Thank you for a really good video but i think the illustration of the ribosome should be fixed. If i'm not mistaken the E site should only occupied the large rRNA subunit. Only the P and A Sites occupied both large and small subunits
What about in Eukaryotes. What are the changes? But...... I think there are some mistakes in the initiation part of this vedio. How can the tRNA binds to the ribosome before mRNA comes? The anticodon arm of the tRNA must bind to the codon of the mRNA. right?🤔 Or does it mean that there is nothing wrong with that and it can be done in this way too🤔? It seems to me that the tRNA should come only after the 50S subunit with the mRNA joins with the 30S subunit. Then only the anticodon - codon complementary base pairing will become correct.
Thanks for the video! I'd like to know what kinds of mutations prokaryotes can get. Can they get cancerous mutations in their DNA or does something else keep prokaryotes from developing cancer?
Hi, You went pretty deep into the details of this mechanism, and because of that, I want to make some comments... I am wondering based on which data you have ultimately placed IF3 in E-site? Based on the current state of the knowledge in this field it is very contradicting. I would rather recommend only mentioning the IF3 without placing it anywhere in this pathway since it creates a false feeling that it's a solid defined fact. In fact, IF3 could be even bound to the 50S subunit and not cause 70S complex dissociation. www.ncbi.nlm.nih.gov/pmc/articles/PMC6120702/