Medical Interventions (TRT, HGH, Stem Cells, etc.) For Longevity | Lifespan w Dr. David Sinclair #5

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In this week’s episode of the Lifespan podcast, Dr. David Sinclair and co-host Matthew LaPlante cover potential anti-aging interventions that are on the cutting edge. They share the latest research surrounding testosterone replacement therapy (TRT), human growth hormone (HGH), peptide supplementation, exosomes, stem cells, and cellular reprogramming. The idea of human rejuvenation and potential paths towards resetting the aging clock is also discussed.
#DavidSinclair #Longevity #Lifespan
Thank you to our sponsors:
Athletic Greens - athleticgreens.com/sinclair
InsideTracker - insidetracker.com/sinclair
Levels - levels.link/sinclair
Our Patreon page:
/ davidsinclair
Lifespan book:
amzn.to/3sUqurT
Lifespan podcast website: www.lifespanpodcast.com
Dr. David Sinclair Social:
Instagram - / davidsinclairphd
Twitter - / davidasinclair
Facebook - / davidsinclairphd
Matthew LaPlante's Social:
Twitter - / mdlaplante
Stay up to date with David's work to democratize biological age testing and insights: www.tallyhealth.com
Timestamps:
00:00:00 Kicking Off Episode Five: Interventions on the Cutting Edge
00:02:39 Expressing Gratitude to the Sponsors
00:05:28 Testosterone Replacement Therapy
00:10:09 Human Growth Hormone
00:13:56 Peptide Supplementation and Regenerative Signaling
00:18:11 MOTS-c, Humanin, and Other Peptides
00:25:05 Exosome Therapy
00:31:56 A Primer on Stem Cells and Yamanaka Factors
00:37:59 Stem Cell Aging and Cord Blood Banking
00:41:42 The Therapeutic Potential of Stem Cells
00:43:37 Cellular Reprogramming
00:51:35 Resetting the Aging Clock
00:56:50 The Future Looks Bright
00:58:15 Next Week’s Episode: External Aging
00:58:36 Subscription and Support Options
Links:
Benefits and risks of testosterone treatment: bit.ly/35I3uTs
Eunuchs are long-lived: bit.ly/3ukL1GU
Longevity is enhanced in mice lacking growth hormone: go.nature.com/3AOTW4k
MOTS-c and age-dependent physical decline in mice: go.nature.com/34aUgi6
Fatty liver disease, obesity, and an analog of MOTS-C: bit.ly/3Ho7GFE
Humanin regulates lifespan and healthspan in mice: bit.ly/3Gy0lm1
Humanin ameliorates diabetes in mice: bit.ly/3ukiFw7
Mouse aging can be modulated via exosomes: go.nature.com/3oi0sM4
Exosomes and ulcer healing in older mice: bit.ly/3oEhPaf
Generating induced pluripotent stem cells: bit.ly/3APMypv
Vision loss after ocular injections: bit.ly/3L2yVIh
Mesenchymal stem cells and human frailty: bit.ly/3s6kzxX
Restoring vision loss in older mice: go.nature.com/335iysI
Reversing epigenetic age in humans: bit.ly/342XXGJ
Please note that Lifespan with Dr. David Sinclair is distinct from Dr. Sinclair's teaching and research roles at Harvard Medical School. The information provided in this show is not medical advice, nor should it be taken or applied as a replacement for medical advice. The Lifespan with Dr. David Sinclair podcast, its employees, guests and affiliates assume no liability for the application of the information discussed.
Special thanks to our research assistants, Adiv Johnson & Sarah Ryan.

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11 июн 2024

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Комментарии : 588

@DrPubz 2 года назад

I have been following Dr. Sinclair since I was 25. I am 22 now.

@jetmirqosja7217 Год назад

Best comment on this thread..🤣🤣

@ela7145367030 Год назад

Seriously, I’ve been lifetime intermittent fasting and every new person, even bankers and doctors who have all my bio/med information routinely say I look 30-35 years younger. They all ask to see my gov ID, especially after repeated blood panels that test pristine.

@arbur3058 Год назад

HAHAHAH thank you for this

@JoseCastro-px7ow Год назад

Lmaoooo 😂

@VanIsleBC 10 месяцев назад

shrieking

@cypriankariuki175 2 года назад

Am a young clinician in kenya.....this podcast always make me feel like am attending longevity lectures in campus. THANK YOU AND GOD BLESS YOU.

@kipkiruivictor3320 2 года назад

wow.. another kenyan over here

@vertical8infinity 2 года назад

Just some FYI. a lot of longevity scientists don’t believe in God. If you want to think like they do, consider different perspectives on reality. Almost no one here is a “god blesser” type

@danthegypsy5871 2 года назад

@@vertical8infinity omgggggggg shuttttt uppppppp

@armandom28 2 года назад

Leave the superstitious religious crap out of this

@kipkiruivictor3320 2 года назад

@@vertical8infinity 😂😂 yeah.. true

@daviessusan1000 2 года назад

A discussion on menopause and HRT/TRT would be brilliant!

@lauramakin834 2 года назад

Yes !!! Definitely

@quantitradersignalservice5735 2 года назад

@@lauramakin834 Totally!!!!!!!!!!!!

@quantitradersignalservice5735 2 года назад

Yes please do.

@lauramakin834 2 года назад

@@quantitradersignalservice5735 Haha

@clueless_orange 2 года назад

Agree! if loosing our estrogen after the 1st half of our lives triggers a few serious diseases like alzheimers, can any of the mentioned treatments cover for that besides taking lifetime HRT?

@husainialiyu5198 2 года назад

At 75yrs I am. very keen on David Sinclairs achievement in longevity science.i take a lot of suppliment.

@dulalrajbaruah2576 2 года назад

I am a G I surgeon but I take particular interest in chronic diseases and old age . It would be super interesting to see if we could really wipe out old age related chronic debilitating diseases in future.

@jeffreysorensen5298 2 года назад

We mostly can it’s called diet and life style

@geekspeak1066 2 года назад

@@jeffreysorensen5298 yea but can u make a pill for that so we can profit off it? We know how to end chronic disease already. Are actually some powerful tools available but people have to want to do it. Something like 90% of all health improvements are realized simply by losing weight. Regardless of the diet.

@theresaho9696 2 года назад

@@jeffreysorensen5298 may I add optimism besides diet, lifestyle?

@jeffreysorensen5298 2 года назад

@@theresaho9696 you are absolutely correct. Most people realize that obesity is the number comorbidity for a poor outcome of Covid but few realize that number 2 is fear and anxiety.

@michelles2299 2 года назад

Quality of life trumps everything

@gro16 2 года назад

Man, Mathew is truly superb in slowing it down and also not loosing any threads. Thank you Sir!

@Alex24998r 2 года назад

Again Dr. Sinclair, your colleague is asking Excellent and Thorough questions , that cover all points a viewer such as me was thinking about- such as the growth hormone discrepancy, among many other questions. Thanks to both of you for putting forth such interesting and fascinating information.

@Artilectual 2 года назад

Thank you for your time and content. As a blue collar know buddy, your work has kept me younger and fitter than I ever really expected possible. I've been following your work for years. So happy to have all this content in one place, cataloged, with such depth. ❤️ 🙏 truly grateful

@Samantha-qf5ee 2 года назад

Looking forward to the entire episode that covers women's hormones (because we don't already live long enough?) Thank you!

@Corrans 2 года назад

Ja I think humans and females in particular live long enough...I am definitely more interested in FEELING good as I age and being healthy and strong. I would happily trade a few years for vibrancy in older years.

@starfox300 2 года назад

I doubt they will look at women hormones lol

@anthonyharmon9265 2 года назад

Sexist

@AnarchyStax 2 года назад

@@anthonyharmon9265 what?

@chriskoort5717 2 года назад

Female hormones in a nutshell: 1 week of emotional outbursts followed by 3 weeks of illogical blabbering.

@SaltedHope 2 года назад

I'm loving this channel! It's my favorite kind of content to nerd out to.🤓 I've been binge watching, like Netflix. We humans and our genetic and cellular makeup are so incredibly fascinating. Thanks 🧬🧫👩‍🔬

@stylebase 2 года назад

What about menopausal women and HRT? Would be interesting to hear about menopause and aging, maybe specific advice for pre and post menopausal women.

@debj1356 2 года назад

Yes, yes, yes!

@lizmallen3461 2 года назад

My doc put me on sermoreline the precursor to hgh. He checked my blood level for HGH and it was low. He started me out on .2 ml injection nightly. Over the course of six months I’ve had my level checked several times. Now I am at .4 ML after six months, the sweet spot. It is safe. It is just telling your body to produce HGH if it needs it and it is in the healthy normal range now. Feeling great

@dianaprice3227 2 года назад

It would be great to get Dr. Sinclair's take on menopause treatment HRT; loss of estrogen = loss of bone. How to improve and reverse bone loss. Increasing quality bone density ... can NMN Stimulates Bone Marrow Stem Cells to Form More Bone ... ? Thank you Dr. Sinclair for what you do!!! 🙏

@starfox300 2 года назад

Who cares about meopausal women?

@stylebase 2 года назад

@@starfox300 It is always lovely to know that there are people who care about their mothers and the future of their girlfriends and wives. :)

@nrs_207 2 года назад

All of this is fascinating to me as someone in my early 30s. I’m really hoping this keeps going in the right direction and quickly.

@magicfitzpatrick 2 года назад

I’m surprised you haven’t talked about one of the best things you can do for anti-aging. Donating blood should be on the top of your list. I would love to hear you talk about the benefits of donating blood.

@mj.sorrondegui 2 года назад

They did mention that on another podcast when they were talking about iron.

@robsolo4024 Год назад

I became legally blind after my pituitary tumor was removed I am praying that an intelligent man like this can come up with something like a peptide or stem cell that can regenerate my optic nerves that were damaged

@MinMin-kv3rv 2 года назад

Every Wednesday now is like xmass morning! Running to check what gifts I got!!! Amazing!

@erica7555 2 года назад

Thank you Dr David Sinclair! Athletic Green is just delivered to my house now. Appreciate your videos it’s so helpful. Thank you! You look great in that blue sweater.❤️

@cherylsimon7619 2 года назад

Love it! Skin aging is what I've been waiting for!!! Can't wait to hear what you have to say on the next podcast🙌🙌🙌❤

@michelles2299 2 года назад

I can tell you what works its simple...... Tretinoin at night spf every single day no sunbathing smoking or alcohol then nutritious food comes next...... food is medicine is my mantra 🙏

@cherylsimon7619 2 года назад

@@michelles2299 agree! I do all of that. Especially after having melanoma. His latest video discusses other things like peptides as well. I hope he does more on those!!!

@quaterman2687 2 года назад

I would like to hear about the new studies on resveratrol that show it has no positive effect. And even takes away some of the positive effects of exercising. Could you discuss it in one of the future episodes? Would be great!

@TimeRiderTime 2 года назад

Thank you for widening the boarder of understanding ageing 🙏 Thank you for your personality and work you put in yourself. Deepest respect🙏

@rustybolts8953 Год назад

Only over the past 5 to 10 years have I finally learned the importance of good rest and sleep to good health. This is an ongoing learning experience. Will report again in 3 years if I am still about.

@grandjunctionguy Год назад

The TRT studies that I've seen, including the one you linked have been a wash for mortality relations. Testosterone levels in men has been at a steady decline for the past 50 years. With there being a positive benefit to cardiovascular health, muscle size (particularly in legs, as in the Marcelo Rodrigues dos Santos and Shalender Bhasin study you linked) also correlating to healthy TRT doses, makes me believe there may even be a correlation to longevity. TRT has been shown to increase patient's insulin sensitivity, and even decreases c-reap (Xue-yan Wu 2009). Hypogonadism, SHBG, hematacrit/hemoglobin, estrodial issues have all been shown to be an issue with administration frequency, rather than the drug itself. It is all alleviated with a more in line pulsatile injection frequency of daily, or every other day. Also, it should be noted that Asian men tend to have a 20-30% higher testosterone than Caucasians. Japanese men in particular tend to live 10-15% longer than Caucasians. There are thousands of different biomarkers to examine here, but the correlation is strong enough for me to grant its efficacy, or at least place it under further examination. That being said, low testosterone has been linked to numerous deleterious effects (terrible sleep, hypogonadism, lack of drive, sexual dysfunction, weak muscles, etc.), all of which are correlated with mortality. In my opinion, the benefits for this far outweigh the cons, and could even be correlated with positive effects.

@joshuasmiley2833 Год назад

Thanks! Thank you David. I have been following you for years. I am yet another person you have inspired and positively changed from the inside out! sincerely, you are appreciated! Joshua, Pedro, Smiley

@Aman.Akshay.Sharma 2 года назад

Great message at the end, thanks Matt and David for this episode

@BJJ_Richie 2 года назад

I was gonna take BPC-157 (Body protective compounds) for joint inflammation, I found out they are really act like a HGH effect with Angiogenesis , which literally creates new blood vessels that will heal organs , etc. etc. but the risk of cancer goes up , because cancers grow and get destroyed , but if we ever were to get cancer , added blood vessels could add to tumor growth as well as other diseases

@huangwee3465 2 года назад

This is very insightful and straightforward. Thanks to both the speakers

@callofthedark 2 года назад

Just finished listening to the entire episode on Spotify & Damn it started a war of neurones in my brain. Sure now I don’t need any pre-workout boost. Thank you once again for everything that you are putting out for all of us to be better. Can’t wait for the next episode.. Excited🤪

@Junaid_x01 2 года назад

Bhai yeh banda top class hai also Dr.Huberman sir

@callofthedark 2 года назад

@@Junaid_x01 it’s Dr. Andrew Huberman

@Junaid_x01 2 года назад

@@callofthedark yeah

@aliengod2039 2 года назад

@daronleblanc3875 Год назад

Great discussion!!! Been a fan since your Rogan interview. Ready your Lifespan book 3 times, Can't get enough of Mr. DS

@Midori_Hoshi 2 года назад

These podcasts are absolutely amazing and life changing! Thank you so much.

@heatherschramm 2 года назад

Please address the hormones that are dominant in women also. Women have issues with dipping testosterone, but estrogen and progesterone also have a huge impact on women as we age.

@qijingfan5656 2 года назад

check buck institution, Dr. Jennifer garrison's OVA

@Q_QQ_Q 2 года назад

THT therapy is for women too . for exact info you may check it with clinics or certified doctors .

@heatherschramm 2 года назад

@@Q_QQ_QYes, I know that and am actually on TRT, but leaving out the glaring effects of loss of estrogen on aging is disappointing. Both have had drastic effects on me and others in my life.

@Q_QQ_Q 2 года назад

@@heatherschramm yes that is true . if you like you can share your experience as well . I think Dr Sinclair is only telling stuff he knows from papers and people he knows or heard of having these therapies which are usually mostly men but women do it like you have mentioned . I saw a podcast where a couple was telling about having done these therapies , i don't remember their name atm .

@heatherschramm 2 года назад

@@Q_QQ_Q my sister and I have joked about the idea of starting a vlog about our experiences and bringing on friends to talk about their experiences. It’s crazy how much variety there is and that very few people talk about it besides hot flashes.

@squirt3179 2 года назад

I’m curious as to when inside tracker and your podcasts will include estrogen and other female hormones in their bio markers. I am 59 years old and a powerlifter, my inner age scored 9yrs younger than my biological age. My testosterone levels were even optimal, however the SHBG levels are an issue and I am sure not allowing me to optimize the testosterone I have. I sincerely hope more female hormones will be included someday? What can we do naturally to increase estrogen levels ? I’m currently investigating this and possibly HRT and would love your thoughts. Menopause isn’t healthy for any woman and affects aging. Thank you for all you do!

@BlueSkies360 2 года назад

Maybe eat foods that increase estrogen, like tofu, cheese, wine,

@quantitradersignalservice5735 2 года назад

9 years younger? Damn girl you are doing something right!

@candicec6513 2 года назад

Testosterone pellets for women improve many symptoms of menopause. An integrative physician experienced in this? I'm going to try it at 65 for reducing fatigue and helping sex drive.

@MSteitz468ify 2 года назад

Donate blood twice a year, it will get rid of the iron women build up after menopause, that's causing most of your problems. You can always supplement with estrogen if you have low levels.

@joannehung2417 2 года назад

Menapause is kind of aging, his theme is to reverse aging, in a sense he is answering all kinds of aging. Don’t pull him into gender issue, come on.

@jawadkarim6615 2 года назад

Thanks unlimited.... awesome and greatest lecture ever in the whole world !... I am so lucky that I could watch your channel. thanks unlimited again

@mirusvet 2 года назад

Thank you very much! Looking forward to the next episode!

@larryshepperson3993 2 года назад

ive been a fan for a long time and this is the best one two punch in longevity.Thanks a million keep up the great work

@thatchessguy7072 2 года назад

Thanks for making this video series!

@robertmariano 2 года назад

This podcast on anti-aging along with the research on CRSPR and gene editing/disrupting really is amazing. The only thing better than this would be a way to transplant consciousness into an already younger version of oneself. I watch this on RU-vid then I listen to it again on the podcast

@michaeltegler157 2 года назад

David and team, Thank you for the continued commitment to optimizing life. A discussion on the Microbiome would be tremendous as I have struggled with GI issues (IBS-C) and believe I have been suffering with invasive candidiasis as I have recently taken fluconasole which provided relief not only in my stomach but also caused the pain and stiffness to go away from joints, back, shoulder, etc. I am 49 yrs old and have taken many antibiotics throughout my life predominantly for sinus related issues which may have caused this condition of excessive candidiasis in my body and am curious to know if there is a way to restore the microbiome and healthy bacteria to optimal levels without Fecal Matter Transplantation as this is not readily available in the US. I'd also be inclined to go away to a clinic of sorts for 30 days if you know of one that would provide the structure and support to restore the microbiome. Thanks again for all of your dedication and work!

@allyjhughes 2 года назад

Can you talk about hair? Male pattern balding and grey hair? And also talk about Finasteride use and its long term effects.

@alexanderohanlon8825 2 года назад

More plates more dates, check his stuff, highly into pharma for hair... personally I'd cycle eating times and meals per day, some days eat loads otherdays don't eat and some days do omad ect.. Next cycle in fasting for long periods (5-10 days) a few times a yr, then give your body signs of abundance by eating loads of meat, organs and fruit the rest of the yr... Understand that ketones boost stemcells. For your hair the above works but also stop using shampoo and conditioner it's poison, just was with warm water then cold after and stimulate blood in that area (massage) and break up calcium deposits

@brianstarr3184 2 года назад

Good morning, Matt. You have a John Heilemann-esque vibe. Take it as a compliment. I think you do a great job of co-hosting, asking enlightening questions and keeping the conversation flowing. David is pretty good, too. Signed, Matt's mom

@bestrongandloveyourself2370 2 года назад

Another very interesting episode! I love this podcast! Can’t wait to know more about aging outside! ❤️❤️❤️

@Chrystabell 2 года назад

David's smile at 42:23 after Matthew's statement is one of great satisfaction! love it

@ethancowart6765 2 года назад

honestly feels good to be hearing someone like david say that peptides are promising and can be helpful if deployed properly and used properly. they have helped tremendously with a tbi that i got from a car accident. ive known this myself for a while but now it seems to be getting more known and looked at for the future.

@y.g.1313 7 месяцев назад

First time a video from Sinclair which is not full of nonsensical statements, rather detailed review of wide range of subjects, he is knowledgeable.

@peterellis4262 4 месяца назад

huh?

@orion10x10 2 года назад

We're in a golden age of podcasts between this and Andrew Huberman podcast

@dahsk7872 2 года назад

So excited to listen to this one. Thx Dr. Sinclair

@Aratohn Год назад

Thank you David & Matthew, such awesome podcasts

@angelinesarol5616 2 года назад

love your pod cast Im 56 and look and feel 36 Topics you cover so fascinating and your partner covers every detailed information

@Aldraz 2 года назад

This was a very interesting episode! I like this topic as it has not been repeated before in other interviews. I hope one day we can just take a pill that's gonna make us younger haha.

@kurthoffmann7160 2 года назад

What would happen if you cycled on and off trt and hgh so that you get the short term benefits, but then stopped those and go into a longevity mode where you do minimal mtor generation and lots of sleep etc..... so cycling between abundance memetics and adversity memetics... so you get gains during abundance mode and then maintenance mode during adversity mode, then cycle back into abundance mode and do it all over again.

@ainsleyameerali7622 2 года назад

Love this !!! Thank you dr David!!! You rock !!!

@joeyfunk4327 2 года назад

Can’t tell you how many people I’ve recommended the book Lifespan too it was great. Very excited to see how well we can Amplify these Sirtuin genes

@user-sb9ml1ef4q 2 года назад

The idea from the book that "aging is a disease and a treatable one" opened my eyes to the possibilities and I'm fascinated since.

@JustVibingFullStop Год назад

Thank you! I love these videos! This is sooo interesting!

@melindastefan2265 2 года назад

I really like to listen to the lifespan podcast, but as a woman I feel women data are invisible in most of the researches. Could you please Dr Sinclair apporach some topics from the aspects of women? Especially when you talk about hormones like in this episode? It would be fab to hear about more similarities and differencies if there are any between a female or male body in terms of ageing! Thank you and congrats! And by the way, I’m Hungarian too as your grandma😊

@ybigirl 2 года назад

Yep. So frustrating when they both say "people" when they mean men. Even rat research is largely on male rats. Grrrr.... Had a conversation with a researcher at the Salk Institute and he said "Well, womens' hormones are so complicated. It is like you are a different person every day." Lousy excuse for ignoring 50% of the population.

@shapdanone Год назад

Matthew is an outstanding conductor

@ottot3221 2 года назад

I had a low testosterones level but no libido problems' (thankfully) but I had hot flashes (I'm male) and osteoporosis due to it. There was no cause found. Due to injections and supplements it improved a bit but my risk of prostate cancer heightened. Then I started to do OMAD and now I don't need the injections anymore. My bones are becoming better and although just 0.1 under what is needed I have almost regular bones. Never thought that could happen.

@vibhaspalding6457 2 года назад

How did you get rid of osteoporosis? Was it injections to begin with and then OMAD? How long before you got rid of osteoporosis?

@psolarhidi 2 года назад

What were your test levels before and after omad? Also, how much weight did you lose, if any, in the process?

@timmorakinyo9529 2 года назад

@@vibhaspalding6457 you get raid of osteoporosis by diets elimination and intermittent fasting ( one meal a day)with excercise, omega 3 fatty acids, vitamins D3/k2 has tremendous impact in getting raid of inflammation of joints knees and hips(osteoporosis/arthritis)

@vibhaspalding6457 2 года назад

@@timmorakinyo9529 Hi I have been taking d2/k2 for more than 3 years, omega 3 fatty acids as oily fish 2 to 3 times a week and as daily supplements og about 2000mg to 3000mg. Doing an intermittent fasting by having short window of eating, eat first meal about 2pm and another light one, like avocado at about 7pm. Also soup/juice diet 2 to 3 days. Low carbs/no sugars, except dark chocolate, 90% cocoa. This year, I have another dexa test. Hopefully they are better scores, than last time. I also do weights twice a week, like hiit, dancing, 3 to 4 times a week, yoga and pilates, twice a week each. So try and keep healthy. I am also on thyroid healing protocol, to get rid of my medication for thyroid. But until the test is done officially, I cannot say if it is working.

@grldchee Год назад

Both times I did low carb my Testosterone tanked. I lost weight, but huge fatigue, bad sleep, low Testosterone. Confirmed by blood test. It cut my T in half and I absolutely felt the effects.

@stevenj6421 2 года назад

I can't even explain my gratitude for having the Most modern science, cutting edge know-how and knowledge and the ABILITY to be shared to the mass populace without being chewed and misinterpret by for-profit news. This IS the greatest #realized #purpose of the #internet itself to #spread #knowledge! Thank you and my sincere gratuity #DavidSinclair

@armieflores6064 2 года назад

So thankful for great information and very interesting podcast

@pNHGpNHG 2 года назад

THOUSANDS of THANKS So Much for Dr DAVID SINCLAIR + Mr MATT LaPLANTE * for your Unlimited + Immense + Continuous contributions to Humanity Prosperity. Those Valuable TIMESTAMPs are extremely useful.

@cynthiarucker1442 2 года назад

Amazing and wonderful. Thank you!!

@Articulate99 2 года назад

Always informative, thank you.

@ivanandreevich8568 2 года назад

Fastest longevity channel to 100K. Congrats!

@commonomics 2 года назад

I’m so excited for the weekly releases, I don’t put that kind of value into any other channel

@chrisknightnaturalwellness9697 Год назад

Awesome Channel and powerful data!!! Thank you !!! ✨💪🏽😎🤙🏽✨

@desnicolaou7966 2 года назад

I am a peri-menopausal 51 year old woman. I would appreciate it if Dr Sinclair could talk abt the menopause & how we can help ourselves maintain good health. I am getting conflicting advice abt taking HRT & I am unsure abt what I should do/take.

@thestreamoflife1124 2 года назад

I'm drinking athletic greens for 3 months. Great product

@viviancastro2783 2 года назад

May I suggest you change the title so you put the number of the episode so that we don’t have to open more to figure out which episode it is? Thank you! Loving it!

@dianavaldez3371 2 года назад

Love the content! Ty! ❤️

@patrickday4206 Год назад

Yamanaka factors have come so far way faster than I expected when I was first reading his research I thought it was going to be 10 or twenty years to make any real progress because of cancer.

@angeldahnke3496 2 года назад

Brilliant. As always!

@LSS495 2 года назад

Most definitely! I have found that in my city (Pittsburgh, PA), which is primarily a traditional medicine community, the majority of physicians are very hesitant to prescribe HRT and claim beyond a certain age, your risk to develop cancer is very high. I know this isn’t supported by current research. Also, there are few functional medicine practitioners who also have MDs - a background I am seeking so I can receive advisement from both perspectives. My DO wouldn’t even consider prescribing bio identical HRT and told me I should find a gynecologist who would. Even these practitioners are very hesitant and keep referring to older research in their explanations. This is SO very frustrating, and leaves many women struggling to find care that could prevent many downstream problems.

@camiloandresleguizamon3624 2 года назад

Excellent podcast

@joeanarumo616 2 года назад

Thank you once again

@loudboomboom 2 года назад

I’d love to hear any progress on restoring dental health and whether or not teeth could be regrown.

@thestreamoflife1124 2 года назад

I have been on hormone replacement therapy for decades. I'm 80 now and do not look my age. Most think I look about 60. Hormone replacement therapy has been my life saver ....

@eternal_stoic_ 2 года назад

LOVE YOUR PODCAST...

@igalbog 2 года назад

As always, interesting to watch and learn about the cutting edge in anti-ageing. Thanks David and Matthew! Dr. Sinclair is looking younger than usual lately - any recent changes in the protocol?

@chrisbusby4395 2 года назад

Hair colour definitely helps

@cindybelle1752 2 года назад

I think they are using a soft focus filter on their videos.

@verderne 2 года назад

Thanks you guys! Blessings.

@lorasolomon5112 2 года назад

Great video info, love your channel...!

@erwinrogers9470 Месяц назад

Great information👍

@stefandaniel4216 2 года назад

I love you David, i can‘t wait to put my hands on your book ( Lifespan) i already apply most of your advices, but i take it slowly, currently eating 2 meals a day instead 3…

@quantitradersignalservice5735 2 года назад

What protocols have you started because of Sinclairs' podcast? I have too and would like to compare.

@stefandaniel4216 2 года назад

@@quantitradersignalservice5735 curently i stopped eating 3 meals a day, i eat only 2. breakfast at 13:00 and dinner at 18:30-19:00, i do exercise 5-6 times a week, aerobic running, and i train in the gym for strength. i want also to start taking a supplement which it contains more or less the same ingredients which Profesor David Sinclair recommends : NAD + Cell Regenerator and Resveratrol 300 mg from life extension. Good Luck!

@SeattleCondoSpecialistcom Год назад

Thanks. Great Content

@stephenlucier 2 года назад

Brilliant!

@shelchicago8997 2 года назад

David Sinclair just aged backward by a week while I aged forward waiting for another episode.

@user-wv9ss2hk8k Год назад

So wish that there is subtitle. It would be immensely helpful for so many of us. We are constantly pausing and rewinding.😢

@eggmendy 2 года назад

Wonderful, wonderful episode, as always. So informative and well-presented! Thank you for doing these.

@NRNF1776 2 года назад

Its funny... I see this video is up, and I know immediately what my husband is doing. Its like magic!

@Ccowdog1 2 года назад

You both are lovely! Lol 😆 thank you for telling us what doctors don't- please do one on menopause!

@Corrans 2 года назад

Yes I'd love one on perimenopause and menopause.

@quantitradersignalservice5735 2 года назад

i'm hoping that Dr. Sinclair reads these posts because if he does he'll get the idea we would love to hear his thoughts on woman's helath.

@TotalyRandomUsername 2 года назад

So you start a channel and get over 100k subscribers in one month. That is astonishing! :) But i am very happy about this channel.

@sergelachapelle7992 2 года назад

I am following these podcasts with high interest... as I am 64 and on TRT, do intermittent fasting, weight train and take NMN and other supplements... (will be adding resveratrol). One issue that was not taken in consideration with regards to aging and testosterone is the fact that life is more than just time. How do you ballance adding life to your time vs adding time to your life. Quite frankly, TRT gave me my life back. My level of energy, motivation and general mood are way up with testosterone.... I would not live like I was before... The added estrogen that comes with TRT is actually cardio protective and has cured my joint pain... Maybe you should stay away of subjects you don't know well or you are biased against... Testosterone can actually be protective against prostate cancer and high levels of testosterone is actually being studies to treat certain forms of prostate cancer... I think your view is a little outdated... The biggest issue I have with all this longevity talk is the fact, it seems, that you have to choose between being vibrant, energetic but short lived or be starving, cold and low energy and live longer... Darn... Everything that makes me feel good seems bad (Mtor activation as I like my meat... testosterone as I enjoy being energetic and productive... ) ... Maybe I am looking for optimization and you are talking about absolute lifespan... Don't get me wrong, I love the podcast... great info to integrate into what I think will be a middle way for me... Cheers

@AncestralFuel 2 года назад

I am with you - started TRT when I was 64 - now 68 - and I have experienced many benefits. I think that what Sinclair misses about TRT is that he has a “theory” that it may send the wrong signals to your body to “grow”. What is interesting is that, although Testosterone is anabolic, it is focused mainly on helping muscle and bone strength. Consequently, you can consume less protein (which too much can create issues) than someone who has low T. I think the bottom line is that the studies are pretty consistent that TRT reduces all-cause mortality while improving quality of life. Big Pharm and the medical industry in general do not like TRT because it cannot be patented and it takes a lot of a doctor’s time to get you dialed in. My understanding is that Sinclair is working on patenting concoctions out of his lab to sell as longevity drugs. Hence, TRT could be considered “competition” in spite of its efficacy.

@alan2102X Год назад

Serge, you are right on all counts. Sinclair is still very much of a newbie to the testosterone space; one can tell this by listening to him. He will probably acquire better knowledge, with time. Meanwhile, don't deny yourself the benefits of testostereone just because he is still relatively ignorant! Also true that there is a balance between strength and vigor, and longevity. More of one, less of the other, or so it seems. Maybe someone will figure a way around that, eventually, but for now it seems you must choose.

@alan2102X Год назад

@@AncestralFuel You are correct also. Testosterone's anabolic effects are such that you can recover from workouts and maintain strength on much lower protein intake; this is a grossly-neglected fact in the longevity space (Sinclair, Attia, and many others). They also neglect -- are probably ignorant of -- the literature describing the benefits that you mention such as reduced ACM, better QOL, etc. They are perhaps ignorant, and/or perhaps tend to dismiss because of prejudice against hormone therapy, especially hormones related to anabolic steroids. Also correct that TRT is non-patentable and involves a lot of old-fashioned patient-focused medical ARTISTRY (what you call "dialling in", which is beyond the science, beyond EBM), and as such will tend to be ignored and dismissed by commercial and some other entities. TRT cannot be successfully practiced by idiots following EBM cookbooks; therefore it will tend to be less popular. Also, yeah Sinclair might have a bias against things that he cannot sell. IDK, but that is the way things go, too often.

@DeusExMachina50 Год назад

Eunuchs may live longer, but what man wants to live like that?!

@richard18219 2 года назад

I wish I had seen this podcast earlier, I had been using peptides to deal with an injury that got worse and to boot, I now have arthritis in my hip and big toe.

@sharonsullivan3322 2 года назад

Rheumatoid arthritis, and sexual performance as we age. Thank you. Podcast very intriguing. Keep it coming. Have fun in Utah!

@JanaLeeME 2 года назад

Bonjour from Switzerland 🇨🇭! Je suis prête 😁

@Lurksin1 2 года назад

Love this area of research. How do you feel about Wim Hof breathing techniques and the research on improving mitochondrial function as well as meditation, hormesis in general for lifespan

@stockstudy8633 2 года назад

Hi David, I studied your book and have been using NMN, etc since Feb 2021. My stem cells have been banked and I have 1.4Billons of my cells IV'ed and IN'ed in my body since 2020.

@cristinavillegas6357 2 года назад

What is NMN?

@markpettus6929 2 года назад

As the great 20th century philosopher Yogi Berra once said, "the future ain't what it used to be". This is a very exciting time in biomedical sciences. Would be very interested in your thoughts on the future of "quantum access" therapies that re-engineer the quantum morphogenetic fields that are the basis of our material blueprint. This, I believe is even more 'upstream" medicine.

@delishme2 2 года назад

Wow I was wondering if they offered a discount. 25 % is great. I'm just about to get back on Resv, Berberine and NMN. I've been using senolytics sparodically, and during pre and post vaccine. After a year off, feeling like crap tbh 😆, so thanks for making feel human and hearing you did the same at some point. I do remember how fabulous I felt a year ago. This time I want to do full bloods, and track properly not just anecdotally. Thank you 😊 ✌️❤️🇭🇲

@andrewwalker8985 2 года назад

The HGH discussion skipped over the TRIM and TRIMX trials done by Greg Fahy, and showing age reversal with epigenetic clocks. Shame - I really wanted to hear Davids view on that work

@houssem_elfhaiel 11 месяцев назад

thank you

@diseasehealthdiets136 2 года назад

Thanks! dr David for amazing apisodes.

@NicoSpeaking 2 года назад

My main takeaway today --> A real and sustainable solution to survive the zombie apocalypse - "brains to go" ... I love this PODCAST! Makes me feel smart. Haha