Regulation of Satellite Cells with Exercise - Dr. Parise 

Invited Session "Muscle stem cells and skeletal muscle plasticity"
Regulation of Satellite Cells with Exercise
Parise, G.
McMaster University
Do Satellite cells have been shown to be indispensable for skeletal muscle regeneration, and there is little debate about their role in
promoting post-natal muscle growth. However the role of satellite cells in promoting exercise-induced muscle adaptation is less clear.
Whether satellite cells are necessary for muscle hypertrophy has been a hotly debated topic and although animal models
demonstrate that hypertrophy can be achieved in the absence of satellite cells, most human data demonstrates that when
hypertrophy occurs with exercise it is usually accompanied by a nuclear contribution from satellite cells. The extent of the role of
satellite cells with exercise remains relatively unknown . Typically, satellite cells are thought to contribute to exercise adaptation by
promoting growth however whether satellite cells contribute to non-growth related adaptation has not been studied to any great
degree. Also, common dogma is that significant satellite cell expansion is required to promote adaptation following exercise but the
question has never been appropriately addressed. Finally, how satellite cells are regulated in humans following exercise remains an
area of great interest. Significant strides have been made over the last few years and we gaining an appreciation for the complexity
of satellite cell biology as it relates to exercise.

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