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Apples are the fruit that is the most associated with lower all cause mortality. People who eat a lot of apples have been shown to have 25% less all cause mortality, which apparently is much better than fruits in general, which lower mortality by than 10%.
Metformin lowers glucose, insulin and inflammation. This alone is life extending. Also, those were all mice studies. Metformin benefits increase after years of taking it.
Hi thanks for the question. I know that the opinions given in the three segments differ. I think that is just where the study is at the moment. Dr Green is a practicing doctor and said what he used. 100 mg of dasatinib, 1g quercetin 2 days in a row every two weeks or 1.2g fisetin 5 days in a row once a month. (though please listen to his section). In the clinical trials I think the dose was 20mg/kg for fisetin for 2 days in a row (NCT ID: NCT03675724)
Hi Bailey, thanks for your comment. It would be great to have some way of measuring the systemic senescent cell burden so that you could titrate the dose to the correct level.
The itp study used young mice. Young animals carry low senolytic loads and are unlikely to see effects from antisenolytics. Why not use older mice? Useless study, raises suspicions
Fisetin was never shown to have life extending benefits. In fact, the Intervention Testing Program showed it had no effect. Same goes for resveratrol and metformin,
@ModernHealthspan I saw that negative result for Fisetin by the Intervention Testing Program. It does not extend lifespan and does not affect senescent cells!
James Kirkland is not keen on selling anything. He's running a dozen trials in a network centered at the Mayo Clinic in humans. I'm waiting on these HUMAN TRIALS results before I pass judgement.
Quercetin has been known to cause kidney damage in doses of 1000mg. Makes me wonder if it is safe to take at any dose. I am taking up to 250mg, but it does make me worry..
Hi thanks for your comment. At lower doses quercetin appears to be protecting the kidneys ("Protective effect of quercetin on kidney diseases: From chemistry to herbal medicines"). But I do see Mount Sinai web site says that there may be issues with 1g/day. One of the key points that all three interviewees made was that the dosing as a senolytic was intermittent. So taking quercetin at 1g perhaps 2 days a month (depending on the exact protocol)
