Nucleotide excision repair

DNA Repair Mechanisms Part 1

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Base excision repair

Quick Biochemistry Basics

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Base excision repair is a DNA repair mechanism that removes the chemically modified bases from the DNA. The Enzyme involved in Base excision repair is DNA glycosylases. The DNA glycosylases, enzyme removes the modified base to create an AP site. This site is then cleaved by AP endonuclease and repaired by DNA pol I and ligase.

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1 окт 2024

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Комментарии : 33

@mohamedelafia4956 2 года назад

i think N Glycolase does not remove the base it just identifies the wrong base. ap endonuclease cleaves the region and the base will be removed from 5 exonuclease than comes polyemrase one with the base and finally dna ligase to repair the cleavage.

@royalindication Год назад

That's exactly what happens if I'm not mistaken

@sameerhussain3709 Год назад

no he is correct you guys are wrong..... read books 📚📚📚

@becheaachi 9 месяцев назад

You think wrong man...glycosylase breaks the n-glycoside bond between the base and sugar

@blueballoon7832 2 года назад

the animation shows a 3' to 5' DNA pol. but the narration say it was a 5' to 3' DNA pol, so which one is it?

@allaboutakoo 8 месяцев назад

dna is always built 5 - 3 prime

@cygthings 6 месяцев назад

The overall direction is 5' to 3' but in that instance, the exposed ends are 3'-OH on the left side and 5'-P on the right side.

@Phoenix-np1iu 4 месяца назад

if i understand correctly, each nucleotide has a 5 prime end and a 3 prime end. the new nucleotide is added so that its 5 prime connects to the 3 prime of the one before it

@haileyyoung7558 2 года назад

you've made a seemingly complicated process very easy to understand, thank you!

@arzuhaqverdiyeva4237 3 года назад

Thanks . L am Azerbaijan💪🇦🇿

@FMshorts17 2 года назад

It's wonderful bro....now I,m feeling that it,s so easy to understand it

@wolfbaron25 2 месяца назад

What does AP Lyase do in this context?

@shashios1236 3 года назад

Very nice 🙏👍

@aditimane3349 3 года назад

Amazing 🤩😍

@quratulain3252 2 года назад

super helpful thank you

@iam7405 3 года назад

❤❤

@deeptiaditya9133 4 месяца назад

Thankyou sir

@Bidi_acho 3 года назад

Thank you🥰

@bhatti7714 2 года назад

Excellent 👌

@AliKhan-ns2dp 2 года назад

Weldone

@husammatar5543 10 месяцев назад

Thank you so much you are really goog to explain.

@cameroonian7 10 месяцев назад

Now that I see it, I understand. Thank you !!

@sushamabhumbe6296 2 года назад

It's helpful ☺️

@Biochemist448 10 месяцев назад

best video ❤

@songohan393 7 месяцев назад

thank you

@Hg80_Jxs Год назад

saved my life

@63554 Год назад

Thank you

@rabiaghafoormalik2026 2 года назад

Weldone

@alimamstudying9462 Год назад

Thank you so much

@judytoma8733 2 года назад

Great

@alanoodalhouqani7036 2 года назад

thank you so much

@anowartheplantbreeder..8660 2 года назад

When DNA glycosylases remove modified base then already 3'OH nd 5'P site open so AP endoculease what actually did??🤔🤔

@tanvirahmed-rr7vt 2 года назад

Nope the phosohodiester bond is not broken as the nucleotide moeity( without the base) still remains at the region..

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