Sickle Cell Disease : Definition, Pathophysiology, Clinical & Lab Findings, Treatment 

My new RU-vid video ! "Sickle Cell Disease" . Topics covered are - What is Sickle Cell Disease ? What is hemoglobinopathy ? What is Haemoglobin S ? What do we mean by Sickle Cell ? How Sickle Cells are formed ? Homozygous vs Heterozygous point mutation of HbS . Role of calcium , potassium channels and water in sickling of RBC . Variables of Sickling . Problems caused by HbS - haemolysis, microvascular occlusion, tissue damage . Vasoocclusive crises . Splenic crises . Autosplenectomy in Sickle Cell Disease . Acute Chest Syndrome . Hand and Foot Disease . Renal problems in Sickle Cell Disease . Why HbS protects from falciparum malaria . Common clinical findings of Sickcle Cell Disease . Common lab findings of Sickle Cell Disease . Treatment options . If you like this video don't forget to comment and like this video in my youtube channel ru-vid.com Subcribe to my channel for more videos coming soon !

Dr. Rabiul Thank you for making all your videos. You explained pathophysiology very well and I am a big fan.

It was in 2014 when I found this video with a friend on his laptop...and here we are in 2022, I found it on RU-vid. Powerful and most expensive information given for free...Thankyou so much

Thank you so mush for your detailed videos. It`s really helping me through medical school. God bless you.

i loved your clarity, you made this so easy to understand, thank you veery much

Thank you very much! I'm working towards an NP degree and I have found many many of your videos to be helpful in achieving understanding!!

Thanks a lot,Sir. All of your lectures are very very helpful and effective. God bless you. Hope we'll get a lot of your lectures soon.

Have found it very very useful. Presentation was clear and wasn't first and was able to get clearly every steps

The video has been very educative and it is concise and succinct too.

Thank you so much for making these.

thank you Dr. Osade for your help

Dr. Rabuil, thank you so much. I've been watching your videos. In fact, you are a polymath.

If it weren’t for you I wouldn’t have passed my finals , thank you sir or should i say the greatest tutor , god bless you and I’ll always pray for you 🙏

Thank you so much Doctor for the amzing lecture. That was very helpful, may Allah bless you ! Greetings from Algeria :)

ur explanation is very nice sir &ur very talented , Thk u 4r giving ur wonderful explanation

thnkuu your all lecture videos are very helpfull May Allah Bless u

Thank you so much for this video. It really helped me a lot to finish my research project regarding Sickle cell anemia!

Thanks. Dear , as a lecturer of haematology , have enjoyed.

Very good! Well done.

Thanks Dr Rabiul. Ur lecture very interesting.

Thank you so much Dr .. much appreciation.. your lectures are really helping me in my medical field.. ive learnt alot from you right from year one

Clear and informative video - thanks.

thank you that was amazingly clear!

Thank you very much doctor for this helpful video... well done

Thank you sir..want more lectures of medicine from you🙏

thank you dr.rabiul for this wonderful class. this session was taught in a very simple way starting of with the required basics; easy understanding and remembering. thank you once again dr. rabiul.

Thanks a lot to make the conception clear❤

I love love your videos!!!!! Im so thankful

So nice video.. sir . fully detailed explanationed.. thanks

thank you boss for your lectures of pathology

Let me be one of your students from Nigeria.... I have to teach this to over 1700 freshmen. Your video was very helpful

Good work Dr. very goog I understand all

Thanx for the powerful information

Can u make more of videos of the human body.. and what the cells needs to not be sickled shaped . I learned alot with dandelion in raising the hemoglobin on a daiily basis.. good job doctor. Good job 👌👍

really this lecture is very helpful

Thank you Dr for your videos they are so helpfull for sure

Thank you sir for the video.. As im doing my research work regarding medication adherence among sickle cell patients who are living in tribal area of Attappady (kERALA). Your video helped me to knw the basics and also it helps me to answer some questions which raised during my preliminary seminars. THNK U.. THANKU SO MUCH

From Tanzania Africa... give me more plz I real understand ur lectures ♥️

Thank you for taking time out of your busy productive investigative studies to enlighten our family world-wide. I was mislead to believe that any form of the anemia or trait was racially specific. I know that even though physically imposing, and it can be, it can also be lived with (Please clarify). I have not been diagnosed (with the trait), but two of my siblings have. It must have just skipped me. Although inherited, not all immediate family members are subjected to the acquiring it. ( Please confirm) We are of origin in Spaniard and African roots. Our ancestors are from Spain, Africa, and finally mixed together in the Caribbean. My brother (has trait), could not be a Navy Combat Pilot because he was subject to blackouts due to the lack of enough oxygen at high altitudes during exesive speeds. I have never been diagnosed by my PCP. Either way, I'm not worried. Should I be? Malaria is the progenitor of the disorder, but does it become associated with geographics, or genetics? Bottom line. Thank you again Professor Haque. My babies live in the Caribbean. I realize I am long winded, but these are my questions and no one has attacked the issue as well and learned as you have. At least to the layman.

Excellent explanation sir.. thanx a lot and keep it up..

Thanks a lot sir...

this was so helpful, am a nursing student in Barbados and it has really helped me,your accent is really funny and the way you say "you know".....thanks

can you give me the website of this disease, the precise one.Thanks

Thank you. do u have video on spherocytosis sir? Anything regarding membrane defect.

Thank you so much Dr. for this wonderful lecture, I am a RN from west Africa( Sierra Leone). I have never given this topic a thought until last year when my my Son's girlfriends( a magistrate) was admitted with a crisis. and since then, She had been having frequent attacks; and had been even transfused. As I am writing this to you now, She is admitted not for the crisis but due to Anemia and had received 6 units of blood.This vedio will help me greatly. Can you please help me again with the name of the drugs you mentioned at the end ? ( in Writing ) so that we can search for them in our country. Thanks and God bless you Sir.

thanks

Thanks for this helpful lecture

Thank you very much for your videos may the ALMIGHTY ALLAH bless you.please doctor i need clinical biochemistry lectures. can you do some for us.from Ghana

Sir my doubt is why in hemolytic anemia reticulocyte count increases and decreases in megaloblastic anemia.

thank u allah bless u this lecture is really use ful

Great work

Thanks for the video.

Good professor

Do you have any papers or written forms of this? It's been really helpful in my research so far

nice and informative...thankx

sickle-cell-disease is a hemoglobinopathy but its qualitative hemoglobinopathy, THALASEMIA is quantitative hemoglobinopathy ... both r hemoglobinopathies. tq

THIS video is very helpful....

Very educative

Allah help you as you help me thank you from my bottom of the heart really very very helpful you are my best teacher ❤❤❤

Dr thanks for your helping

thanku so much sir for uploading vedio ,I request for uploading the topics disorder of WBC and lymphoid

thank u sir very very much .............. your videos are really helpful

I LOVED THAT U R AMAZING THANK U SO SO MUCH GREETINGS FROM IRAQ :)

Thank you for your video

Thanku sir. Ur videos helped a lot. Please also upload videos on Parkinson's disease , epilepsy,eczema,pemphigus,rehematoid arthritis and other similar topics. Plzz sir

most important things you never touch ,complications and clinical implications.

god bless you sir thank you very much

U r a life saver...thnk u!!

Thank you sir...😍

Thank.you.so.much.sir.

Still useful in 2020

🙏🙏tq so much sir

Well done. Nice video

Why the sickle cell goes to lipid bilayer and water is looosed kindly explain thanks

Jazakallah khair

good explanation

I like ur videos sir...keep Posting few more topics

Dr thank you thank you so much

Hello Dr. will the Covid vaccination enhance clots with Sickle Cell Trait disease.

God bless you

thank u very mush sir

I don't know haw I thank you Really is very helpfull You save may exam thank you Dr a lot and a lot and I Will be big fun for you

Thank u👍🏽 Greetings from kerala ❤

what could be causing the point mutation in the beta-globin?

I just received my test result and don't understand the reading and the doctor doesn't seem to understand himself,please any specialist here who can help?because I'm tired of asking questions from this doctor.

Thank you alot

What is target cells ?

thank u sir

Thank u sir❤️

So nice teaching sir

Sir glutamate replacement dunno beta chain main husakta Hain ya sirf ik main hugi??

Thanks you alot

thank you soo much from india

this is very well informing.. i have a question is there a way i can e mail it to you?

Thank u

thank you very much for the best explenations of the sickke cell disease.i will be waching all your videos.i will like to know more about my pains because most of people are saying that sickle cell trait should not have these pain.i'm an African woman 47 y 8 m.i live in brunei where I have been diagnose with sickle cell trait and i'm not suffering of anythink else.my bp this morning is 125/88 my pulse 73.my sugar in the border line.i just started to have a lot of pains.nice doctor from Pakistan working here at ripas hospital tall me to go to see the doctor immediately because there are no auther patient because there're just few African or auther scd patient here.the hematologist told me that same bruneians have tallasemia.i have no raison to imagine any pains I just will lie to have same more info.thank you and god bless you.

Sir plzz upload haemolytic anaemia videos

THANK U BRO,

what's different of pathophysiology and pathogenesis ? thanks

Dr thanks for your helping it's amazing