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THE PROTEASOME, UBIQUITINATION, AND PROTEIN DESTRUCTION 

Neural Academy
Подписаться 626 тыс.
Просмотров 57 тыс.
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Sources:
The best article: "The Logic of the 26S Proteasome" (2018) - Collins and Goldberg
"E2 enzymes: more than just middle men" (2016) - Stewart et al.
"ATP-dependent steps in the binding of ubiquitin conjugates to the 26S proteasome that commit to degradation" (2010) - Peth et al.
"The Ubiquitin-Proteasome Pathway and Proteasome Inhibitors" (2001) - Myung et al.
"Linkage between ATP consumption and Mechanical unfolding during the Protein Processing Reactions of an AAA+ Degradation Machine" (2003) - Kenniston et al.
"JB Special Review - Recent Topics in Ubiquitin-Proteasome System and Autophagy" (2017) - Saeki
"Complete Subunit Architecture of the Proteasome Regulatory Particle" (2012) - Lander et al.
"AAA Proteins and the Origins of Proteasomal Protein Degradation" (2011) - Ammelburg
"Proteasomal AAA-ATP-ases: Structure and Function" (2012) - Bar-Nun and Glickman
"Proteasome System of Protein Degradation and Processing" (2009) - Sorokin et al.
Molecular Biology of the Cell (6th Edition) - Alberts, Johnson, Lewis, Morgan, Raff, Roberts, Walter
3D Proteasome Model from: www.turbosquid.com/FullPrevie...

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25 авг 2019

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Комментарии : 27   
@WhereismyCoffee
@WhereismyCoffee 4 года назад
Dude this is actually really educational. Thanks man
@dentongamble8150
@dentongamble8150 3 года назад
*new protein is created* “life! I feel such purpose!” *ubiquitin attaches* “kill me!” “Awww shoooot”
@emilysullivan8387
@emilysullivan8387 Год назад
What a fantastic video. Congratulations on your content! Im only sorry to come across it today and not earlier.
@daniellerehani7713
@daniellerehani7713 4 года назад
You are a life saver. Thank you so much! Keep up the good work!
@Dr._Dawit_Girma
@Dr._Dawit_Girma 4 года назад
Great explanation. Next can be autophagy
@thenaturalsourceofourhealth
@thenaturalsourceofourhealth 2 года назад
An excellent video and graphics!
@alexandersolodovnikov4840
@alexandersolodovnikov4840 Год назад
Thanks for a great vid, really easy and very informative!
@ferdiefatiga3443
@ferdiefatiga3443 3 года назад
Thanks for this vid! 😊
@josetrujillo738
@josetrujillo738 10 месяцев назад
Awesome videos. Thank You
@maryh_463
@maryh_463 4 года назад
Fantastic video! Looking for the "that's another video" on disaggregation chaparones??
@tianyinjia
@tianyinjia 3 года назад
Fantastic, thank you
@aaquib608
@aaquib608 10 месяцев назад
great lesson. Please cover autophagy as well
@shrutisingh8842
@shrutisingh8842 4 года назад
outstanding explanation 👌👌
@K_splace
@K_splace 4 месяца назад
Thank you so much for this informative video 😍🤓
@durunfelipe12
@durunfelipe12 4 года назад
nice explained! add subtitles, helps a lot.
@mbinyuisidiki9726
@mbinyuisidiki9726 4 месяца назад
wow! this is awesome, thank you very much. please cover p53 mutation
@mohammadjehad1107
@mohammadjehad1107 3 года назад
wonderful video could u tell us the program that u use to design this, please
@legnosobalu
@legnosobalu 3 года назад
grazie, molto chiaro
@jayshreedas8002
@jayshreedas8002 2 года назад
Great video 👍 Keep it up
@dan-ni3772
@dan-ni3772 2 года назад
It helps me a lot
@alistudy6059
@alistudy6059 2 года назад
PERFECT !!!
@alveenamukhtiar5062
@alveenamukhtiar5062 2 года назад
hye recently i need to do an experiment to include ubiquitin specific antibody as to check the whether my proteosomal inhibitor is working used on Hela cells... this will be a western blot... if you can kindly provide any demonstration on how would the gel be formulated and what will be the visualization and how can we read the results.
@SuperYoujames
@SuperYoujames 4 года назад
Death of kiss~ Thx
@basyalpalpa5680
@basyalpalpa5680 7 месяцев назад
@aayushibajaj9893
@aayushibajaj9893 4 года назад
Difference between Protein half life and Protein Degradation.
@suzironson
@suzironson 4 года назад
apoptosis and necrosis
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