Sliding filament theory explains how muscles contract at a cellular level. Learn more and test yourself with our quizzes here: www.teachpe.com/anatomy-physi...
@@paramanandbalara3602 Thanks man for your information 😊... I've passed out but I'll keep it in mind for my current first year physiology lectures on NMJ and during tricky exams
The myosin motor domain is what's doing the ATP hydrolysis. Myosin with no ATP bound is locked to the actin filament. ATP binds the myosin head, causes conformational change in both the head and lever arm, releasing the head from the filament and swinging it forward. ATP is hydrolyzed into ADP + Pi, which causes another conformational change in the head, increasing its affinity for actin, causing it to bind to the actin filament again, this time forward from where it was at the beginning. Pi is released, which causes the lever arm to return to its original position, pulling on the actin filament as it does so. ADP is then released, and another ATP binds the myosin head to release it and start the cycle over.
I feel your pain, but did you know that you can make the video play more slowly? If you click on the gear shaped icon under the video, it will give you a choice of speeds to play at. You can also turn on closed captions, and turn the voice off if you wish.
Can someone explain this to Me If we strap our hand to a machine which helps us move our hand move in and out and we let loose of it then how is it moving because we aren't sending neuro signals meaning the sites of bonding are still closed how is the muscle still contracting then??????
@@ahadzx8875 I think you are correct, and multiple sarcomeres are then stacked and connected one after another within the myofibrils, as far as I know so far.
There at the end..my muscles are not able to relax back. It's hell. On any activity when I finally get loose (usually in water floating and stretching) it takes only a few minutes and i get super tight again. I had t9t10 damage in spinal. Got one leg paralyzed but I was, am able to get that leg working after 3.5 years. My muscles in legs an glute are so tight, but I get them loose with hours of work and water..yet to feel them get so tight I can't walk after 100 yards. My Drs are clueless and really don't give a dam..
Ca 2+ not Ca +. Acetylcholine = uh see - tul or uh-see-tl. Named after the acetyl groups in Chemistry. Not ass-e-til. Excellent illustrations + a few corrections in the voiceover = perfect.
