The Impact of Hispanic Ethnicity on Disease Characteristics in Multiple Myeloma 

Dr. Kara Cicero, Columbia University Medical Center, presents a study on the impact of Hispanic ethnicity on disease characteristics in multiple myeloma
Background:
While the racial disparities in multiple myeloma between those of African descent and Whites are well-documented, there is a paucity of data on other racial/ethnic minorities, such as Hispanics. Most recently, Kaur, et al. (Clin Lymphoma Myeloma Leuk, 2021) found that compared to other ethnicities, Hispanics residing in New York were younger at diagnosis, had a higher proportion of early-stage disease, did not differ by cytogenetic abnormalities, and had better overall survival with equal access to treatment. However, specific FISH probes tested and treatment regimens in myeloma have substantially changed since 2018. To our knowledge, no study has characterized the biology and clinical outcomes of Hispanics since 2018, a question of import given the national drive to improve outcomes and access to cancer care in minorities.
Conclusions:
Although age at diagnosis, ISS/R-ISS stage, clinical presentation, and rates of HDM-ASCT did not differ by ethnicity, Hispanics were found to have a 2.5-fold higher incidence of del(1p) by FISH. Validated as an adverse cytogenetic prognostic marker in myeloma (Perrot et al., JCO, 2019), the significant increase in del(1p) may translate into decreased PFS, a trend seen here. Longer follow-up is needed in a larger cohort adequately powered to assess whether such cytogenetic differences in Hispanics result in significantly worse long-term outcomes.
Authors:
Kara I. Cicero, MD, MPH, Alfred I. Neugut, MD, PhD, Andrew H. Doyle, Divaya Bhutani, MD, Amer Assal, MD, Ran Reshef, MD, MSc, Markus Y. Mapara, MD, Suzanne Lentzsch, MD, PhD and Rajshekhar Chakraborty, MBBS
ASH Abstract #3582: ash.confex.com...
_______________
Improving Lives | Finding the Cure
Founded in 1990, the International Myeloma Foundation (IMF) is the first and largest organization focusing specifically on multiple myeloma. The IMF’s reach extends to more than 525,000 members in 140 countries worldwide. The IMF is dedicated to improving the quality of lives of myeloma patients while working toward prevention and a cure through our four founding principles: Research, Education, Support, and Advocacy.
Subscribe to our channel: / imfmyeloma
Visit our website at: www.myeloma.org
Find us online:
Facebook: @myeloma | / myeloma
Twitter: @IMFMyeloma | / imfmyeloma
Instagram: @imfmyeloma | / imfmyeloma
LinkedIn: / international-myeloma-...
Support the IMF | Donate Now! secure.myeloma...
Category
Nonprofits & Activism
License
Standard RU-vid License
In most cases, captions are autogenerated by RU-vid.