Niacin (Vitamin B3): Flushing Away Heart Disease. [4 Studies]

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References:
[1] Superko HR, Zhao XQ, Hodis HN, Guyton JR. Niacin and heart disease prevention: Engraving its tombstone is a mistake. J Clin Lipidol. 2017;11(6):1309-1317. doi:10.1016/j.jacl.2017.08.005
[2] Schandelmaier S, Briel M, Saccilotto R, et al. Niacin for primary and secondary prevention of cardiovascular events. Cochrane Database Syst Rev. 2017;6(6):CD009744. Published 2017 Jun 14. doi:10.1002/14651858.CD009744.pub2
[3] D'Andrea E, Hey SP, Ramirez CL, Kesselheim AS. Assessment of the Role of Niacin in Managing Cardiovascular Disease Outcomes: A Systematic Review and Meta-analysis. JAMA Netw Open. 2019;2(4):e192224. Published 2019 Apr 5. doi:10.1001/jamanetworkopen.2019.2224
[4] Garg A, Sharma A, Krishnamoorthy P, et al. Role of Niacin in Current Clinical Practice: A Systematic Review. Am J Med. 2017;130(2):173-187. doi:10.1016/j.amjmed.2016.07.038
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Опубликовано:

10 сен 2023

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Комментарии : 1,4 тыс.

@joshhart8722 10 месяцев назад

There’s zero doubt in my mind that niacin works. I’ve been taking it daily for about five years and my lipid profile has completely transformed. My PCP actually asked me what I was doing because she’s never seen HDL levels as high as mine in someone my age.

@4x4fronsc 10 месяцев назад

what dosage?

@joshhart8722 10 месяцев назад

@@4x4fronsc I take Inositol Hexaniacinate 500mg twice daily. The amount of niacin is 400mg per dose, so 800mg per day.

@amgis5218 10 месяцев назад

Absolutely spot on. Niacin increase NAD levels in the blood and muscle tissue, leading to body reshaping, with less abdominal fat and more muscle. It’s the most effective and cheapest supplement I’ve ever taken, with visible improvements and blood panel improvements.

@dwdwone 10 месяцев назад

Didn't he say slight improvement if you were healthy?

@bscsmscs1578 10 месяцев назад

what was your LDL 5 yrs back & what is your number now?

@jeremiahcourter8352 10 месяцев назад

I take niacin with magnesium before bed and it GREATLY improves my sleep.

$@defractelasticity$

@defractelasticity 5 месяцев назад

Niacin also gives me insanely amazing sleep. Unfortunately is messed up my stomach the next day and also makes me lethargic and depressed. Such a bummer because I love the burn.

@infosplus1772 5 месяцев назад

What dosage you take please

@MsJayski 4 месяца назад

Dose please

$@defractelasticity$

@defractelasticity 4 месяца назад

@@infosplus1772 issues arose after a few days of use. Doses ranged from 500mg to 1500mg. The lethargy and depression was likely caused by it causing me to over methylate. I’ve heard low doses can “borrow” methyl groups and prolong use could result in under methylation, and high doses can act in a way to cause over methylation. Feeling sick to my stomach was also the worst.

$@defractelasticity$

@defractelasticity 4 месяца назад

@@MsJayski see my reply to the other person

@agballew9604 10 месяцев назад

I’ve been a big fan of Niacin for years, especially it’s positive impact on brain health…!

@Vn-ye3km 2 месяца назад

What effects did you get. Thanks

@sherylfetik4126 10 месяцев назад

When you take Niacin, you can actually feel the effects of your blood vessels dilating. It sometimes causes redness, or flush. I gave Niacin to my mother, and believe that it helped to improve her circulation to her legs and feet. I believe that Niacin helps me. I usually take 500 mg. per day.

@emlane-zz6zb 10 месяцев назад

thank you for sharing. I'm gonna try a supplement

@charlieparkeris 10 месяцев назад

500mg would turn me into an itchy tomato.

@klecoxs2 10 месяцев назад

@@charlieparkeris😂😂😂

@klecoxs2 10 месяцев назад

Is that in one dose ?

@sherylfetik4126 10 месяцев назад

On most days, I take 500 mg in a one dose pill, with food and some other supplements. Generally, I buy it from Swanson vitamins. I gave this also to my mother, who lived to be 96. The flush, and occasional itchiness lasts for a few minutes, and goes away. I would suggest not rushing to use heavy equipment, immediately after taking Niacin, as you will feel it working. I believe that it is an aid to healing, as it increases circulation to the extremities.

@pondboy3682 10 месяцев назад

Physionic: "What is niacin being compared against?" Ad interrupts: "Grass fed butter!" Me: 😂😅

@Physionic 10 месяцев назад

Hahaha!

@AnonMedic 2 месяца назад

😂😂😂 lmfao

@Funsoul8 Месяц назад

GRASS FED BUTTER IS HIGH IN VITAMIN. K2 ..❤

@amgis5218 10 месяцев назад

You are missing the biggest benefit of niacin (the type that causes flushing): it significantly enhances NAD levels, especially in the older populations. Many studies exist showing how NAD levels increase multiple fold in muscle tissue with 1 g daily dosage in older adults. These adults experience higher muscle mass, lower abdominal fat, and better physical health because of niacin. I can vouch for its effectiveness in body reshaping as a man in my late forties. If I had to choose just one supplement to take, it would be niacin. Yes, I saw dramatic improvements in my blood lipids. But it was its positive benefits on my body composition and huge improvement in the gym that I noticed the most. It’s better and much cheaper than NMN, with the same outcomes.

@ShowMeWhatINeedToKnow 10 месяцев назад

HOw much did you take?

@amgis5218 10 месяцев назад

I take 1 g daily, which is much lower than the dosage recommended for lipid remodelling (usually 2 g daily). I am taking niacin to increase my NAD levels, which 1 g daily is more than enough for. Even 500 mg daily will increase NAD significantly. But even at 1 g daily, it has increased my HDL (best ever result in my life) and lowered my triglycerides (again best ever number in my life). And at 1 g daily, it's very unlikely to have any negative effects on blood glucose control. I have experienced no side effects, except for the flushing, which I have now gotten used to. @@ShowMeWhatINeedToKnow

@LTPottenger 10 месяцев назад

you only need 250mg

@ldjt6184 10 месяцев назад

To achieve what? @@LTPottenger

@amgis5218 10 месяцев назад

@@LTPottengerall the clinical trials use 750 mg to 1 g for boosting NAD+ in skeletal muscle tissue. Not one study uses 250 mg. Not one. And for lipid management, it’s 2 g minimum per day according to standard clinical practice. I don’t know where you pulled that 250 mg number from. You just talking whatever.

@TheTrock121 10 месяцев назад

I stopped taking Niacin or Nicotinic Acid about 3 months ago when I ran out of my first bottle. With no other changes to my diet I quickly gained about 5 lbs. I'm ordering more right now!

@susannahwhite7561 10 месяцев назад

What brand?

@TheTrock121 10 месяцев назад

@@susannahwhite7561 The brand doesn't matter, but you want the kind that causes the flush, i.e Nicotinic Acid. This time I ordered time release capsules so I won' feel like my hair is catching fire.

@Rocky7729 5 месяцев назад

You can get niacin with red meat

@Fearzero 3 месяца назад

@@Rocky7729Ya along with saturated animal fats, heme iron, cholesterol and neu5gc all highly correlated to shorter lifespan in 50 plus year studies.

@keng7758 10 месяцев назад

Your reviews and detailed analysis are quite awesome! Love your work!

@gtau3144 10 месяцев назад

After an inner ear disorder that stressesd my brain enormously, affected my walking talking and vision I tried every thing to improve. I found any thing that increased methylatiom made me worse so I started on Niacin to decrease methylation and improved . It was a life saver. There are studies going on with respect to genetic repeat ataxias.

@stevenabeles616 10 месяцев назад

Seems to help with meniers disease.

@kylelochlann5053 10 месяцев назад

What protocol did you use?

@gtau3144 10 месяцев назад

@@kylelochlann5053 I take 1g per day of Niacin, in 3 doses after food. Niacin amide does not help. Kind of used to the flush now as I started in 2019.

@kylelochlann5053 10 месяцев назад

@@gtau3144 Thanks, perfect. Few people realize the significance of the form of niacin.

@Always-xl9db 10 месяцев назад

1g of Nivotinic acid daily? Thats quite a bit. How is ur liver function? Any affect on glucose levels?

@srmitch9260 3 месяца назад

Niacin (nicotinic acid) completely “cured” my acne. I have had acne for many years well into my 20s, I’m not 26 completely acne free. The transformation since taking 500mg daily of flush niacin, my skin has DRASTICALLY improved. Fascinating substance

@calvinpurdy2668 10 месяцев назад

I have been taking 3 grams of "flushing" Niacin after dinner for several months now, and my blood lipid profile improved dramatically. I'm staying with it, not only that, but at almost 70 years of age, I have noted a remarkable reduction in age spots on my face and hands.

@theworld9272 10 месяцев назад

Can you provide a link to the niacin you bought?

@MrCeo1978buddy 10 месяцев назад

@theworld9272 I just looked it up on Google and it said niacin flush

@theworld9272 10 месяцев назад

ok,thanks@@MrCeo1978buddy

@dearartms 10 месяцев назад

we need more videos on most known vitamins, they are so helpful

@benroberts1446 10 месяцев назад

agreed. Right now I'm taking a derivative of B1 (Thiamine). It's helping me deal with an issue but I'm concerned of what the health implications are of taking it long term (maybe there is no downside though/only benefit?). Derivatives aren't the same as the typical form too.

@FrenchViking466 10 месяцев назад

I have a bit of an issue with everything synthetic, my body doesn't seems to like those type of supplements.

@Always-xl9db 10 месяцев назад

Are u taking TTFD form of B1? Or Benfothiamine?

@aurapopescu1875 10 месяцев назад

Watch Dr. Peter Osborne's channel, he has extensive courses on all vitamins and much more.

@aurapopescu1875 10 месяцев назад

@@FrenchViking466Eat lots of meat, no need to take supplements.

@nassermj7671 2 месяца назад

!!! This is better explained than those MD's who seem so busy to expound

@Bodtec66 10 месяцев назад

Niacin, including Inositol Hexanicotinate, has long been known to be a terrific antihistamine which we know has a great deal to do with other heart disease effects like very painful variant angina, which I have experienced hundreds of times. Certain triggers, for example like MSG, aspartame, caffeine, etc...might trigger the coronary arteries to constrict whereas Niacin, prophylactically or even during acute attack, can and does dilate those vessels. I have done this in practice for myself hundreds of times and for clients in my previous life, hundreds of times very effectively and obviously very safely as the amazing Niacin genius, Dr. Abram Hoffer would attest Niacin is for so many things from heart disease to schizophrenia and from histadelia to "allergies". All The Best, T

@sueyu3603 10 месяцев назад

Different types but it can rise bilirubin n does with me Gilbert’s

@michaelcox1071 10 месяцев назад

He means a previous profession or stage of life.

@manicniceguy2341 9 месяцев назад

Damn was wondering why I could smell better. I just started taking Niacin today. Along with my Magnesium and Fish Oil Tumeric. I don't think it has any side effects at work where I picked up a Bottle at Walmart.

@papazjose1274 9 месяцев назад

@@michaelcox1071 Sad that in 2023 you have to clarify what this means

@danielmoser2741 9 месяцев назад

Yes Dr. Hoffer is wery good i read the Book

@bowser2005 10 месяцев назад

My problem with a lot of niacin studies is they use laropiprant to control the flush. I believe the laropiprant is what blunts the benefits of niacin. The vasodilation effects of niacin are a positive.

@jamescalifornia2964 10 месяцев назад

I agree. Ford Brewer MD points this out as well ... 💊

@paulpellico3797 10 месяцев назад

exactly i feel our hero left us danglin a tad. WHAT is taken with the niacin is of the utmost importance. AND not consuming heavy carbs within the 4 hour window of the niacin is deadly important.

@profdrlt 10 месяцев назад

Agree. Newest form of Niacin - Inositol Hexanicotinate allows you to take high dose without flushing, but it has not been trialed.

@jamescalifornia2964 10 месяцев назад

@@profdrlt / There is sustained release form niacin that many use 👌

@paulpellico3797 10 месяцев назад

@@jamescalifornia2964 i love physionics soooooo much more than brewer. physionics is the polar opposite, and really MOST health videos. with physionics.....i need to take naps partially through his videos. i feel like the dumb kid in the back of the class making underarm fart noises thinking this makes me a participant in the class. brewer just rambles, darts around a lot with unfinished sentenses or thoughts a lot and his sidekick is difficult to understand, with many videos leaving you with little data and a lot of generalized, unfinalized, unsolid statements and positions. physionics is the polar opposite.

@MARILYNANDERSON88 10 месяцев назад

Thanks for reaching us with important science news. Your presentations are on our level+astretch.

@ThomasConservative 10 месяцев назад

Great video, answers a lot of questions I never thought to ask but needed to know.

@Physionic 10 месяцев назад

Glad it was helpful! And, thank you!

@JCPProductions01 10 месяцев назад

I take 250mg with flush every 2 or 3 days. I got blood work before and after supplementation, and my triglycerides cut in half, and my hdl is very favorable. The flush also has helped resolve some discoloration under my eyes as well.

@larryc1616 10 месяцев назад

The required dosage is 1200-2000mg/day in split dosages

@JCPProductions01 10 месяцев назад

@larryc1616 the required dosage lmao. Okay. I'll stick with my dosage that's been working. I have a prostaglandin sensitivity. Too much niacin I can'tbreatheh for a short period. It can stimulate the same response as asthma patients with inhaler because of the prostaglandins

@Zoso449 10 месяцев назад

250mg/day is optimal for me too. Minimum effective dosage

@ash9x9 10 месяцев назад

and they say 1200-2000 mg!? That is crazy@@Zoso449

@alexsaraceno6144 10 месяцев назад

Hey bud, what's a flush ?

@tomwandersee73 7 месяцев назад

I take full flush niacin for better circulation to all the tiny blood vessels in my body. The effect on triglycerides and HDL is appealing but the lowering of LDL not so much. There are studies coming out that correlate extreme longevity to higher LDL scores. Cholesterol is in every cell of your body and very abundant in our brains. Thus, all the dementia and Alzheimer's nowadays due to low cholesterol and statins. I've been full carnivore now for 20 months and it's become obvious that a high fat, high protein diet is the proper human diet. EVERYTHING has improved. At 64 years old with a 6-year-old daughter, it pisses me off that I had to figure this all out by myself on RU-vid but am grateful I finally found the holy grail of nutrition.

@OfftoShambala 2 месяца назад

Glad you are doing well… however there are those doing extremely well, recovered from lots of chronic illness from raw vegan and whole food vegan… but 90% needs to be organic. I think the thing is to stop the sugar, the fake sugar, preservatives, pesticides, various toxins etc that most people eat daily nowadays… meat and non poisoned fresh fruit and veg as Whole Foods… are what we are meant to eat… it’s about getting the toxic food out of your life. Sure, have a brownie for your birthday… or some potato chips w onion dip at a bbq … your body can deal with that most likely… if those types of things are truly rare… it’s about only eating Whole Foods… I don’t like the vaccines they pump into animals… and they are trying to put vaccines into spinach at some riverside university in California. Hope you continue to do well!

@daveforgot127 Месяц назад

You are nuts

@mclovin8739 Месяц назад

It seems those who follow carnivor always feel great, and those who go vegan claim the same, and the common factor is the lack of carbohydrates

@bertlindsay Месяц назад

@@OfftoShambala agree, they are all elimination diets. But there's definitely benefits is quality grass fed meat consumption

@Sydopath Месяц назад

What relevance is the age of your daughter, to your over-opinionated rant about meat? What is “obvious” to you, may not be a factor with others. You should study the enigma of flawed cause & effect claims with uncontrolled in-vivo studies

@Vinnie-cv5qv 10 месяцев назад

Another great analysis. Now my son watches your posts. He has a degree in bio/chemistry and is a true geek who loved his Organic Chemistry 3 class. He said no thanks to med school and loves teaching chemistry hoping he can encourage his students to pursue careers in the sciences. He is asking his students to watch your channel.

@Physionic 10 месяцев назад

That's really wonderful, and thank you to you and your son, Vinnie.

@MostAlpha 10 месяцев назад

Chemistry Wizard indeed.

@orion9k 10 месяцев назад

Take this every day, 500mg pure powder, the flush effect is so wonderful, a bit pricky and stingy on the skin at times but I really enjoy it 🙏

@jamescalifornia2964 10 месяцев назад

The " pins and needles" effect ... 😳

@cater4anytink45 10 месяцев назад

@@jamescalifornia2964me too I love the warn feeling

@ldjt6184 10 месяцев назад

I'm glad you enjoy. I do not.

@mrofnocnon 10 месяцев назад

Me too!

@gtbigdog3507 10 месяцев назад

I don’t mind pain and I hate it

@usonaasher3023 10 месяцев назад

We called it the happy pill in the 70..because it improved our mood 😊

@sunmoonstars3879 2 месяца назад

It was part of the initial AA protocol, it literally cures addiction and boosts the mood!

@NoLimitsNatty 10 месяцев назад

Thank you, as always excellent information 🙏🏼

@Ken-wg4zy 10 месяцев назад

Interesting subject, presented and explained well by you. Looking forward to more video's on niacin. Also if possible dosages to take based on researchers findings. Keep up the good work. Thanks!

10 месяцев назад

That's incredible news to me! Thanks for the awesome video, as always!

@Physionic 10 месяцев назад

Thanks, Andre.

@Draziell 10 месяцев назад

Dr. Hoffman e posteriormente o William Walsh usavam altas doses de niacina para tratamento de esquizofrenia e outras patologias mentais devido os efeitos nas histonas (transcrição gênica).

@manrodstrupe7312 10 месяцев назад

@@PhysionicB3 = PP ?

@ianrichardmorrissey6082 8 месяцев назад

My combined cholesterol number has always been around 275, I started taking 1 x 500 ml no flush Niacin morning and night and after 2 months my cholesterol dropped to 195. I’m 69 years old and due for a bloodwork test at the end of December so I’m really itching to see my test results. For the record I eat a very healthy well balance diet, limited alcohol and do not smoke, hike, bike and walk my dogs 3 times a day.

@twoissas 7 месяцев назад

Sounds like a great combination!

@leonardwebster8236 7 месяцев назад

@@twoissas de

@lawnmower11 6 месяцев назад

I had similar 30% reduction using flushing niacin NA in the past year

@veronicav1779 5 месяцев назад

Niacin no flush doesn't have same beneficial effect as Niacin flush so don't know how you improved your numbers, good news for you anyway

@harrytoyshirt4146 5 месяцев назад

Cholesterol isn't bad.

@terrycameron9728 10 месяцев назад

Thanks Nicolas, you’re a very gifted natural communicator. I found this to be very clear. I await your further videos on niacin as I’ve been on NMN for about 10 months. ❤

@mahmodali9394 10 месяцев назад

NMN is a waste of money It doesn't get into the cells you can listen to peter atia thoughts about that, old school B3 will Skyrocket your NAD

@bernadettebecher4689 10 месяцев назад

Thank you- great information!

@trinispur3787 3 месяца назад

I started taking Niacin about a year ago. At that time my overall cholesterol levels were very good ~120 total, 42 HDL, ~120 Tri, ~70 LDL and lower amount of VLDL. I had been on Crestor for many years. However I was still having a lot of heart problems and I could never get my HDL up or my Tri down. So having seen a few videos on Niacin I decided to take it starting with 500mg once a day. Because of the flushing effect I moved to taking it at night just before I went to bed. Within 6 months my Tri had come down to the 80s and my HDLs into the 50s. In December I increased my intake to 1000mg per night and last month my blood work indicated my Tri in the 50s and my HDLs in the low mid 60s. This was the first time my Tri to HDL ratio had gotten below a 1:1 level which is the current gold standard for a lipid profile. My LDLs increased about 10% during that time but is still in the very acceptable level. I have recently halved my statin dose and will monitor how that affects things within the next 3 months. Overall I’m very happy with the results so far. Do your own due diligence as this is not intended to be medical advice or a recommendation as each person will have different outcomes.

@nirajshuklaNL 10 месяцев назад

Downloading this to watch on the plane tomorrow. You're so consistent with the great info.

@Physionic 10 месяцев назад

Have a safe flight!

@allboutthemojo 10 месяцев назад

@Physionic I am generally healthy and fit ( play sports and exercise 4 to 5 x per week) but my ldl is very high, hdl is good, triglycerides low and lipoprotein A very high. My doctor has been trying to convince me to start statin. I didn't because I'm not totally convinced about statins. I started Naicin ( sustained release, not the flush free kind) and Garlic pills. My hdl increased quite a bit, ldl dropped by 20 percent, triglycerides went even lower but I still have to get my Lipoprotein A measured, which the doctor says is the main concerning marker of all. Unfortunately, there just aren't enough videos about Lipoprotein A. Any suggestions on how to learn about it and your opinion? Thanks

@user-sy3wd5jn4n 10 месяцев назад

Thank you for muddying the water. I still consider it a miracle supplement.

@flatty9159 10 месяцев назад

Helped my ED for sure.

@tylergates4075 12 дней назад

How long did it take to notice results? Dosage?

@theancientsancients1769 10 месяцев назад

I took Niacin for my Long covid palpation issues in 2021 and surprisingly my cholesterol dropped from 215 to 170 or 5.7 to 4.5 the palpitations reduced too once cholesterol went down

@DeusExMachina50 10 месяцев назад

How much did you take?

@ShowMeWhatINeedToKnow 10 месяцев назад

HOw much did you take?

@bwp2bruce 10 месяцев назад

To those asking how much did he take, the recommended dosage is 500-1000 mg daily. That's what I take. No palpitations.

@marcelguldemond2523 10 месяцев назад

I’m trying niacin for LC as well, but I’m currently taking 200mg because the flushing I get with 500mg is insane. Trying to work my way up.

@kasiar1540 10 месяцев назад

Look into magnesium and mg deficiencies

@nikkmann149 10 месяцев назад

Keep up the great work man. Could definitely see you blowing up and becoming as popular as more plates more dates in the health and fitness realm. I'd argue your technical explanations and breakdowns for the lay person are even better than his.

@BenOchart 10 месяцев назад

I used to get hive rashes. Red itchy rashes. I took 100mg of raw niacin and got a massive hive break-out ... I never had another hive rash again. I consider niacin a miracle vitamin. Not the toned down niacinamide but raw real niacin.

@spockboy 10 месяцев назад

Love your channel.

@Mike-yv9cq 9 месяцев назад

thank you Buddy Holly! good info

@qstaratma9096 6 месяцев назад

😂😂😂😂😂

@TheFirstManticore 10 месяцев назад

I am a 76-year-old female. I take about 250 mg. Niacin daily- or just enough to get a flush. I take it for "sense of humor," as I hear reports that it is helpful for this. I tend toward depression, and anyway, a sense of humor is good for everything. I take Niacin, not Niacinamide. One can, in time, develop a tolerance to Niacin such that there is no flushing, but this has been very slow to arrive; a few years ago I only took 125 mg, and I am now considering taking 375 mg. Even this is not a huge dose, so this therapy is pretty cheap. Years ago I took statins, but my doctor has not been prescribing them lately, so the Niacin may be a factor in this also.

@JerryWDaviscom 10 месяцев назад

I'm 66 and take 500mg almost daily, and another 500mg at night sometimes to give me a deeper sleep.

@maodanz1672 10 месяцев назад

Me too i will take 1500 mg or more spread out if im sick or cleansing with vit c ref .dr hoffer . Dr saul

@ollymounara605 10 месяцев назад

@@JerryWDaviscom is that niacin or niacinamide? Because I flush so hard if it take my B complex without food that only contains 10mg that I can't imagine what would happen by a high dose like that. I do have niacinamide at 500mg, but that will get me a headache if I do not take MethylB12 and or TMG along with it as it uses up methylation.

@1flybyguy 9 месяцев назад

@@ollymounara605I take 500mg niacin (not niacinamide) daily and some days won't get a flush and some days the flushing will make me red from head to toe and blotchy rash on the chest and back, hot and tingly. It lasts less than an hour, but I'd take it when not having to go out in public if that redness would cause embarrassment. Wondering if my not experiencing the flush on some days is tolerance, but I still get it so can't figure that one out.

@evelynmitchell2888 7 месяцев назад

I have read that Thiamin vitamin B-1 is also mood elevating.

@vajaindransramasamy4107 10 месяцев назад

Excellent information on Niacin.

@oibal60 10 месяцев назад

Thanks again for this.

@donnolsen 10 месяцев назад

This is difficult to grasp without knowing the Niacin dosage of the studies.

@venom999333 10 месяцев назад

1000-2000mgs Take a 500mg in the morning & 500mg at bedtime Add a 3rd pill in the afternoon if you want but more than likely 1000mgs should be enough. If you want do a random 3rd pill a few times per week. Flush isn't a problem. First time yes. Second time, not so bad. Eventually it's barely noticeable most days. So, take a vitamin B3 to help save your life or rely on pharmaceutical chemicals that cause you numerous harmful side effects. B3 side effect...flushing. Difference here is adult or a child? Which are you?

@gz625 10 месяцев назад

1,5-2g rectally

@dr.robertjohnson6953 10 месяцев назад

And that makes it a usless study. But such is the way of epidemiology, USELESS IN SCIENCE.

@venom999333 10 месяцев назад

@dr.robertjohnson6953 not when you know that the dosage is 1000mgs to 2000mgs. Doctors study medicine & don't usually bother to learn what healthy eating & nutrition can do. Because why would they? They treat the symptoms with medicine. Their whole purpose in life. Most won't treat the route cause if it doesn't involve some type of medication. No money in that. Someone comes in with heart burn issues. Scope then it's either a pill for rest of life or surgery. No other options. Forgetting to mention that losing 10lbs would also cure the issue. No need to mention that part because no money to be made there! 😉

@mrmcallister 10 месяцев назад

@@gz625😂😂😂😂😂😂😂😂 omg. Are you serious ?

@jrb_sland 8 месяцев назад

Aging [75] Canadian man here. I've been consuming 2500 mg of niacin daily for the last 30 years every since I complained to my GP about the high cost of the Zocor [a statin] that he had recently prescribed & which had shown positive benefits on a recent before/after set of blood tests focusing on cholesterol levels. He suggested I try niacin but warned me about the well-known 'niacin flush' side effect. I made the switch, adapted to the flushing, and so far, so good. My blood numbers are routinely well within currently recommended levels. But I'm still waiting for compelling evidence that lowering cholesterol is long-term beneficial, however...

@teddybearroosevelt1847 6 месяцев назад

You can also take it with chia seeds dissolved into water. The chia seeds multiply in size thereby acting as a buffer and this lets the niacin get released over time, thereby getting rid of the flush.

@dragonofdolittle1332 10 месяцев назад

Just found your channel. Fantastic!!

@pwlacombe 10 месяцев назад

You do statistical analysis of people watching your videos. You can't get enough.

@mystrength5640 10 месяцев назад

The raised Glucose/ insulin is a concern, looking forward to more info! Thank you great Video!

@Semsdoyle 10 месяцев назад

I did my own study and concluded NIACIN was of no use what so ever. I was trying to find the BEST WAY to clean my dishes. So I studied NIACIN effect VS the cheapest dish detergent I could find. At no time was I able to get the NIACIN to lather nicely, all the NIACIN dishes remained dirty…..Yeah, amazing the bias of these studies when there is no money for them to make.

@michaelfortunato1860 4 месяца назад

Outstanding. Thank you.

@orion9k 10 месяцев назад

So you basically spend 14 minutes explaining that niacin has no positive nor negative effects on health according to studies 😅 It's still one of my favorite supplements, way better than nmn for energy boost, it really wakes me up if the flush hits hard 🙏

@jamescalifornia2964 10 месяцев назад

Live for the flush 😊

@Riley512 8 месяцев назад

You are the only one (and me) who noticed this. Also not much criticism of the studies, although most people here chiming in provides contradictory results.

@orion9k 8 месяцев назад

@@jamescalifornia2964 Oh yea! Sometimes I will even do it twice per day, once for breakfast in my smoothie and once for 10min before workout.

@Libertas_P77 10 месяцев назад

I’ve been taking Niacin (flushing version) at 1g daily for 7yrs, because of historical studies going back DECADES (before big pharma with a vested interest in us taking their statins over a cheap, off label vitamin), that show substantial long term health benefits. There’s some legacy papers from the 1970’s where they followed a group beyond the original study, and the ones who stayed on it showed substantial reductions in various degenerative age associated conditions. It’s to me a no brainer alongside 1g of NMN, because Niacin utilises the Preiss-Handler pathway.

@Physionic 10 месяцев назад

That study you’re referencing is called the ‘CDP’ study. It’s a big one.

@hrabmv 6 месяцев назад

thank you for your experience! i took 200 mg for 2 days and my skin improved overnight so that i am scared how good this works...there must be some bad side effect to it, i was thinking....my skin REPAIRED in 2 days...from being red for few years now since covid basically! niacin is good for bones too!! for eyes, yes i did notice i crave sugar bit which i did not have before!

@rowslynch6342 5 месяцев назад

@@Physionic HELP Please ??? So a 35% reduction in LDL along with a 35% increase in HDL. Isn't that a POSITIVE outcome for combating Inflammatory processes ??? HELP !

@Stanley_Baby 3 месяца назад

@@rowslynch6342 Yes to a very large extent

@00Tenrai00 День назад

What variant do you take ? Nicotinic acid? Please get your liver function test done. Niacin >500mg/day causes liver toxicity…

@avoycendeether8869 10 месяцев назад

This is a good one. I've probably spent at least an hour listening to this while reviewing those papers....I only ever tried niacin in acute doses before hot ~hour endurance events (crit, sprint triathlon, 10k, etc) with the idea that skin flush dumps heat quicker and improves performance...so a little niacin and greenleaf/sims sodium loading. Never knew niacin had an impact on blood lipids. Crazy.

@charlieparkeris 10 месяцев назад

Love this channel.

@superdavedfw 7 месяцев назад

I've been taking niacin over the past +/- 6 months and I have steadily reduced my total cholesterol count by about 20 points. From about 250 to about 230, which doesn't sound like much, but the bigger improvement is my LDL (the bad) went from 158 to 131 and my HDL (the good) went from 38 to 55. My Doctor has been trying to get me to do statins for a while and I've been fighting her on it. I started out doing 300 mg a day (3X100 mg) and now I'm doing 800 mg a day (1X500 & 3X100). Best to take with a meal to help avoid the itchy, red skin and flushing, but in time, you will build up a tolerance to where it's less irritating. Still a work in progress that seems to be working!

@tommyleejohnson7308 10 месяцев назад

Thanks. Struggle with the biology/chemistry. However, love the stats!

@stalbaum 5 месяцев назад

I think the positive cardiovascular effect of niacin is from flushing, essentially mechanical, and not from modulation of fats.

@MrDavid8460 6 месяцев назад

Super interesting video!

@lindapestridge3073 10 месяцев назад

Thank you Nicolas.

@kwilliams1958 10 месяцев назад

Looking forward to more analysis, Nic. "To supplement Niacin or not, that is the Question!" From what I have read and listened to, whether Niacin is beneficial or not for heart health lends itself to "maybe, yes, and no." I think this series can be most beneficial to this community.

@gz625 10 месяцев назад

If you have problem with lipids AFTER you changed your diet - go for statins. Niacin is mostly useless drug with side effect of rising sugar level. I don't see real benefits.

@spandon 10 месяцев назад

Great work as always, many thanks. Does any of the study data used here specify if B3 was delivered in isolation rather than within broader 'B vitamin group' supplementation, other supplementation elements and factoring for dosage level etc?

@mikem2397 9 месяцев назад

30 days niacin balanced cholesterol for me. Love it

@alineharam 5 месяцев назад

new study of dangers with Niacin. Please give us an update to this wonderful episode.

@fatboydim.7037 10 месяцев назад

Niacin is often touted as a NAD booster in Longevity.

@maj8301 10 месяцев назад

Does that mean my NADS will get bigger? Is it painful?

@alejandrososa5146 4 месяца назад

@@maj8301slow down, Beavis

@Stanley_Baby 3 месяца назад

When they did studies on NMN and NR, a great deal of NAD in the organs was Niacin derived rather than from NMN and NR

@adamchen5076 5 месяцев назад

Nice work Nick, I’ll be joining your club biochem. It’s nice to see the continued relevance of the Krebs cycle 50 years after I first laid eyes on it in the pages of Lehninger.

@doctorrobert60 10 месяцев назад

In addition to the risk of elevating blood sugar one must avoid extended release niacin that some people try to limit the flushing. Extended release niacin has the risk of hepatic inflammation. Love your video by the way!

@CaptnYestrday 10 месяцев назад

From what I've gathered in the studies and meta studies, high dose(500mg-1g+) niacin flush should be taken once a day after dinner. This takes advantage of the first couple hours of carb sugar clearing effect and avoids the dangers that niacin introduces to blood glucose and insulin resistance during the 3rd through 6th hour window after ingestion. 😅 Just no snacking after dinner!! An interesting question to pose would be " when after dinner? Immediately following or just before bed. "

@mrofnocnon 10 месяцев назад

True but only a very slight risk.

@Coasterdude02149 10 месяцев назад

@@CaptnYestrday What if your snacks are usually celery sticks, cherry tomatoes and cucumbers? Yes, I am serious.

@papazjose1274 9 месяцев назад

@@Coasterdude02149 Then change your diet because if you are fat eating celery sticks, cherry tomatoes and cucumbers, you got a bigger problem that Niacin can't correct. Also, no healthy person should be snacking. Just pure logic, nothing personal,

@lone982 10 месяцев назад

2 Friends with very high cholesterol aged one over 60 and the other over 70 years old. Both have a zero coronary calcium score. So much for the heart disease theory.

@BerlinerDK 3 месяца назад

Yes we have been lied to. People with low cholesterol are losing the mind, libido and die younger.

@deela1058 3 месяца назад

Can U please provide some links to read tge research you revuewed. I would really apprectiate reading them. New viewer happy subsciber

@TammieBuckeye 10 месяцев назад

Thank you..

@Vegguit 10 месяцев назад

I have been taking 1250mg of B3 in the form of nicotinic acid (niacinamide does not work) for 35 years, I started after reading the '8-week cholesterol cure' in the late '80s I am 61 now, have a cholesterol level of over 300 but have a CAC score of zero. I have had a CAC twice in the last three years and both times had a zero score. which is rare in a man my age. Also, B3 is now know to be an NAD+ booster similar to NR or NMN. Just me 2 cents

@redberries8039 10 месяцев назад

Good to hear. I've been on about 500mg per day for about 10 years

@genomedia44 10 месяцев назад

Do you break that up into smaller doses? Given that most people experience the flush as low as 30-50mg

@jamescalifornia2964 10 месяцев назад

@genomedia44 / I use the sustained release kind. Also a TMG supplement. There are some studies that show niacin can lower CV inflammation. Interesting supplement ... 👌

@redberries8039 10 месяцев назад

I also take with TMG (as per a poster above)

@Always-xl9db 10 месяцев назад

How is your glucose and liver function?

$@arnoldfrackenmeyer8157$

@arnoldfrackenmeyer8157 10 месяцев назад

Bravo! Excellent video! I have learned from failed research and development just because a substance favorably alters blood lipids, doesn't mean it prevents heart attacks and strokes. I was hoping you would include Absolute Risk Reductions and Number Needed to Treat to avoid a CVD event with Niacin.

@papazjose1274 9 месяцев назад

Have you checked out the rest of his videos series on Niacin yet?

$@arnoldfrackenmeyer8157$

@arnoldfrackenmeyer8157 9 месяцев назад

@@papazjose1274 No, this was the first I had seen.

@darcyfernandes8922 10 месяцев назад

Very good.

@Sara-wb2bs 10 месяцев назад

Also, take Boron and Selenium for the heart.

@sdbrickoven 10 месяцев назад

What's important to note in all these studies is the amount of niacin that was used, in order for niacin to work for your heart disease, you need to take 3 grams to 5 grams a day, and apparently it works much better if you spread it in three doses a day. In other words, minimum of one gram, three times a day.

@jamescalifornia2964 10 месяцев назад

Most probably take sustained release formula. 💊

@Always-xl9db 10 месяцев назад

Sustained release would not have that effect. Nicotinic acid, not niacinamide.

@JoeyD913 10 месяцев назад

@@Always-xl9db Endur-acin extended release niacin is Nicotinic acid...

@larryc1616 10 месяцев назад

I've seen the effective dose of nicotinic acid is 1200-2000mg/day in divided doses. I take 500mg/3x day

@JoeyD913 10 месяцев назад

@@larryc1616 I take 1000mg twice a day of the Endur-acin.

@lindaabernathy4876 10 месяцев назад

Thiamine is very interesting. Especially the lipophilic forms. And how about nicatinamide/niacinamide?

@kevshan6518 5 месяцев назад

Love your videos. Have you done one on vitamin K2 ? Thanks 😁👍

@Physionic 5 месяцев назад

Not yet - thank you, though

@kevshan6518 5 месяцев назад

@@Physionic thanks for reply 😁👍

@Vn-ye3km 2 месяца назад

@@Physionic Thanks for the non biased info.. could you pls let us know if 1) Niacin with flush or without is best 2) Niacin or NMN with dosage Thanks

@JH-yu6yf 8 месяцев назад

I took 500mg of normal nicotinic acid (niacin), not slow release, for a month. I took it with 2g vitamin C, and did that at least once/day (before bed). My LDL went down 100 points, from 150 to 50, and my HDL went up, in just one month.

@fabienpaillusson7390 10 месяцев назад

I have read the book by Dr Abram Hoffer entirely dedicated to Niacin and its therapeutic uses upon megadosing. It's a mine of information by a doctor who had enough integrity to test the supplement dosages he recommended to his patients before prescribing them. He thought that otherwise he could not relate to how his patients would feel under the potential side effects, including the (in)famous flush.

@mahmodali9394 10 месяцев назад

Thank you for sharing your thoughts, i wish more people learn about the late great Abram Hoffer and his work, may God bless his soul in heaven's

@addams40 10 месяцев назад

OMG THE FLUSH GOES AWAY WITH CONTINUED USE. READ..

@tomyhasse 10 месяцев назад

I read the same book and it is a true evidence that Niacin is working

@ianstewart8243 10 месяцев назад

The flush is not a "side effect"

@fabienpaillusson7390 10 месяцев назад

@ianstewart8243 it's a side effect insofar as the reason why people take niacin is not for the flush itself

@Frogman214 10 месяцев назад

Request a meta analysis of studies out there on Niacin boosting NAD and any longevity, repair or health span effects. Thanks for your consideration.

@ben-qz8qe 10 месяцев назад

Thank you for sharing information. Is there any particular brand of niacin that is readily available at this time?

@MMimi-mg4qt 8 месяцев назад

It cured to me something that looked like the begining if the arthritis. A friend of mine had nasty hip pains and now she is cured.

@ZappyOh 10 месяцев назад

Who would skip any of this?

@jmc8076 10 месяцев назад

If you have a busy life? I have friends who would like to watch all of the videos they want to but have careers, family, etc.

@tomdeweese9547 10 месяцев назад

USA Pharmaceutical Companies hope everyone misses it.

@JuanNgtse 10 месяцев назад

@@jmc8076we all skipped it, let's be real.

@madisonone8929 10 месяцев назад

Start with 100mg full flush immediate release Nicotinic Acid. Then slowly titrate to 200, 300 to 500. I would recommend 750 and stop there. Full flush immediate release niacin has no effect on Insulin resistance. It’s the slow release that cause blood glucose issues. One amazing factor in human health is the maintenance of NAD. 33% of full flush immediate release Nicotinic Acid will convert to NAD. Niacin significantly reduces Lp(a), a sudden death marker. To mitigate flushing pop Quercetin pill half hour before with lots of water or take Niacin with apple sauce. You can go higher to 1000 mg. You should see significant improvement in lipid panel. Of course your doctor is gonna hate you that you are not on Statin.

@rickprince3765 10 месяцев назад

Wakes me up in the morning for about 15 minutes

@henrytsang2923 9 месяцев назад

Great work! I note there’s quite a lot of discussion on niacin and nad+ levels as different forms of b3 are believed to have anti-aging effects. Do you have any insight on that?

@terrifictomm 10 месяцев назад

Wow! The mention in the Cochrane Study of the risk of increased glucose intolerance was just that. A Mention! Like one line. But SO IMPORTANT to me! I took 3g of niacin for over six months with my doctor's knowledge. To say, I had his approval might be stretching it. High brought it up as a supplement. He thought it might help lower my cholesterol. I can’t be certain that the niacin caused an increase in my fasting glucose. But I do know that several years ago my fasting glucose when I wasn’t eating any carbohydrates, or extremely low carbohydrates, was about 120. These days my fasting glucose, eating no carbohydrates, is between 160 and 190. Before when I wasn’t eating carbohydrates I was actually able to skip my insulin. Now I can’t. This certainly wasn't a Study and I’m certainly not an N=1. But it is possible that the niacin supplementation increased my glucose intolerance.

@k8eekatt 10 месяцев назад

Thanks for sharing your experience

@shawnshawn7477 10 месяцев назад

It's well known that Niacin can cause blood glucose issues. This is why it isn't recommended as a treatment if you have a history of diabetes. I am curious if you had your actual insulin level, not just glucose tested? The insulin level would be a better indicator of insulin resistance. Lowering LDL might not be a good thing....

@terrifictomm 10 месяцев назад

@@shawnshawn7477 My fasting insulin has been measured twice in the past 18 months. It was 19 the first time and 16 the second.

@terrifictomm 10 месяцев назад

@@shawnshawn7477 My triglycerides to HDL Ratio is 2.1. So almost good. I wasn't trying up lower my LDL, but raise my HDL.

@kasiar1540 10 месяцев назад

Look into magnesium. Dr. Levy has a fantastic book about it and diabetes is mentioned

@MichaelCzajka 10 месяцев назад

Niacin works: 500 mg/day of inositol nicotinate (& folate 5 mg with some B6) immediately reduced my cholesterol, Free Fatty Acids (FFA's), homocysteine, HBA1C and CRP in a week. Surprised my doctor how quick it turned around... even though it was his idea. Added a bit of Alpha Lipoic Acid later to normalise a fatty liver. :-) N.B. Inositol hexanicotinate is a slow release form of niacin that still works but doesn't give you the painful flush. The flush is still there... only reduced to a non-irritating level. I was already taking a B-complex.

@TheJaYSolo 2 месяца назад

did the ALA work for your fatty liver?

@MichaelCzajka 2 месяца назад

@@TheJaYSolo Yes

@mahiuddintalukder7573 10 месяцев назад

Dera Sir, It would be great if you could create a video that explores any connection between niacin and schizophrenia. Thanks and best regards.

@felicisimomalinao1981 5 месяцев назад

Excellent.

@deJohnethan 10 месяцев назад

Great video! Would love to see a video about TMG / Betain. Whats your opinion on this supplement? According to Dr Brad Stanfield it seems quite promising and his statements are usually backed with good evidence. Im surprised you didnt pick up on the TMG topic yet?

@Physionic 10 месяцев назад

It takes me 2-12 weeks for each investigation considering I read every study and take detailed notes on every study, and guess how many people ask me to cover things for them? ;-P I'm not fast, but I'm thorough.

@Always-xl9db 10 месяцев назад

Yes, plz do 😊🙏 TMG is of high interest to many of us with MTHFR polymorphism (very common), because we can’t methylate B-vitamins that well. I’m taking 2g everyday,

@jtk5867 10 месяцев назад

So very informative - thanks for that. Would it be possible to extrapolate from this data, to model the functional mechanisms of B3 vs NAD vs NMN? Thanks.

@cynthiahansen2341 10 месяцев назад

I was wondering this also..nr?

@infosplus1772 5 месяцев назад

The very crucial infos are peoples comments what they have experienced with B3, Thank you so much for very useful video please make an update

@narniadan 10 месяцев назад

this was extremely helpful info

@Burnrate 10 месяцев назад

When I learn about mechanisms it is always interesting to look at the evolutionary context of why the mechanism exists. What circumstances would make a human more likely to survive with that specific series of chemical events occurring? From a simple glance at foods high in B3 it seems like they are also foods that are high in fat; this makes me think it's a built in defense against high cholesterol. When you consume the fat you get the altered chemical pathway to reduce the impact of the fat in your blood. When you don't have these high fat foods you also don't have the B3 and your body is using more of the limited fat you are taking in. This is all ruined by the modern hyper processed foods and weird stuff we eat but looking at meat and whole foods it makes sense.

@thomassaddul 10 месяцев назад

The only bad fats ate PUFAs

@DanteLikesRock 10 месяцев назад

this video is about D3 not B3.

@thomassaddul 10 месяцев назад

@@DanteLikesRock B3 not D3

@DanteLikesRock 10 месяцев назад

@@thomassaddul true. my bad

@connor6309 10 месяцев назад

I’m confused by your comment, as lean meats and whole grains do contain high levels of niacin but have low fat content

@lorddouglas6659 10 месяцев назад

I have been taking 250mg/daily Nicotinic Acid (Niacin with Flush) for 2 years. My Triglycerides went down from 251mg/dL to 115mg/dL. My HDL rose and my LDL dropped. You have to take the flushing type. Taking non-flush Nicotinamide does not reduce the Triglycerides.

@digitalbath6057 10 месяцев назад

Is it prescribed or you took it on your own?

@carmella88 7 месяцев назад

I'm so scared to do this bevause I already have anxiety I heard it can cause panic attacks

@TheJaYSolo 2 месяца назад

do you believe the niacin was what made your triglycerides go down that much? Is there anything else you did for your triglycerides?

@theanimenoob599 10 месяцев назад

Thankyou Sir

@wasmara 5 месяцев назад

thank you

@marcelguldemond2523 10 месяцев назад

Great video, as someone else pointed out, the form of niacin studied might be important, if indeed the flushing version does vasodilation where the other versions do not. As well, it would be great to see a video on niacin and long covid, as many people with LC find it helps them a lot.

@elinino5275 10 месяцев назад

There should be some studies on long covid. I know many people that have it. It's terrible!

@The_10th_Man 10 месяцев назад

@@elinino5275no refunds

@papazjose1274 9 месяцев назад

@@elinino5275 Kind reminder that Big Pharma do not want you to be taking Niacin, but their own meds

@dankurth4232 9 месяцев назад

When taking niacin it is recommended also to take TMG (Trimethylglycine) to protect the liver. Niacin uses up (quite heavily) methyl groups, which the liver needs to detoxify and metabolize food. The ratio should be 2 TMG to 1 Niacin dose. Otherwise Niacin has a vast range of health benefits. It is recommendable to take both Niacin and Taurine because this synergeticly increases the respective impressive cardio vascular benefits

@Lulu-kt6gr 7 месяцев назад

Omg you can’t take anything without balancing it with something else. Totally makes sense but makes me wonder why we supplement anything at all !!

@dankurth4232 7 месяцев назад

@@Lulu-kt6gr both niacin and TMG are independently helpful (niacin improves general health and in particular heart and cardio-vascular health) TMG lowers homocysteine and significantly improves liver functions. This is called synergy, thus it makes a lot of sense to take both - together!

@Lulu-kt6gr 7 месяцев назад

@@dankurth4232 Synergy…yes I’m aware of the word- lol. But have you ever thought about how all of the minerals should be balanced for that synergy to take place? Too much potassium knocks off the sodium; you need to take calcium, magnesium, D3 and K2 in balanced amounts, and it’s even dangerous to take too much magnesium because you could mess with the electrical impulses of the heart. Then there’s iron and copper…I’m not sure if the vitamins affect each other but I know the minerals do. I take so many individual supplements that I’m starting to think it’s ridiculous. If one is legitimately not getting enough nutrients from food, that’s probably the only time we truly benefit from supplements. If you’re vegan, you need B12. That’s about it.

@Lulu-kt6gr 7 месяцев назад

@@dankurth4232 and I just looked up TMG and supposedly it is not recommended for people with high cholesterol. If I hadn’t seen that, I might’ve really been doing the wrong thing for myself. So there you go - a great example of my point.

@cordyone 6 месяцев назад

I just buy a bag of glycine and use it as a daily sugar replacement in my cereal and my tea. usually this is about 10 grams. I dont use TMG for that reason

@angelmiller9359 6 месяцев назад

You need a really cool sciency back drop 😏. I take it from time to time, I’ve had really high triglycerides in the past, I feel like it’s helped but for a few rare people, like my husband, one can have an allergy to it. It was not a good time after he took it and his anxiety over what was happening freaked him out even more 🤦🏻‍♀️. Thank you for the time you put into these videos, following up now with the next video on it.

@addams40 10 месяцев назад

I suffer from ptsd, and I have one of the best accupuncture doctors you can find. He said he wants me to get to 3g of niacin a day. Divided doses always of course. This is MY example of dosing.

@1flybyguy 9 месяцев назад

I've been supplementing with 500mg of niacin daily for over a year, and indeed, my LDL went down 25% and HDL up 25% on average. My highest level of LDL was 145 mg/dL before niacin, and after, it's been under 100 consistently. As far as elevated blood sugar, I don't know if that'd be shown in my HbA1c, but that hasn't fluctuated by much... pretty steady. I'd do everything I could to not take a statin drug, or any drug for that matter.

@nattydred2593 10 месяцев назад

My Dr and I switched me off Statins to Niacin about 15 years ago, and I haven't looked back. My calcium score actually went down a little the first five years. LDL generally at 75 or lower, HDL around 60. Blood pressure low normal, heart rate reduced to 60. I don't know if it was related but I did start to gain some weight. I address that with a Fasting Mimicking diet once or twice a year, and a restricted feeding window of 11-12 hours.

@nutterz641 10 месяцев назад

Thanks for sharing. What dosage are you on?

@nattydred2593 10 месяцев назад

@@nutterz641 2000mg SLO-NIACIN (Main pointe Pharma) every morning along with Kirkland fish oil, magnesium, quercetin. We started at 1500, and after about a year of monitoring lipids and liver enzymes, increased to 2000. If I miss a day the flushing the following day is more intense, but for me, manageable. I should add that most days I intentionally walk 7500 steps in about an hour, and switched to a pescaterian diet ( fish 2 or 3 times a week), high in beans and vegetables, with no processed grains or seed oils. EVOO only.

@ShowMeWhatINeedToKnow 10 месяцев назад

When you say your calcium score, you mean your coronary artery calcium score? How much niacin did you take?

@BigDees19 10 месяцев назад

When you gained weight it's cause you are more than you moved

@StreetTruckinTitan 10 месяцев назад

You really dont have to worry about higher LDL. Its HDL and trigs that we should worry about keeping in a healthy range. You need a higher LDL for hormone production.