Toll-like receptors (TLRs) play an essential role in the activation of innate immunity by recognizing molecules from pathogens like we have LPS from Gram negative Bacteria.
TLR signaling pathways arise from intracytoplasmic TIR domains, which are conserved among all TLRs and these TIR Domains are stimulated and activated by binding of Ligands towards the TLR proteins.
In this pathway we need the following Proteins :
1.Lipolysaccharide Binding Proteins.
2.CD-14
3.MD-2
4.TLR
5.MY D88
6.TIRAM
7.TRAM
8.TRAF
9.IRF.
10.NFKB
11.AP-1
12.IKK
and many other molecules .
From this pathway we get the transcription of Cytokines , Chemokines , Interferons .
27 фев 2022
