The DNA Damage Response | Repair the DNA or Commit Apoptosis?

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Опубликовано:

6 сен 2024

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Комментарии : 18

@stevenshivers6082 3 года назад

Correction to your video: Succintly, phosphorylated retina blastoma renders dissociation from E2F. Subsequently, E2F can translocate to the nucleus to confer increased expression of E2F target genes, including E2F (positive feedback loop) and cyclin E to propogate entry into S-phase. CDK = Cyclin-Dependent-Kinase. Per definition, kinases phosphorylate (add phosphor groups to) targets. Thus, CDK will phosphorylate retina blastoma to confer its dissociation from E2F.

@user-nq9xu9cb4j Месяц назад

Yes the CDK2/Cyclin E phosphorylates PrB, which can release the factors that allow G1 to S.

@reezis1619 4 года назад

doesn't the retinoblastic protein release E2F after phosphorylation?

@jonathanlehmann2059 4 года назад

I thought so too. From ‘Signal Transduction, Principles, Pathways, and Processes’, page 141: “Phosphorylation of the pRB family proteins by CDKs during G1 phase causes pRB to dissociate from E2Fs, allowing transcription of target genes that stimulate progression into S phase.”

@reezis1619 4 года назад

@@jonathanlehmann2059 Yeah. That is what it says in my textbook as well

@jonathanlehmann2059 4 года назад

milk is cheap protein Good to know, thanks. Mine is a 2013 book, so it’s possible that the field has changed since then, maybe.

@AnchaliJunn 2 месяца назад

Very nice explanation 😺

@alhaeri1 2 года назад

in my opinion it should be more like high degredation of p53 in the case of low stress and low degredation of p53 in the case of high stress

@killianpapail9324 Год назад

Isn't the cdk4/6-cyclinD complex which phosphorylates Rb to release E2F ?

@dontmissthelittlethings 2 года назад

Thanks for the information.

@sudiptasarma 11 месяцев назад

nicely explained.

@fatahiyakashif8199 3 года назад

pRb is inactivated when phosphorylated and then it releases E2F which enters the nucleus and acts as a transcription factor for proteins that help in G1 to S phase transition.

@seanclark6438 4 года назад

Just double checking but is P21 negative my regulated by MDM2

@fayazferoz7978 4 года назад

it is p53 that is degraded by the action of MDM2

@seanclark6438 4 года назад

Fayaz Feroz Thanks couldn’t quite remember, when revising this I looked up all the gene loci, thanks to the wink wink to revise p53 and non of it came up on the exam