Next-generation covalent BTKis in the CLL treatment landscape 

Lydia Scarfò, MD, Vita-Salute San Raffaele University & IRCCS San Raffaele Scientific Institute, Milan, Italy, discusses next-generation covalent BTK inhibitors (BTKis) for the treatment of chronic lymphocytic leukemia (CLL). She highlights that zanubrutinib and acalabrutinib have a more selective inhibition profile compared to the first-generation BTKi ibrutinib. This selectivity is expected to provide similar efficacy with fewer adverse events (AEs), particularly in reducing cardiotoxicity. This interview took place at the 29th Congress of the European Hematology Association (EHA) in Madrid, Spain.
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