So you have to go to custom run and in the mechanics you can turn off every game mode and leave one on. I also turned off all enemies except WLF and dogs. As for the modifiers to have the same of a certain modifier on every encounter all you have to do is disable every modifier except one that you want to use with 6 modifiers cap limit maxed out. I was Able to do invisible enemies every encounter and melee attacks set enemies on fire for all holdout melee only challenge on the channel