Nonsense mutation 

This DNA mutations lecture explains about the nonsense mutation of gene. www.shomusbiology.com/
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In genetics, a nonsense mutation is a point mutation in a chain of DNA that results in a untimely stop codon, or a nonsense codon in the transcribed mRNA, and in a truncated, incomplete, and commonly nonfunctional protein product. It differs from a missense mutation, which is a point mutation the place a single nucleotide is modified to intent substitution of yet another amino acid. Some genetic issues, akin to thalassemia and DMD, outcome from nonsense mutations.
Nonsense mutation: A mutation (a change) in a base in the DNA that in advance stops the interpretation (studying) of messenger RNA (mRNA) resulting in a polypeptide chain that ends prematurely and a protein product that's truncated (abbreviated) and incomplete and mainly nonfunctional.
The nonsense mutation converts a codon (a triplet of bases) that encodes an amino acid into a discontinue codon, person who specifies the termination of translation. There are three nonsense codons (UAG, UAA, and UGA) in mRNA. One among them comes commonly at the finish of each polypeptide. A nonsense codon is a stop codon which is out of location.
Catching such a faulty messenger RNA (mRNA) before a truncated and probably unsafe protein is synthesized is the job of what is called the nonsense-mediated mRNA decay (NMD) pathway.