Regulation of Gene Expression: Operons, Epigenetics, and Transcription Factors

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We learned about gene expression in biochemistry, which is comprised of transcription and translation, and referred to as the "central dogma" of molecular biology. But how is this process regulated? How does a cell know which genes to express and when? Well it's pretty complicated, but let's just get our feet wet by looking at operons, epigenetics, and transcription factors!
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Опубликовано:

14 окт 2017

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Комментарии : 317

@JC-xk8vh 6 лет назад

There should be a RU-vid university and all the best RU-vid Professors should teach there. You Sir would be one of them.

@carlycutegirl 5 лет назад

Agreed

@abdourahmanjallow9308 5 лет назад

agreed

@alexdeschipper 5 лет назад

disagreed, he didn't mention one protein/one gene

@alexdeschipper 5 лет назад

I'm sorry he did give example of genes but it hardly scratched the surface of different regulation of gene expression, where are all the lncRNA, miRNA, siRNA, different histone deacetylases and (de)methylases, cytosine methylases. No mentioning of tissue specific promotors, I don't know it just felt like a lot was missing

@ProfessorDaveExplains 5 лет назад

@@alexdeschipper it's an introduction to the topic.

@ProfessorDaveExplains 5 лет назад

Hey everyone, at 9:34 I drew a methyl group under the word acetylation and an acetyl group under the word methylation, sorry for this ridiculous error! Please correct in your minds. Oh also, I've been informed that at around 1:50, even though the labels have disappeared by that point, I previously marked the mRNA as 5' on the left and 3' on the right, and ribosomes read mRNA molecules 5' to 3', so technically the ribosome should have translated the mRNA left to right. Sorry for that small error as well!

@younanoah8229 5 лет назад

thanks for the correction

@strattieshots 5 лет назад

no forgiveness 😤

@dheerendrapandey4494 5 лет назад

you are too good.......I understood that mistake by see that. but you are too responsible.....I have no words to thank you!! GOd bless you!!!

@alwaysfreezing 5 лет назад

ok daddy

@munmunchakraborty5262 4 года назад

I am too much pleased after hearing your lecture.Thanks sir.

@yasmine9046 2 года назад

This is truly amazing how complex notions can become so easy to understand when clearly explained. I’m grateful for your channel. Lots of love from France.

@Psiredem 2 года назад

Je suis aussi français et je suis totalement d'accord ! (I'm French as well and I wholeheartedly agree!)

@franceberat6928 Год назад

Parfaitement d’accord!!! C’est dommage que l’on est pas des aussi bonnes vidéos en français , il faudrait se mettre à la page

@jebo2810 5 месяцев назад

Pareil mdrr

@LostInThaStereo 5 лет назад

You just helped me survive my O. Chem final.... now I'm discovering you cover my Genetics final too. Just... wow.

@poonamshah2480 2 года назад

Thanks alot Professor Dave. Your teaching videos are not just clearing the concepts but arousing the curiosity to learn more about the topics.

@yoyoyakkamon4343434 6 лет назад

Professor Dave out here saving my A Level Biology grade amen

@pablosamuelestradaochoa4127 2 года назад

You seriously CAN'T IMAGINE HOW MUCH I LOVE YOUR YT CHANEL. OMFG, SUCH A GOOD, "FRIENDLY" (easy to understand) AND YET ACADEMICLY SUFFICIENT CONTENT, WOW! Im an instant new sub, keep up the excelent work!

@fajitaboys 4 года назад

I'm literally coming here from Khan Academy--thats how high calibre you are of an educator. To be fair, the KA video I didn't like was a one-off, as generally they are pretty good. If anyone is wondering--watch this video by Prof D instead of "Regulation of transcriptions" in the KA MCAT>Biomolecules>Gene Control.

@alannacronk9419 6 лет назад

bless this man and his plaid

@subhamdatta3521 3 года назад

yes

@lauragordon6414 Год назад

Wow! I was not looking forward to even this 13 minute clip. But, WAS I WRONG. Your presentation is by far one of the best. Again, most of us are visual learners and the animation along with your teaching was spot on and kept me interested and rarely was I lost or confused. Thank you so very much!

@feralscooter 5 лет назад

Awesome video. Very clear and to the point. Ive been watching a lot of videos trying to wrap my head around this stuff -- this video made it stick.

@antwoinemorris7946 2 года назад

This was very short and precise. I understand clearly all that he said more than how my professor taught it. Thank you professor 🙏🏽 🤗

@shreyasimhadri3863 3 года назад

YOU, prof Dave, are an AMAZING teacher. Thank you so much for your videos that I will be binging as a novice neuroscience major!!!!

@colloredbrothers 5 лет назад

I was interested in diet and people used to talk a lot about insulin metabolism at first, now I'm learning about genetics and gene expression because of research I did into the keto diet and its histone deacetylase inhibiting qualities, thank God for the internet and people like you Professor! I never really liked school but I do love learning with a passion.

@polixaw1337 2 года назад

Learning with passion is all you need!

@flyingbunniess 5 лет назад

Professor Dave! I have been watching your videos for at least a year now. You got me an A- in Gen Chem 2, are currently helping me ace Organic Chem 1, and microbiology! THANK YOU. YOU ARE THE BEST

@najdah1991 3 года назад

thank you so much professor dave, you made it in a very simple explanation!

@RedHeadSH0T 2 года назад

This is one of THE BEST biology videos on RU-vid!

@happyeunjee1 6 лет назад

thank you so much~~~ This video had a lot of the details I needed to review :)

@o.n.c5853 5 лет назад

i enjoy your lessons alot as they have been so so helpful..keep it up

@Noamm92 3 года назад

hands down this is the best video on youtube of this subject man

@jorisvandevelden7317 Год назад

thanks professor Dave ! u made my nightly study session a lot more endurable

@mikeE997 5 лет назад

Thanks for the video. Much more direct and concise than KA. Exactly what I needed for quick review on operons for the MCAT.

@daryljonesfoster4102 5 лет назад

What is MCAT ?

@prabh69ps 5 лет назад

Thanks and Plz give this professor a nobel prize for making this vedio ❤️

@karimnaraki7376 4 года назад

this explanation was so great thank u professor

@witty_me 2 года назад

Another wonderful session, thanks a ton

@vickyimery47 3 года назад

You’re an amazing teacher, thank You so much. 👌🏻🙏🏻🙌🏻

@zerothehero123 5 лет назад

Just found your channel and I absolutely love it! Very in depth videos for real science geeks! Subbed and liked!

@emptypotatoskin 4 года назад

Wow this cleared so much up. Thank you!

@lehuang1924 4 года назад

Your video is so great! Thank you so much!

@shinywarm6906 3 года назад

Beautifully clear. Thanks

@tomisakin 4 года назад

This guy and AK lectures have saved my from my profs reading slides and calling it teaching

@SahanTheMighty 3 года назад

This is the first video I’ve watched in your channel and the opening credit had me in stitches 🤣😂🤣😂

@tranghuyen4227 6 лет назад

I love biology and chemistry

@biobrotherslectures793 5 лет назад

A big fan of you sir !! Your video tutorials helped me a loot ❤

@ailujotkins619 28 дней назад

You explain so easily that even if i don't know english very well i can understand you AND the topic. Incredible thank you

@demitriwelling1348 2 года назад

Excellent explanation, thanks again.

@user-ml6dz7hi9f 5 лет назад

professor Dave you are a best teacher for chemistry and biology thanks for your efforts

@IndeventuresMitch Месяц назад

this is an absolutely wonderful video specifically, thank you so much. you have no idea

@marianasayuriudo5429 3 года назад

Thank you very much for your brilliant explanation.

@louisdefilippi8982 2 года назад

This is an excellent review!

@nassimazer1608 5 лет назад

Thank you so much this video really helped!!

@gamingsaiyanyt6492 3 года назад

Sir u are brilliant and fabulous explainer of concepts .Thanks a lot May God bless you and keep making such videos. 😚😚

@Zetsuke4 4 года назад

THis is explained soo good omg

@sdbeauty1027 5 месяцев назад

Ugh so I took Gene expression this past fall and had to drop because I refuse to get a C in the course so I’m retaking it this spring. I so wish I found this video before because I honestly had no clue what was going on in the class, but this has helped me organize the concepts so much better! Thank you so much.

@MrRamaeri Год назад

God bless you professor, thank you for your presentation.

@leonwennerholm3832 3 года назад

You are my secret weapon when it comes to study. :-D

@joegabrail7175 5 лет назад

Bless ur soul professor dave

@carlinasabella8732 3 года назад

this video is extremely helpful, thank u very much

@phanindraprasadpoudel4801 3 месяца назад

Wow! wonderful teaching Prof. Dave! More than in a University.

@angelocastro2697 5 лет назад

This is very helpful. Keep it up! You just got my sub :)

@naginakhan1ify 5 лет назад

Very well explained!!!!

@MrKhya123 6 лет назад

Thank you professor. You got subscribed

@itsthatleo3970 4 года назад

*I love it that this video is exactly whats in Campbell*

@puneetsingh8633 5 лет назад

Very nice video....easy to learn

@arnoldkatontoka8482 3 года назад

You're a great professor, your delivering techniques with clear expressional pictures makes it easier to understand things. But also suppose you're teaching someone who's being introduced to a topic the first time, you know, not to super summarize scientific concepts.

@cheriedvm4509 2 года назад

Very helpful video!

@CaferOzdemir 6 лет назад

Great work as always Dave ! A small mistake: at 1:50 translation is happening in the wrong direction, it should start at 5’

@hakersupatytsupra9556 4 года назад

@michellebadura8349 3 года назад

Yes, this is driving me nuts also. Translation starts from the 5' end with the methyl-G cap, then the mRNA feeds through the ribosome and finally the 3'-poly-A tail end comes out.

@junedaniel2981 2 года назад

But shouldn't it go in the opposite direction. Because on the "parent" strand its 3-5 but building the opposite so thats 5-3

@nonosaramago Год назад

RNA is single stranded 🤨

@tkdlover19 Год назад

This is super helpful, but it would be even more helpful if you put in the corner which organisms these concepts apply to, since some of these only happen in bacteria and others in eukaryotes, and still others in both. This is something that confuses me all the time, so if you make more videos along these lines in the future, that would be very informative!

@MyMinecrafter97 6 лет назад

Great video!

@animatetheidea7945 6 лет назад

Nice expleined, thanks.

@angibeller.gildemontes4872 5 лет назад

Brilliant!! Thanks for this 🙏🏽🙏🏽🙏🏽

@subhamdatta3521 3 года назад

yeah

@Zetsuke4 4 года назад

More of these please

@christopherapuan9968 2 года назад

Thank you for this!

@manuehbadachi2961 6 лет назад

you're awesome! thanks

@adamastiti5825 2 года назад

thankyou for the explanation

@lehlohonolokhumalo665 6 лет назад

Best explanation.

@mhamidusman 5 лет назад

excellent prof

@kaitlynwitkowski1108 3 года назад

Why you explain it so much better than my textbook..

@bzzzvzzze 4 года назад

Awesome video!

@sunehrikiran5638 6 лет назад

you're the best professor !

@subhamdatta3521 3 года назад

yeah

@aryaa7334 2 года назад

I've graduated HS and passed the need to study these (taking econ in college) but i still remain loyal to watching dave

@amalialatifa6248 2 года назад

this is help me a lot. amazing

@sandhya9646 2 года назад

thanks professor dave easy to learn 😃😃😃😃😃

@aliheidarzade1375 6 лет назад

thanks so much..it was usefull for me

@ericmakakantare3523 2 года назад

good one

@EKCPUNJAB 3 года назад

Is transcription a controlling factor in enzyme production for translation or transcription itself??

@abdullahinuhuyau5173 2 года назад

Thanks Proff.

@emilemil1871 4 года назад

I’m literally an idiot and I understood this just fine omg dont forget your hat king 👑 😌😌

@DudeWhoSaysDeez 6 лет назад

there is a minor error in this video: at 9:37, you color coded the three groups, but they are not properly matched below. The methyl group should be green, and the acetyl group should be red

@ProfessorDaveExplains 6 лет назад

ah man what a dumb error! thanks for catching that.

@DudeWhoSaysDeez 6 лет назад

Yeah it may be alot of work to re animate the video, but you could put an annotation with the correction

@amandarossell5167 4 года назад

Awesome video! Only thing that it had acetylation with a methyl group and methylation with an acetyl group. Minute 9:38

@sahwash3532 3 года назад

Thanks

@MeditacionesAlma 6 лет назад

Thank you

@amirkhaleghy6960 3 года назад

Thank you so much

@thetop1076 4 года назад

just loved it, such tough concepts explained cleanly ! bless professor Dave

@khunlavil3600 4 года назад

thank for saving me

@bioscienceswithshahtareenswati 2 года назад

Amazing sir..💖❤

@dandansong6826 2 года назад

Really perfect explanation! I have a question, so only e.coli has operator to turn gene transcription on\off, is there also operator in human?

@petersiska7510 2 года назад

Well done

@manuelcyril4454 6 лет назад

sorry sir i have a problem In an operon, the location of the regulatory region occurs before, within or after the structural genes.?????

@Murrayt-vu3cq 6 лет назад

nice Rembrandt lighting

@salmasyahfani817 3 года назад

thank you

@ismaildin69 3 года назад

Professor kindly you may help me how to identify TF of my gene sequences or TF of my genes motifs

@yusinurahmah8551 4 года назад

i pay my college to teach me but i always ended up on youtube because of some or so many reasons

@kogocher 4 года назад

very educational

@DoFliesCallUsWalks 2 месяца назад

13 minutes beat 3 hours on the official AP course.

@nipunsharma7418 6 лет назад

A theoretical physicist in making

@rainbowsandunicorns9233 3 года назад

Thankyou sir ✌

@harithav1803 2 года назад

I have a question professor.. If we can find and block transcription factors in some way which are activating proto oncogenes then its a possible way to supress tumours?