The Science of Keeping the Brain Healthy | Lifespan with Dr. David Sinclair #7

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In this episode of the Lifespan podcast, Dr. David Sinclair and co-host Matthew LaPlante dissect the topic of brain aging. They explore evidence suggesting that the brain ages more slowly than other parts of the body and highlight how cognitive function is impacted by aging. Different interventions aimed at preserving brain health are also discussed, including a plant-based diet, exercise, metformin, NAD boosters, and sufficient sleep.
#DavidSinclair #Longevity #BrainHealth
Thank you to our sponsors:
Athletic Greens - athleticgreens.com/sinclair
InsideTracker - insidetracker.com/sinclair
Levels - levels.link/sinclair
Our Patreon page:
/ davidsinclair
Lifespan book:
amzn.to/3sUqurT
Lifespan podcast website: www.lifespanpodcast.com
Dr. David Sinclair Social:
Instagram - / davidsinclairphd
Twitter - / davidasinclair
Facebook - / davidsinclairphd
Stay up to date with David's work to democratize biological age testing and insights: www.tallyhealth.com
Matthew LaPlante's Social:
Twitter - / mdlaplante
Timestamps:
00:00:00 Introducing Episode Seven: Aging of the Brain
00:04:39 Thanking the Sponsors
00:07:38 Ex-differentiation as a Driver of Aging
00:09:22 The Brain Ages Slowly
00:14:17 Cognitive Function and Plasticity
00:17:44 Three Longevity Pathways: mTOR, AMPK, and Sirtuins
00:23:26 Plant-based Diets and B-vitamins
00:28:32 Homocysteine, Plaque, and Vasculature
00:32:35 Fatty Acids
00:35:48 Physical Activity
00:39:14 Metformin
00:46:02 NAD Boosters
00:50:33 Increasing Blood Flow
00:53:20 Sleep
00:58:02 Overall Message: Keep your Brain Healthy
00:58:50 Next Week’s Episode and the Future of Medicine
01:01:21 Options for Subscription for Support
Links:
The cerebellum in the brain ages slowly: bit.ly/3JC9CLL
Neuronal cells have a lower epigenetic age: bit.ly/3HVZsVA
Sirt1 regulates aging in mice: bit.ly/3sGZPNC
Mediterranean diet and brain health: bit.ly/3uUpYuL
Mediterranean diet and dementia risk: bit.ly/34Igp7H
Aerobic exercise improves executive functioning: bit.ly/34Dv5oJ
Exercise and mouse models of neurodegenerative disease: bit.ly/3516IRn
Strength exercises elevate the expression of BDNF: bit.ly/3GTLqCs
Metformin enhances cognitive ability in fish: bit.ly/3sLtWn2
Alzheimer’s disease and metformin: bit.ly/3GSdTJ5
Metformin use correlates with a reduced risk of dementia: bit.ly/3GT0KPO
NAD boosting and Alzheimer’s disease: bit.ly/367C2P2
ALS, nicotinamide riboside, and pterostilbene: bit.ly/3Bm2VKN
Vascular aging and NAD in mice: bit.ly/34Uemgx
In mice, overexpressing Sirt1 in the brain extends lifespan: bit.ly/3HNRyh3
Sirt1 ameliorates amyotrophic lateral sclerosis in mice: bit.ly/3LvUWiO
Sirt1 protects against Alzheimer’s disease in mice: bit.ly/34KZXUe
Sirt1 and neuroprotection in a mouse model of Huntington’s disease: bit.ly/3BqymDJ
Sleep loss reduces lifespan in flies: bit.ly/3Jt6BgA
A single night of sleep deprivation increases amyloid-beta: bit.ly/3uSNGaU
All-cause mortality correlates with sleep duration: bit.ly/3rQl14f
Please note that Lifespan with Dr. David Sinclair is distinct from Dr. Sinclair's teaching and research roles at Harvard Medical School. The information provided in this show is not medical advice, nor should it be taken or applied as a replacement for medical advice. The Lifespan with Dr. David Sinclair podcast, its employees, guests and affiliates assume no liability for the application of the information discussed.
Special thanks to our research assistants, Adiv Johnson & Sarah Ryan.

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11 июн 2024

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Комментарии : 782

@Jmartestuesday Год назад

It is 7:30 PM here at my house. I was listening to your discussion about aging till you got to the part about the need for exorcise. I stopped the You Tube video and got off the comfortable office chair and went for a 2 mile walk. I dont particularly enjoy walking. I do enjoy being ABLE to walk. I'm 91 and am interested in being able to walk and to think properly. Your talks on You Tube are a blessing to me, thanks.

@MPV_Puneeth 7 месяцев назад

Your awesome 👍

@Steppinonshii 5 месяцев назад

Take the drugs man. What do you have to lose ?

@j2.a.m.pthomas121 2 года назад

I don’t typically comment, but wanted to confirm that I appreciate Matt’s role (cohost) in this podcast. He tends to ask the very questions I have as a listener.

@JDEG100 2 года назад

True, I think the same.

@levondarratt787 2 года назад

Same here....Matt is so good!

@heracles89 2 года назад

I thought that too - great series and introductions into the science of longevity

@zeromodulus1679 2 года назад

Yes, he's a good "layman" so to speak.

@stevenj6421 2 года назад

What makes JOE ROGAN so great!

@19Jetta 2 года назад

I know I say it almost every week, but thank you again for doing this podcast. I am aware it takes your time and effort and no doubt you have lots of other things you could be doing. This is just an incredible resource!

@DocJaeBass 2 года назад

Yeah, me too, I always want to comment, but generally it's the same thing. Thanks for saying it for me.

@19Jetta 2 года назад

@@johnf4680 I will have to respectfully disagree. Any scientist that wants to explore the edge of science is going to generate controversy. but the proof is in the pudding, as they say. I have followed some of his protocols around NMN and resveratrol and am getting some pretty great results

@JesusMartinez-hl7zj 2 года назад

Thanksdavidi needmore nmnihavelifesoan b k

@zebragiraffe1 2 года назад

I work with many elderly people in their 80s and 90s, and most of them are not overweight, can still walk short distances and many use their smart phones to stream into their hearing aids or use the app to control the hearing aid volume and programs. They are inspiring.

@SirGolfalot- 2 года назад

Dr. Sinclairs' videos are an inspiration. I was exercising, fasting, eating right, and taking supplements until the spring of 2020. Time to get focused on longevity once again.

@theresaho9696 2 года назад

Hi, 2020 you start right, and now is 2022 add a few more things like mentioned in this clip. Congrats!

@sciencensorcery 2 года назад

Folic acid is not B-12. It's the synthetic form of folate, which is B-9. Many people are unable to properly utilize folic acid and need to take folate - but some people also need that folate to be pre-methylated. And others can react poorly to methylated folate (I experienced this myself a few months ago and the effect was staggering). It's a bit complex but worth looking into before you supplement (or if you start and don't take to it well) so you know which form you need!

@PaLOmAFAiTh0 2 года назад

@sciencensory maybe tmg is a good source? How did you understand your reactions at supplement, what blood test did you do?

@Sk0lzky 2 года назад

Any ideas why the methylated folate might be causing adverse reactions?

@lizmallen3461 2 года назад

That’s me!

@henniannariina5877 2 года назад

The part that some people don’t tolerate methyl folate was new to me!

@vonwolly2 2 года назад

David Sinclair was talking about homocysteine when referring to folate both vitamin B12 and Foley acid both lower homocysteine he probably just got them confused. Another thing that lowers homocysteine's nac . My father had extreme high homocysteine I got it down to six with 5 g to 6 g of nac . People with the MThFr gene need to take large amounts of folate I have that gene. Too much folate can raise the heart rate and some people though

@SheilaBella 2 года назад

What a great episode! Thank you both! I have to agree with the others who commented that MATT’s role in this is KEY! I never comment but I just had to say how I have an easier time learning this stuff because of his participation.

@AnnTsungMD Год назад

Agree! Amazing episode, this kind of content that will help us how to care for our health more.

@tiararoxeanne1318 Год назад

The dynamic between the two is very good. They complement each other, neither one is upstage the other. Maybe it's scripted?

@Mohandas.Gandhi 2 года назад

"Today we'll be talking about the most important organ in the body, the brain." -David's Brain

@Angry.Hippie 2 года назад

Sounds biased

@joyceherreid7586 Год назад

People like him can save the world. If we listen.

@cecipalacios1007 2 года назад

Great podcast! As a 68 years old my focus in healthy aging! Thus, I completely agree with Dr Sinclair said that we need to take care of our brain not only for us but for our family as well.

@cryptowhale916 2 года назад

Your profile picture looks like, you are 40... please give us some advice on staying young...

@mitchtickets 2 года назад

Main takeaway, "Without a functioning brain, we are really quite useless." -Dr. David Sinclair.

@pjc7085 Год назад

A lot of people get away with it....

@AnnTsungMD Год назад

Brain is arguably the single most valuable organ in the body. It's just right that it is given emphasis to keep our brain on top-notch condition.

@radhakrishnanmanickavasaga124 6 месяцев назад

😅😅

@seokoes 2 года назад

one of the few person on youtube that i deeply respect , thanks David for all of fantastic work and sharing to public.

@paigewalker2077 2 года назад

This episode was the one that finally got me to share this with my parents- the others were super inspiring to me, but not enough to make me feel like my elderly parents might actually take action. "The Average onset of dementia is 80 years old" - this episode made me feel like I'm doing a disservice NOT to share this with my parents! Thank you for making this info available to the masses!

@AnnTsungMD Год назад

Keeping an active social life, regular exercise, and continuing activities the person enjoys, or finding new ones, can help to reduce behaviours that are out of character. Hope these can help your parents as well. ❤

@janeca10 2 года назад

Special thanks to Dr. Sinclair for delivering true science to our homes. I love neuroscience, so this is a fantastic episode!I Also would like to comment that the conversation format is great. Matt does a really good job. Tks everyone that makes this happen.

@yayangtapir4130 2 года назад

Mathew is looking younger day by day....I think he is listening to david to start all the supplements. His collection of hats is awesome...😁😃

@jeanpollack5102 11 месяцев назад

I love the interaction between dr. Sinclair and Matt

@HardForking 2 года назад

The best podcast I've found. You guys are fantastic, please keep this going. I've followed David's works for a number of years and put him right up there as one of the best humans we have on this planet.

@pops4457 2 года назад

I feel so blessed to have found this podcast at 24, thank you both tremendously🤟🏻

@barbaralachance5836 2 года назад

Lucky you!❤️ I wish I had started wearing tons of sunscreen earlier.

@vaughanmoody Год назад

@@barbaralachance5836 if it’s any consolation, sunscreen has lots of chemicals in it that can get into your blood through the skin, which is not good. Getting a little bit of sun, and mostly staying in the shade is the best/safest option, in my humble opinion.

@vaughanmoody Год назад

@@barbaralachance5836 I agree, he is lucky to be listening to this at the age of 24. I feel grateful I wasn’t aged 90+ when I listened to this. Best wishes for many healthy decades ahead!

@shelleyhuskey1870 2 года назад

David you are a special person! Thanks for everything you do. I have learned so much from you and your books.

@jeanashchuchinov6593 2 года назад

I love your podcast, I can’t get enough. I was happy to hear you are going to have a season two lol

@AnnTsungMD Год назад

i like his podcast too. so much valuable info.

@claudettesechler149 2 года назад

Just look forward to your podcast..it is so innovating and love hearing about the wonderful things about the health field that I can apply to myself! Just wish I could have dinner earlier instead of later but it is a special time to enjoy a great meal, glass of wine with my hubby and chit chat, laugh, listen to great music..that’s a great health fix for me!!

@stephenyoung3550 2 года назад

As an extremely busy professional and getting a little older, I enjoy learning about avenues that could help keep me optimizing my overall function/performance. Great podcast and the 2 hosts work really well together.

@AnnTsungMD Год назад

We all want to live longer in this Earth. And Dr. Sinclair is helping us. His dedication and passion is truly inspiring.

@michelem226 2 года назад

I've been vegan for 20+ years. B12, not folate is definitely the most important to supplement with for brain health on a vegan diet. Permanent damage to the nervous system can happen with prolonged deficiency. For Omega-3s, the recommendation is 1 Tablespoon ground flaxseed per day or to take algae-based supplement for vegans. The algae-based supplements are expensive but more reliable than flaxseed.

@paulconnects7348 2 года назад

Would love to get some recommendations I became vegan 2 years ago but you know more than I for sure

@michelem226 2 года назад

@@GabrielCazorlaPersson1 I tend to agree. People who don't eat fish should take a supplement. Flaxseed oil might be an option too.

@michelem226 2 года назад

@@paulconnects7348 I would suggest tracking your eating for a handful of random days using Cronometer and see how your nutrition is going.

@chrisbusby4395 2 года назад

@@michelem226 it’s not what you eat ,it’s what you absorb and convert and simply using a chronometer whilst some help is only part of the answer

@michelem226 2 года назад

@@GabrielCazorlaPersson1 flaxseed oil is highly concentrated in ALA, so the conversion to EPA/DHA may be enough. It's probably better to take a DHA/EPA supplement, though, because there's more certainty there.

@Amyloushetty 2 года назад

Best podcast / YT! So glad this channel was created it really easy to follow and so much valuable information. X

@valjohnson5835 Год назад

I listened to all of your episodes on the Podcast App. within days. The content is interesting and informative. Both co host are amazing and thought provoking. Love you both! I really appreciate the way Dr. Sinclair explains the science behind everything and the way Matt asks questions or presents information. This is the best duo I have come across. Please continue to do more episodes. I have learned so much and you have inspired me to make some meaningful changes in my life. Thank you!

@mvc9871 2 года назад

I see that David Sinclair has posted a video and come directly to give it a like, even before I watch it.That is how good everything he does is. Thank you sir.

@stephenlucier 2 года назад

This is amazingly informative, please don’t stop at 8!

@francestorreysirdevan4774 2 года назад

Best podcast ever. Love and appreciate the work you both and your team do and share. Thank you all!! A question about fasting for David: what do you prescribe for your children? Is one meal a day your recommendation to anyone of any age? If not, what age do you recommend starting that protocol? Additionally, I wanted to share that algae oil is a perfect vegan EPA/DHA source/supplement that circumvents the fish oil route. In fact, it’s what the omega 3 rich fish consume too! Highly recommended!

@dkollaritsch 2 года назад

yes..please keep going with this podcast! It is so very important for us all.

@sunshinecitypersonaltraini7228 2 года назад

Really enjoying the progression of these, excited for the next episode!

@patriciasozalac.4133 2 года назад

I just love this podcast. Thank you for sharing all this information!

@LCarefortheworld 2 года назад

Thank you for doing the podcast! Feeling lucky I get these incredible information from the source I can trust!

@learnmore6120 2 года назад

I am applying for Harvard postgraduate next year hopefully I will be able to meet David.

@Aman.Akshay.Sharma 2 года назад

What do we know about lifestyle protocols not related to diet/sleep and how they age the brain? For example reading, spaced repetition, music, cognitive training, new experiences etc? Andrew Huberman’s episode on how play impacts plasticity was really interesting, so I’m curious how this all ties into ageing.

@jessicalt4121 2 года назад

Great question!

@jawadkarim6615 2 года назад

A Big Salute for David Sinclair.

@Frazer247 2 года назад

I have read the book Life Span twice. I have watched most of David Sinclair's RU-vid clips and interviews. I have given several copies of the book as gifts to friends. I have been following David's recommendations to improve my overall health for the past two years. However, witnessing how "religiously" David defends the use of Resveratrol despite all the new research studies that say the opposite, has made me question the "objectivity" and "authenticity" of David Sinclair as a scientist. I have no doubt David Sinclair is a great businessman. "Objectivity" is a true characteristic of a "real" Scientist.

@karendagrava544 2 года назад

Where are the new studies saying the opposite about Resveritrol? I’ve been seriously considering taking it based on David’s enthusiasm.

@eatmyfeelings6585 2 года назад

@@karendagrava544 In a study, Fluorescent dye activated Sirt1 whereas Resveratrol did not. I feel like David may be affiliated with some supplement company...

@barbarafairbanks4578 2 года назад

@@karendagrava544 I don't think the resveratrol studies discounting it as a longevity supplement are 'recent', per se. I know there was quite a brouhaha a number of years ago over Dr. Sinclair's longevity claims for resveratrol. AND that some biofirm company he sold the rights to for Resveratrol For millions $$$ ended up refuting his claims for longevity for humans, specifically - because they found the study findings were not repeatable. And... that biofirm company washed their hands completely of Resveratrol, and lost millions as a result. (IIRC, from bits & pieces I've heard/read about the Sinclair/Resveratrol 'scandal' - I think this was how it went down), and it very nearly ruined his reputation and his credibility in the scientific community. I remember his talking about how upsetting this was for him, and how - as it turned out - he eventually proved 'everyone wrong and redeemed himself'...according to him. This was all discussed in a Huberman interview, IIRC, when he had Dr. Sinclair as a guest on his podcast. I'll have to re-listen to that Podcast - I may have been distracted during that part. My impression, after listening to that Huberman Podcast, was that the Sinclair Resveratrol controversy was all settled... EXCEPT, that it does currently seem NOT to be 'settled' - not at all (in the public domain, which has a tendency to keep past judgements alive and well) - judging from some of the comments here. So, yah, idk what to believe about Resveratrol either, at this point. 🤷‍♀️

@ci4396 2 года назад

@@eatmyfeelings6585 can you link me that study? all i can find is that resveratrol helps preventing heart disease and and helps to stop sars-cov-2 replication in the body. sounds a like supplement worth taking. its cheap and seems like it still has proven benefits and no negative side effects, from what i can tell. happy for anyone to show me whats bad about it

@-ahjoshie302 2 года назад

@@barbarafairbanks4578 If you read the papers yourself, you will see the flaws in the studies, ones that Dr Sinclair has already addressed. Whether you consider it a satisfactory response or not if up to you, but I think it makes sense. Also, all of the tests the company did on resveratrol were not longevity related, they were related to cancer and liver disease (essentially finding further uses for the supplement).

@bigpicturegains 2 года назад

Practical takeaways you can implement immediately: Get good quality adequate sleep, exercise, eat well and ensure you are getting enough essential fats.

@successfulperson3304 2 года назад

Thank you!

@Monsterpaw.. 2 года назад

Probably going to need to watch these 100 more times 🤯 Thank you for making these videos 🥰🙏

@ATFstein 2 года назад

Incredible information and I absolutely love the tandem here. You have my vote for WAY MORE CONTENT WAY MORE. You and Andrew Hibernian need WAY MORE CONTENT. I literally listened to all of your videos and his in less than 3 days. Can’t get enough

@quarantees8736 2 года назад

Fantastic episode again guys, thank you 😊

@bestrongandloveyourself2370 2 года назад

I just got my first Inside Tracker Inner Age test results and I am 10 years younger than my chronological age! It made me so happy! 😁 I hope that if I follow Inside Tracker recommendations and advices given on this podcast I will be able to become even younger! 😊 Thank you for the information that you are sharing! 🙏🥰

@vickydaisy_rose 2 года назад

Love both of you and your podcast. Thank you for making it happens.

@Mum2cuties 2 года назад

I’m an optometrist and I’m glad you emphasised the importance of an eye examination to assess general vascular health.

@AnnTsungMD Год назад

Absolutely agree it’s the window to the central nervous system.

@t.j.robertson9565 2 года назад

I look forward to watching these podcasts. Thank you for sharing your life’s work 💙

@carlor.s.4742 2 года назад

I'm always amused when experts say "talk to your doctor about it." The vast majority of Drs know very little about nutrition to start with. I asked my Dr if he could get a HOMA-IR test for me & he had zero clue as to what I was talking about. With info readily available on the net now, some patients are light years ahead of their Drs!

@mhelsher1 2 года назад

I love this casual, engaged and authentic conversation. I'm more a creative writer/philosopher than a scientist. But I thank god for good scientists like these two. I think we're coming into a better age -- the age of conversation (which has always been my greatest teacher), wherein the sound bite media slowly, and quite painfully, dies.

@dottiepolly8564 2 года назад

Keep up the good work Mr Sinclair 👍👍👍👍👍👍

@natalieaxl804 2 года назад

Thank you, Dr, David 🙏

@renencar2684 2 года назад

What i like in this interview is it is so organize and you can track back what you have missed.kuddos new follower

@greenLaVitameadows 2 года назад

Thank you always ! Reassuring to know with great experts

@sandrathomas6216 2 года назад

I was extremely impressed by this podcast. I learned a great deal of new things. I would love for you to follow up another podcast series.

@johny16G 2 года назад

Blessed day with new upload. Thank you!

@callofthedark 2 года назад

Let’s Go..As much as I am excited to hear each episode, it makes me countdown to the last couple of episodes left.😣

@peterellis4262 4 месяца назад

My mother at 60 began a computer consulting business with one of her contemporaries. Mom died in 2021 at 92. By that point she had lost a mental step or two, but was still fully aware and alert.

@plantbasedathleterealtor6145 Год назад

Excellent! I’m grateful for your podcasts 💫🙏🏻

@nicolasguarin3302 2 года назад

This probably the only podcast that will give you ROT (return on time). Great knowledge.

@rolfjacobson833 2 года назад

Thank David. Your series has been incredible. Are you on Patreon? i will support your channel more

@Viva-Persia 2 года назад

I just subscribed to Dr S. channel.. having followed his lectures in the past .. thank you for the awesome stuff..

@palden4579 2 года назад

I am 58. Most of my years, after my 'teenage slim time', I was about 10 pound overweight. Around at 45 I developed some knee pain for many years and like so many of my pals, I thought it is just the body worn out because of the hard work as a nurse. So, it is just normal life...! But then I discovered the Ketogenic diet, and after 2-3 weeks my knee pain was gone and never come back. I almost never experience ANY pain at all in my body. If I tell this to my oldest sister, 62, that she should stop eating sugar and do low carb eating, she screams at me: "My body, and knees are worn out, nothing can bring it back!!". She just don't believe me, that the sugar and carbs is the ONE who give the inflamation and the pain, AND it is reversable! It's sad, that almost no one knows, that with eating low carb and no sugar, all the inflamation will be gone and one will feel normal again!! It should be called out from the Rooftop!

@jheichelbech 2 года назад

If you die in the matrix...the person with Alzheimer's cannot describe their disease. Fuck the knees, keto is for the brain. Read compression of morbidity.

@Lamz.. 2 года назад

U feel you completely. People are addicted to carbs. It's like trying to convince an alcoholic that hangovers disappear if they stop drinking. They know but do not want to hear it, very frustrating. Leading by example works best in my experience.

@Chris-kr7gg 2 года назад

So you stopped fruit and all grains, did you start exercising again and what foods became your staples ?

@palden4579 2 года назад

@@Chris-kr7gg Yes, no fruits or grains. I'm Vegetarian and eat 1-2 meals a day. My meal is mostly vegetables. Don't want to eat legumes, so I eat some Beyond meat or Impossible for more protein. Sometimes Eggs, but no Milk and rarely Cheece.

@Lamz.. 2 года назад

@@palden4579 Have a look at the ingredients of the Beyond and Impossible meat. It's all crap. Better leave those out and eat more eggs and fish, if you want to eat vegetarian. Don't exchange your previous crappy diet for other crap. Real food is what it's all about, my friend. There's lots to be gained even more that way.

@eddiehanson2738 2 года назад

Thank you. This is life-changing viewing.

@bigbitsmama4802 Год назад

Fascinating! I am listening here for my whole family, I'm going to do what I can to help everyone learn & thrive. My 80 year old mom was just taken off metformin and put on insulin. I was So disappointed. I think I'm going to go with her to her next doctor's appointment. tot tot

@ChannelJtotheD 2 года назад

Amazing podcast. Yes, I’m enjoying listening to all of your videos and at the same time gaining so much knowledge with coping with longevity n living a healthy and productive life. Thank you immensely.

@AnnTsungMD Год назад

So happy for you. Im glad you found someone like David to guide you.

@georgerodriguez7594 2 года назад

Thanks for doing this podcast. Very good information, live changing.

@qski1 2 года назад

Looking forward to the next season, please continue! I would be interested the most in the effect of excercise (various types/cardio/weights) on aging.

@whiteninja9481 2 года назад

See you this summer!

@dannycashman8446 Год назад

I work permanent night shift, but am also health seeking and actively training / exercising regularly (3 gym sessions & between 7-10 miles walking 5 times a week). I sleep on average 7.5 hours during the day. Blood work is all ok over the last year. looking forward to checking by biological age to see what the night shift is doing in terms of aging. I love if more studies were done on someone like myself to see the long term effects of night shift work is mitigated by other health seeking behaviours. Thanks for the podcast I've enjoyed the series a lot.

@123ChrisG 2 года назад

Please can you respond to Dr Brad Stanfield regarding resveratrol. He has made a few videos on this. Thankyou!

@altiarissuralis8535 2 года назад

Absolutely. And Dr. Brenner's. I'm not taking sides, but wish there was more discourse about this.

@DrBradStanfield 2 года назад

Would be a great discussion

@bysupriya 2 года назад

Agree these contradictory information around these studies really confuses general users!

@ToTheSky17 2 года назад

He might not want to discuss about resveratrol because a lot of companies will be mad. He'd rather talk about NMN which is a clear winner.

@aceofhearts158 2 года назад

Thank you for making this podcast. If you guys continue with the podcast, I would greatly appreciate further elaboration on this topic. I am only 29, but my brain has deep white matter lesions, which are very uncommon at my age, but very common in the elderly. If you guys could explore the research on this topic, it would be greatly appreciated. I've been looking into as many papers as i can find on the topic, but I don't have the same access to the journals that you have. Thank you

@valeriehopebennett 2 года назад

thanks to DR SINCLAIR AND MATT FOR SUCH HEALING ADVANCED INFORMATION WHICH WE ALL NEED FOR SELF EDUCATION ON IMPROVING OUR HEALTH AND LIVES.

@kantrajk277 2 года назад

Thank you so much ❤️🙏

@kdcounseling 2 года назад

Perfect timing thank you 😊

@jonahalldors5488 2 года назад

Love your episodes! such a great information you are sharing.

@loudboomboom 2 года назад

Thank you guys so much for this invaluable information.

@ritascolaro4059 9 месяцев назад

David, you have done some incredible work. When I mention it to anybody, they tell me not to believe anything on utube! I am hoping you can get the pill out in time for ME! I am the same age as your Father, so maybe there’s hope for me! I just want to keep doing whatever! Just being active and achieving will be enough for me! I pray that you will bring out your pill soon!🙏

@CryptoQuest 2 года назад

valuable information as always thank you for making this.

@omittapir5986 2 года назад

Great episode Dr Sinclair and Matt. Please start new podcasts pronto.! ☺

@CelluloidBlonde 2 года назад

I have enjoyed your series very much. Thank you for the information. I would like to hear more about peptides if you do future podcasts.

@Articulate99 2 года назад

Always informative, thank you.

@jeanninemurphy8071 2 года назад

Thank you for your brilliant work!

@robking3489 2 года назад

Dr Sinclair, please address the controversy regarding GSK dropping the company you sold to them and the discrepancy of resveratrol findings. Thank you!

@raheemh.9891 Год назад

I am so glad finding you and following you. By the way i am 52 with diabetic . I am learning a lot. Thanks so much.

@sandrakillalea1150 2 года назад

This is an Excellent episode; they all are. Thank you for the part of you, you both, that is altruism.

@BiohakerNYC 2 года назад

Thank you both👏👏👏

@makemoneymedia5771 2 года назад

Thank you so much I love you guys!!!!

@brendaspalding867 2 года назад

David I’ve seen you on Joe Rogan’s podcast. You’re one my favorite guest. I’m so happy that you’re doing your own podcast. I love Joe but I love him more when he has people like you on. I’m a fan. I hope you keep it going.

@LumiRapper 2 года назад

Genius levels of knowledge!

@murrmurr765 2 года назад

Exceptionally episode as always. You really complement each other well!

@ljacobs5478 Год назад

Great video! I’d love to hear about ADHD in your next season!

@JohnDeanMusic 2 года назад

Love Matts hats and overall sense of fashion.

@melissashare7543 2 года назад

This podcast provides so much beneficial information to help reverse aging with easily accessible protocols and regimens. Fisetin is one supplement that has not been discussed yet and I am interested in knowing if you think that it may be beneficial for reversing age or age related degeneration? I know that the Mayo Clinic is currently running studies on this presently and I am interested in possibly adding this to my regimen. I would appreciate your thoughts on if it may be effective and if it is safe for humans to consume? Thank You for sharing your knowledge!

@perkyzombie 2 года назад

Thank-you so much for sharing all this research, for myself it has not fallen upon deft ears. I love rigorous science and all it's intricacies. God bless.

@Thebusysuperhuman 2 года назад

Thank you very enjoyable and useful as always

@AnnTsungMD Год назад

Great episode. Thanks for this!

@loriej2687 2 года назад

Love this topic!

@skyrider4789 2 года назад

😁😆So funny with the opening -- "So far" 0:46 Thanks guys. Keep up the great work!

@altiarissuralis8535 2 года назад

Thank you Dr. Sinclair, been following you for a while. 👍 Recently, there’s been some debate and pushback from Dr. Charles Brenner, and as a layperson I can’t seem to understand all the technical details. Can you eventually shed some light on this disagreement? Thanks.

@Mashynia 2 года назад

great episode! thanks 💛

@Sk0lzky 2 года назад

Resveratrol can also be found in red wine vinegar and balsamic vinegar so if you can't afford supplements and don't drink alcohol give it a try! Posca is a very refreshing drink, and surprisingly tasty once you get past the initial acidic hit (aroma more than anything, it's actually not very sour for some reason. Tastes like weird, fruity mead)

@cd2888 2 года назад

You would have to drink 10,000 glasses of wine per day to get the amount of Resveratrol they’ve used in studies. The alcohol and sugar in red wine do far more damage than the trace amounts of Resveratrol would.

@Sk0lzky 2 года назад

@@cd2888 I'm aware, but because they keep mentioning red wine I decided promoting a very underappreciated non-alcoholic drink would be a good idea :v

@lynnnestor7985 2 года назад

Brilliant content …yet again!

@ligiasommers 2 года назад

Best podcast !!! And I study many of them !!!! 🙏🏻✨🌹🌟🌟🌟🌟🌟 I am using AGreens and will check the others

@shyrinekessentini167 2 года назад

Can you please do a podcast about repairing the cells in the body caused by cancer treatments, stress, radiation…thx

@Norseman311 2 года назад

I had a huge dose of radiation as a kid. Would like to know this.

@V.Hansen 2 года назад

You need to recycle them, 3+ days of fasting and senolytics like quercetin and fisetin.

@williamnunn8847 2 года назад

thank you david for the advice on NMN. I am going to get on this quick, as i have chronic insomnia at the moment, from mental health. i exercise with HIIT and calisthenics. i take zinc, vitamin d and ashwaghanda but realise this is not enough at the moment.