RNA polymerse cannot unwind double-stranded DNA, but proteins associated with it can. In prokaryotes this is performed by sigma factor, and in eukaryotes it is performed by TFIIH.
I am really thankful to you for making such great videos and helping to all the students out there. You are an excellent teacher. Keep up with the good work. :) Love from India
You make this so much easier to understand! You explain everything so well in just 12 minutes and my lecturer takes a whole hour and I still dont understand her! Thank you so much!
I am also grateful sir ...my lecturer takes the whole 2_hour trying to explain this but still, I find it difficult to understand him. Please, can you make more biology videos.
"So, just like there is a seque... just like there is a seque... uhm... just like there is a sequence." Finally got it the third time. LOL i cracked up. still great video man! Way better than my lazy professor who doesn't want to explain anything. thanks!
AK LECTUREES thank you so much for all your contributions.. i personally had lot of difficulties with biochemistry. i literally had almost no idea what's going on, only just learning by heart.. but now i do understand better... am also recommending some colleagues to get watch your lectures.. You are fantastic in a way of explaining factors precisely and simply.. I have one single question. Could you please or someone from the Commenters give me an answer to it? The question is: What is meant by 3' in the mRNA? TIA
a couple questions: What happens with the RNA polymerase? Does it remain attached to the RNA molecule? Where is the RNA polymerase being produced? Does it free itself from the RNA and DNA and just goes to find another promoter region? Are there multiple promoter regions that are followed by different coding and if so how does it know which region to transcribe from?
A quick question for clarification: Are the initiation factors you reference here the same as general transcription factors referenced by others? Thank you!
At 6:38 - DNA Helicase brakes the Hydrogen bonds in the DNA, the enzyme topoisomerase is the one that unwinds DNA from its helix . Otherwise great lecture!
Unwinding and breaking hydrogen bonds should be read the same but the enzyme topoisomerase adds negative supercoils to alleviate the stress for supercoiling
The Flash Unlimited how is this negative supercoiling done at the particle level at the electron level are you saying that the hydrogen bond antiparallel scheme has to be biased with an electrically stable configuration to separate 1/2 of the DNA strand to become RNA to be used in protein synthesis Albeit that is a scaffolding problem the nut or the magic or the mystery are the four nucleotides the phosphodiester this is a scaffolding structure albeit very important would anybody argue that point or that observation the nucleotides are the magic the other parts are the scaffolding to allow the nucleotides to resonate dialectically housed insulated enough by the phosphodiester backbone with the two nucleotides hydrogen bonded with four nucleotides available as two double ring configuration the other two are single ring configuration as a complementary pair schema As where the DNA lattice is complimentary in-form as a structure created as a phosphor and sugar backbone allowing the nucleotides to be housed on this phosphor lattice as electrically neutral as a purine and pyrimidine nucleotide molecules bonded by a hydrogen bond in complementary form With an innate coding of four nucleotides consisting of Elementary particles using the electron shell Theory these elements hydrogen oxygen carbon nitrogen with a phosphor sugar background as a structural lattice to hold or house these nucleotides as electrically neutral as possible are responsible for weaving our reality as biological species I like to put this out the deeper meaning is going to be the spin trajectory of mass or matter I believe it's going to come down to a force called spin trajectory as an elementary metric of our reality coalescing into what we see as conveyed to some as mathematics string theory Hence the super coiling problem hence the hydrogen bond coiling of thr DNA lattice scaffolding spin trajectory the elementary force of the universe if you can figure out the spin trajectory constant that probably would help a lot in predictability I believe it still comes down to a 50/50 deal it will always be a flip of the coin when it comes to predictability using the sciences physics mathematics and the logic called "predictability" will always be 50/50 Deal
Topoisomerase is a class of enzymes, and the most common example is enzyme gyrase. Their function is to relieve torsional stress that arises during the process of unwinding
abdul shehata meh its hard to give advice on the MCAT because it really depends on how you learn. i didn't take any courses and just studied on my own. i'd say just create a solid study routine and stick to it! don't let anything get in the way of your study time. don't spend too much time trying to learn the minute details and leave plenty of time to take practice exams.
yeah man. I have started but do not have a solid study routine. Some days I do 6 + hours and others I do Nothing. goota get that routine I guess. also if i can teach someone for example transcription like how you exactly do it, you thin thats a good sign for a good mcat grade?
