Serine Protease: Background & Catalytic Mechanism - Biochemistry | Lecturio

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This video “Serine Protease: Background & Catalytic Mechanism” is part of the Lecturio course “Biochemistry”
► WATCH the complete course on lectur.io/serineprotease
► LEARN ABOUT:
- Catalytic properties of serine proteases
- Cleave peptide bonds
- Specificity of cutting
- Common active site composition/structure
- Catalytic mechanism of serine proteases
- Cut of the substrate for enzyme
- Location of the peptide bond
- The central part of serine protease
- Common features of the active site of serine proteases
- Enzyme backbone
- Folded polypeptide chain of enzyme
- Catalytic triad of active site
- S1 pocket of enzyme
► THE PROF:
Your lecturer is Professor Kevin Ahern. He is currently teaching biochemistry and biophysics at the Oregon State University, where he has also successfully completed his Ph.D. in biochemistry. Beside writing poetry and songs about several topics including medical ones-believe it or not as well-he has written the popular ebooks “Biochemistry Free and Easy” and "Kevin and Indira's Guide to Getting Into Medical School." His edutaining videos on RU-vid were watched over 2.75 million times making him a medical education RU-vid star.
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Study for your classes, USMLE Step 1, USMLE Step 2, MCAT or MBBS with video lectures by world-class professors, recall & USMLE-style questions and textbook articles. Create your free account now: lectur.io/serineprotease
Now it’s your turn! Watch the video and find out the correct answer to the following question: What is the function of S1 pocket of a serine protease?
A. It requires serine for binding.
B. It is the location of the catalytic triad.
C. It determines the binding/cutting specificity of the enzyme.
D. It stabilizes an unstable tetrahedral intermediate.
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Опубликовано:

5 окт 2015

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Комментарии : 52

@NoticeMeSenpaiii 6 лет назад

I've spent hours reading trying to understand enzyme mechanisms. This video made this so clear to me. Thank you so much!

@Bud_wizardz 4 года назад

Best lecture I can find on Serine Protease! Thank you!

@vanessapersi9150 Год назад

Wow could not be more clear! Thank you, this really prepared me for my biochemistry exam!

@biomimetica 6 лет назад

This explanation is so crisp and descriptive, it helped me fully understand every step really well :) Thanks!

@mollyoconnell7847 2 года назад

I don't know how many hours now that I have been trying to understand serine protease and how they work. Come across this video and get it instantly! Thank you so much!

@Veezenn 8 лет назад

I've searched for this a long time. Thank you!! :)

@lecturiomedical 8 лет назад

+Veezenn Glad you´ve found us! In his advanced biochemistry course (www.lecturio.com/medical-courses/biochemistry-advanced.course) you will find even more detailed explanations. Take a look ;)

@AsherBrandt 4 года назад

This guy is such a good teacher. Wow

@aishaliane 4 года назад

This explanation was EXCELLENT! Two thumbs up 👍👍.

@cambeesley 4 года назад

Perfectly explained. Thank you!

@akhileshtayade1916 5 лет назад

It's beautifully explained. Thank you!

@sylviecarr1201 3 года назад

Amazing! So well explained.

@vkookie459 3 года назад

Thanks a lot, it's a marvelous explanation

@nehadelsalamouny1786 2 года назад

Excellent explanation. Thanks a lot!

@jessicabednark6710 8 лет назад

Very clear explanation! Thank-you for your help!

@lecturiomedical 8 лет назад

+Jessica Bednark We have to thank you for such a kind comment. ;)

@akritino7437 7 лет назад

Kevin Ahern sir ?!?!? I really love the way explains biochemistry concepts !! :D :D :D Amazing professor ! :D

@lecturiomedical 7 лет назад

Hi :) Prof. Ahern doesn't use RU-vid but he will be happy to answer your question at www.lecturio.com/medical-courses/biochemistry.course You need to register first and then will also have access to hundreds of other free medical videos.

@jyotikumari-vc4ep 3 года назад

Thank you for the easy explanation.

@SanadAlfadhel 2 года назад

Great lecture

@blendamedeiros125 5 лет назад

Thanks a lot!! Very good explanation 👏👏

@kiaraluciano8665 4 года назад

This was one of the best explanations I've ever had :')

@dnagoatgaming1159 6 лет назад

man this is probably the best

@qianyu9477 7 лет назад

Very helpful! Thank you!

@stodd2403 7 лет назад

Really good! well explained and visualized

@lecturiomedical 7 лет назад

Thanks so much for your support!! We're happy you're enjoying the courses. Also feel free to create a free account at www.lecturio.com to get more free video courses.

@cmlon Год назад

this guy is really great

@bnirtlepmc 7 лет назад

omg thamk you so much!! Amazingly clear

@lecturiomedical 7 лет назад

Thank you :) We are glad to help!

@heavyunit161 8 месяцев назад

I really appreciate this video, sir. 🙏

@lecturiomedical 5 месяцев назад

Thank you for your comment! If you enjoyed the video, don't forget to subscribe and turn on notifications to stay updated with all our RU-vid videos. 🤗 Additionally, for more learning opportunities, we invite you to sign up here and explore even more of our free content, along with all the study features that can help you ace your exams: lectur.io/freecontentyt

@LaplacesDevil2 6 месяцев назад

Thank you so much! I am studying for biochemistry exam and presentation that we used in lecture is terrible! In this video ı understand this mechanism perfectly! Thank you!

@lecturiomedical 6 месяцев назад

Thank you for your comment, do not hesitate to start your free trial as Lecturio could become your best study-buddy. Watch the complete course on lectur.io/serineprotease and figure it out by yourself :)

@Saed7630 5 лет назад

Amazing!

@rajarshidey1385 3 года назад

So indepth and simplified,,,, I swear you are the Real Jesus Sir!!

@Melanie-zm8ct 6 лет назад

Thank you 👏🏻

@tisananitisakulkan9194 5 лет назад

Thank you very much

@angolajuan4044 5 лет назад

Hi, I was wondering is the lecturio app is free? What are the advanced course of biochemistry? Thanks

@onatovonatovic526 3 года назад

thank you

@yashparikh7970 8 лет назад

that was an awesome explanation. tysm. sir in 2 nd stem how come the carbon had double bond even after forming tetrahedral confirmation with oh here instead of nh in first step where it was a single bond.

@lecturiomedical 8 лет назад

+yash parikh Hello Yash, thx for your kind comment. As I am only the RU-vid manager at Lecturio Medical Education Videos, this detailed question is a bit to difficult for me to answer. But did you know that we also have an elearning plattform for medical education where you can watch even more free lectures and ask questions to the professors. Try for free at www.lecturio.com/medical-courses Thanks again!

@princessgisy 8 лет назад

Thank You VERY much!!!!!

@lecturiomedical 8 лет назад

+Giselle Diazzi Hey Giselle, you are welcome! Thx for oyur nice comment and feel free to watch even more free lectures on www.lecturio.com Thanks again!

@susanredna688 5 лет назад

Kevin Ahern

@deelupriyadarsh4859 2 года назад

So what's released is a NH2-R and COOH-R with the enzyme acting as catalyst, here it is seen that amine and an acid is released, this shows that serine protease releases acids and amines, so is the protease inhibitors targeted to supress the release of excess acids and amines, (in this case of the serine protease) of course there are other proteases but an analogy can be assumed

@georgiehensman5281 2 месяца назад

THANK YOU :)!

@lecturiomedical 2 месяца назад

You're welcome! Do you hesitate to start your FREE trial on our website/app to access much more valuable content: lectur.io/freecontentyt

@dlajapal 7 лет назад

Hi! I followed this to a T, thank you so much for explaining it in such depth. I do however have one question. Around 9:10, right when the NH2R gets released, and the remaining portion of the peptide covalently bonds to Serine, there seems to be a missing CH2 on the serine side-chain. I could be wrong, but that's the only part I am not following. Thank you again!

@lecturiomedical 7 лет назад

Hey! Thanks for checking us out. Our lecturers do not use RU-vid but they will be happy to answer your question at www.lecturio.com/medical-courses/amino-acid-metabolism.course. You need to register first and then will also have access to hundreds of other free medical videos.