I had 2 lab courses simultaneously during 2 semesters of covid. We just had to put on a mask and get to it. Was horrible, couldn't see anything with the protective glasses fogging up haha
You want all of the compound to dissolve in the solvent (= no crystals) at the point where the solvent would start to boil. But when you cool down the solvent the solubility decreases which leads to forming of compound crystals. When solution has cooled to room temperature you want all of your initial compound to be as crystals, and not dissolved in the solvent, for a maximum yield. Only the impurities should be dissolved in the solvent at room temperature.
Possible with any method, especially reverse additions. One possible cause of oiling out is that drops of the product solution are surrounded by the antisolvent, in which the solubility is very low, and this low solubility creates localized regions with very high supersaturation ratios. Many variables to consider here. Before mixing to the molecular level is achieved, the localized high supersaturation forces the product out of solution without allowing sufficient time for ordering of molecules to enable crystal development. The resulting oily particles have a tendency to clump together before the Occluded solvent migrates throughout the solution. As the mixture is aged, the oiled-out particles may transform into amorphous solids or become "crystalline" (with poor lattice structure)
Question : in the case of two solvent, what is the problem if I do first hot filteration for more purification if there are insoluble impurities suspended with my new copmound?
Oke this explains things very well and is very educative but for the love of all that's holy, please stop blasting that alarm audio, my poor ears.. It would also be appreciated if a reupload of this video with higher video resolution were released.
chunkymonkey2782 If I understand correctly, oiling happens when the boiling point of the solvent exceed the melting point of the sample. So when sample is dissolve at boiling point of the solvent, the solution created would have the sample "oiled" out instead of crystallize out. If this happen, you should reselect your solvent...