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► THIS VIDEO explains sickle cell anemia, an inherited form of anemia characterized by malformed, sticky, and rigid red blood cells shaped like crescent moons or sickles. These irregular cells can obstruct blood vessels, leading to decreased oxygen delivery and painful complications.🩸
🧬 Sickle cell anemia is caused by a genetic defect where hemoglobin S replaces hemoglobin A, resulting in abnormal red blood cells. Inheritance of two defective genes from both parents leads to the disease, while one gene causes sickle cell trait, a carrier state.
👨👩👧 Couples planning children can undergo genetic testing due to the hereditary nature of the disease, which primarily affects individuals of African, Mediterranean, Indian, Saudi Arabian, and Hispanic descent.
🔬 The video delves into the pathophysiology, explaining how abnormal hemoglobin causes chronic hemolysis and acute vaso-occlusive crises, leading to organ damage and excruciating pain.
► THE PROF 👩⚕️
Dr. Paula Ruedebusch is a Family Nurse Practitioner, Researcher, and Teacher in Colorado, USA. She obtained her Doctor of Nursing Practice (DNP) at the University of Colorado in 2012, and Master's Degree from the University of Northern Colorado. Previously, she was Assistant Professor at Seattle Pacific University from 2017 to 2020. Due to her achievements, she earned the Seattle Pacific University Graduate Teaching Award in 2018 (SPU Graduate School), and was nominated for the UW Distinguished Teaching Award in 2016 (University of Washington). 💉🩺 Within Lecturio, Dr. Ruedebusch teaches courses on Pediatric Nursing. 📋
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► CHAPTERS
00:00 Introduction of Sickle Cell Anemia
00:11 Healthy Red Blood Cells vs. Sickle Cells
00:27 Impacts on Blood Flow
00:33 Treatment and Management
00:42 Names and Genetics
00:52 Autosomal Recessive Inheritance
01:12 Carrier State
01:30 Probability of Inheritance
02:30 Ethnic Prevalence
02:48 Hemoglobin's Role
03:01 Transformation of Red Blood Cells
03:32 Chronic Hemolysis
04:00 Vaso-Occlusive Crisis
04:22 Pathology of Sickle Cell Anemia
25 июн 2024
