Professor Steven Nissen - Lipoprotein(a): a new target for therapeutic intervention 

The question is, is Lp(a) a marker for thrombotic vascular inflammation or is it a cause? Is it an arsonist or a fireman? I've seen information for both sides and I'm confused 🤔

Research the Pauling Therapy. Get a LP(a) blood test. You can buy them for $50 online. It will be your baseline. Then implement the Pauling Therapy for 12 months. Get another LP(a) blood test. You got nothing to lose and everything to gain.

Why do some elderly people with very HIGH (lifetime) levels of Lp(a) have perfectly normal coronary arteries (i.e. ZERO plaque) and pristine aortic valves (i.e. NO calcium whatsoever)?

I read that grains can raise apoprotein(a). Also read read higher carb diets raise it as opposed to higher fat

I’m a Dr from the U.K. who had this done last week. I’m 44 years of age, my VO2 max is 42ml/min/kg, I’m a type I diabetic, with 23% body fat but 47% muscle (dexa equivalent scan), on Atorvastatin 20mg nocte, last HbA1c of 61 mmol/L (I know 🙄), very active, zone 2, powerlifting, BJJ, moderate ETOH, never smoked and my Lp(a) has come back at 176 mmol/L!? 75mg/dL). There is NO ASCVD in my family except for my mothers brother who had a fatal MI aged 58, after getting on a treadmill, he was unfit and a lifelong smoker and he is one of 13 kids, all otherwise well and some I n their 70’s and a mild MI in my paternal grandfather and that was at 71 following AAA surgery and he had alcoholic neuropathy from his 40’s, smoked 60 a day (you read that right) for over 50 years (with the naturally accompanying emphysema) and the only exercise he ever took in his life was going to and from the pub. The Old man and his brothers all smoked 60 a day for at least 25 years but did physical work their whole lives, now aged 73, 74 and 75 and the eldest lad with DM II has mild ASCVD the other are 2 fit as; my cousins like the rest of the family (I have at least 50), have no Hx of stroke/TIA/angina/MI so out of 70 or so people there is a soupçon of ASCVD in people with significant risk factors and nothing else. How in Gods name is my Lp(a), that high? Poorly controlled diabetes? I’m a Dr and I’m scratching my head here, so any advice would be appreciated 🤷🏻‍♂️

When will Pelacarsen be approved? I have a LP(a) of 199 and need to get on it.

My LPa is 413 NMol/L. I've had triple bypass and one stent. I've asked my cardiologist about any clinical studies and he doesn't seem interested in helping me. He wants my LDL as low as possible and says thet's the only thing I need to do aside from diet and exercise. How do I get in touch with someone for a study?

Thanks Dr Nissen so much for sharing valuable informations 👍. I'm at high risk Lp a constantly 150. 3MIs, last 2020 - STENT. By recommendation of My last cardiologist Stating, that's All.

My LPa is 90noml and Dr said i have slight aortic stenosis im 38 whst you think my prognosis?

How do I find out if I am Lp(a) null? I have done a DNA test through 23 and me. Is the data already in there to be found? In my case I have good reason to doubt my non-detect Lp(a) level is genetic as the literature states. I am wondering if my non-detectable level Lp(a) might be an epi-genetic effect of my rare combination of diet (low carb/carnivore and OMAD) and exercise metabolic regime (long distance thru-hiker who spends months on-trail hiking 10 to 12 hours per day). None of my 3 siblings have Lp(a) levels that are non-detect. With respect to Lp(a), the literature does not speak to the effects of a zero carb/carnivore diet or daily high intensity long duration exercise. From what I have been able to discern, my combination of diet and exercise constitute a metabolic regime for which there is no published data or research. My Lp(a) is non-detect (

You keep repeating, behavioral influencers have nothing to do with risk. Did I miss the part where you cite the studies to back this alarmist opinion? This is absurd when it's obvious that smoking, high carbohydrate and high triglycerides and a sedentary lifestyle will absolutely influence outcomes in this and all populations. I don't think we need a study to prove this.

Does lowering LDL also lowers Lp(a)? If it does, this might be why lowering LDL seems to be good statistically. But why it probably would have no effect if the Lp(a) is low. This is purely speculation by someone rather ignorant. But perhaps someting a researcher would like to find out. The reason for this speculation is that I think there's something odd about LDL levels having any effect. Hign level in older people seems to be good for mortality, contradicting that lower levels are good. If there's something in my speculation, that might leed to some kind of explanation of that.

Strange! Why statins raise lipprot*a? Mine goes down- 10 points in one year.

I am Lpa null.(rs41259144). I have a cytosine to thymine substitution at position 160601075 of chromossome 6 that less than 1 in 1,000 people have that causes truncation and loss of function of Lpa protein. Several people in my family have lived to be over 100 including my great-uncle who is still alive at 105(I am 43), but I don't know if this is related to that or not. My blood work shows non-detectable Lpa and VLDL particles. I also have a missense variant of APOB gene at rs72653092 that causes a substitution of an actine for a thymine that and change in coded amino acid that results in extremely low levelsof LDL-c with elevated triglycerides. My blood work confirms LDL-c of 20 mg/DL. Oddly, my triglycerides are alsolow mostly because I eat little fat. This misense mutation occurs inn 1 out of 800 people.

My mother's lp(a) done after she got MI(2006).. Was17mg/dl!

Where can I get genetic testing for this? 3 brothers and a dad. All widow maker in their 50’s. I have 247 nmmols. I have a cac of 512. I worry about my kids.

I have driven down my LPa with Magnesium Glycinate and Liposomal Vitamin C at 10 grams

Anyone know of any lpa trials?

Will donating plasma lower my LPA

Mine is 477 consistently!! I have 8 stents now I eat pretty healthy. I ate horrible before. 5 new stents since pretty clean eating. I've gotten a low as 317 and sometimes up to 517. I dont know why

Enroll me !!!! I have never met anyone with Lpa levels as high as mine