Great topic Marlon! I've honestly found that with good quality headphones, you can get enough representation of the sub 100Hz range to make good mixing decisions. I have a sub but it honestly stays turned off!
I believe that’s totally possible, its a safe bet that you have great ears, too. I think the catch is as you said “good quality headphones - for accuracy.”. Or utilizing software that is meant to aid you in mixing on cans. Or maybe even the Slate Digital system. Thanks Daniel, for watching, and sharing!