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The Science of Muscle Hypertrophy - The Role of Satellite Cells (Part I) 

Physiology Made Easy
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This video provides information on the role of satellite cells for muscle hypertrophy. These cells are activated by the mechanical load exerted on the muscle from resistance training.
Part II discusses the science behind muscle growth and can be found here: • The Science of Muscle ...

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22 ноя 2017

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Комментарии : 48   
@sflora951
@sflora951 5 лет назад
Fantastic video series. Coming from an engineer, your attention to detail while maintaining a sense of simplicity is very refreshing.
@physiologymadeeasy216
@physiologymadeeasy216 5 лет назад
Hi Sean, thank you very much for taking time to leave this positive comment. I am really pleased that the information comes across well. I hope to keep a similar approach for future videos.
@bv_benhur2087
@bv_benhur2087 10 месяцев назад
Excellent Lecture
@rix908
@rix908 4 года назад
I have Gillian Beret syndrome,First time I would like to say you're very educated and able to share that with us thank you I enjoy learning I've spent months reading PubMed so thank you again
@physiologymadeeasy216
@physiologymadeeasy216 4 года назад
Hi Lee, thank you very much for this comment. I am learning while doing these videos so it's great to get this feedback. Pubmed is a great source of scientific information, so keep up the reading and your quest for knowledge.
@yogawithmatt
@yogawithmatt 4 года назад
Very useful video for someone reviewing the physiology of hypertrophy! Thank you!
@physiologymadeeasy216
@physiologymadeeasy216 4 года назад
Thanks Matthew. Very pleased you found it beneficial.
@stevetijerina2290
@stevetijerina2290 3 года назад
Thank you Dr. for your channel and sharing your wealth of knowledge. I actually watch these videos during myofibrillar training sessions (deadlifts, squats and bench pressing) for learning and motivation. I hope I used the term correctly, still learning 🙂
@physiologymadeeasy216
@physiologymadeeasy216 3 года назад
Hi Steve, thanks for taking time to leave this nice comment. I am pleased that the information is being applied to your training. I hope your training is coming along nicely. Keep an eye out for my new strength training video to be releases very shortly.
@emmacaney3468
@emmacaney3468 6 лет назад
Thank you - This is very helpful!!!
@physiologymadeeasy216
@physiologymadeeasy216 6 лет назад
Your welcome Emma! :)
@taxi481LP
@taxi481LP 3 года назад
Great man, thanks for the education.
@physiologymadeeasy216
@physiologymadeeasy216 3 года назад
I am pleased the video was useful to you!
@kamalasaiba1232
@kamalasaiba1232 4 года назад
vary help full and nice video ... thanks
@physiologymadeeasy216
@physiologymadeeasy216 4 года назад
Thanks Kamala. All the best with your studies.
@brainpower6807
@brainpower6807 6 лет назад
Great video.
@physiologymadeeasy216
@physiologymadeeasy216 6 лет назад
Thanks for leaving this positive comment Dima :)
@arpitashanbhag2881
@arpitashanbhag2881 3 года назад
It was helpful. Thank you sir!
@physiologymadeeasy216
@physiologymadeeasy216 3 года назад
I am pleased you found it useful Arpita!
@xprinceduranteofficial9275
@xprinceduranteofficial9275 Год назад
It seems that you've forgotten the other steps. The first is, of course, the quiescent satellite cells, the second is the activated satellite cells (induced by muscle damage), the third is the differentiating of myoblasts, the fourth is the formation of myocytes, the fifth is the formation of myotubes and, the last but not the least, the maturation of a new muscle fiber. It would have been very important if you'd included the maturity of muscle cells because the satellite cells no longer become as such as soon as they've already divided and differentiated from being myoblasts to myocytes, and eventually, to myotubes.
@physiologymadeeasy216
@physiologymadeeasy216 Год назад
Thanks for this comment. I have made a separate video discussing those steps in more detail. See here: ru-vid.com/video/%D0%B2%D0%B8%D0%B4%D0%B5%D0%BE-zpZ-AqlX_Rs.html
@abhisharma868
@abhisharma868 4 года назад
Hey bro what is the difference between Build muscle and build strength
@alexaras5767
@alexaras5767 2 года назад
I'm very late but I have a question. Since satellite cells are not active until they need to repair a muscle, when they do so does the body make new ones? Also does each satellite cell have a limited number of nuclei it can donate?
@jdknesek
@jdknesek 3 года назад
@Dr Sandoo - Is the genetic material that is donated to the damaged fiber identical to what was in the damaged cell to begin with? Or is the genetic material donated from "larger" fiber which will make the smaller damaged fiber larger once it repairs itself also? In other words, is there a kind of natural selection going on where the genetic material of smaller fibers is replaced by that of larger cells which makes the smaller cells become larger ones?
@physiologymadeeasy216
@physiologymadeeasy216 3 года назад
Hi Doug, this is a very good question. My understanding is that the genetic material is identical, but that the instruction of whether a new myotube is created or whether existing cell is replicated is likely to depend on various other physiological factors in the muscle such as hormone concentrations, blood vessel formation, nerve innervation, nutrition, and the amount of muscle damage. As such, it is hard to pinpoint whether the genetic material changes or favors larger muscles. This article is a VERY LONG READ, but may be useful about providing scientific information about this remarkable cell: www.ncbi.nlm.nih.gov/pmc/articles/PMC4073943/
@coachrahulchauhan3525
@coachrahulchauhan3525 5 лет назад
awsome,,,,,,Your video made my day
@physiologymadeeasy216
@physiologymadeeasy216 5 лет назад
Thanks Rahul! All the best with your training.
@thecasual4698
@thecasual4698 4 года назад
Great video, yeah buddy!
@physiologymadeeasy216
@physiologymadeeasy216 4 года назад
Thanks!
@herrmanselcher1632
@herrmanselcher1632 3 года назад
🥜
@mohammadshoaibshafeemohamm6313
Hi Aamer, how many grams of protein is required per day to maximise muscle growth ?
@mswanged98
@mswanged98 5 лет назад
keep it up 🔥👌
@physiologymadeeasy216
@physiologymadeeasy216 5 лет назад
Thanks - more videos coming soon!
@K2-Fitness
@K2-Fitness 4 года назад
Hi, I was just wondering, when your speaking about the satellite cells repairing, you go from saying muscle fibre to myofibre and back a few times while describing the structure you drew (around 4 minutes or so) you initially describe it as a muscle fibre which is being repaired and made larger by satellite cells, but then around 5.23 mark you say its the myofibre, Are muscle fibres and myofibers the same thing? I.e a muscle cell? And then the myofibrils are the individual smaller components which make the myofibre/fiber? Fantastic videos BTW. Just confused myself a little as I was following along doing my own diagram of the exact processes I think. And if so, are the fibres/myofibers stimulated to hypertrophy and grow larger by the 2 methods in video 2? I.e increased number of individual component myofibrils + increased cellular fluid retention which causes the overall fibre to become larger ?
@physiologymadeeasy216
@physiologymadeeasy216 4 года назад
Hi Fiachra, yes your understanding is generally correct and you have summarised the key points well. In general, the two processes of hypertrophy in video 2 are likely to be inter-related and affected greatly by the type of training stimulus.
@sorinstrizu7919
@sorinstrizu7919 3 года назад
Myo fibers (cells) not same as myofibrils ( bundles of sarcomeres)
@xprinceduranteofficial9275
@xprinceduranteofficial9275 Год назад
You are right in some sense, but the hypertrophy isn't actually directly linked to just an increase number of myofibrils. One muscle fiber can have very few myofibrils and have large size of sarcoplasmic reticulum and mitochondria. If you can understand the basics of hypertrophy, then it'll be very easy to know that there are two types of hypertrophy: the first is the myofibrillar hypertrophy and the second is the sarcoplasmic hypertrophy. What you were saying about the increase number of myofibrils is very much similar to myofibrillar hypertrophy, and an example of people who don't have much muscles but are so strong are strongmen, powerlifters, calisthenics enthusiasts, gymnastics, and a lot more. But everything can be clarified in what you said like to what degree of hypertrophy are you talking about? Are you talking about the hypertrophy of Ronnie Coleman who is a bodybuilder or the hypertrophy of Eddie Hall who is a strongman? I'm pretty sure that strongmen also have muscles inside but they're not just visible because they need some fat to make the lift proportional to their bodyweight and also they need fat for energy stores. In conclusion, I can say that hypertrophy isn't really an equal addition of increase of myofibrils and increase of cellular fluid or sarcoplasmic reticulum because the sarcoplasmic hypertrophy states that the fluid is greater than the amount of myofibrils.
@Ilethsamael
@Ilethsamael 4 года назад
Would you say it is possible to have satellite cells to give the fiber more nuclei in the case of proper hormonal stimulation even if fiber hypertrophy is not occurring to a meaningful degree?
@jorgemedrano6162
@jorgemedrano6162 Год назад
Hi what's the timeline between proliferation, differentiation, myotubes and final stage?
@physiologymadeeasy216
@physiologymadeeasy216 Год назад
This video should help clarify this point: ru-vid.com/video/%D0%B2%D0%B8%D0%B4%D0%B5%D0%BE-zpZ-AqlX_Rs.html
@hentaihav3n
@hentaihav3n 3 года назад
thank u for this sir! (:
@physiologymadeeasy216
@physiologymadeeasy216 3 года назад
My pleasure!
@japonicaren
@japonicaren 5 лет назад
I think you mean quiescent. Kwee-ess-ant Great video but marker writing could be a lot bigger.
@physiologymadeeasy216
@physiologymadeeasy216 5 лет назад
Thank you for taking time to leave this feedback. Your right about quiescent - sometimes spelling, talking and thinking creates these odd spellings on the board! My apologies. I will try to make the marker writing larger in future videos. This is exactly the type of feedback I need to make these videos as beneficial as possible to you all.
@japonicaren
@japonicaren 5 лет назад
+Human Physiology Video Tutorials - Dr Aamer Sandoo Likewise - I appreciate the reply. I think the markers were small but visible when I switched to a desktop. On a mobile (wifi hi res) MYOFIBER was readable. Everything else was a struggle. Looking at the set up you had there (distance of camera and framing), any text smaller than your thumbs final knuckle to tip length is going to be tough to read. About the size of the distance of your thumbs two knuckles would be ideal for small text. Couldn't think of any other 'handy' sizing guide so... rule of thumb? :-) I'm clean out of puns. Hope that helps and keep the content coming.
@physiologymadeeasy216
@physiologymadeeasy216 5 лет назад
Thanks Budo. I will try the approach you suggested in future videos. I may also consider having graphics cut into shot now that I have access to better video editing software. Thanks again and all the best in your learning.
@Ri-yf5oq
@Ri-yf5oq 4 года назад
Then why skeletal muscle is permanent tissue??
@physiologymadeeasy216
@physiologymadeeasy216 4 года назад
I am sorry, I do not understand this question. Could you rephrase, and I will try my best to answer it.
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