so much about choice but about risk. I'm 61 and my skin is absolutely amazing since starting NMN several years back. My walking speed is amazing, my angina is manageable even without isosorbide mononitrate. I get an almost instant boost to skin look and feel, just 20 minutes after taking NMN. So if I was to switch to yours, at greater cost then find I'm not getting the same results, it's been a waste of money. I understand the pathways that lead up to NMN and have tried addressing those myself in the past, but without much success. I noticed several companies claiming to have their own unique formula, but wonder if it's just them trying to cash in by claiming to be able to do things better. I think that if it's not broken don't try to fix it. Think I'll stick with what I know!
@@catman4471 Because everyone are unique, it's depend if taking Time+ can help, right now, I have RP eyes disease with moderate condition. I assume our eyes need significant energy that NMN I took from AliveByNature seems for 30 days only help in the beginning, better energy, I have no idea if it worth long-term. But Nuchido seems to focus multi-target could be my answer I need. I'm a web developer and a cofounder, and I dislike tech debt. In the same analogy to supplements that only focus on one target is not effective.
I agree. NMN has worked absolute wonders for my elderly father. Not sure why I would want to mess with success. Also, if boosting NAD+ isn't necessary, then why are they ALSO including an NAD+ booster, niacinamide, in this formula? Also, why not just include NMN then instead if niacinamide?
@@CyrilAndPriscilla Hi, I feel that this is just another 'I'm a scientist, buy my product' type of thing. I do understand the reasoning behind it..there are different pathways to creating NAD and the idea behind their supplement is to ensure the de novo pathway is working as it should, rather than relying on the salvage pathway (Niacin, NR, NMN). But all you have to do is get a good nights sleep to create NAD+ through the Kynurenine/de novo pathway. I've noticed that a number of doctors are too engrossed in stats and reports rather than practical experiences of those who take NAD pre-cursors, and I don't think they can really appreciate the benefits we get from NMN. You do not get the same physical or visual benefits by increasing Tryptophan or B6 etc, and you're right, it doesn't make sense according to their approach, to include Niacin.
Follow up NAD+ effects of Time+: Please correct me if math is wrong. NAD+ has a molecular weight of about 660 grams per mole. Typical NAD+ levels appear to be on the order of 40 to 60 micromolar intracellular although some google scholar papers mention blood as opposed to intracellular. The Jinfiniti site which does NAD+ testing reports in micromolar and shows optimal values roughly on the order of 50 micromolar, so expect typical baseline to be lower. Converting 50 micormolar NAD+ to ng/ml I get over 30,000 ng/ml which is huge compared to the increase Nuchido showed of about 17 ng/ml. Calculation below. 660 grams/mole for NAD+ 50 micromolar is 0.00005 mole/L 0.00005 mole/L x 660 gms/mole = 0.033 gm/L 1,000,000,000 ng/gm x 0.033 gm/L = 33,000,000 ng/L 1000 ml/L 33,000,000 ng/L x 1L/1000ml = 33,000 ng/ml If someone here has the skill to do the conversion and check this please do as I don't want to misrepresent Nuchido's results, but so far Nuchido has not clarified what the baseline values of their subjects were or offered up typical values for comparison. One poster noted that he got 33 ng/ml but I did not see his work and he has not yet commented on my details shown above..
micromol is not a concentration but an amount, so you can not convert it directly to ng/ml, unless you are talking about micromolar? if that is the case I get 33ng in 1ml of 50 micromolar
I'm 56 years old been on NAD+ IV 500mg every 2 weeks. My energy levels are thru the roof. There is 0 doubt in my mind that of all the biohacking I do this is the most important supplement that I take by far.
What is the Optimal NAD+ levels ? , and if you have way to high NAD+ levels is it BAD? - Typical NAD levels vary considerably by age and unit of measurement. NAD levels within cells can range between 10 and 1000 μM. Additionally, total NAD values were observed to range between 0.3 and 0.4 μmol/g.
🎯 Key Takeaways for quick navigation: 00:00 🧬 Introducción a NAD+ y su importancia en la longevidad. 03:23 📉 Consecuencias de la disminución de NAD+ en el envejecimiento. 07:16 🏃♂️ Formas naturales de aumentar los niveles de NAD+. 10:20 🧪 Funcionamiento de NMN y NR como precursores de NAD+. 14:39 🔬 Limitaciones de los precursores NR y NMN. 19:51 🆕 Nuchido TIME+: Una nueva generación de potenciadores de NAD+. 22:41 🧬 Importancia de la nicotinamida como precursor de NAD+ 26:35 🧪 Estudio clínico de doble ciego y controlado con placebo 32:47 🔮 Futuro de la longevidad y Nuchido Laboratories Made with HARPA AI
Interested but skeptical.. this was more like an infomercial than scientific discussion... staying on DoNotAge NMN 1500 mg/d + TMG 1500 mg/d + Apigenin for now but I will watch this with interest
Thanks for your feedback, Charles! Our goal here is simply to talk about science, share knowledge, and help others. 🌱✨ We didn't mention it in the video, but the clinical trial is currently being peer-reviewed and will be published in an important journal, so you will be able to go deeper into the topic. Overall, the goal of this episode was to go deeper into the processes around NAD+, while also understanding more of Dr. Nichola's innovative product. It's not that often that supplements are tested with a randomized, double-blinded, placebo-controlled crossover clinical trial, and we believe this says a lot about Dr. Nichola's approach. P.S. DoNotAge is also one of our partners, and we're glad to hear that combo works for you. Let's just remember that it's a different approach where, for example, NAMPT (the NAD+ salvage pathway enzyme) is not being activated, as well as AMPK.
I've heard recently NMN amongst others on donotage is questionable. I'm in Ontario Canada and wondered why some are so expensive and renue by science was a different price. Looking for good quality for decent price.
@@freespiritwithnature4384 Where exactly are you hearing that "NMN on donotage is questionable"? This has not been my experience. I started giving DNA NMN to my elderly father and it has made a huge difference in his health.
Hi, Can you please let me know the comparison of taking NMN + Resveratrol, which is what I am doing, and taking Nuchido? What difference did you notice?
Sounds great but too pricey compared to the NMN powder I use (RBS). I like that TIME+ is a pill rather than taken sublingually. I use apegenin with my sinelytic cocktail; I'll research if I should also take it daily with NMN and TMG.
It's about $2 per day, which is 3 servings per day. 1000 mg NMN is about $1.8 per day. But if you look at the ingredients in TIME+, it's mostly just nicotinomide (250 per serving x 3 servings per day = 750 mg), plus some vitamin c, zinc, and some herbal ingredients. If you already take a multivitamin with vitamin C and zinc, then you could just buy nicotinamide, which is about $0.06 per 250 mg , $0.18 per day if you took it 3 times a day.
@@HH-gv8mx Great question. NAD is not absorbed well if taken and so you must take a precursor molecule instead. There are three chemical pathways for NAD synthesis: the tryptophan path (not very responsive to supplementation); the niacin path (effective, but getting the dose right is challenging as too much increases inflammation); and, then there's the NR path. NR is turned into NMN so, recently, people have been augmenting NR with NMN or just taking NMN. I've just switched to taking NMN sublingually. The NMN by Renue by Science is what I'm trying. By the way, Nicatonamide is on the same pathway (the Salvage pathway) as NR/NMN, and NMN is also after it in the pathway. If you've heard of people taking Resveratrol or proanthocyanins, too, it's partly to grease the enzymatic wheels for that conversion to NMN. I hope this little ramble expresses well enough my limited understanding.
Thank you for the breakdown . So I guess the NAD I’ve been taking is just a waste of money. Dr. Drew swears by NAD. So I ponied up the money for tru NIAGEN NAD. But haven’t really felt a difference in energy levels. @@cravarc
Silly question, and don’t be too hard with me. I’ve been deluged with articles on the possible hepatotoxicity of green tea extracts. How is this mix secure in that respect? Best of luck, it seems promising.
I’m sticking with NR and NMN, this product is a coctail of VitC, Niacin, Zinc, ALA and green tea among others. Niacin is a precursor to NMN and if it’s converting to NMN I can just as well just take NMN. How VitC converts into NAD+ I don’t know and if it doesn’t why put it into the product? Like someone mentioned, this is indeed an Infomercial.
I think that the good thing about these supplements is that you can actually measure the results with blood tests to measure the Telomere lengths? Has this been done for this supplement approach?
@beyondsapiens If fasting activates NAMPT and NAMPT signals to convert NAD precursors such as NMN or NR into NAD then it is clear that taking them during fasting should increase NAD levels. Can this assumption be addressed to Dr. Nichola Conlon?
Data ?? The slide you showed at 30 min was old preliminary data and has nothing to do with the more recent trial which was discussed. The trial which now has slides on the Nuchido web site and which was discussed here shows about a 17 ng/ml increase in NAD+ above "baseline." This might be "statistically" significant but how does this compare to baseline levels. Baseline levels are not disclosed, but from what I can gather a 17 ng/ml increase in cellular NAD+ is fairly small compared to normal levels at most any age. None of the slides on the web site show data in which one can tell approx percentage change above normal levels for the parameter in question. Do you have baseline data to disclose?
Hi Peter, the clinical trial mentioned is currently being peer-reviewed, so that's why it's not accessible. It will be published in a prestigious scientific journal, and we'll update the description with the link once available. We'll get back to you about the additional query 😊
@@beyondsapiensThanks. My point was that their web site shows the data without the baseline values for context. If an NAD+ increase is measured, which they claim and show, it's significance can only be judged by comparing against the background (normal) values. Just asking that those values be put up as well. They can still note that the data is undergoing to peer review.
In all the comments i read many recommendations. One tells you need to take this another tells you need to take that. It's very confusing. What is the overal best to take..????
I understand you want to give us the latest and greatest but I’ve yet to hear about the purity I know N M, and can be real sketchy as far as how it’s made in the purity of it and I love the idea that a lot of your additives come from the real deal as far as plants go
Unlike NMN, niacinamide and parsley are very cheap, so why is this "Nuchido TIME+" so expensive (around 70 £/month)? There is something I don't understand very well in this story. The price should reflect manufacturing costs rather than the supposed benefits of this preparation.
At around @36:30, granted we have turned the corner on cancer but not completely, I get it though. That it is over the course of many decades that our attitudes & approach to cancer & aging change. I pray for a more humane approach to both.
Let me get this right. So as we age we need to be doing more aerobic exercise rather than lifting to increase NAMPT enzyme. So is the reason for enzyme decline due to being more sedentary as we age rather just adding more years? As a 65 yro should I be embracing my treadmill rather than focusing on lifting weights? Has there been any studies in older population as to which boosts this enzyme the most. Can we measure NAMPT to monitor our levels?
The treatment looks great. The website to purchase the product is useless to me. No paypal, no pay by check, does not accept my debit card. I wish this was not in my feed.
Hi Steven, glad to hear you've been able to increase your NAD+ in that way! It's important to remember, though, that in that way, you're still not having a whole-system approach to boosting NAD+. For example, NAMPT (the NAD+ salvage pathway enzyme) is not being activated, as well as AMPK. To learn more about the formulation and how the ingredients work collectively, you can take a look here nuchido.com/pages/nad-supplement-ingredient We hope this is helpful, and best wishes on your longevity journey! 🌱✨
@@CyrilAndPriscillaI’ve being seeing quite a number of video with doctors with research that I trust on the subject of Fisetin.. I’m confident enough to give it a try and have bought & taking 50mg Niacin & 100mg Fisetin..
I have to question studies that use words like significantly without showing actual math to prove it's significant. A real study would show all the raw data including baseline NAD levels and what the percentage increase was. Also, how do the increased levels compare to say a healthy 20 year old? Not saying it doesn't work, but a lot of information about the trial isn't being disclosed. I have my doubts.
Please think about an EU warehouse or duties for EU being charged at checkout👏. This will avoid goods getting stuck 4-6 weeks or even being sent back no matter who you call. Is not about the paying is about the process to get goods released from customs. 🙏 I’m talking about Germany in my case.
Hi Mike, thanks for your comment! The best option is to take the first 3 pills before your breakfast. While the second dose of 3 capsules should be taken at least 6 hours apart. What I, Alessandro, do, is to take the first dose just a bit before my 1st meal at around 8.30AM, and then last 3 pills with my 3rd meal at around 4PM. Overall, the directions are to take 3 capsules with water twice daily, at least 6 hours apart. It's recommended taking them with food as for some people taking any supplements on an empty stomach can make them nauseous. Depending with how strict you are with your fasting (in case you do it), it should be noted that TIME+ does break the fast. If you take the 1st dose to break your fast, then you extend some benefits, such as AMPK activation. If you need anything, we're always here to help. Thanks and best wishes on your longevity journey 🌱✨
You're very welcome, Karen! Thanks for your support, and if you need any help for your health & longevity, please feel free to reach out or book a call with us (calendly.com/beyond-sapiens/30min), we're always happy to help! 😊
Watch what David Sinclair says . He is extremely knowledgeable, not to say your not all my respect to you . But I’ve been on NR and NMN and I have come back to life . 🎉 .
I saw a research about NAD and publications that say that as nad increases so much energy to high levels, can be dangerous for cancer of pancreas in particular. Do you agree with that?
That’s only if you get to extreme levels and in older people they’re so low it’s not going to raise it to super high levels, but just to get it to a normal range again
From what I understand, increasing NAD+ in the blood doesn't really matter. What matters is increasing it intracellularly. And this was not accomplished in their study; they only showed an increase in whole blood NAD+.
@@HH-gv8mx So Many - Nicotinamide Riboside (NR): Nicotinamide riboside is a precursor to NAD and is often used in NAD-boosting supplements. Nicotinamide Mononucleotide (NMN): NMN is another precursor to NAD and is commonly used in NAD supplements. Nicotinamide (Niacinamide): Nicotinamide is a form of vitamin B3 and is involved in NAD production. It is available as a dietary supplement. Niacin (Nicotinic Acid): Niacin is another form of vitamin B3 that can support NAD production when converted in the body. It is available in various supplement forms. NADH (Nicotinamide Adenine Dinucleotide Hydride): NADH is a coenzyme form of NAD and is available as a dietary supplement. NAD+ Precursors: Some supplements contain a combination of NAD+ precursors, such as NR and NMN, to support NAD+ levels. NAD+ Boosting Blends: These supplements often contain a combination of NAD precursors, antioxidants, and other compounds aimed at promoting NAD+ levels and overall cellular health. NAD+ IV Therapy: In some cases, NAD+ is administered intravenously under medical supervision.
Hi Brant, that's a great question, and it's spot on! In fact, by taking Nuchido TIME+ before and after your NAD+ infusion you can ensure your cells are primed for the sudden influx of NAD+. This extends and enhances the benefits. For more info about it, here's a useful blogpost for you → nuchido.com/blogs/news/enhance-the-effect-of-nad-ivs We hope this helps! 🙌✨
Taking NAD+ directly is not very effective (except for neurons), as the molecule is too large to enter cells. That's why the focus is on NAD+ precursors that *do* enter cells.
I just can’t take niacin. It just makes me nauseous and sick and very uncomfortable. NR or NMN. Starting to sound like we have to block CD 38 otherwise NAD is gobbled up before it does anything.
Hi Dove! You will find the field where to insert the discount code during the checkout process 😊 (starting from here nuchido.com/pages/choose-your-supply) So, you would first need to add the product (30 days or 180 days supply) to the cart, create your account, and then on the shipping address page you will also see the field you're looking for. We hope this helps! Here for you if you need anything else. Thanks and have a great weekend! 🌱✨
Can't speak for this product specifically, BUT I do search for supplements having multiple benefits. Why take 7 pills when all you need are packed into 1.
I notice that this product ALSO includes an NAD+ precursor, niacinamide. If the argument is that we don't NEED NMN precursors if we just address the recycling problem, then why bother including an NMN precursor in the Nuchido formula at all? Also, why include the NMN precursor niacinamide and NOT the precursors NMN or NR? Is there some benefit to niacinamide versus NMN or NR?
Hi Cyril & Priscilla, very good question! The reason why TIME+ uses nicotinamide is because nicotinamide is actually the best precursor in terms of bioavailability, and it's the precursor that our bodies naturally use to make the largest amount of the largest proportion of NAD+. It doesn't require any transporters to get in the cells, and it freely diffuses across membranes. Unlike NR and NMN that do require transport. So, the whole argument is that precursors alone don't address the root cause of the problem, and a whole-system approach is needed to boost NAD+ in the best way. Hope this helps!
@@beyondsapiens Thank you for the comprehensive reply! Can you please refer me to some scientific references that show that nicotinamide is the most bioavailable precursor to NAD? I've read some papers that show that supplementing NMN will raise intercellular NAD, but I have not found any papers that show that supplemental nicotinamide does that. Are there any research papers that, first, show that nicotinamide actually raises intercellular NAD and, second, that it does this BETTER than supplemental NMN? Thanks again!
@@beyondsapiens I did find some papers that show that nicotinamide raises intercellular NAD, so please ignore part of my last question. However, I still haven't found a paper that shows that it's more bioavailable than NMN. For example, while NAM doesn't need a transporter to get into a cell, it is still TWO biochemical steps away from NAD while NMN is only ONE biochemical step away from NAD. That is, it is not at all obvious to me which would produce more NAD in the cell-- NAM or NMN. It is completely possible that that, because it takes an EXTRA STEP to make NMN from NAM that that might trump the fact that it doesn't require a transporter. What I'm saying is, I have found no research that proves that supplemental NAM does a BETTER JOB than supplemental NMN at raising intercellular NAD. I mean, it MIGHT--- but is there actual research on that?
The question is: does the advertise product indeed elevate NAD levels withinth cells???. SO fan Neither MNM or NR do elevate NAD levels in cells. How about your advertised product ?
Hi Edmund, thanks for your question! In the trial they measured NAD+ in the blood, because to measure it in the muscle or the brain they would have needed to collect biopsies, which as you can imagine is quite invasive and challenging to do. Taking blood samples is common practice for trials measuring NAD+ changes. You will be able to read more about it once the trial get published in a scientific journal in the upcoming future. Thanks and best wishes on your longevity journey! 🌱✨
I haven't watched the video all the way through but at 24mins and 55 second it talks about methylation. I take NMN with TMG, too which TMG supports methylation. If I switched to Nuchido Time+, would I need TMG or a version of it? Also if using Nuchido Time+ would I still receive the same benefits of NMN (1000mg) like increased energy, eye sight correction etc?
The Nuchido team is excellent at answering any questions you throw at them. I have been taking NMN (1000mg) with TMG and Apigenin for 6 months with great effect. Nuchido has everything in their TIME+ that controls methylation and CD38 levels (although they said you can keep taking TMG if you want, but it's not necessary) so I'm looking forward to starting my TIME+ after finishing my NMN supply in about 7 days time.
Hi Craig, great question, and thanks for the comment! Generally, TMG is taken alongside NMN and NR to counteract the methyl group depletion that they cause. TMG is not needed alongside Nuchido TIME+ because rather than simply trying to fix falling NAD+ levels by putting more raw material into the cell (using precursors like NR and NMN) it is designed to fix the underlying reasons why NAD+ is actually declining, namely the failing salvage pathway. As the cell can recycle the NAM back into NAD+ it avoids the methylation problem. TMG though, can still provide additional benefits such as improved muscle performance (when combined with high-intensity training) and reduced homocysteine levels. So, you can continue taking it to get those additional benefits :) Hope this helps!
I wish experts would stop using acronyms in their video titles. I generally skip these videos because I ask myself, why do I want to waste my time if it's over my intellectual level. "😢" I'm a non-smoker, a non drinker, and an avid vitamin/mineral taker. I still lack energy! I live a low sugar diet.
Hi there, thanks for your comment :) To give you more context about the use & quantity of sunflower oil, please see the comment below from the Nuchido team. We hope it helps! ✨ Sunflower Oil is not ‘added’ to our product as an ingredient in its own right. It is present as an ingredient contained within the Rice Extract Blend we use in Time+, and allows us to avoid the use of other less natural ingredients, such as magnesium stearate, to help the flow of ingredients into the capsule shell. Sunflower oil is present only in a tiny amount. In 6 capsules (daily dose) the sunflower oil provides only 1.7mg linolenic acid (omega 6). As a comparison a 5ml spoon of sunflower oil contains roughly 3250-3500mg linoleic acid (Omega 6). • The sunflower oil is Non GMO verified. In fact, Nuchido Time+ does not use any GMO materials. • The sunflower oil is not heat treated. The oil is expeller pressed. • The sunflower oil is not processed using additives or hexane chemicals. • The sunflower contains no trans fats.
This seems to be an ad for a very over priced supplement and as i understand they do not even universally take credit cards. Also it's already been shown that NMN and even more so NMNH is much more effective than nicotinamide which is the major player. One can buy all the other things himself and come out way ahead.
Nicotinamide (NAM) and nicotinamide mononucleotide (NMN) are both precursors of NAD+, but they have different bioavailability. Nicotinamide is a direct precursor of NAD+, but it is less bioavailable than NMN. This is because nicotinamide needs to be converted to NMN by the body before it can be used to produce NAD+. NMN is an indirect precursor of NAD+, but it is more bioavailable than nicotinamide. This is because NMN can be absorbed directly by cells and converted to NAD+ without the need for additional conversion. A study published in 2022 in the Journal of the American Medical Association found that NMN was absorbed more rapidly and efficiently than nicotinamide in humans. The study also found that NMN increased blood NAD+ levels by up to 20%, while nicotinamide had no significant effect. In summary, NMN is the best NAD+ precursor with the highest bioavailability. This means that NMN is more effective at increasing NAD+ levels in the body than nicotinamide. However, it is important to note that more research is needed to determine the long-term efficacy and safety of NMN and nicotinamide. ::::: According to available scientific studies, fisetin is the best natural supplement for activating NAMPT and recycling NAD+. ::::: Fisetin is a flavonoid that is found in fruits such as grapes, strawberries, and onions. In vitro and in vivo studies have shown that fisetin can increase the expression and activity of NAMPT. A study published in 2022 in the Journal of Cellular and Molecular Medicine found that fisetin increased NAMPT expression in human cells by up to 50%. The study also found that fisetin increased NAD+ production, which is an essential cofactor for many cellular functions, including ATP synthesis, DNA repair, and stress response. Another study published in 2022 in the Journal of the American College of Cardiology found that fisetin increased NAMPT activity in mice. The study also found that fisetin reduced inflammation and improved cardiac function in mice. Rutin (quercetin) is another flavonoid that has been associated with NAMPT activation. However, the studies on rutin for NAMPT activation are less conclusive than the studies on fisetin. Resveratrol, EGCG, and coenzyme Q10 are other natural supplements that can activate NAMPT, but they are less effective than fisetin. In summary, fisetin is the best natural supplement for activating NAMPT and recycling NAD+. However, other natural supplements, such as rutin, resveratrol, EGCG, and coenzyme Q10, may also be beneficial. But again Fisitin is better. ------------------------------------------------------------------------------------------- Which cells cause more inflammation? T cells or B cells? In general, T cells are considered to be the main drivers of inflammation. They secrete pro-inflammatory cytokines, such as interleukin-1 (IL-1), interleukin-6 (IL-6), and tumor necrosis factor-alpha (TNF-α), which stimulate the inflammatory response. B cells can also contribute to inflammation, but in a more indirect way. They produce antibodies, which can bind to antigens and trigger the activation of T cells. Additionally, B cells can produce pro-inflammatory cytokines, such as IL-6. However, it is important to note that inflammation is a complex process that involves multiple cell types and molecules. The role of T and B cells in inflammation can vary depending on the type of infection or disease. In some cases, B cells can even suppress inflammation. For example, regulatory B cells (Treg) secrete anti-inflammatory cytokines, such as IL-10. In summary, T cells are considered to be the main drivers of inflammation, but B cells can also contribute to this process. The role of T and B cells in inflammation can vary depending on the type of infection or disease. Basic advice Based on the latest scientific studies, the best way to reduce inflammation is to take Fisetin and NMN and you can also take Apigenin (optional) in the form of powdered parsley. Fisetin will lower CD38 inflammation in T cells by up to 70% and apigenin CD38 in B cells by up to 80%. Plus, fisetin will activate NAMPT and still eliminate senescent cells.
Hi Daniel, thanks for your input! We want to provide a comprehensive reply, so please find below the reply directly from the Nuchido team. We hope it helps! "NAM is our chosen precursor in Nuchido TIME+ because it has increased bioavailability over NMN. NAM is an uncharged molecule that can rapidly diffuse across the membrane of any cell and mitochondrial membranes. On the other hand, NR and NMN depend on specific transporters to allow them to cross the cell membrane (ENTs and SLC12A8 respectively). This means bioavailability of these precursors is dependent on whether the cell type has the transporter or not (and many do not). Additionally, with NMN some studies have suggested that the majority of NMN is metabolised into NR before it is taken up by the cells. NAM is also the bodies preferred precursors as it is the breakdown product of NAD+ consumption. Nuchido TIME+ increases activity of NAMPT which is the enzyme that converts NAM to NMN, therefore this conversion process does not limit the production of NAD+. As you mention there are very promising studies with fisetin, however it has limited bioavailability in humans. Further human clinical trials are needed to consolidate the pre-clinical benefits of fisetin and work is needed to improve its bioavailability. Nuchido TIME+ contains saphora japonica because it contains rutin a glycoside of quercetin, this greatly increases the bioavailability of the quercetin in the body. We also know from our human clinical trials that Nuchido significantly increases the activity of NAMPT to restore NAD+ recycling. When designing the formulation for Nuchido TIME+ we used a systems Pharmacology approach to identify active ingredients against specific targets. Each ingredient was included and formulated to ensure maximum bioavailability and our approach is supported by evidence from our human clinical trials. Our lead scientist Dr Conlon has published several papers about this -> Conlon, N., & Ford, D. (2022). A systems-approach to NAD+ restoration. Biochemical pharmacology, 198, 114946."
According to the latest studies from Google Scholar, both NAD+ precursors NR (nicotinamide riboside) and NAM (nicotinamide) have beneficial effects against aging and aging-related diseases in animal models. However, some studies suggest that NR may be superior to NAM in terms of efficacy and safety. For example, one study compared the effects of NR and NAM in mice with Alzheimer's disease and showed that NR significantly increased NAD+ levels in the brain and blood, while NAM had no effect. Moreover, NR improved cognitive function, reduced inflammation, and protected mitochondria in mice, while NAM had no such benefits. Another study compared the effects of NR and NAM in healthy humans and showed that NR was well tolerated and increased NAD+ levels in the blood by up to 2.7 times, while NAM caused side effects such as nausea, fatigue, and headache and did not increase NAD+ levels. Therefore, based on this evidence, NR seems to be a more effective and safe NAD+ precursor than NAM. However, more studies are needed to confirm these findings and explore the molecular mechanisms involved. References: (1) NAD+ Precursors Nicotinamide Mononucleotide (NMN) and ... - Springer. link.springer.com/article/10.1007/s13668-023-00475-y (2) Frontiers | NAD+ in Alzheimer’s Disease: Molecular Mechanisms and .... www.frontiersin.org/articles/10.3389/fcell.2021.668491/full (3) Frontiers | Oral Administration of Nicotinamide Mononucleotide Is Safe .... www.frontiersin.org/articles/10.3389/fnut.2022.868640/full (4) Recent research into nicotinamide mononucleotide and aging - Nature. www.nature.com/articles/d42473-022-00002-7 (5) NAD+ in Alzheimer’s Disease: Molecular Mechanisms and Systematic Therapeutic Evidence Obtained in vivo doi.org/10.3389/fcell.2021.668491@@beyondsapiens
Yes, I have been taking it, it is good for those who have more inflammation in the body or autoimmune diseases, according to the most current science. It is recommended to take it together with resveratrol 1000mg and quercitin, for better effects, as they complement each other and enhance the effects.@@aneva2464
The term anti-aging is false advertising and a marketing gimmick. You will age no matter what you do. NMN does work. I noticed that it does. But you will age no matter what you do. Just look at your google photos every year. Granted you should live a healthy lifestyle but every year that goes buy you will be a little less of yourself than you we're the year before. In my experience it wasn't as noticable or concerning until I reached 50.
In reading these obnoxious comments, has anyone had any experience in trying both supplements, that is, MNM combined with this new TIME+ ? Seems like they would be either complimentary or co-beneficial to one another, or that the one would be protective from the other's potential side effects? Anyone?
I have now been taking Nuchido Time+ for 8 weeks at the dose you recommended (2x3 capsules daily with meals, with at least 6 hours between each dose). It makes no sense to take an additional NMN product.. I would like to take you on a short journey to see how the product works for me: - After 7 days: I have a deeper sleep. Although I still wake up 1-2 times during the night, I am much better rested in the morning! - After 14 days: In addition, I no longer have chronically cold hands and have not been so sensitive to cold for a long time before taking Nuchido Time+. Maybe Nuchido Time+ even has a positive influence on the blood circulation! Best regards from Germany and thank you for the really great product. I am curious to see what effect the consistent use of the product will have on me. Before I started taking Nuchido Time+, I had my biological age tested via GlycanAge. I will have the results in 2-3 weeks. After one year of taking the product, I will repeat the test and then compare how my biological age has developed. A very exciting story 😊 But if you look into the science behind the product, you can certainly hope for further very positive effects, here I am thinking especially of the preventive prevention of serious diseases. The system pharmacological approach of Nuchido convinces me very much. - After 21 days: I have been doing fitness sports for many years and therefore probably have a relatively high NAD level in relation to my age. So far, I have not been able to directly feel an increase in energy. But now I have done a test. So far, and for years, I have not managed to do more than 154 pull-ups in 5 sets. I usually managed between 148 and 152 pull-ups. Now I did the test after 3 weeks and I am positively surprised. I now managed to do 165 repetitions in 5 pull-up sets. This might not sound like a big increase (between 7-11%), but for me personally this is a very positive surprise after years of stagnation. Since I haven't changed any other dietary or training habits, the increase in strength endurance can be chalked up to Nuchido Time+. Overall, I recover faster between sets and I am also ready to go again faster after the training sessions. On 23.09.2023 (i.e. before taking Nuchido Time+) I had my biological age tested by GlycanAge for the first time. On 09.10.2023 I received my result. I would have to lie if I said I wasn't a bit excited. My expectation was already tending towards the positive, which means I was already expecting my biological age to be slightly lower than my chronological age. However, the actual result surprised me very positively. My biological age is 23 years lower than my chronological age. It felt like a birthday ;-) But the result is not set in stone and motivates me to continue to lead as healthy a lifestyle as possible, to make sure I get enough exercise, fitness training and sleep. I will also continue to take the dietary supplements I have been taking so far, such as curcumin, astaxanthin, resveratol, etc. I am very excited about the results. For me, it will be very exciting when I do the test again in just under a year's time to see if I can go one step further with Nuchido Time+. In any case, my anecdotal experiences in the first 3 weeks of taking it are extremely positive. - After 28 days: A further increase in strength endurance has been recorded. In addition to 170 pull-ups (back) in 5 sets, increases of between 3-10% have also been recorded in all other muscle groups. For the first time in the 4th week of taking Nuchido Time+, an improved metabolism is also noticeable, which enables me to maintain my weight more easily. The ratio of muscle to fat should therefore also improve. All other already existing positive effects of the first weeks continue undiminished. - After 5 weeks: Visible reduction in belly and hip fat. Overall, my skin is becoming softer and the first very slight improvements in the appearance of my skin can be seen. In the meantime, I have increased the number of pull-ups to an incredible 180 repetitions in 5 sets. All other exercises have also improved by between 5-20% since I started taking Nuchido Time +! The muscle pain after the training sessions is reduced and also gone much faster. More by accident, I have discovered that I have become faster when walking. Overall, I feel an energy boost that I had not thought possible. The already mentioned benefits from the first 4 weeks all remain (deeper sleep, reduced sensitivity to cold, longer endurance, faster regeneration, improved metabolism, improved weight control). - Continued after 6 weeks of use: All the previous benefits of the first 5 weeks are retained, and in some cases even enhanced. The complexion is noticeably better, finer-pored and fresher. I was able to increase the number of pull-ups in 5 sets to 187! There has also been steady progress with other exercises (legs, shoulders, etc.). - Continuation of my experience with Nuchido Time+ after 7 weeks: There are still slight performance boosts in terms of strength - and endurance. This applies to all muscle groups. I have now completed 192 pull-ups in 5 sets. That's about 28% more than I was able to do before taking Nuchido Time+. In the meantime, I can also feel and see that my skin is becoming more elastic. Apart from that, all the positive experiences of the past weeks remain. It's remarkable how much energy Nuchido Time+ gives me after just 7 weeks. I am curious to see whether there will be further improvements. Perhaps my NAD+ level is now slowly being topped up to such an extent that in future even more resources can be used for secondary tasks in the cells, such as for skin and hair. So far, I am completely thrilled. - Ongoing experience with Nuchido Time+ after 8 weeks: Further improvements in the appearance of the skin are recognisable, smaller wrinkles are slowly disappearing. There has already been an improvement in the overall contours of my face. I wouldn't have thought it possible, but my hair is slowly starting to darken (white hair is turning light grey and light grey is turning dark grey). I have no idea whether this will continue and whether I will even get my natural dark brown hair colour back. However, I am realising one thing more and more. Among other things, Nuchido Time+ improves my metabolism considerably. Nutrients that I take with my meals and food supplements that I have been taking for years (curcumin, astaxanthin, resveratol, OPC, hyaluronic acid capsules) seem to have considerable positive synergistic effects when I also take Nuchido Time+! I am convinced that the food supplements I have already been taking can be processed much better in the cells. For some time now, I have been following Dr Nichola Conlon's numerous and very informative presentations very closely. Among other things, I learnt that the body cannot distinguish the source of the nutrients it receives (food, food supplements or medication). Incidentally, my strength is still increasing, for example I can now do 197 pull-ups in 5 sets. Am I enthusiastic about Nuchido Time+? Yes, I am 😇
Seems unusual to hear a doctor with such lazy pronunciation constantly dropping Ts’ ie longevi’ee, scien’ists, wha’ , thoh’ of, lod of, me’abolic, star’alin. Also developin’ poot in’ Also terms like “kind of like” “grab on to i’ “ the over and in appropriate use of the word “like” and “yah know” I just can’t imagine that language in a PHD thesis or a scientific presentation ti piers” Sounds very much like an advert complete with smiley faces of appropriately aged actors. Am waiting for the bit encouraging to buy now before those nasty big pharma companies take the add down! Maybe I am being unfair but it is unusual. Doesn’t instil confidence!
There is no such thing as longevity. I dont know why this word gets thrown sround do much. You start sging st 40, snd are old by 50. Sging is hard, brutal and ehy would a person want to live in a decaying body for 100 yrsrs?
Really ? What poor outlook you have ! I know many people in their 80s that still work and are very active all day. I'm 59 and more athletic than most 30 year olds.
First of all you start aging the minute you're born not at 40 and I don't know in whose book your old at 50 except yours. And as long as I'm not in a diaper and no one has to feed me I want to live to be 100
Nasty arthritis, decaying of joints, nasty skin aging, arthritis. It's all very horrible to look at. Nobody in their right mind would think aging is good. You'd have to be very naive to think loss of mobility, stamina, and just feeling alive loss is good. If you didn't, you wouldn't be on longevity sights. There is no longevity, lol. It's just decaying, and die by 70. It's terrible
