I believe NileRed is the largest chemistry channel on RU-vid. 6.5+ million subscribers (July 2024). His "lab" is an industrial space, in the greater Montreal area. He has a staff of at least 4 employees. Chloroform is probably the least concerning volatile chemical he has dealt with. All chemical reactions are done under fume hoods, in a lab better equipped than most universities. Breaking expensive glassware is routine, and he'll spend thousands on a piece of equipment, that will be used on only one video ! HowtoCookThat channel's review on NileRed's "expensive cookie" video is priceless. Great chemist. Terrible cook.
Which I think is something I wish yt's were more transparent about in general. Nobody faults you for being successful, it's ok to walk around your space and show that your too big to be a one man show. It's not so relavent in Nile's case, but I've seen so many youtuber's/streamers try to act like they don't have a full staff of editors, brand liasons, etc and they're just one person sitting in an apartment hustling.
@@godowskygodowsky1155 the story behind aspartame is apparently that the discoverer licked their fingers to get better grip on paper after having accidentally contaminated their fingers
These NileRed reactions are awesome! I like that you actually contribute more than just the video with your pharmacist/chemistry knowledge and actually going and doing the Epsom salt bath, all for what could just be a basic reaction video! Please keep them coming, even for videos where he doesn’t work with medications!
I was going to say something similar. It's really informative! Also, her chinese knowledge would really come in handy in the medical lab i'm working, we have multiple chemicals with only english and chinese use instructions, but the english one being burried in the last corner of the package, sometimes accidentily thrown away
I think that's the secret to the truly successful react channels. You look at channels like Charismatic Voice, she's a darling of the react space because she tears a song down and adds a ton of commentary on top from someone that actuallly knows what they are talking about. It's also why she somehow gets the actual artists on her show. It would be fun to eventually see this channel interview NileRed.
@@doragonsureia7288 Well sure, they are basically joining a zoom call. Still, she's not big enough for their agent to see it as a marketing chance. The fact that behind the scenes she gets in touch with their agent and the artist is like sure I'd love to is frankly amazing. Its less surprising with groups like Voiceplay that kinda exist in that space already, it's more surprising with traditional touring artists.
The yellow color from this reaction 11:02 is caused by the partial oxidation of free Thiamine molecules to form Thiochrome, which is naturally a pale yellow due to its conjugated 3-ring system that acts as a chromophore for visible wavelengths centered around 370nm, extending well into the blue range. That leaves us with mostly red and green, which we see as yellow.
Translation: The Thiamine is reacting with oxygen to create a molecule with 3 carbon rings put together in a chain. Apparently, this carbon ring chain causes the yellow color
You dispense it a lot 😂😂 WOW how very astute of you to admit that, my question is why do you pharmacists always make screw ups, when all you have to do is follow orders and push buttons?
It really is, the most straightforward way is the Haloform reaction, usually done in aqueous solution with sodium hydroxide, acetone, and molecular chlorine, although you can use sodium hypochlorite as the base and the chlorine source at the same time if the reduced yield isn't much concern. Pipette the bottom layer once it's done and separated, dry in anhydrous sodium sulfate, and fractionate out at 61 Celsius. Very useful stuff to have around
And unlike what is typically shown in movies and the like, it's not like one little whiff will make someone pass out instantly. It will displace the oxygen in a person's system, causing unconsciousness, but over an extended period, not within seconds. Still terrible to breathe in though.
I would highly recommend NileRed's chloroform synthesis video. It was one of his earliest projects where he was still working out of his parents' garage.
@@kassiog.6595 Bromine is relatively 'mild' compared to what other RU-vidrs have been playing with like uranium salts, volatile chromium (chromyl chloride), germane, osmium tetraoxide, hydrogen selenide, methyl iodide, fulminating gold,...
@@kassiog.6595 StyroPyro casually remarking in one of his videos: “Oh yeah, there’s some brown gas being released, I think that’s some of the uranyl nitrate breaking down there. You don’t want to breathe that.”
Nigel's Trash Taste interview is pretty great and is worth a watch (though probably not a good one for a reaction), just as an FYI. He goes into some of the behind the scenes and his background and stuff, including the stuff he doesn't like doing or substances he doesn't mess with and why.
1:49 Epsom, England is on a spring line, and therefore probably has springs around, and those springs are likely to have soluble minerals dissolved in them from the surrounding areas.
If you're interested in anything Nile has done (i.e.: making urea as a precursor to this video) I would highly recommend it. To be honest, I would recommend watching all his videos, as they're quite interesting :) Good video here btw!
Nigel has a BOC in Biochemestry and a minor in Pharmacology. And what I even like most is that he works actually preaty save. (Aside from broken glassware on the floor...) He also has no excisting apptitude for using tools... It´s always fun when he strews away from pure chemistry and get´s a hammer in his hands... or Files... But at the end he is one of the most educational channels with one of the highest qualitys on whole youtube.
*You got to watch "Am I still lactose tolerant? - Lactose Gene Therapy Update" from The Thought Emporium* He made a Homemade Gene Therapy with a gene edited virus. PS: The main (first video) he made is also very interesting and goes into the making of the modified virus.
NileRed is one of the best examples of chemistry safety on RU-vid imo. He does work with some dangerous stuff and always preaches safety and even has a video on one of his channels about lab safety. On the flipside, you have someone like Explosions & Fire who holds a PhD in Chemistry and makes some really dangerous stuff in less than ideal environments. It's honestly a fun channel to check out if you want to see just how dangerous chemistry can be and how much you can make from chemicals you can buy from places like pool stores.
I mean, given that the container was already cracked, it isn't a big deal that he destroyed it. It's not recommended to use any cracked glassware in experiments because it's more likely to fail, which lead to a massive problem with some experiments.
First of all, great video/reaction. Epsom salt bath is also good for MRSA infections as it softens the skin and allows the boil to break easier. I spent a couple years personally fighting MRSA and had seen several doctors about it before an ex-army medic (A doctor when I saw him) recommended it. Prior to this I had to go to the doctor every time I had a new MRSA infection just to break the boil. Afterward I had maybe 5-7 further infections and only had to go to the doctor for the one on my forehead.
I just discovered your videos and I have to say, the way you add little tidbits of background info about the steps hes taking is really clear and concise and it adds a lot to the video. I often find myself skipping parts of these sorts of videos because folks ramble on way too long, but you are very concise and informative!
Asking if you should watch another NileRed video: Yes. Honestly my favorite part of watching these "professional reacts to" type channels is when those professionals react to things that are just a bit outside of their field. Its always really interesting to watch them learn something new and cool while connecting what they have to offer to the subject. So it'd be interesting to see your takes on other NileRed videos that AREN'T explicitly medical based, because I'm sure there are other compounds or processes that come up that are related to the pharmaceutical field. Or any other field adjacent topics or channels which might not be your expertise but are of interest to you. I have enjoyed these NileRed videos, they style of them, your presentation of them, and would watch more like it.
Fun fact: 3M stands for Minnesota mining and manufacturing. Originally the company produced parts for mining equipment and would ship these parts in cardboard boxes. They developed a clear packing tape for this purpose and also started selling the tape to customers. They found they were making more money off the tape and that is when they became an adhesives company and later a chemical manufacturing giant.
The worst seizure medication with ridiculous side effects = Gabapentin. Back when we still used actual paper book versions of the PDR, Gabapentin had 6 or 7 of the dark grey pages.
@@patheddles4004 yeah, it's a huge list and not everyone demonstrates those side effects. My mom has had to take it for YEARS, since around 1997, to prevent seizures. She hasn't had one since she's been on it. She get's groggy and irritable if she forgets to take it, but that's about it.
pregabalin at high doses made this bird i know have nasty agressive behaviour she swore she didnt remember n cried looked horrified when i finally filmed it and showed her, (id put up with it until i reacted then get told i started it and im nasty total lies id take sooo much before reacting, normally id say its just tears cos shes bang to rights but she really did seem to be in shock at not remembering hours at a time and it seemed to stop at 600mg too so i kinda do think it was the meds.. i didnt notice it when i tried them tho but id take way less and not long term as her it so i dno.. Itwas very odd tho she genuinely seemed unaware of her behaviour until i had recordings.. (btw it was a huge 3x300mg prescription plus 2xOxycontin 60mg!. But she Sometimes took more as they accidentally gave double pregabs every month so she really had 6 a day available for couple years it only even stopped cos she had so many saved at 1 point she stopped collecting it and they realised as a result of it hanging round uncollected that it had accidentally listed both Lyrica and Pregab as separate items lol)
I didn't know that the word sitz bath is used in English. It must come from the German language. Sitzbad would be the German word for it. sitzen means sit.
FYI the epsom salt wasn’t in the final product, and if there is, its a very very small amount. The bad taste came from impurities that dissolved in the water.
Nile-Red always warns people not to do what he does, cause with edible chemistry it of course should be safe to eat, but you'll never know the purity of what you make, so please don't heat up epsom salt and drink the water so you don't need to buy some medicine... Also, Nile-Red also always does alot of research in whatever he makes and usually knows what chemical reactions he does and what side products he might create. If you don't know what you're doing, don't do it and don't eat it.
Taking drugs be like do you want to swap seizures for liver issues, severe muscle pain, skin rashes, dizziness, tremors, headaches and sleep problems. Um can I just have the seizures please lol
It all depends on how bad the problem you're treating is, and how severe the side effects you experience are (if any). For example, my best friend and I both take depression medication, but different ones. At one point though she tried one that I was currently on at the time. I had experienced zero side effects from said drug, while she experienced like four or five of them that were uncomfortable and distressing enough that she stopped taking it after a couple of months. Another one we both tried made me mildly sleepy and didn't do anything for the depression, while it gave her like five side effects (including the sleepiness) but it at least worked for the depression lol. Our bodies are all incredibly, infinitely complex, and pharmaceutical science is nowhere near comprehensive enough yet to be able to provide medicines tailored specifically to each person's biology. Until it is we all have to play the pros/cons game and decide what risks we're willing to take.
@@darmakx99 Yes I understand that side effects are not going to happen to everyone but you have no idea of that when you take it for the first time so as I said you either chose the problem you've got or potentially a dozen different problems you might get and if you are the right type of person then the placebo effect of taking a drug that might cause headaches might give you headaches anyway even though the meds aren't doing it.
Benzoin resin has also been used as a temple incense for a very long time and is often used as an ingredient in some orthodox Christian church incense blends as well.
@InaYu2024 I only know because I'm a co-owner of a small spiritual shop, and we sell benzoin gum alongside all of our other resin incense like Frankincense and copal. Humans will find extensive use from anything that doesn't kill them and I find that fascinating.
Is reacting to one of my favorite youtubers ✔ uses Minecraft sound effects ✔shares useful knowledge and expertise ✔ has a sense of humor ✔ has cute (and not obnoxious) accent ✔ What else could you ask for?
You can probably imagine what the making Urea video is like, but if pressed I would say you should watch all of NileRed's videos because they're great content.
Another illuminating reaction video - much appreciated. One quibble: I suspect your Epsom salts bath was like a regular hot-water bath because that's more or less what it was - looks like you diluted the product a whole lot more than the instructions anticipated. Glad the hot-water bath relaxed you and sorted out your wrist pain though.
At last I find a Pharmacist in youtube that i both like to listen to and she's cute, not only in appearance but also in the way her videos are edited, killed me the anime like sound effect at 13:14... XD loving it!!! keep the good work! cheers!
Just so you know, chloroform is a fairly common organic solvent. Its not unusual to use it in synthesis, though maybe dubious to use in medication (considering its harmful side effects).
We use Epsom salt a LOT in the UK for our baths. I'm not sure if it's doing anything special, but it gives the bath a bit of a sparkly feeling, like you're taking a bath in slightly carbonated water.
Chemists have tasted every thing, even cyanide,azide, sodium azid, potassium azide, chloroform, taste was a diagnostic way to discern the chemicals before we had tools to do it, it has a very long history in chemistry
I love the reaction you had to chloroform, we use it quite often for NMR Spectroscopy so its something we always have in organic chemistry labs and such.
NileRed and chloroform and stuff... He's done some interesting chemicals, and when it's something easily done, but shouldn't, I think he purposefully skips a step and also says so in the video, if i recall correctly. Not all info should be easily accessible... But the only time I know of that he was contacted by the government was when he bought that really big beaker or flask... I don't really remember what it was, but it's something so big it's only ever used for industrial stuff or making illegal drugs. That was a fun video! 😄
Regarding phenytoin disuse: Out of all of my epilepsy patients, only 4 of them are still using phenytoin regularly. I don't see any MDs even trialing new epilepsy patients on it, there are like, a dozen or two other meds that MDs prescribe first before phenytoin. Virtually all new patients find one that works before ever needing to try phenytoin.
Urea has a ton of agricultural uses, depending on the donor. There is a very large human contingency out there that swear by giving their garden soil a pre-planting dousing of urea in the easiest way possible. Don't ask my how I know this, I just do... and they're not wrong.
Chloroform is one of the easiest to produce, most refrigerants and anesthetics are Flourinated Hydro Carbons, and or Chlorinated. Early anesthetics was Chloroform, Ether, or combinations there of.
Oh hey, I think I've used that mouthwash (15:40) after I had a gum graft! If it wasn't that brand it was something very similar or a generic or something. Had to use it because you can't brush for a week or two after the surgery so instead you just nuke all the microbes in your mouth with mouthwash and deal with your teeth feeling gross. Also, for my surgery at least, we couldn't swish or spit the mouth wash so you had to tilt your head around all over in funny angles to get your whole mouth covered and then just open your mouth and let it drip out, which was not the most fun thing ever.
We have chlorhexidine over the counter here in Denmark. You can buy it at any pharmacy. I had an infection in the mouth, but it turned out it was fungal and all the chlorhexidine did was disturb the natural presence of bacteria in the mouth and let the fungal infection spread faster.
You don't seem to know but back in the beginning of chemistry, everything was described with a taste back when no spectrometer or something like that was available, this was one accurate way of knowing what substance you have.
As part of the NS police training, they took us to an anti terror exhibition, which described the different gases, Sarin is basically the most dangerous... (those people on the Tokyo platform essentially died before any help can reach them...)
After Explosions and Fire, it's official. NileRed is a certified "piss chemist" who has been pee-r reviewed by plural experts from more than one disciplines.
I've binged half her channel in the day or so, and frankly her awareness of gaming, anime, general geek culture is low-key amazing. After she's exhausted NileRed's videos where he makes 20 cents of naproxen out of lye and fabric softner (I'm joking) I'd be really interested to see her react to people doing content in her field. In example SciShow (Hank Green) has done a few videos on Thalidomide and its history and current usage.
i love coming across this video and hearing "chlorhexadine" and being like, oh that's what nate the hoof guy uses on cow hooves! the multiverse expands lol
