The very first beat: How a heart starts to pulse

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One moment there's nothing, the next... a heartbeat. As a vertebrate embryo grows, its heart tissue starts to pulse well before it's needed. But how does the developing heart actually co-ordinate that very first beat?
Using microscopes and glowing fluorescent proteins, researchers have been able to watch zebrafish embryos during this key point in development and examine the process in real time.
Read the paper: www.nature.com/articles/s4158...
For more stories like these sign up for the Nature Briefing: An essential round-up of science news, opinion and analysis, free in your inbox every weekday: go.nature.com/371OcVF

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26 сен 2023

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Комментарии : 579

@mrniceguy4277 7 месяцев назад

This took probably many years and several PhD projects lol. Especially developing the method. Congrats to the authors of this study!

@michaelberres7278 7 месяцев назад

@@RepentandbelieveinJesusChrist5 nobody asked for story time

@sontodosnarcos 7 месяцев назад

Why lol?

@johnwest6690 6 месяцев назад

All those years of study for some deluded kid who's scared of death to deny it because "Mub god!!"

@ishkibable 6 месяцев назад

It took all of history to get to where we are today

@GEOFF0906 6 месяцев назад

The most important story you'll ever hear, and believe me, one day you will know how important. “The fool says in his heart, ‘There is no God.’” (Psalm 14:1)@@michaelberres7278

@alanmlkbanda 7 месяцев назад

I saw the thumbnail, read the word beat and saw that shape and dark background and for real thought this was an ad for new headphones

@AB93000 3 месяца назад

Same for me ;)

@FutureAIDev2015 7 месяцев назад

Also, what causes the first electrical activity in the embryonic brain? Is that also jumpstarted by noise?

@rangoman1815 7 месяцев назад

It is God's design!

@Mob1bo 7 месяцев назад

@@rangoman1815😂

@Matthew.Morycinski 7 месяцев назад

Any system with built-in feedback will begin to oscillate when there is enough amplification, low enough damping, and a delay. The really interesting question is what purpose it served, before evolution found this pulsation to be useful for moving blood.

@JasonMomos 7 месяцев назад

@@rangoman1815 yeah, I would keep looking instead of dedicating every mystery to the skydaddy.

@rgudduu 7 месяцев назад

@@Matthew.Morycinski , interesting line of thought

@ypcomchic 7 месяцев назад

Such an amazing video. I remember watching a video about the guy who created this whole setup to be able to see this in the lab. He truly is a genius.

@Cjnw 6 месяцев назад

@@RepentandbelieveinJesusChrist5*Blessed Gańpat Dēva* 🕉️!

@alejandrodelcastillowestte8721 7 месяцев назад

I couldn't help but smile when I saw and heard the first beat. mesmerizing

@TumbleTrashOfficial 7 месяцев назад

props to the camera man for recording his own heart surgery.

@AllensTrains 7 месяцев назад

Quite interesting. I never knew that the first heartbeat was such a hit and miss affair! Thanks for uploading.

@jorn-michaelbartels9386 7 месяцев назад

Wonderful video! Furthermore, like all nature videos, the presenter has a perfect pronounciation. Nice to listen to!

@whyomgwhywtf 6 месяцев назад

Search for 'Benedict Cumberbatch penguin' and change from "all" to "most" 😂

@dasrahul505 7 месяцев назад

I don't know why RU-vid suggested me this, but I am glad it did

@chairforce0ne 7 месяцев назад

thanks for these visuals, really fascinating

@hannesaltenfelder4302 7 месяцев назад

The first beat of a heart is more or less by chance, because it becomes more sensitive to electric charges in the environment? Does the size of the heart matter? Does that mean, if an embryo is in an environment, where there is absolutly no electrical charge, the heart can't start to contract? Could this be the reason, why most big animals develop inside their mother? And what about... crocodiles for example? Is there a difference between cold-blooded and warm-blooded animals?

@Matthew.Morycinski 7 месяцев назад

A conjecture: oscillation will happen with vanishingly small input, basically thermal noise that is always everywhere. The circuit keeps tuning up until it becomes an oscillator, basically.

@markusberg2770 7 месяцев назад

The sinoatrial node (SA) is a dedicated group of cells within a heart that produce a chemical “action potential.” Basic chemical function of the SA node relies on sodium, potassium, and calcium. See Wikipedia for a detailed explanation.

@rubiks6 7 месяцев назад

It is impossible that the heart of a living embryo will ever be in an environment where there is absolutely no electrical charge. It is in the embryo. There are constantly countless electro-chemical processes going on throughout the embryo.

@sweetsweetganymede 7 месяцев назад

Thank you to the researchers for enlightening us

@MajorKoenig156 7 месяцев назад

very nice video, thanks! i like how it presents high-level science with a slight emotional twist and remains calm in its tone

@Pyriphlegeton 7 месяцев назад

Very interesting footage, thank you!

@reversemyopia 7 месяцев назад

Congrats for figuring this out ! I do think the explanation offered is very close to truth.

@miguelbissieres3736 7 месяцев назад

Beautiful video. Thank you for sharing it! I am amazed.

@nivedithadakshinamurthy8788 7 месяцев назад

Truly amazing 💟 and very informative too

@mujkocka 7 месяцев назад

This is a very good question! I never thought to ask!

@dericksilva281 6 месяцев назад

This video is so poetically beautiful!

@heiiwjwbebidosbeiwojwjeheh6046 7 месяцев назад

one of the most beautiful things i have seen

@brainstormingsharing1309 7 месяцев назад

Always keep it up! 👍

@wassupnick 7 месяцев назад

this is so beautiful

@batgh0ul 6 месяцев назад

man, nature is weird as hell. i find it so cool how things aren't at all a pattern, like the cells starting to beat at different times, from different spots, just as a consequence of growing at their own unique time. randomness is beautiful.

@F-Man 7 месяцев назад

Yet there are many who still maintain that this is not life.

@DoctorDipshits 7 месяцев назад

Why are you trying to start an argument, this video has nothing to do with abortion. Grow up.

@puerco911 7 месяцев назад

@@DoctorDipshitswell said, thank you

@puerco911 7 месяцев назад

A beating heart is not life.... If you are looking for that its between your ears.... You are looking at the wrong video

@Volcano22207 7 месяцев назад

@@puerco911he’d probably have a field day seeing organoids

@ronal8824 7 месяцев назад

as much as I'd love to argue the folks knocked some sense into me. there is a time and place

@freshrot420 6 месяцев назад

That right there, is when life starts.

@camilaribeiras6311 6 месяцев назад

Literally the first few seconds of the damn video speak of just an electrical pulse in a cluster of cells. Thats not life YET.

@freshrot420 6 месяцев назад

@@camilaribeiras6311 Look, idc what you do with your abortions, but that's when the current goes from off to on. It's the most definitive embodiment of the on switch as there will ever be.

@julianbabilonia8562 6 месяцев назад

@@freshrot420I like your analogy of the switch. Abortion literally works like a switch. First, the heart is beating. Abortion happens. Then heart stops beating (and is dismembered). Pro choicers literally continually advocate for the legal protection of unborn animals (like birds and turtles) as well as animals as a whole, but not the unborn of their own species (humanity). It’s sickening.

@freshrot420 6 месяцев назад

@@julianbabilonia8562 Right, life is more important than anything. We are so fortunate to be able to facilitate this electrical charge from the Earth, the Sun, or possibly the galaxy and universe. Wildly amazing it even works. When this charge returns to ground is our current, clinically defined end of life, so why would the start be any different.

@NyanCatMatt 6 месяцев назад

"People say life begins at conception, I say life began about a billion years ago and it's a continuous process." -George Carlin

@maxdon2001 6 месяцев назад

Great video!

@1495978707 7 месяцев назад

Amazing work! As a physicist to me, this is just what I would've expected. But it's still necessary to actually test and see for sure, and it's amazing that they figured out how

@umu-i-d2785 7 месяцев назад

Spontaneous Synchronization

@Jin.media-production 7 месяцев назад

This video is going to have million views (currently 97k) amazing content

@CIBERXGAMING 6 месяцев назад

it just happened to happen and it works so it stayed.

@Muscleduck 7 месяцев назад

Fantastic imagery. I wonder if science will one day crack the code more definitively.

@guldenaydin9918 7 месяцев назад

Thank you...

@ONNDMAD 7 месяцев назад

Incredibile what we have started to see ❤

@christinegerard4974 7 месяцев назад

Fantastic.

@Nekomesha 7 месяцев назад

So basically fibrillation until everyone is in time

@eengeeoo 7 месяцев назад

Facinating.

@gf4453 6 месяцев назад

Beautiful ans excellent video

@DeewarPutr 7 месяцев назад

The first beat of a heart is more or less by chance, because it becomes more sensitive to electric charges in the environment - But where does the actual cellular "sense" for the increased electrical sensitivity come from? Anthropomorphizing the cell with sense doesn't actually explain away the cause for a sense to exist in the first place. An electron bound at a singular location can "sense" that it's around a positive charge by the pulling force of attraction that exists in and around the field for the charge all the way till infinity. Why or how does that sense arise?

@AbCd-kq3ky 7 месяцев назад

I imagine this might have something to do with ion channel expression.

@DeewarPutr 7 месяцев назад

@@AbCd-kq3ky No doubt, ions existing devoid of their neutralizing charges give rise to those fields, does the existence of ions then predicate synchronized biological impulses? If yes how do neutral molecules "know" it's ripe time to ionize and participate in an almost "spontaneous" delocalized phase transition? I feel collectively there is more going on that what meets the eye.

@FutureAIDev2015 7 месяцев назад

The way I understand it heart cells, like any other electrically excitable cell like a neuron, have what are known as ion channel proteins, some of which are sensitive to external changes in voltage. That is, they open or close when the voltage across the membrane they're embedded in crosses a threshold.

@Secretlyanothername 7 месяцев назад

In this video they don't really know. But they've watched it many times in zebras, so they got some cool videos with colors.

@stevenjones6780 7 месяцев назад

Yes, from our limited perspective we may not be able to escape "Anthropomorphizing" deeply enough to truly understand these sorts of process...

@justinwheeler5614 7 месяцев назад

Great video. Nice to get away from the terror in the world, once in a while.

@wakamolebiscuit 7 месяцев назад

This is actually the most horrifying video I've ever seen. Watching humans being used as labrats.

@mishayt1989 7 месяцев назад

@@wakamolebiscuit They use fish embryos in the video.

@dorukbebek 6 месяцев назад

Wow, so amazing, this is the first time I've seen this and it looks like magic. GOD i Love you !

@graciegj63 6 месяцев назад

Watching this makes me feel so humble and grateful to God. 😊

@FSXProPilot 7 месяцев назад

lovely!

@rgudduu 7 месяцев назад

High quality content

@Iamthewarner557 7 месяцев назад

“And Allah has brought you out from the wombs of your mothers while you know nothing. And He gave you hearing👂, sight👁, and hearts❤ that you might give thanks (to Allah)." Qur'an (16:78) Allah almighty our creator says, O mankind, what has deceived you concerning your Lord, the Generous, Who created you, proportioned you, and balanced you? In whatever form He willed has He assembled you. Qur'an 82 (6:8)

@rinzler9775 7 месяцев назад

Amazing

@melichanlee3583 3 месяца назад

Wow! So first heart pulse is a field response ...?! Wonderful research (thanks zebrafish for your bodies)

@busrakorkmaz8315 7 месяцев назад

So beautiful

@rubiks6 7 месяцев назад

Each heart that beats in every creature - who wrote the code to make that happen? Every cell's location and function is controlled by code. Who wrote that?

@crabeatingchips1857 7 месяцев назад

God.

@rubiks6 7 месяцев назад

@@crabeatingchips1857 - Indeed.

@jmc99.14 7 месяцев назад

Our god Allah

@jmc99.14 7 месяцев назад

Allah said (And certainly did We create man from an extract of clay. Then We placed him as a sperm-drop in a firm lodging. Then We made the sperm-drop into a clinging clot, and We made the clot into a lump [of flesh], and We made [from] the lump, bones, and We covered the bones with flesh; then We developed him into another creation. So blessed is Allah, the best of creators. )

@weltschmerzistofthaufig2440 2 месяца назад

No one need to write that, Rubiks. No one synthesises biomolecules; selection mechanisms optimise the functionality of biological structures in order to promote survival. This is the result of billions of years of evolution.

@mp-zb8rj 7 месяцев назад

Insane

@mazo691 7 месяцев назад

Immaculate contraction.

@betula-pendula 5 месяцев назад

Great!

@vidyakumargv 7 месяцев назад

Everything starts from the primordial sound om.🕉️

@shiro_3611 7 месяцев назад

huh... i never thought about my first ever beat

@FutureAIDev2015 7 месяцев назад

This is really cool. So the heart cells are first activated by noise?

@Secretlyanothername 7 месяцев назад

They need ears first.

@facebookinger 6 месяцев назад

Take care of your heart. From the very first moment you were born your heart never stops beating to give you life.

@GreenBeanCrochets 4 месяца назад

the heart beats before you are born

@MusicHead480 7 месяцев назад

Crazy

@user-ff1fv6ub7c 7 месяцев назад

This is the kind of video that is usually like 11 years old

@marioalbertolagunesperez2021 7 месяцев назад

Life so beautiful

@Craloye 2 месяца назад

Life is Charming!

@gregnichols2140 6 месяцев назад

what is the difference between a heartbeat and just an electrical signal? This seems to be a key argument for when life begins

@farmcactus5280 6 месяцев назад

a heartbeat is the muscles in the heart contracting, an electrical signal is a wave of electricity

@stupi_ugli 28 дней назад

Those cells were alive before a heart beat.

@kairu_b 7 месяцев назад

Nice

@aku7598 7 месяцев назад

Its by chance that giving heart pumping action thus providing the reward, nutrients needed by the cells through flowing blood.

@mrtienphysics666 7 месяцев назад

"The heart works continuously during its lifetime, through adrenaline rushes and exhaustion until our final moments ... but it couldn't happen without that very first heartbeat."

@purpl3grape 7 месяцев назад

Until it gets removed and placed into another human in an organ transplant. "Heart, you're not DONE yet. Get back in there and pump!"

@mennovanlavieren3885 6 месяцев назад

Except if you silence those first cells others take over and start pulsing because it is an electrically unstable system.

@philmaumau 7 месяцев назад

how precious it is👍..!! to discover our first heartbeat followed by 3 billion more .. and predict when the last one will stop!!

@uc22_swo1p 7 месяцев назад

Several years later Bullies: ahaha let’s insult and beat it’s ass until it kills itself XD

@LexTheLionLocc 6 месяцев назад

The problem that I have with this video is it is saying that the cells just become sensitive to electricity around them and thats what kickstarts it. So where is the electricity coming from? Whats generating that? If its just naturally in tissue then whats generating that? Is it static electricity? Is it an electrical field from the earth? If its none of these or something else then one could say the electricity is being generated by the cells themselves and not the surrounding environment. So the next question would be, how are the cells creating electricity?

@farmcactus5280 6 месяцев назад

the electricity is coming from the nutrients gained from the umbilical cord turned into energy.

@LexTheLionLocc 6 месяцев назад

@@farmcactus5280 but doesn't there have to be circulation in order to recieve nutrients which requires the heart to already be beating?

@farmcactus5280 6 месяцев назад

@@LexTheLionLocc so how do single cell organisms split without a heart? o:

@LexTheLionLocc 6 месяцев назад

@@farmcactus5280 so what you're saying is the cells are acting like red blood cells circulating nutrients to each other?

@farmcactus5280 6 месяцев назад

@@LexTheLionLocc when the hell did i say that?

@channelforrent 6 месяцев назад

Spirit of life

@toscatattertail9813 6 месяцев назад

The sounds we hear at the OB/GYN as a "heart beat" are produced by the ultrasound machine to indicate an electrical pulse....not a fully functionally heart.

@janosadelsberger 7 месяцев назад

That's so cool

@ben4190 7 месяцев назад

I suddenly got scared of dying watching this... But really interesting! =)

@graciegj63 6 месяцев назад

Never fear. God makes our hearts beat. For all of the heart cells to beat at once every single time inside every woman is nothing short of miraculous.

@Ja_wat 7 месяцев назад

This is the work of God

@karldeportepetznick4774 7 месяцев назад

Aw sh*t here we go again

@Ja_wat 7 месяцев назад

@@karldeportepetznick4774 😂

@GeekIWG 6 месяцев назад

Indeed! Praise the Lord!

@yourewrong264 6 месяцев назад

nope

@asiano3385 6 месяцев назад

Where? I see only things like living beings and life as a whole.

@legalizemolly2771 6 месяцев назад

Mf be like “tHaT’s A PeRSon!!”

@ribvicky 7 месяцев назад

The entire biological system is astonishing actually. There's chemical activity, mechanical engineering, there's physics involved, also the position of heart closer to the head because of the gravity issue and much much more. So, how could cells have this knowledge on their own?? Someone surely has designed all this who knew about chemical activity, physics and engineering. Our heart has valves which is a very basic mechanical system found in pumps etc. I believe someone in our own image designed all this...

@bcwbcw3741 7 месяцев назад

That's a nice piece of motivated reasoning. Pay no attention to the huge amount of understanding who this happened from the evolutionary biologists.

@stevenjones6780 7 месяцев назад

Yes truly astonishing- how vulnerable and yet resilient creation can be. The cell groups reacting to each other remind me of "flock mentality" like Black Swallows or fish schools moving in unison. There is definitely intelligent design behind it all...

@mrsnoo86 7 месяцев назад

designed? designed for what? for killing each other for survival? food chain? lmao. even human can't produce its own Vitamin C and can't survive without water. 😂

@jmc99.14 7 месяцев назад

Allah said (Say, "He is the Most Merciful; we have believed in Him, and upon Him we have relied. And you will [come to] know who it is that is in clear error.")

@jmc99.14 7 месяцев назад

@anthonyalbillar-montez5946 6 месяцев назад

Time, time is my left eye.

@madarauchiha2584 7 месяцев назад

Me holding on to my chest watching the video. Quite scary if it stops beating suddenly

@jmc99.14 7 месяцев назад

@damntrain5145 7 месяцев назад

nice story bro@@jmc99.14

@CreepyMemes 7 месяцев назад

@@damntrain5145 bro just proved islam is wrong

@dylan-dylan-dylan 6 месяцев назад

I thought it was an AirPod

@OmkarDeole 7 месяцев назад

Wow wow wow

@MelliaBoomBot 4 месяца назад

Beauty ❤

@ianbuick8946 7 месяцев назад

Searching for miracles for all the wrong place.

@anandaditya479 7 месяцев назад

Is this suggesting the cells electrical signals synchonize to give us a heartbeat.

@yankees4551 6 месяцев назад

Have you seen those metronomes on the rolling board? They all start to click in unity due to gravity. Does the same thing happen with cells? Which means it's not going to happen on the moon... Not enough gravity... Can someone react?

@mr.unknown411 7 месяцев назад

What we humans fail to understand is that life is a miracle and there necessarily does not have to be any kind of reason for life to exist

@KasKade7 6 месяцев назад

Life starts, or death starts. Both are true.

@Tankej0527 7 месяцев назад

Morphodynamics!

@slimerone 7 месяцев назад

if we observed this on Mars would it be considered the discovery of life?

@rahoolv 7 месяцев назад

I'm sorry. I don't get it. So the answer is you don't how or why it starts it's first beat?

@LucasReiiiis 7 месяцев назад

Muito interessante!

@andrewmartin9995 7 месяцев назад

You are Mexican

@stevanezaradikirana2790 7 месяцев назад

Praise be to God alone.

@GeekIWG 6 месяцев назад

Amen! He is Good!

@asiano3385 6 месяцев назад

Thank you. Existence of diseases is nice.

@trishash79 7 месяцев назад

Video Entitled The very first beat: How a heart start to pulse. @2:09 The Video? Perhaps nothing in particular!

@ericswain4177 6 месяцев назад

What starts to pulse or Hart beat ? If I told you you would never believe me.

@sharkylal 6 месяцев назад

One day the abstracted data all around us may be utilized and understood.

@alfiqh9105 7 месяцев назад

After all those many experiment conducted by experts from respectable discipline, the culprit that start the peacemaker and electrical signaling concluded as "MAYBE NOTHING".. uwu

@dummie4guitars 6 месяцев назад

We are lucky to be organic.

@michaelwalters3970 7 месяцев назад

It's just an electrical pulse does absolutely nothing for quite awhile.

@Jazzglenn 6 месяцев назад

Doesnt matter, they're just a clump of cells.

@puerco911 7 месяцев назад

I dont think its haphazard way, firstly its coded into the DNA, second its simply the building of an electrically charged field, and third is electro-chemical energy needed to sustain it..... So kinda of like a battery really

@muddassir252 7 месяцев назад

سبحان اللّٰہ

@fado792 6 месяцев назад

The first beat can be in a couple of contracting cells. Nothing human at all.

@2Bluzin 7 месяцев назад

Oddly we dont need the heart later in life if a good enough mechanical one can do the job, yet even that needs an electrical charge.

@puerco911 7 месяцев назад

It needs energy, but not necessarily electric, for a mechanical heart

@Xiefux 7 месяцев назад

@@puerco911 you mean like a wind up mechanism like a clock? like a person would have a key on their chest they need to turn every few hours so their heart can beat?