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Medical Interventions (TRT, HGH, Stem Cells, etc.) For Longevity | Lifespan w Dr. David Sinclair #5 

David Sinclair
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30 окт 2024

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Комментарии : 589   
@DrPubz
@DrPubz 2 года назад
I have been following Dr. Sinclair since I was 25. I am 22 now.
@jetmirqosja7217
@jetmirqosja7217 2 года назад
Best comment on this thread..🤣🤣
@ela7145367030
@ela7145367030 Год назад
Seriously, I’ve been lifetime intermittent fasting and every new person, even bankers and doctors who have all my bio/med information routinely say I look 30-35 years younger. They all ask to see my gov ID, especially after repeated blood panels that test pristine.
@arbur3058
@arbur3058 Год назад
HAHAHAH thank you for this
@JoseCastro-px7ow
@JoseCastro-px7ow Год назад
Lmaoooo 😂
@VanIsleBC
@VanIsleBC Год назад
shrieking
@cypriankariuki175
@cypriankariuki175 2 года назад
Am a young clinician in kenya.....this podcast always make me feel like am attending longevity lectures in campus. THANK YOU AND GOD BLESS YOU.
@kipkiruivictor3320
@kipkiruivictor3320 2 года назад
wow.. another kenyan over here
@vertical8infinity
@vertical8infinity 2 года назад
Just some FYI. a lot of longevity scientists don’t believe in God. If you want to think like they do, consider different perspectives on reality. Almost no one here is a “god blesser” type
@danthegypsy5871
@danthegypsy5871 2 года назад
@@vertical8infinity omgggggggg shuttttt uppppppp
@armandom28
@armandom28 2 года назад
Leave the superstitious religious crap out of this
@kipkiruivictor3320
@kipkiruivictor3320 2 года назад
@@vertical8infinity 😂😂 yeah.. true
@husainialiyu5198
@husainialiyu5198 2 года назад
At 75yrs I am. very keen on David Sinclairs achievement in longevity science.i take a lot of suppliment.
@nrs_207
@nrs_207 2 года назад
All of this is fascinating to me as someone in my early 30s. I’m really hoping this keeps going in the right direction and quickly.
@dulalrajbaruah2576
@dulalrajbaruah2576 2 года назад
I am a G I surgeon but I take particular interest in chronic diseases and old age . It would be super interesting to see if we could really wipe out old age related chronic debilitating diseases in future.
@jeffreysorensen5298
@jeffreysorensen5298 2 года назад
We mostly can it’s called diet and life style
@geekspeak1066
@geekspeak1066 2 года назад
@@jeffreysorensen5298 yea but can u make a pill for that so we can profit off it? We know how to end chronic disease already. Are actually some powerful tools available but people have to want to do it. Something like 90% of all health improvements are realized simply by losing weight. Regardless of the diet.
@theresaho9696
@theresaho9696 2 года назад
@@jeffreysorensen5298 may I add optimism besides diet, lifestyle?
@jeffreysorensen5298
@jeffreysorensen5298 2 года назад
@@theresaho9696 you are absolutely correct. Most people realize that obesity is the number comorbidity for a poor outcome of Covid but few realize that number 2 is fear and anxiety.
@michelles2299
@michelles2299 2 года назад
Quality of life trumps everything
@gro16
@gro16 2 года назад
Man, Mathew is truly superb in slowing it down and also not loosing any threads. Thank you Sir!
@daviessusan1000
@daviessusan1000 2 года назад
A discussion on menopause and HRT/TRT would be brilliant!
@lauramakin834
@lauramakin834 2 года назад
Yes !!! Definitely
@quantitradersignalservice5735
@quantitradersignalservice5735 2 года назад
@@lauramakin834 Totally!!!!!!!!!!!!
@quantitradersignalservice5735
@quantitradersignalservice5735 2 года назад
Yes please do.
@lauramakin834
@lauramakin834 2 года назад
@@quantitradersignalservice5735 Haha
@clueless_orange
@clueless_orange 2 года назад
Agree! if loosing our estrogen after the 1st half of our lives triggers a few serious diseases like alzheimers, can any of the mentioned treatments cover for that besides taking lifetime HRT?
@Alex24998r
@Alex24998r 2 года назад
Again Dr. Sinclair, your colleague is asking Excellent and Thorough questions , that cover all points a viewer such as me was thinking about- such as the growth hormone discrepancy, among many other questions. Thanks to both of you for putting forth such interesting and fascinating information.
@stylebase
@stylebase 2 года назад
What about menopausal women and HRT? Would be interesting to hear about menopause and aging, maybe specific advice for pre and post menopausal women.
@debj1356
@debj1356 2 года назад
Yes, yes, yes!
@lizmallen3461
@lizmallen3461 2 года назад
My doc put me on sermoreline the precursor to hgh. He checked my blood level for HGH and it was low. He started me out on .2 ml injection nightly. Over the course of six months I’ve had my level checked several times. Now I am at .4 ML after six months, the sweet spot. It is safe. It is just telling your body to produce HGH if it needs it and it is in the healthy normal range now. Feeling great
@dianaprice3227
@dianaprice3227 2 года назад
It would be great to get Dr. Sinclair's take on menopause treatment HRT; loss of estrogen = loss of bone. How to improve and reverse bone loss. Increasing quality bone density ... can NMN Stimulates Bone Marrow Stem Cells to Form More Bone ... ? Thank you Dr. Sinclair for what you do!!! 🙏
@starfox300
@starfox300 2 года назад
Who cares about meopausal women?
@stylebase
@stylebase 2 года назад
@@starfox300 It is always lovely to know that there are people who care about their mothers and the future of their girlfriends and wives. :)
@magicfitzpatrick
@magicfitzpatrick 2 года назад
I’m surprised you haven’t talked about one of the best things you can do for anti-aging. Donating blood should be on the top of your list. I would love to hear you talk about the benefits of donating blood.
@mj.sorrondegui
@mj.sorrondegui 2 года назад
They did mention that on another podcast when they were talking about iron.
@SaltedHope
@SaltedHope 2 года назад
I'm loving this channel! It's my favorite kind of content to nerd out to.🤓 I've been binge watching, like Netflix. We humans and our genetic and cellular makeup are so incredibly fascinating. Thanks 🧬🧫👩‍🔬
@melindastefan2265
@melindastefan2265 2 года назад
I really like to listen to the lifespan podcast, but as a woman I feel women data are invisible in most of the researches. Could you please Dr Sinclair apporach some topics from the aspects of women? Especially when you talk about hormones like in this episode? It would be fab to hear about more similarities and differencies if there are any between a female or male body in terms of ageing! Thank you and congrats! And by the way, I’m Hungarian too as your grandma😊
@ybigirl
@ybigirl 2 года назад
Yep. So frustrating when they both say "people" when they mean men. Even rat research is largely on male rats. Grrrr.... Had a conversation with a researcher at the Salk Institute and he said "Well, womens' hormones are so complicated. It is like you are a different person every day." Lousy excuse for ignoring 50% of the population.
@Samantha-qf5ee
@Samantha-qf5ee 2 года назад
Looking forward to the entire episode that covers women's hormones (because we don't already live long enough?) Thank you!
@Corrans
@Corrans 2 года назад
Ja I think humans and females in particular live long enough...I am definitely more interested in FEELING good as I age and being healthy and strong. I would happily trade a few years for vibrancy in older years.
@starfox300
@starfox300 2 года назад
I doubt they will look at women hormones lol
@anthonyharmon9265
@anthonyharmon9265 2 года назад
Sexist
@AnarchyStax
@AnarchyStax 2 года назад
@@anthonyharmon9265 what?
@chriskoort5717
@chriskoort5717 2 года назад
Female hormones in a nutshell: 1 week of emotional outbursts followed by 3 weeks of illogical blabbering.
@rustybolts8953
@rustybolts8953 Год назад
Only over the past 5 to 10 years have I finally learned the importance of good rest and sleep to good health. This is an ongoing learning experience. Will report again in 3 years if I am still about.
@cherylsimon7619
@cherylsimon7619 2 года назад
Love it! Skin aging is what I've been waiting for!!! Can't wait to hear what you have to say on the next podcast🙌🙌🙌❤
@michelles2299
@michelles2299 2 года назад
I can tell you what works its simple...... Tretinoin at night spf every single day no sunbathing smoking or alcohol then nutritious food comes next...... food is medicine is my mantra 🙏
@cherylsimon7619
@cherylsimon7619 2 года назад
@@michelles2299 agree! I do all of that. Especially after having melanoma. His latest video discusses other things like peptides as well. I hope he does more on those!!!
@Artilectual
@Artilectual 2 года назад
Thank you for your time and content. As a blue collar know buddy, your work has kept me younger and fitter than I ever really expected possible. I've been following your work for years. So happy to have all this content in one place, cataloged, with such depth. ❤️ 🙏 truly grateful
@y.g.1313
@y.g.1313 Год назад
First time a video from Sinclair which is not full of nonsensical statements, rather detailed review of wide range of subjects, he is knowledgeable.
@peterellis4262
@peterellis4262 9 месяцев назад
huh?
@joshuasmiley2833
@joshuasmiley2833 2 года назад
Thanks! Thank you David. I have been following you for years. I am yet another person you have inspired and positively changed from the inside out! sincerely, you are appreciated! Joshua, Pedro, Smiley
@quaterman2687
@quaterman2687 2 года назад
I would like to hear about the new studies on resveratrol that show it has no positive effect. And even takes away some of the positive effects of exercising. Could you discuss it in one of the future episodes? Would be great!
@MinMin-kv3rv
@MinMin-kv3rv 2 года назад
Every Wednesday now is like xmass morning! Running to check what gifts I got!!! Amazing!
@heatherschramm
@heatherschramm 2 года назад
Please address the hormones that are dominant in women also. Women have issues with dipping testosterone, but estrogen and progesterone also have a huge impact on women as we age.
@qijingfan5656
@qijingfan5656 2 года назад
check buck institution, Dr. Jennifer garrison's OVA
@Q_QQ_Q
@Q_QQ_Q 2 года назад
THT therapy is for women too . for exact info you may check it with clinics or certified doctors .
@heatherschramm
@heatherschramm 2 года назад
@@Q_QQ_QYes, I know that and am actually on TRT, but leaving out the glaring effects of loss of estrogen on aging is disappointing. Both have had drastic effects on me and others in my life.
@Q_QQ_Q
@Q_QQ_Q 2 года назад
@@heatherschramm yes that is true . if you like you can share your experience as well . I think Dr Sinclair is only telling stuff he knows from papers and people he knows or heard of having these therapies which are usually mostly men but women do it like you have mentioned . I saw a podcast where a couple was telling about having done these therapies , i don't remember their name atm .
@heatherschramm
@heatherschramm 2 года назад
@@Q_QQ_Q my sister and I have joked about the idea of starting a vlog about our experiences and bringing on friends to talk about their experiences. It’s crazy how much variety there is and that very few people talk about it besides hot flashes.
@pNHGpNHG
@pNHGpNHG 2 года назад
THOUSANDS of THANKS So Much for Dr DAVID SINCLAIR + Mr MATT LaPLANTE * for your Unlimited + Immense + Continuous contributions to Humanity Prosperity. Those Valuable TIMESTAMPs are extremely useful.
@callofthedark
@callofthedark 2 года назад
Just finished listening to the entire episode on Spotify & Damn it started a war of neurones in my brain. Sure now I don’t need any pre-workout boost. Thank you once again for everything that you are putting out for all of us to be better. Can’t wait for the next episode.. Excited🤪
@Junaid_x01
@Junaid_x01 2 года назад
Bhai yeh banda top class hai also Dr.Huberman sir
@callofthedark
@callofthedark 2 года назад
@@Junaid_x01 it’s Dr. Andrew Huberman
@Junaid_x01
@Junaid_x01 2 года назад
@@callofthedark yeah
@aliengod2039
@aliengod2039 2 года назад

@desnicolaou7966
@desnicolaou7966 2 года назад
I am a peri-menopausal 51 year old woman. I would appreciate it if Dr Sinclair could talk abt the menopause & how we can help ourselves maintain good health. I am getting conflicting advice abt taking HRT & I am unsure abt what I should do/take.
@TimeRiderTime
@TimeRiderTime 2 года назад
Thank you for widening the boarder of understanding ageing 🙏 Thank you for your personality and work you put in yourself. Deepest respect🙏
@stevenj6421
@stevenj6421 2 года назад
I can't even explain my gratitude for having the Most modern science, cutting edge know-how and knowledge and the ABILITY to be shared to the mass populace without being chewed and misinterpret by for-profit news. This IS the greatest #realized #purpose of the #internet itself to #spread #knowledge! Thank you and my sincere gratuity #DavidSinclair
@thestreamoflife1124
@thestreamoflife1124 2 года назад
I have been on hormone replacement therapy for decades. I'm 80 now and do not look my age. Most think I look about 60. Hormone replacement therapy has been my life saver ....
@Chrystabell
@Chrystabell 2 года назад
David's smile at 42:23 after Matthew's statement is one of great satisfaction! love it
@michaeltegler157
@michaeltegler157 2 года назад
David and team, Thank you for the continued commitment to optimizing life. A discussion on the Microbiome would be tremendous as I have struggled with GI issues (IBS-C) and believe I have been suffering with invasive candidiasis as I have recently taken fluconasole which provided relief not only in my stomach but also caused the pain and stiffness to go away from joints, back, shoulder, etc. I am 49 yrs old and have taken many antibiotics throughout my life predominantly for sinus related issues which may have caused this condition of excessive candidiasis in my body and am curious to know if there is a way to restore the microbiome and healthy bacteria to optimal levels without Fecal Matter Transplantation as this is not readily available in the US. I'd also be inclined to go away to a clinic of sorts for 30 days if you know of one that would provide the structure and support to restore the microbiome. Thanks again for all of your dedication and work!
@erica7555
@erica7555 2 года назад
Thank you Dr David Sinclair! Athletic Green is just delivered to my house now. Appreciate your videos it’s so helpful. Thank you! You look great in that blue sweater.❤️
@viviancastro2783
@viviancastro2783 2 года назад
May I suggest you change the title so you put the number of the episode so that we don’t have to open more to figure out which episode it is? Thank you! Loving it!
@BJJ_Richie
@BJJ_Richie 2 года назад
I was gonna take BPC-157 (Body protective compounds) for joint inflammation, I found out they are really act like a HGH effect with Angiogenesis , which literally creates new blood vessels that will heal organs , etc. etc. but the risk of cancer goes up , because cancers grow and get destroyed , but if we ever were to get cancer , added blood vessels could add to tumor growth as well as other diseases
@robsolo4024
@robsolo4024 Год назад
I became legally blind after my pituitary tumor was removed I am praying that an intelligent man like this can come up with something like a peptide or stem cell that can regenerate my optic nerves that were damaged
@grandjunctionguy
@grandjunctionguy 2 года назад
The TRT studies that I've seen, including the one you linked have been a wash for mortality relations. Testosterone levels in men has been at a steady decline for the past 50 years. With there being a positive benefit to cardiovascular health, muscle size (particularly in legs, as in the Marcelo Rodrigues dos Santos and Shalender Bhasin study you linked) also correlating to healthy TRT doses, makes me believe there may even be a correlation to longevity. TRT has been shown to increase patient's insulin sensitivity, and even decreases c-reap (Xue-yan Wu 2009). Hypogonadism, SHBG, hematacrit/hemoglobin, estrodial issues have all been shown to be an issue with administration frequency, rather than the drug itself. It is all alleviated with a more in line pulsatile injection frequency of daily, or every other day. Also, it should be noted that Asian men tend to have a 20-30% higher testosterone than Caucasians. Japanese men in particular tend to live 10-15% longer than Caucasians. There are thousands of different biomarkers to examine here, but the correlation is strong enough for me to grant its efficacy, or at least place it under further examination. That being said, low testosterone has been linked to numerous deleterious effects (terrible sleep, hypogonadism, lack of drive, sexual dysfunction, weak muscles, etc.), all of which are correlated with mortality. In my opinion, the benefits for this far outweigh the cons, and could even be correlated with positive effects.
@patrickday4206
@patrickday4206 2 года назад
Yamanaka factors have come so far way faster than I expected when I was first reading his research I thought it was going to be 10 or twenty years to make any real progress because of cancer.
@robertmariano
@robertmariano 2 года назад
This podcast on anti-aging along with the research on CRSPR and gene editing/disrupting really is amazing. The only thing better than this would be a way to transplant consciousness into an already younger version of oneself. I watch this on RU-vid then I listen to it again on the podcast
@allyjhughes
@allyjhughes 2 года назад
Can you talk about hair? Male pattern balding and grey hair? And also talk about Finasteride use and its long term effects.
@alexanderohanlon8825
@alexanderohanlon8825 2 года назад
More plates more dates, check his stuff, highly into pharma for hair... personally I'd cycle eating times and meals per day, some days eat loads otherdays don't eat and some days do omad ect.. Next cycle in fasting for long periods (5-10 days) a few times a yr, then give your body signs of abundance by eating loads of meat, organs and fruit the rest of the yr... Understand that ketones boost stemcells. For your hair the above works but also stop using shampoo and conditioner it's poison, just was with warm water then cold after and stimulate blood in that area (massage) and break up calcium deposits
@ethancowart6765
@ethancowart6765 2 года назад
honestly feels good to be hearing someone like david say that peptides are promising and can be helpful if deployed properly and used properly. they have helped tremendously with a tbi that i got from a car accident. ive known this myself for a while but now it seems to be getting more known and looked at for the future.
@ottot3221
@ottot3221 2 года назад
I had a low testosterones level but no libido problems' (thankfully) but I had hot flashes (I'm male) and osteoporosis due to it. There was no cause found. Due to injections and supplements it improved a bit but my risk of prostate cancer heightened. Then I started to do OMAD and now I don't need the injections anymore. My bones are becoming better and although just 0.1 under what is needed I have almost regular bones. Never thought that could happen.
@vibhaspalding6457
@vibhaspalding6457 2 года назад
How did you get rid of osteoporosis? Was it injections to begin with and then OMAD? How long before you got rid of osteoporosis?
@psolarhidi
@psolarhidi 2 года назад
What were your test levels before and after omad? Also, how much weight did you lose, if any, in the process?
@timmorakinyo9529
@timmorakinyo9529 2 года назад
@@vibhaspalding6457 you get raid of osteoporosis by diets elimination and intermittent fasting ( one meal a day)with excercise, omega 3 fatty acids, vitamins D3/k2 has tremendous impact in getting raid of inflammation of joints knees and hips(osteoporosis/arthritis)
@vibhaspalding6457
@vibhaspalding6457 2 года назад
@@timmorakinyo9529 Hi I have been taking d2/k2 for more than 3 years, omega 3 fatty acids as oily fish 2 to 3 times a week and as daily supplements og about 2000mg to 3000mg. Doing an intermittent fasting by having short window of eating, eat first meal about 2pm and another light one, like avocado at about 7pm. Also soup/juice diet 2 to 3 days. Low carbs/no sugars, except dark chocolate, 90% cocoa. This year, I have another dexa test. Hopefully they are better scores, than last time. I also do weights twice a week, like hiit, dancing, 3 to 4 times a week, yoga and pilates, twice a week each. So try and keep healthy. I am also on thyroid healing protocol, to get rid of my medication for thyroid. But until the test is done officially, I cannot say if it is working.
@grldchee
@grldchee Год назад
Both times I did low carb my Testosterone tanked. I lost weight, but huge fatigue, bad sleep, low Testosterone. Confirmed by blood test. It cut my T in half and I absolutely felt the effects.
@sciencensorcery
@sciencensorcery 2 года назад
As a child, I was growth hormone deficient and underwent GH therapy for most of my adolescence. Aside from catching up growth and development, people who are growth hormone deficient (whether as children or adults) take GH because being deficient puts us at higher risk for lots of major health issues and risk factors including visceral fat, high cholesterol, osteoporosis, cardiovascular issues, etc. So I was surprised to hear Dr. Sinclair say that populations with lower GH have fewer health problems. I'm also curious now: I understand his point about those who take GH recreationally or as a "body hack", but for those of us for whom it was/is medically necessary, what effect does the later-but-accelerated development have on us in terms of overall longevity? I was a late bloomer but developed pretty quickly when I did. I'm 40 now and am usually told I look much younger which seems like a good sign, but I'm wondering what effect the GH deficiency and treatment might have had on things. Has there even been any research on this? I feel like whenever GH is discussed even among scientists it's always in the context of recreational/elective use and it's hard to find information relevant to my situation. (I previously left this comment on your appearance on the Huberman Lab podcast but never got a response so I'm leaving it again here!)
@kaylabryson1932
@kaylabryson1932 2 года назад
I would never trust David SInclair. His past is definitely shady
@enkidu001
@enkidu001 2 года назад
@@kaylabryson1932 my past has it's ""shady"" aspects. But you know what?.. i am actually a good guy (the type who knows how an orphanage looks from inside, not from the news) , really trying to understand me and surroundings . Reality , if it's not too cocky . While someone saying NEVER trust X sounds like a really bad guy, a guy who does not even understand relativity (and we have more than 100 years to digest it). More, there is nothing to ""trust" , because this is science. It might bring contradictions, it might bring arguments, but it's not about ""trust"" . Always go for more than one source if it is as important as aging. But don't take ""never"" in your arms, it is limiting. Just saying. PS. Sorry for my poor english, started late with this, while already speaking 4 other languages and became lazy. Good luck.
@redpilllense7125
@redpilllense7125 2 года назад
@@kaylabryson1932 Yet here you are, listening/following the great Dr. David Sinclair. Perhaps you're just a "perfect" human being, but I digress.
@shawnshawn7477
@shawnshawn7477 2 года назад
I have heard David say you should keep your testosterone levels up in a different interview (can't recall which one at the moment). This certainly contradicts that statement. I think if your levels are low, you need to keep them in the normal range.
@NoFaithNoPain
@NoFaithNoPain 2 года назад
@@shawnshawn7477 Too low kills you quicker - try getting lutenising hormones for prostate cancer - I know... heart attack highway :D
@daronleblanc3875
@daronleblanc3875 2 года назад
Great discussion!!! Been a fan since your Rogan interview. Ready your Lifespan book 3 times, Can't get enough of Mr. DS
@stefandaniel4216
@stefandaniel4216 2 года назад
I love you David, i can‘t wait to put my hands on your book ( Lifespan) i already apply most of your advices, but i take it slowly, currently eating 2 meals a day instead 3…
@quantitradersignalservice5735
@quantitradersignalservice5735 2 года назад
What protocols have you started because of Sinclairs' podcast? I have too and would like to compare.
@stefandaniel4216
@stefandaniel4216 2 года назад
@@quantitradersignalservice5735 curently i stopped eating 3 meals a day, i eat only 2. breakfast at 13:00 and dinner at 18:30-19:00, i do exercise 5-6 times a week, aerobic running, and i train in the gym for strength. i want also to start taking a supplement which it contains more or less the same ingredients which Profesor David Sinclair recommends : NAD + Cell Regenerator and Resveratrol 300 mg from life extension. Good Luck!
@shapdanone
@shapdanone Год назад
Matthew is an outstanding conductor
@LSS495
@LSS495 2 года назад
Most definitely! I have found that in my city (Pittsburgh, PA), which is primarily a traditional medicine community, the majority of physicians are very hesitant to prescribe HRT and claim beyond a certain age, your risk to develop cancer is very high. I know this isn’t supported by current research. Also, there are few functional medicine practitioners who also have MDs - a background I am seeking so I can receive advisement from both perspectives. My DO wouldn’t even consider prescribing bio identical HRT and told me I should find a gynecologist who would. Even these practitioners are very hesitant and keep referring to older research in their explanations. This is SO very frustrating, and leaves many women struggling to find care that could prevent many downstream problems.
@mirusvet
@mirusvet 2 года назад
Thank you very much! Looking forward to the next episode!
@thestreamoflife1124
@thestreamoflife1124 2 года назад
I'm drinking athletic greens for 3 months. Great product
@commonomics
@commonomics 2 года назад
I’m so excited for the weekly releases, I don’t put that kind of value into any other channel
@loudboomboom
@loudboomboom 2 года назад
I’d love to hear any progress on restoring dental health and whether or not teeth could be regrown.
@kurthoffmann7160
@kurthoffmann7160 2 года назад
What would happen if you cycled on and off trt and hgh so that you get the short term benefits, but then stopped those and go into a longevity mode where you do minimal mtor generation and lots of sleep etc..... so cycling between abundance memetics and adversity memetics... so you get gains during abundance mode and then maintenance mode during adversity mode, then cycle back into abundance mode and do it all over again.
@sergelachapelle7992
@sergelachapelle7992 2 года назад
I am following these podcasts with high interest... as I am 64 and on TRT, do intermittent fasting, weight train and take NMN and other supplements... (will be adding resveratrol). One issue that was not taken in consideration with regards to aging and testosterone is the fact that life is more than just time. How do you ballance adding life to your time vs adding time to your life. Quite frankly, TRT gave me my life back. My level of energy, motivation and general mood are way up with testosterone.... I would not live like I was before... The added estrogen that comes with TRT is actually cardio protective and has cured my joint pain... Maybe you should stay away of subjects you don't know well or you are biased against... Testosterone can actually be protective against prostate cancer and high levels of testosterone is actually being studies to treat certain forms of prostate cancer... I think your view is a little outdated... The biggest issue I have with all this longevity talk is the fact, it seems, that you have to choose between being vibrant, energetic but short lived or be starving, cold and low energy and live longer... Darn... Everything that makes me feel good seems bad (Mtor activation as I like my meat... testosterone as I enjoy being energetic and productive... ) ... Maybe I am looking for optimization and you are talking about absolute lifespan... Don't get me wrong, I love the podcast... great info to integrate into what I think will be a middle way for me... Cheers
@AncestralFuel
@AncestralFuel 2 года назад
I am with you - started TRT when I was 64 - now 68 - and I have experienced many benefits. I think that what Sinclair misses about TRT is that he has a “theory” that it may send the wrong signals to your body to “grow”. What is interesting is that, although Testosterone is anabolic, it is focused mainly on helping muscle and bone strength. Consequently, you can consume less protein (which too much can create issues) than someone who has low T. I think the bottom line is that the studies are pretty consistent that TRT reduces all-cause mortality while improving quality of life. Big Pharm and the medical industry in general do not like TRT because it cannot be patented and it takes a lot of a doctor’s time to get you dialed in. My understanding is that Sinclair is working on patenting concoctions out of his lab to sell as longevity drugs. Hence, TRT could be considered “competition” in spite of its efficacy.
@alan2102X
@alan2102X 2 года назад
Serge, you are right on all counts. Sinclair is still very much of a newbie to the testosterone space; one can tell this by listening to him. He will probably acquire better knowledge, with time. Meanwhile, don't deny yourself the benefits of testostereone just because he is still relatively ignorant! Also true that there is a balance between strength and vigor, and longevity. More of one, less of the other, or so it seems. Maybe someone will figure a way around that, eventually, but for now it seems you must choose.
@alan2102X
@alan2102X 2 года назад
@@AncestralFuel You are correct also. Testosterone's anabolic effects are such that you can recover from workouts and maintain strength on much lower protein intake; this is a grossly-neglected fact in the longevity space (Sinclair, Attia, and many others). They also neglect -- are probably ignorant of -- the literature describing the benefits that you mention such as reduced ACM, better QOL, etc. They are perhaps ignorant, and/or perhaps tend to dismiss because of prejudice against hormone therapy, especially hormones related to anabolic steroids. Also correct that TRT is non-patentable and involves a lot of old-fashioned patient-focused medical ARTISTRY (what you call "dialling in", which is beyond the science, beyond EBM), and as such will tend to be ignored and dismissed by commercial and some other entities. TRT cannot be successfully practiced by idiots following EBM cookbooks; therefore it will tend to be less popular. Also, yeah Sinclair might have a bias against things that he cannot sell. IDK, but that is the way things go, too often.
@brianstarr3184
@brianstarr3184 2 года назад
Good morning, Matt. You have a John Heilemann-esque vibe. Take it as a compliment. I think you do a great job of co-hosting, asking enlightening questions and keeping the conversation flowing. David is pretty good, too. Signed, Matt's mom
@joeyfunk4327
@joeyfunk4327 2 года назад
Can’t tell you how many people I’ve recommended the book Lifespan too it was great. Very excited to see how well we can Amplify these Sirtuin genes
@ivanandreevich8568
@ivanandreevich8568 2 года назад
Fastest longevity channel to 100K. Congrats!
@LianaBuzea
@LianaBuzea 2 года назад
Okay, so episode 6 hopefully will be on hair (re)growth too. This is a big issue for me right now. Perhaps for many other women too. I will keep in mind about GHK Copper (I hope I spelled that right). It was mentioned halfway through this episode (and the warning about peptides and their negative side-effects). Thank you! 🙏
@brentonfantozzi4129
@brentonfantozzi4129 2 года назад
Micro needling, minoxidil, and oral Castor oil will regrow hair... Do your own research and make an Informed decision before doing it
@Q_QQ_Q
@Q_QQ_Q 2 года назад
one reason for hair loss is ( in men ) is increase in DHT on face and head . on face DHT increases hair like beard or face hair . on head high DHT results in hair loss . it can be something similar in women too but idk .
@pink1lipstic
@pink1lipstic 2 года назад
I hear you, it's a huge issue for me as well, I've been losing a lot of hair due to the hormonal imbalance for the last 6 years and it's still so heartbreaking...also I can't find a treatment that really works and keeps this under control
@brentonfantozzi4129
@brentonfantozzi4129 2 года назад
Microneedling, topical minoxidil and oral Castor oil... It should solve the problem
@ャンティオカ
@ャンティオカ 2 года назад
The idea from the book that "aging is a disease and a treatable one" opened my eyes to the possibilities and I'm fascinated since.
@angelinesarol5616
@angelinesarol5616 2 года назад
love your pod cast Im 56 and look and feel 36 Topics you cover so fascinating and your partner covers every detailed information
@huangwee3465
@huangwee3465 2 года назад
This is very insightful and straightforward. Thanks to both the speakers
@Corrans
@Corrans 2 года назад
I guess a valid question to ask is: how much is longevity worth it if we feel miserable? What I am getting at is that the adversity memetics are generally not fun, don't make us feel too great in the moment (fasting, hot and cold extreme etc) and yet "abundance hormones" like TRT and HGH seem to make people feel so healthy. Would we rather live a bit shorter and feel amazing? Or have longer, more miserable times? Also, as doc hinted, restoring levels to healthy baseline doesn't seem to be problematic?
@orion10x10
@orion10x10 2 года назад
We're in a golden age of podcasts between this and Andrew Huberman podcast
@andrewwalker8985
@andrewwalker8985 2 года назад
The HGH discussion skipped over the TRIM and TRIMX trials done by Greg Fahy, and showing age reversal with epigenetic clocks. Shame - I really wanted to hear Davids view on that work
@Ccowdog1
@Ccowdog1 2 года назад
You both are lovely! Lol 😆 thank you for telling us what doctors don't- please do one on menopause!
@Corrans
@Corrans 2 года назад
Yes I'd love one on perimenopause and menopause.
@quantitradersignalservice5735
@quantitradersignalservice5735 2 года назад
i'm hoping that Dr. Sinclair reads these posts because if he does he'll get the idea we would love to hear his thoughts on woman's helath.
@Aldraz
@Aldraz 2 года назад
This was a very interesting episode! I like this topic as it has not been repeated before in other interviews. I hope one day we can just take a pill that's gonna make us younger haha.
@EliasHossein799
@EliasHossein799 2 года назад
Thanks unlimited.... awesome and greatest lecture ever in the whole world !... I am so lucky that I could watch your channel. thanks unlimited again
@Aratohn
@Aratohn Год назад
Thank you David & Matthew, such awesome podcasts
@igalbog
@igalbog 2 года назад
As always, interesting to watch and learn about the cutting edge in anti-ageing. Thanks David and Matthew! Dr. Sinclair is looking younger than usual lately - any recent changes in the protocol?
@chrisbusby4395
@chrisbusby4395 2 года назад
Hair colour definitely helps
@cindybelle1752
@cindybelle1752 2 года назад
I think they are using a soft focus filter on their videos.
@markpettus6929
@markpettus6929 2 года назад
As the great 20th century philosopher Yogi Berra once said, "the future ain't what it used to be". This is a very exciting time in biomedical sciences. Would be very interested in your thoughts on the future of "quantum access" therapies that re-engineer the quantum morphogenetic fields that are the basis of our material blueprint. This, I believe is even more 'upstream" medicine.
@larryshepperson3993
@larryshepperson3993 2 года назад
ive been a fan for a long time and this is the best one two punch in longevity.Thanks a million keep up the great work
@elensayista8988
@elensayista8988 2 года назад
Fascinating idea that of HGH + diabetic drugs to reverse aging + improve physical performance. One thing I noticed for facial aging is if you want to reduce wrinkles or dark circles you need not be losing fat at the same time, or preferably even increase calories. Why? Its seems that whatever topical therapy you apply can dry your skin if you dont have fat to sustain it. I even use honey+curcumin+green tea, which isnt supposed to dry, and it still dries if I dont take care for it. Btw if it dries then your face looks more aged not less, thats why its an important issue and challenging the idea that we always need to decrease sugar to look younger.
@shelchicago8997
@shelchicago8997 2 года назад
David Sinclair just aged backward by a week while I aged forward waiting for another episode.
@bestrongandloveyourself2370
@bestrongandloveyourself2370 2 года назад
Another very interesting episode! I love this podcast! Can’t wait to know more about aging outside! ❤️❤️❤️
@joeyfunk4327
@joeyfunk4327 2 года назад
TRT leads to muscle growth and typically more food intake to support growth which is the opposite of caloric restriction
@Nando_lifts2021
@Nando_lifts2021 2 года назад
Yea makes me hungry after workouts gah lee
@Aman.Akshay.Sharma
@Aman.Akshay.Sharma 2 года назад
Great message at the end, thanks Matt and David for this episode
@Midori_Hoshi
@Midori_Hoshi 2 года назад
These podcasts are absolutely amazing and life changing! Thank you so much.
@thatchessguy7072
@thatchessguy7072 2 года назад
Thanks for making this video series!
@sonnymatthews5452
@sonnymatthews5452 2 года назад
I would like to know David's testosterone levels, and what range would be considered optimal? At what point should you supplement?
@Ondrej.U
@Ondrej.U 2 года назад
Serious question: Has anyone studied or even considered mTOR activation cycling? What I mean by that is high mTOR activation for couple days and then low activation. The reason to do this would be to build muscle for several days, then rest and clean up the body. From everything I know about mTOR and autophagy (very limited knowledge), it seems to me it's not necessary to have mTOR downregulated and autophagy activated constantly. What I'm trying to test is if there's upper limit of autophagy activation or some point where longer autophagy activation has diminishing returns. The other limiting factor is how long it takes for autophagy to activate (2-4 days?) The main variable is length of each cycle, it could be days, weeks or maybe even longer. I know about intermittent fasting, which is great, but it seems to me that autophagy activation requires longer mTOR downregulation. eg. I cannot eat large steak every evening and expect it to work. There's also a reason why Dr. Sinclair stays on low meat diet over longer periods of time. Why even think about this? Building muscle has a lot of other health benefits, especially in elderly people. Dr. David Sinclair, could you please elaborate a bit on this topic? Thank you!
@stockstudy8633
@stockstudy8633 2 года назад
Hi David, I studied your book and have been using NMN, etc since Feb 2021. My stem cells have been banked and I have 1.4Billons of my cells IV'ed and IN'ed in my body since 2020.
@cristinavillegas6357
@cristinavillegas6357 2 года назад
What is NMN?
@ChessMasterNate
@ChessMasterNate 2 года назад
Okay, I have watched all the videos thus far, but have heard almost nothing on the accumulation of intercellular junk, and just a bit about junk inside the cell, and what can be done about it. Because it looks to me like this is a major player in the current limits of human lifespan. There is more than one kind of heart disease, and the one killing the 100+ crowd is often Wild-type transthyretin amyloid (WTTA), where transthyretin amyloid builds up in the heart and some other tissues making the tissue stiff, and it becomes very tiring to even stand. 25% of men over 80 already show signs of this beginning. And this is just one of 25 or 30 proteins that can misfold and accumulate in the body. Then there is glucosepane. This Advanced Glycation End Product can't be removed by the kidneys, even if they are healthy, even if the other AGEs can be. This also builds up stiffening tissues and is implicated in a number of aging diseases. And what about lipofuscin? Maybe that will be covered when skin is the topic, but this crud is also in the brain, muscles, the heart and other internal organs. Then there are the studies about the intentional conjoined mice, where they saw the health of the older mouse improve, and the younger mouse go downhill. And after a series of studies they determined that it was chemicals in the blood of the older mouse that was the problem, and by plasmaphereses they could restore the older mice to health. That to me suggests that there are accumulations not just in tissue but in the blood. I don't know if healthy kidneys is the answer to that or if there are things the kidneys can't do anything about, like that glucosepane, which needs periodically removed. Then there is scar tissue. There are injuries within the body from infections and whatnot, and the body chooses speed over accuracy during repair, but if you live long enough, these sloppy repairs will also accumulate. We also accumulate infections that the body can't ever completely eliminate. Older people have much more of these than younger people. Things like toxoplasmoses, and cytomegalovirus. Ultimately, I don't think these things are benign. It is likely they wear down defenses, or promote diseases we haven't yet tracked down to them. I sure would like this accumulation topic discussed.
@K370-d2v
@K370-d2v Год назад
So wish that there is subtitle. It would be immensely helpful for so many of us. We are constantly pausing and rewinding.😢
@NicoSpeaking
@NicoSpeaking 2 года назад
My main takeaway today --> A real and sustainable solution to survive the zombie apocalypse - "brains to go" ... I love this PODCAST! Makes me feel smart. Haha
@OctopusBonus
@OctopusBonus 2 года назад
❓In a previous episode, David mentioned that too much iron is bad. But how much iron is too much? What is the maximum level for Hemoglobin [g/dl] and Ferritin [ng/ml]? Which values are optimal (for an adult)?
@musaire
@musaire 2 года назад
Ferritin 12 to 50 ng/mL is ideal
@musaire
@musaire 2 года назад
ferritin-wise
@musaire
@musaire 2 года назад
that is - more than 50ng/mL is show n to be ferrotoxic already
@chrisknightnaturalwellness9697
Awesome Channel and powerful data!!! Thank you !!! ✨💪🏽😎🤙🏽✨
@richard18219
@richard18219 2 года назад
I wish I had seen this podcast earlier, I had been using peptides to deal with an injury that got worse and to boot, I now have arthritis in my hip and big toe.
@peterz53
@peterz53 2 года назад
@52 min on thymus regeneration: See research of Janet Lor which showed that older (65 to 80) who cycled alot over many years preserved their thymus output of T cells and had immune function of people decades younger. It's also known from other research that exercise increases NAD+ and modulates other metabolic factors towards younger states.
@Q_QQ_Q
@Q_QQ_Q 2 года назад
exercise and diet is best .
@Dr_Dieta
@Dr_Dieta 2 года назад
Please take a look at Diazoxide neurological and antiaging benefits. 🙏 It's well studied
@debsarno2532
@debsarno2532 2 года назад
Do u think it would help Parkinson’s? I
@Dr_Dieta
@Dr_Dieta 2 года назад
@@debsarno2532 yes.
@SergiyMichael
@SergiyMichael Год назад
There are better ways to kill oneself doctor. Please ppl do not listen to that dude.
@monnoo8221
@monnoo8221 Год назад
@@Dr_Dieta you are brave, indeed. Messing around with a potassium channel opener is, currently, not a good idea. In those neurn we have 3 different types of potassium channels, and symptoms gt relieved if the SK channels get BLOCKED. There is absolutely NO consensus about how to handle them. If you mess around with potassium channels systemically you quickly age to terminal age.
@frenchmontana423
@frenchmontana423 2 года назад
guys! when are you going to speak about the skin and hair part of all this?!?! you guys mentioned that you'll go into detail with it! please and thanks
@rosiek649
@rosiek649 2 года назад
First time I’m seeing he looks healthy and skin is glowing only little inflammation on left shoulder and little on left side and front of the elbow. well done I can respect you now. If you’re advocating for your job or what you believe in show the evidence in your body.
@gruuvmunky
@gruuvmunky 2 года назад
Question- what specifically counts as 'fasting' time with regards to the health benefits IE-Autophagy? If you eat once a day at dinner time. That food is digested for quite awhile. If it's still in your digestive system in the morning & affecting your blood levels...then when does the actual fasting time start? Thanks for any info!!!! Love this channel
@partsunknown9738
@partsunknown9738 2 года назад
I second this.
@Stimros_halabad
@Stimros_halabad 2 года назад
Id listen to Andrew Hubermans episode on this
@HillingTyler
@HillingTyler 2 года назад
Yeah Huberman made it sounds like by the morning time, in this example, you'd be fasted for sure. I get the gist that it's like 4 hours after you eat that the fasted state starts to set on
@valerieoconnell9223
@valerieoconnell9223 2 года назад
Listen to Dr Jason Fung, as well.
@movement2contact
@movement2contact 2 года назад
You could just get a ketone breathalyser, since different foods will digest differently, not to mention everyone's different...
@TotalyRandomUsername
@TotalyRandomUsername 2 года назад
So you start a channel and get over 100k subscribers in one month. That is astonishing! :) But i am very happy about this channel.
@sirt1353
@sirt1353 2 года назад
I started really praticing and supplementing for anti-age due to hair loss. Do you know what could really help with help regrowth and regeneration?
@ciarog6116
@ciarog6116 2 года назад
Are you referring to peptides that were made in Russia and now available here? These are said to heal the heart,liver, brain and other organs. What do you think? They are said to extend lifespan by 30%, but I think that means expected lifespan of an already ill person. They are made from animals or synthesized.
@hekatesketch2622
@hekatesketch2622 2 месяца назад
Watching these episodes while I teach myself programming and cybersecurity xD and thinking about it, my current dietary clock is about the same anyway. It really wouldn't be too hard for me to just eat once a day, already doing that anyway! Just need to start adding more fresh produce at dinner, and exercising after eating. we've got a treadmill, and I should be using it anyway, to recover from recent medical situations.
@ainsleyameerali7622
@ainsleyameerali7622 2 года назад
Love this !!! Thank you dr David!!! You rock !!!
@JustVibingFullStop
@JustVibingFullStop 2 года назад
Thank you! I love these videos! This is sooo interesting!
@QueenBeeDigital
@QueenBeeDigital 2 года назад
The FDA just doesn’t want us to take our health into our own hands. Period.
@QueenBeeDigital
@QueenBeeDigital 2 года назад
Because then how would big pharma make as much money?!
@JanaLeeME
@JanaLeeME 2 года назад
Bonjour from Switzerland 🇨🇭! Je suis prête 😁
@cynthiarucker1442
@cynthiarucker1442 2 года назад
Amazing and wonderful. Thank you!!
@dahsk7872
@dahsk7872 2 года назад
So excited to listen to this one. Thx Dr. Sinclair
@joeanarumo616
@joeanarumo616 2 года назад
Thank you once again
@archiedewa
@archiedewa 2 года назад
we must take seriously research to longevity and invest more to it
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Lifespan: Why We Age-and Why We Don’t Have To
1:06:55