SN2 SN1 E1 E2 Reaction Mechanisms Made Easy! 

Some people are natural teachers and most professors aren’t

paying someone who’s not even doing there job. it’s disappointing but that’s how life is now :(

Indeed he is good teacher. But you can learn from it because you have some basic knowledge about it.

The other 2 hr and 20min is explaining why all this shit happens. This is just a cheat sheet. Useful yes. But if you don’t know what E2 means, it’s useless.

@@Grak70 except in those two hours and 20 mins he ain't explaining shit. Just rambling on expecting it to click in our brains.

How'd your test go?

@@PunmasterSTP I got a 76 for the final (which was WAY better than what I was expecting) and I passed the class _with a B!!_ 😊😊😊 not a terribly high one, but I wouldn’t have been able to even have half a shot at passing without his videos!

@@norainnoflowers1551 I'm glad to hear that!

And I'm glad to read these comments 😃

Me, except I am taking organic chemistry… for the second time.

Hey I was just curious. Did you decide to take that standardized test?

I know it's been a year, but how'd your exam go?

@@PunmasterSTP i know it's been 8 months, but how'd your exam go?

@@buqbooQ I wasn’t actually in a class, I just tutor some people in various subjects and come on educational channels to brush up on stuff. But I do remember my ochem tests back in college and they were fairly tough.

LOL same girl Ohio State?

@@saniahussain6074 Go bucks! Good luck

just in time for my exam tomorrow!

Good luck!!!

@@-snazzysnek-5570 Hey how'd your exam go?

@@justingenco7413 How'd the exam turn out?

@@PunmasterSTP I don’t remember lol but I’d like to think this helped for sure! In biochem this semester

and pharmacists'

Absolutely

And entomologists'

Yeah that part confused me it’s in a protic solvent….

Fair point- I think that was just a slip-up on his part As far as I can tell, he's basically trying to say that the base always takes precedence over the solvent. That said, yes. SN2 only occurs in protic solvents. He should have put a protic solvent there, so just act like there is. Pretty sure he just made a mistake- hope this helps

@@saadinhalf SN2 occurs in aprotic solvents not protic solvents.

The substrate is on secondary carbon and has a stronger base in the reaction, so even though the protic solvet is used, the SN2/E2 would occur. If it is a protic solvent but no strong base, then SN1/E1 would then occur. If you look at his table at the beginning of the video he lists the reactions depending on the solvents/bases used.

he also did this for the following problem with the sterically hindered base. usually hes good but this is kinda throwing me off

-OCH3 is a strong base, so you would not be able to form C+

Kinda late but for whoever else was wondering, looking at problems like these I believe that even in the presence of protic solvent, as long as you have a strong base it will go E2/SN2. The solvent is a rule to follow, but more of a hint that MAYBE the mechanism will want to go E1/SN1, you have to look at the whole mechanism as a hole and figure out what will really happen. Usually most mechanisms can be dictated by looking at possible carbocations and the strengh/bulkiness of the base/nucleophile Edit: Think of it like this, the NaOCH3 used will ionize into Na+ and OCH3-, it will continuously create another OCH3 by taking the H from CH3OH, therefore regardless of having a protic solvent, you’ll always also have strong base/nucleophile present. Now, here’s a tricky part, at the end then which will you get most of SN2 or E2? For this you have to look at the SIZE of the base/nucleophile. Anything smaller than ETHANOL will act as a base = Elimination product Anything larger than ETHANOL will act as a nucleophile = substitution product WITH THE EXCEPTION OF: Acetate ion, Sulfurs, and negative carbons!

@@georgieacero7043 Hi, thanks for the explanation, may I please ask what you mean by "smaller" or "larger" than ethanol? Atomic mass?

@@user-jk8iu8io8o it’s a pleasure! And I simply mean the size when drawn on paper, it’s a simple trick that works

Sterically hindered basically means the reaction can't happen coz group is too bulky, in a way it literally body blocks the incoming nucleophile if the compound has multiple branches that's why tertiary C is bad for Sn2

It's like heavy groups surrounding an atom. As you can think of a carbon atom surrounded by 3 methyl groups which doesn't allow other molecules to attack on it. It basically gives repulsions to the attacking molecule.

yes the substrate is the electrophile

Idk if this is too late but no it’s not possible because the stereochemistry of the leaving group it’s taking the place of is not in the plane itself. Depending on where the OCH3 comes from depends on which isomer form it becomes!

i meant 3 cyclohexane

that's what I was thinking, just reached out with this exact question to my prof. and we will see how she responds!!

Since its an elimination reaction, the water attacks a beta hydrogen, not the carbon, so we draw the hydrogen so we can visualize it

It has a pKa of 16, same as OH. So it’s equally basic. Same goes for any -OR, as far as I’ve learned

You know that normally OH- is basic as it was the case for an acid like NaOH kOH, BaOH CaOH, just with OH- itself they are strong bases. Now if we replace H with an R group( electron donating), it will cause increase in charge over the oxygen which makes it more electron dense than OH- and hence a stronger base (think of it as a lewis base) than OH-, and OH- itself is a strong base (pOH~ 12-13)

At least this is a more logical way to think of it. I might not be considering somethings but anyway

I’m not sure because I’m not an English native speaker. But I guess it is a base that is very voluminous, so like it has a lot of large groups around it and acts as very bad nucleophile because of steric interactions. An exemple would be : ethanolate is not a bulky base but the base of 2-methylpropan-2-ol is a bulky base thanks to the 3 methyl around the carbon linked to the negative O.

Sorry for my English btw, I’ve tried my best haha

Bulky base is something which has CH3 ( methyl group ) giving so much of steric hindrance to the molecule. Like , sodium tetra butaoxide. It's structure kinda looks like three methyl groups attached to the carbon atom which indeed is giving the overall molecule much hindrance.