Rewinding the clock on aging blood vessels 

indeed

It's a shame he gets botox and dyes his hair.

@@capri2673 Well he does eat mostly vegetables I don't blame him

@@capri2673 ha good one. i noticed that too

You all think that’s gonna happen as it will decrease the profit that’s being enjoyed by big Pharma, creating jobs for people, hospitals, clinics, the taxes collected by the government, the economy will collapse!!!

settle down, this is a peripheral part of the aging picture. Light is more important than any other variable when it comes to health.

You are way to quick in calling plain salespeople a genius !

@@clincpb8903 Read his book Lifespan...

How so? He seems like a garden variety academic to me.

Why doesn't he back any brands? Can anyone find higher purity or better pricing than donotage.org ?

I totally agree with you.

Not yet

Google: GlaxoSmithKline and David Sinclair. You’ll come to know more about David. A lot more.

no way to quit sugar and processed foods, cafes, restaurants etc. Most people live in cities. Life will be miserable (like in a lockdown, in a prison). That will kill more people than help. A multi-vector action from many institutions is needed to change the whole lifestyle of industries.

Quit oil, not sugar.

Start eating more organic vegetables and fruits.

I did, and somehow even that still isn’t helping the blood flow to my brain.

Quit life

why we age and why we don't have to. i got it too, this guy mister sinclair is my hero. far from being hungry for profits, he does it so that humanity can benefit from his discoveries

there is no engineer. It is evolution. Yet, in order to understand evolution.... well, i better stop, because it gets too complicated

The almighty God in his infinite wisdom,

@@c-4839 when d they understand that such nonsense is pure blasphemy, in their own system??? How can you apply sth like "wisdom" here' how can you say "almighty"? How cold you at the same time' It would mean that cruelty is an important part of wisdom. You are stupid, on your wn scale.

Natural & evolutionary engineering in a way i write :)

Human bodies are incredible amount of maintenance unless you’re rich is a real pain in the ass

How, explain please

You can eat all these things without being vegan.

@IAM REAL LOL. Every vegan Ive seen looks like a crackhead

Plus, contrasting showers. Going from hot to cold a few times.

@J Wil It's not everyone's cup of tea J, but I started taking a Lemon Ginger Blast (not the tastiest thing in the world) for breakfast about 3 months now and I was completely gray hair and my locks and the back of my head is the original colour again, I'm not shitting you I'm being honest. I didn't notice immediately but people started pointing it out and some of my work colleagues even joked about hair colour products. I was due for an ear operation and as part of the pre-op set of tests they checked a number of things including blood pressure (high blood pressure runs in my family) and it had almost returned to normal and the mucus that was trapped inside my ear (eustachian tubes) was almost completely gone. They said they would go ahead with operation if it was my wish but added it was unnecessary given the new results. I don't have shares in vegan products and I don't really care that much who is impressed by me so there is no advantage for my to lie. Try it yourself if you are suspicious. The great Bruce Lee as asked how he was a genius given he was ahead of his time in his chosen field of knowledge, he said "I'm not a genius, I just try everything and keep what works and discard what is useless". So give it a try and be patient to let the results manifest. peace bud.

@@cornstar1253 Then supplement with what they are lacking. If their knowledge is incomplete, then fill in the blanks. Don't choose 1 system over another, combine them and experiment and see what works.

DingbatToast Thanks Ding. 👍

And yet you can't see the positive aspects to the research.... interesting... :)

DingbatToast ha! Yes!

@@Devonellah and yet you can't see the humour in my comment?

Before you hate for what I am going to suggest, please understand I am a few thousand miles away from you and there is no reason to hate me. I just would like to suggest that you read the Quraan . Its available online. May Allah bless u with good health and happiness in this world and thereafter.

sweet man!! Super happy for ya! Any side effects?

@@shanealharbi8664 yes, one side effect my penus grew 3 inches

@@Sh0n0 Ol´braggart :P

Which BRAND of NMN pease mate !

Yes which brand do you use?

Same here, if anyone can find a less invasive cancer cure or even better a dead certain prevention, then he can.

He isn’t answering question

It's probably synergetic on senescent myocytes. -Meat based KD sprinter

@@donalkinsella4380 :DD

@@donalkinsella4380 😂

LOLOL

@Alien On a Bike are you suggesting they specifically found elderly mice to trial this on? I'm pretty sure it would work no matter your age. They're too young? Wtf do you know? Lol.

Aaron Reeder Obv youre joking? Or... anyway the video said it only helped old mice.

Or better use something that is not contaminated with lead and pcb. Like flax seeds, chia seeds, walnuts.

But... At my age, I'm happy to have a rigid pipe !

@@DARisse-ji1yw I thought I had a rigid pipe the other day😃. . . . . . . ...but it was just rigamortis setting in😔🥺

Johnny Fly : sorry not the same at all. You can get the purified ones.

Avatar007 True. Calamari DHA purified is pretty good. Omega "pastured" eggs. Frozen Wild Alaskan Salmon burgers from Costco 480 mg of just the DHA, per burger.

What are you going to do with the information?

@@T9RX3 Dr Patrick will surely tell you 😘 She's interviewing this doctor: ru-vid.com/video/%D0%B2%D0%B8%D0%B4%D0%B5%D0%BE-5DtWqzalEnc.html

Vitamin B3?

Or nad+

Wtf is that ???????

Thank you do much.

And how much of this NMN do you have to take for it to be effective?

Taking opc

Cold therapy - look up Wim Hoff :)

fasting

take the herb rosemary the long lived in the blue zone use it on food hence better micro -circulation

I recently researched and found out that after the age of 40 people drop off about 50% in Nitric Oxide production which is responsible for softening the blood vessels making blood flow easier which in turn creates better circulation. To increase NO taking Beet Root powder and Citrulline will bring them back up to optimal levels that you can check at home with Test Strips bought on Amazon. Also discovered that many people are deficient in vitamin K2 not to be confused with just vitamin K. Vitamin K2 is responsible for proper absorption of calcium into our bones, being deficient causes leaching from the bones making the bones weak but the calcium then collects in our arteries (which harden) and kidneys restricting blood flow. Restrict blood flow and a host of problems are created. The good news is it can be reversed naturally. Studies have shown over a 4 week period after taking vitamin K2 the amount of calcification buildup was reduced considerably. So at the end of the day if blood flow isn’t restored over time and because some areas of our body take first priority when blood is rationed the others next in line either get less or none which causes small vessels to die thus causing nerve damage (neuropathy).

Yes it is called TRU.

meygaag kabacalaf I think the drug metformin activates the sirt Genes, MTOR, and one other gene. All of which are fasting and exercise mimicking. NAD does something with that too. I’ve also read that reserveratrol is a fasting mimicker. If you want I can Point you to some good sources that I use.

Whichever one you choose make sure that it contains vitamins that are biologically available in other words 'activated'. If you'd like to know why then please feel free to get back to me.

tatsumakisempyukaku - Please share your knowledge. This is fascinating.

Verse Writer - Could you please explain what ‘activated’ vitamins are and why they’re important? Thanks

I do nmn nad resveretrol berberine coq10 and low dose niacin (super itchy and hot),,,

Hi Gricycle . Do you think this will work on the white scar tissue that is in the teeny blood vessel’s inside of the brain . MRI a yr ago there was some ,now lots . Have autoimmune disorder but what would you recommend I buy to begin with. Lasix is usually not liked by Drs because of diuretic effects, but would you with the Nicotinamide ? Where would I buy this / do you recommend a website ? I thought about Nitic Oxide. What are your thoughts?

Nicotinic acid is better than nicotinamid

@@freespiritwithnature4384 hello dear Spirit, I don’t have specific answer but wanted to send blessings your way. Also, may I recommend Dr. Joe Dispenza’s work 💫 (meditations, books, lectures, testimonials/stories of transformation)

Are you and Dr. Sinclair actually so close that you're on a first-name basis with each other, or are you just an American?

D LG if you dig into it, NMN does some things better, same with NR and ditto on Niacin. Kinda like vitamin K1 can kinda do a bit of K2’s jobs and K2 can kinda do a bit of K1’s jobs, but the body will only limp along if you only have the one form. That is, NMN, NR and Niacin are poor, but not completely useless substitutes for each other.

aztekkthundergod in which aspect? Mobilizing free fatty acids? Lowering cholesterol into normal ranges? (Niacin’s the gold standard at that almost twice as good as Statins) Promoting proper HDL and LDL levels? Short-term lipolysis/fat-burning? Upping NAD levels? Taking someone pretty much instantly out of an LSD induced state? Curing schizophrenia? Niacin’s a beast. I’m guessing you’re referring to the NAD levels. For me, mega dosing Niacin gave a very negligible boost in energy, suggesting a very low to at best moderate affect on NAD levels.

@aztekkthundergod I don't know where you got that information, but niacin most certainly has not been "debunked." As a treatment for existing cardiovascular and other issues, yes, 1500 mg per day or more might be needed, but as a preventive measure to ward against these chronic ailments, even 500 mg per day can be effective. I take 500 mg 2x daily and it has absolutely been effective, helping to keep my cholesterol, blood pressure, blood sugar, etc all in check.

@aztekkthundergod I'm not interested in just the studies. It's just as important to know who funded the studies and what interests they have. Pharma companies pay researchers to publish bullshit 'studies' constantly in an attempt to discredit the natural treatments that compete with their drugs, so make sure you're looking for that. In any case, I've done my own research into niacin, numerous times over the years, and I'm more than satisfied with my findings...and, of course, my own experience with it.

@aztekkthundergod probably a funded study by the statin drug makers

NMN supplementation didn't do anything for young sedentary mice but did boost exercise capacity in young mice that had been exercising regularly for a month.

Absolutely! It directs snd keeps calcium in the bones and teeth where it belongs instead of in the blood where it turns one to stone by stiffening the arteries. This in turn causes strokes snd heart attacks!

How do you know that the blood is acidic? Do you do a lactate test?

This is superstitious nonsense

@@markobabic487 Thanks! Looks like they moved the completion date up to June 1, 2020.

Yes. Intermediate fasting and dark uncooked greens.

@@markobabic487 how do they ADMINISTER the Nicotinamide Mononucleotide

@@markobabic487 Marko, od kje prihajas?

What about now?

this stimulates cell regeneration as well and helps red bloods cells. I'm guessing you're able to get more and process more oxygen using this

@@Cherub72 OK

I've just received my batch of nmn, taken 200 mg for two days now but I'm very sceptical because it taste strongly of lemon with a slight taste of amphetamine.. I mean, if they are adding amphetamine to this, no wonder people feel energized when they take large doses ..

@@orion9k NMN does taste slightly lemony. If you've purchased from a reliable supplier you've got nothing to worry about. Also, you should experiment with doseage as guidelines vary from around 250mg to 1g per day. Your current age and health contribute to the amounts you might need. If you're over 50 you're nad levels are possibly 50% lower than when you were younger, but again that also depends on your current state of health, diet and exercise routine.

@@catman4471 Thanks for your reply. So I got my NMN along with B3 Niacin (Nicotinic Acid, the one with flush which I actually find pretty awesome) and also B6. The B6 made me feel completely weird so I stopped that after taking 25 mg morning and 25 again afternoon, I felt really on the verge/borderline of psychosis... The B3 nicotinic acid really gives a positive effect, I feel warm and slightly more energetic when I take it. The NMN still hasn't done much for me, I took 300 mg today, but I will keep increasing dose. I just bought Creatine today as well, heard a lot positive stuff about that too. I'm 37, I weight lift 2 hours 3 times per week, I try not to overeat with carbs and proteins even thou many promotes this when weight lifting, I think I'm around 1800 calories per day and around 80-90 grams of proteins, I'm 182 tall and 70 kilo. I also eat a lot of oils like MCT, Olive and Fish oil, I'm getting like +1 gram of DHA and also taking magnesium, zinc, MSM, Spirulina tablets, 5000 units of d vitamins with k2 added and between 6000 and 8000 mg vitamin C per day (2000 mg in the morning and per meals/smoothies) which actually has helped to make my sun allergy and long recovery time from weight lifting go away, but I have no idea what levels my NAD is, I just know that I'm trying to get my energy levels up, I'm tired all the time and my brain is foggy a lot through out the day, I've become very stress sensitive since 2019, so I'm trying everything I can to get my shit together.

@@orion9k Hi, NAD levels start decreasing around age 35 so you won't really notice much of a difference especially as you're getting ample exercise. You might like to look into taking Berberine though, around 900mg in 2 or 3 doses spread throughout the day, but not on days that you exercise. It helps with energy and muscle definition amongst other things such as stress and brain fog.. I like flush Niacin and often take between 500mg to 1 gram depending on if I've run out of NMN or not, and I take it in the evenings as it helps me sleep once the flush has gone. If you have health issues then you might like to think about gradually increasing the NMN until you find a level that suits you, but if otherwise healthy you should stick to a lower dose just as a top up for now seeing as you have already purchased some, but you could save the expense for another few years. Vitamin D Complex is excellent too, so you should be doing alright with your stack.

All my best to your health! Keep it up

Resveratrol does nothing

@@orion9k Even NMN and NR doesn't do anything. I have tried them both.

@@DK-ox7ze what doses? Everybody on RU-vid who does reviews on nmn says it works really well but there has been a lot of fake nmn products on Amazon as I've heard, maybe you had a fake product ?

@@DK-ox7ze I just got my nmn today, 15 gram ✔

@@orion9k From where?

Dabayare: The patent was most likely bought by a group of wealthy Dentists, and sits on a shelf collecting dust....never to be released. The money is in the treatment, not the cure.

Dabayare it call Vitamin K2

this is what i'm waiting for

Yeah, what ever happened to it.???

It would destroy the dental industry.

Neil A D NMN is metabolized to NAD so buy NMN or any supplement that increases NAD

@@gguniiit2953 Sure, It's super expensive buying this retail so I was getting quotes from China. Just can't be sure the product is any good though

@@gguniiit2953 my mom had stroke few years back.can i give her NMN for her ,bcoz shes having mitral value disease for which she underwent minor surgery 2 years ago ..can i have your contact number for further enquiries

😂

As expected

Good joke, but he he clearly meant Eminem, the rapper!

🤪 And I prefer plain.

OMG Nmn confused with mnms. It reminds me of old commercial:" I said I wanted a bud light" intern: " you mean not bulb light.?!"

1can you please share this study?

Here is the link to a small study of 8 older adults By Baylor University. Thanks Caleb Veloz. www.ncbi.nlm.nih.gov/pmc/articles/PMC8002905/pdf/CTM2-11-e372.pdf sorry, but is free and copy and paste works

@Caleb Veloz The way NAC (N-Acetylcysteine) and Glycine works are as precursors to Gluthathion, which is the cells most aboundant antioxidant. The level of Glutathion is reduced with age. So it's probably good to try to keep it up. To supplement with these two precursors is more efficient than supplementing with Glutathion itself! It wouldn't suprise me if Glutathion would keep some of the NAD+ consumers in check. Anyway, it can't hurt!

How are the calves the 2nd heart?

@@chrispayne750 Because the ass is the second brain.

Huh??

@@chrispayne750 the calves are the second heart, bc they help the veins return blood to the heart.

@@aqualane1 Train yourself to let go and stop caring what others think. Most would just think you're silly or crazy but screw what they think! You may free others by doing so ...

@God 2 God the only thing I need is health happiness and love. Without any of those life ain't worth living . To those three things I'm addicted

Weed dilates the blood vessels, works for me ...58 and going strong, strong enough to take up gymnastics.

Patrick Foley - Al Gore invented this thing called the Internet. It’s wonderful! You might get a book and research it! You’ll be fascinated. 😁

Another useless Md

@@pbfoley amazon

MNM. Is business--> That’s all.

Yes, please, consider this molecule for stroke. I had massive neurological problems and I felt a difference from the first week I used it, after many years of struggling to get well.

Madison One I was diagnosed with almost a 50% blockage in my carotid arteries and was prescribed 1500mg Niacin by my naturopath. My doctor had no solutions or treatment for me other than suggesting I “pop in once in a while and have my blood pressure checked.” If I was not warned about the severe flush I would have ended up up in the ER. Scariest and the most unpleasant experience. Needless to say after a while I stopped taking it because of the flush. I will try your approach. Thank you.

I have tried to take it many times at 100mg but each time without a fail I get headaches....

Yvette - There are numerous strategies to taking Nicotinic Acid. You need 32 Oz of water, apple sauce, quercetin 500 mg pill & fish oil. After dinner go for walk then an hour before bed pop quercetin after 20 minutes follow by Nicotinic Acid pills, fish oil with Apple Sauce, squeeze packets are convenient. Drink first 16oz water when you experience initial tingling of flush then you drinking the other 16oz get the Nicotinic Acid moving. It takes 1.5 hours to fully move it after you swallowed. Also eating salad with dinner helps salads have quercetin which suppress prostaglandin d2 that causes flush. But flush is good, that’s when the body pulling out all the bad cholesterol out & boosting HDL. After a certain time you won’t experience flush & then a day off Nicotinic Acid & get back on it. The flush will come back. Flush is the secret to long healthy life. It’s not an allergy. There are no known case of anyone dying from flush. But this is something you have to titrate into slowly. Nothing to be panicked.

Madison One thank you so much for taking the time to respond. I will definitely consider your suggestions. Much appreciated 🙂.

Donal Kinsella I have not tried but I will educate myself on it and definitely consider it. Thank you

Why tmg? What it helped with

@Nifty Nan The reason to take TMG (TriMethylCystein) is usually to supply the body with extra Methyl groups. When the body gets rid of excessive vitamin B3, it consumes Methyl groups. (>Reference Chris Masterjohn). The Glycine is just an extra bonus if you also take NAC. Taking NAC usually doesn't cause any problems. But it's just the Cysteine you want. And if you get enough from your Protein, maybe that's enough. The research has so far been made with very high doses of NAC and Glycine. Suprisingly high doses! It would be nice to know how much you really need. I'm beginning to suspect that much of the problem with Glutathion is caused simply by older people not getting enough of protein. They might need 1.2 g/kg bodyweight. And not the RDA of 0.8 g/kg.

lol!!

Yes, indeed, I just taught that he used some „ help“ on his face and hair 😂

The hair is brown.

Thank you. That was more informative than the video and took a fraction of the time

John Linsky look at history it will tell you whose more violent.

You are good as gold 💯

What's the role of Niacin in this?

Google algorithms make sure the truth reaches as few people as possible.

There is no cure for aging, but you can slow it down. If NMN is made by the body then I wouldn't call it medicine, perhaps supplement would be a more accurate term. There are many supplements you can take to slow down aging. NMN is one of them which is fairly expensive. But what the hay, you can't take it with you so if not well spent, at least not wasted. I consider it an investment in quality of life.

I think geneticists would have to find a gene (or make one) that allows our cells to produce NAD at the necessary level to remain biologically young. That would be a cure.

@@Dogbertforpresident the NMN affects the epigenetics of your mitochondria in your cells. So, it turns off or on certain genes that make you age. So....

There is a cure for aging!

me

It would give me a chance to finish my. To do list

@@donalkinsella4380 Moringa is as good if not better, cheaper and easier to grow large quantities of. Broccoli sprouts are a good second choice or during winter or cold climates.

@@donalkinsella4380 from Fahey: "Moringa contains a powerful isothiocyanate known as moringin, which is just as potent as sulforaphane, and in some assays actually more potent.". He also said he drinks 2-3 cups of Moringa tea per day. I have 30' tall (as well as shorter) Moringa trees in my yard that grow like weeds with no care or freezer or jars or counter space or multiple rinsing or blending required. There is a reason they call it the miracle tree. I grow Neem as well, which is also nicknamed The Village Pharmacy. (I add various sprouts including broccoli and sunflower to my daily vegetable juice as well.)

@@donalkinsella4380 I don't think it would thrive indoors, but a greenhouse will work fine. I am in Florida and it grows great here. Even if it freezes back to the ground in the winter, it comes back like gangbusters in the spring, growing 8 to 10 feet within a couple of months. Even more impressive is the Ube yam which grows faster than Kudzu! It has super health benefits as well. I eat the leaves off the vine, and in salads.

Jason Lynch he’s going that route because supplement companies scam people a lot. I kind of wish he wouldn’t but whatever.

@@KekeeBlack Like Pharmaceuticals don't scam people?

I know right ! I was waiting for it , BUT THE VIDEO ENDED !!

He said it, NMN supplement. It boosts NAD levels and helps improve muscular blood vessel growth in older individuals.

@@OneironauticalOne what is MNM?

@@digimom82 nmn nicotinimide mononucleotide google it.

FASTING and its FREE!

Renuebyscience and Codeage are the gold standard and silver standard respectively. - Meat based KD sprinter

ukidding, of course he does. Harvard “elitists” aren’t trying to help the general population. They think we’re cattle.

Keto plus IF

Edamame broccoli cabbage cucumber avocados and tomatoes

@@tazboy1934 Precisely what I was thinking,

It's called exercise.