Pentose Phosphate Pathway - Regulation, Purpose and Importance in Human Health

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Video lesson on the pentose phosphate pathway (hexose monophosphate shunt), the purpose of the pathway and the importance in human health.
Hey guys! In this lesson, I talk to you guys about the pentose phosphate pathway, what the purpose of the pathway is, how the pathway is regulated, and why the pathway is so important in human health and some health conditions that can arise from problems in the pathway.
If you found this video helpful, please like and subscribe for more lessons like this one! :)
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**MEDICAL DISCLAIMER**: JJ Medicine does not provide medical advice, and the information available on this channel does not offer a diagnosis or advice regarding treatment. Information presented in these lessons is for educational purposes ONLY, and information presented here is not to be used as an alternative to a healthcare professional’s diagnosis and treatment of any person/animal.
Only a physician or other licensed healthcare professional are able to determine the requirement for medical assistance to be given to a patient. Please seek the advice of your physician or other licensed healthcare provider if you have any questions regarding a medical condition.
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Although I try my best to present accurate information, there may be mistakes in this video. If you do see any mistakes with information in this lesson, please comment and let me know.
I am always looking for ways to improve my lessons! Please don't hesitate to leave me feedback and comments - all of your feedback is greatly appreciated! :)
Thanks for watching! If you found this video helpful, please like and subscribe!
JJ

Опубликовано:

6 апр 2017

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Комментарии : 67

@suza.5306 2 года назад

Amazing video. Clear, concise, and easy to understand. Thank you!

@anastasjam5561 5 лет назад

Thanks so much for your videos! It's really helpful to have as an extra resource.

@jonen9494 6 лет назад

This makes biochem so much more bearable. Thanks!

@ivanarepic6057 3 года назад

hopefully ill feel the same one day

@35Bassell06 6 лет назад

Great video. Super helpful for my Biochem class, cheers and keep up the good work

@ZahdShah 3 года назад

Brief summary: PPP drives the formation of reducing agent, NADPH (used in fatty acid synthesis), and pentose sugars which are used for glycolysis and nucleic acid synthesis. Glucose-6-phosphate, catalysed by enzyme glucose-6-phosphate dehydrogenase, reduces NADP+ into NADPH. The final net result of this oxidative branch pathway is ribulose-5-phosphate and 2 NADPH molecules. Ribulose-5-phosphate can get converted into xylulose-5-phosphate which is further converted into fructose-6-phosphate. Fructose-6-phosphate is utilised in glycolysis where glucose is broken down into pyruvate to generate ATP. Ribose-5-phosphate is also used for the production of PRPP which determines pyramidine and purine nucleotide synthesis. This process mainly occurs in the liver and adipose tissues where NADPH can be utilised to donate electrons required for fatty acid synthesis. PPP is regulated by the activity of glucose-6-phosphate dehydrogenase where NADPH can allosterically inhibit its activity at high concentrations.

@fwiomb 9 месяцев назад

thanks! relating the mechanism to its purpose in the bigger picture is really helpful.

@vincel.a5034 Месяц назад

not a medicine student but a biotechnology student and wow bro you always save me in the last minute. you're heavenly sent 👌

@tamemomar5724 3 года назад

You're a legend man. Thanks a lot

@brycekworth 7 лет назад

Beautifully concise and informative.

@playerfromwest1561 6 лет назад

Saved my night god bless... it was soooo helpfull

@mapa9512 3 года назад

Very interesting and understanding. Thank you!

@ssanvee8340 11 месяцев назад

Absolutely love your way of teaching!!❤❤

@anuoluwapojojo7306 Год назад

You did justice to this video. Thank you so much!

@marthabenson7629 3 года назад

This makes biochemistry much easier to understand.

@phsal5182 2 года назад

I think it would be much easier to follow along if you also presented the chemical structures of the starting materials, intermediates and products. I think this would help with understanding, vs just cramming. Thank you for your videos.

@nisanilyagz6991 6 лет назад

it was helpful, thank you so much

@yogayantra 5 лет назад

thank you so much. It is so clear.

@thabelomaginya248 5 лет назад

Love the video.brief and helpful thnx

@katarinala 6 лет назад

Very helpful! Thank you.

@JasonLeon-baybeeee 2 месяца назад

Thank you bro. Very helpful!

@d8457 3 года назад

Great lecture!

@drswetaruparel 4 года назад

Very helpful !!! Thanks a lot... 👍

@ashkan.eb1 5 лет назад

U rock! thanks for the video

@kennedyotieno9440 2 года назад

Thanks so Much ...you saved My day sir

@yasirmohammedali 3 года назад

Thank you ... Have a great day

@Kay-wk6lt Год назад

Thank you for this ❤️🤍

@salauddinaiube1810 2 года назад

thanks you.very informative class.

@suvidhijain8219 2 года назад

This really helped me with my class 11th finale exams thank u 😁

@priyasharma-qk7hv 3 года назад

Explanation is 2 good❤️

@marcalanbarcinas7813 5 лет назад

thank you sir!

@drgoldhealthcare 5 лет назад

Clinically so relevant... Thank you

@ryandiaz2096 5 лет назад

Thank you JJ for all your amazing videos!! It would be great if you could do a lesson on the areas of the brain that lack a blood-brain barrier (I think circumventricular organs.. hypothalamus, etc.). A lot of people I ask at my university do not know much about the areas of the brain that lack a BBB and their physiological functions. I would love to learn more myself on this topic and it would be much appreciated if you were able to make a video. Thank you either way!

@lindav1189 Год назад

Babies with high and prolonged jaundice do not have the BBB and within the first week of their lives, they can go from being born perfectly healthy to severely brain damaged. Kernicterus, sadly destroys a child. The mothers of these children say they can't even look at their baby's first days, and most have PTSD from the disaster. Women go home and THEN the jaundice hits, some doctors even downplay it. This is not part of newborn testing in most of United States.

@lindav1189 3 года назад

I have Mediterranean variant; I have almost no g6pd. Every time I have surgery, I go into hemolytic anemia. It is X recessive, but due to lyonization, someone like I, can be very fragile and react with the slightest oxidative stressor. I was just in the hospital requiring transfusions because I pet a dog that had just gotten the flea and tick ointment administered on their neck.

@edward_finn Год назад

thank you jj

@dikecharles9078 3 года назад

Excellent

@waterbottler8782 2 года назад

Thanks!

@zizo853 2 года назад

thanks a lot

@vidasarbah873 Год назад

You are the best

@suadomer9349 3 года назад

Thank you for your effort it’s really helpful & simple✨ but why don’t you involve the remaining of the non oxidative part of the pathway Thank you for reading, and giving me the chance to comment 😊

@theclassroomdoc 5 лет назад

Thanks very interesting. I'm just wondering if you can explain why the supplement d-ribose which works on the PPP pathway is used to increase ATP as apposed to just glycolysis.

@pankajkalita3725 6 лет назад

Nice explaination.Can you tell me by which enzyme Glucono -1,5- lactone 6P was converted into 6- phosphogluconate ?

@JackeelG 6 лет назад

Lactonase

@GpCyc1 5 лет назад

@@JackeelG more precisely 6-Phosphogluconolactonase

@wallmethod 4 года назад

Hahaha From G-6-PO4 (g6pd) - 6phophogluconolactone (GLUCONOLACTONE HYDROLASE) - 6phosphogluconate (6phosphogluconate dehydrogenase) - Ribulose-5-PO4........

@ameerhyder3168 6 лет назад

Kia bt hai bhai

@deevynpeace2519 2 года назад

ppp occurs in the cytosol of the cell

@lindav1189 3 года назад

Those in Africa have the A- variant, which is very mild.

@wallmethod 4 года назад

Gluc-G-6-PO4-(g6pd)-6phosphogluconolactone (gluconolactone hydrolase) - 6phosphogluconate (6phosphogluconate dh) - Ribulose5PO4 (ribulose-5-PO4-3-epimerase) - xylulose-5-PO4 (transketolase) - ribose-5-PO4 Where did you got your source?

@ericmakakantare3523 Год назад

helpfull for usmle

@panayiotisantoniou5095 4 года назад

a question; is the reaction at which Fructose-6-Phosphate , erythrose-4-phosphte and xylulose-5-phosphate part of the cycle or it ends where you finished it?

@panayiotisantoniou5095 4 года назад

btw amazing video! You helped me alot sir