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Tretinoin dangers? VA study explained 🤔 Dermatologist

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Tretinoin dangers? VA study explained 🤔 Dermatologist ‪@DrDrayzday‬ on the safety of tretinoin for long term use. Increased deaths observed in VA study of tretinoin 0.1 cream. Is Retin A safe? Retin A dangers, death and lung cancer risk debunked. #tretinoin #antiagingskincare #dermatologist
10 reasons you tretinoin isn't working • 10 REASONS WHY YOUR RE...
5 myths about tretinoin • 5 myths about retinol ...
References
Weinstock MA, Bingham SF, Lew RA, et al; Veterans Affairs Topical Tretinoin
Chemoprevention (VATTC) Trial Group. Topical tretinoin therapy and all-cause mortality. Arch Dermatol. 2009;145(1):18-24.
Katz KA. Topical tretinoin, lung cancer, and lung-related mortality. Arch Dermatol. 2008;144(7):945-946.
The Alpha-Tocopherol, Beta Carotene Cancer Prevention Study Group. The
effect of vitamin E and beta carotene on the incidence of lung cancer and other cancers in male smokers. N Engl J Med. 1994;330(15):1029-1035.
Omenn GS, Goodman GE, Thornquist MD, et al. Effects of a combination
of beta carotene and vitamin A on lung cancer and cardiovascular disease. N Engl J Med. 1996;334(18):1150-1155
Wang XD, Liu C, Bronson RT, Smith DE, Krinsky NI, Russell M. Retinoid signaling and activator protein-1 expression in ferrets given beta-carotene supplements and exposed to tobacco smoke. J Natl Cancer Inst. 1999;91(1):60-66.
Rigas JR, Miller VA, Zhang ZF, et al. Metabolic phenotypes of retinoic acid
and the risk of lung cancer. Cancer Res. 1996;56(12):2692-2696.
Rosenberg EW, Skinner RB Jr. Topical retinoids: another piece for the retinoid cigarette-lung cancer puzzle? J Thorac Oncol. 2006;1(7):732.
Liddell FDK. The interaction of asbestos and smoking in lung cancer. Ann Occup Hyg. 2001;45(5):341-356.
Latriano L, Tzimas G, Wong F, Wills RJ. The percutaneous absorption of topically applied tretinoin and its effect on endogenous concentrations of tretinoin and its metabolites after single doses or long-term use. J Am Acad Dermatol. 1997 Mar;36(3 Pt 2):S37-46.
FTC: This video is not sponsored.
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Disclaimer: This video is not intended to provide diagnosis, treatment or medical advice. Content provided on this RU-vid channel is for informational purposes only. Please consult with a physician or other healthcare professional regarding any medical or health related diagnosis or treatment options. Information on this RU-vid channel should not be considered as a substitute for advice from a healthcare professional. The statements made about specific products throughout this video are not to diagnose, treat, cure or prevent disease.

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27 авг 2024

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Комментарии : 987

@pockyeatingpanda 2 года назад

I can’t believe your content is free. The amount of time (aside from your entire schooling and career, of course) that you must put into these informative videos is admirable. I love watching your vids on my lunch break- I work in dermpath!

@DrDrayzday 2 года назад

Glad you enjoy it!

@AM-qr4ys 2 года назад

You really are amazing! We appreciate you

@khadijayahtaoui2157 2 года назад

@@DrDrayzday you are the best

@zullyashergo8876 2 года назад

me too

@Islandlivinggal 2 года назад

It’s not free. RU-vidrs get paid for the content they make, hello?!

@marjorieburnett980 2 года назад

So helpful. I found that trentinoin works on my very mature 71 year old skin. Then I see a popular RU-vid channel mentioning this. I get so tired of people trying something and if it doesn’t work for them they decide it is dangerous and bad for everyone! Thank you for sharing ❤️

@atom7134 2 года назад

Truly a one of a kind content creator. We're so lucky to have Dr Dray! Very few creators could consistently put our content like this. So informative and valuable. Always a joy to watch. Thanks for all your work. Happy Tuesday!

@Loveandyoutube 2 года назад

Disagree. Completely mono-chambered, no openness. Informational and fantastic, unfortunately not open and willing to research new findings.

@loganmomable 2 года назад

This content is what sets Dr Dray and this channel head and shoulders above the rest!🙏

@julienigh5992 2 года назад

so true!

@jess5135 2 года назад

Her name is Dr SUAREZ Does anyone know she’s the only dr on RU-vid using a fake last name ?

@toric9518 2 года назад

@@jess5135 it’s short for Andrea

@nikkiallen9629 2 года назад

I totally agree!!

@reginanunley2099 2 года назад

@@jess5135 of course…these people are RU-vidrs, not our best friend or personal physician - many of the RU-vidrs use shortened or partial name- so??? Dr. Dray is really one of the best for skincare on RU-vid..try not to get off subject and enjoy the vids..

@cady4917 2 года назад

Thank you for keeping us up to date with the latest skincare news and providing educated commentary. Your channel is a wonderful resource. Thanks for all the work you do! Been tuning in for the last 4 years.

@DrDrayzday 2 года назад

Thanks for watching

@politicalpuppy17 2 года назад

@@DrDrayzday I've studied some statistics, so correlation v causation discussion is familiar. However, a use of non-prescription topical retinoids daily (partly also body) for a year and then unexplained liver issues (all kinds of tests done, no answer) made ne wonder a bit. Taking a break now but will consider continuing once well.

@vra735 2 года назад

This vid was very interesting. I use to work with clinical trials in cancer research and I think it is so important that people understand what a clinical trial is and how it works. Education empowers people. More please. Thanks for all the scientific time you give us and for your entertaining vlogs!

@chanimarie6753 2 года назад

The COVID vaccine is a clinical trial so we're all too familiar with clinical trial studies.

@aprildragas2807 2 года назад

Association is not causation. Yes. This phrase reminds me of an article I read that was titled Increased death and hypertension linked to napping during the day. Well everything I know about napping during the day previously had always suggested it was healthy. When I read the article, I learned that it’s not necessarily the napping causing high blood pressure and death, it’s the correlation between people napping during the day having poor sleep patterns at night, the nap itself was not the issue but the lifestyle link of people who need to nap during the day may not be getting enough sleep or adequate sleep at night.

@thisis.michelletorres444 2 года назад

The fundamental problem is obviously that the patients were already ill. If they were also smokers, which seems to be the case, I don't see how this study has much value. I think they need to follow healthy subjects and see if a pattern emerges. Considering how prolific use of Tretinoin is this is frustrating.

@meganNefarious 2 года назад

I wouldn't be frustrated... millions of people use tretinoin and have been for years.... If it was killing people...we would know lol..

@SueRosalie 2 года назад

yes, a pretty lousy study design if there was no proper control group.

@latinaalma1947 2 года назад

I have used Tretinoin for 20 yrs. Still alive at 74...I even have a ten year 3 packs a day cigarette history I am not proud of from age 20 to 30. Most everyone smoked then...I promised myself when I finished grad school I would stop and I used the psych techniques I had learned to get off cigarettes. Essentially I knew I had a behavior chain of how cigarette use was triggered in my life ie associations with other daily actions and habits : first cup of coffee light my first cigarette. Put the keys in the car ignition in the am headed to uni, push in the cigarette lighter, start the car light a cigarette and much of it was study related as well. I stopped cold turkey on a trip to a conference to present a paper. I realized I would be in a great city I wanted to see and EVERYTHING would be different including coffee with chicory at Cafe du Monde each morning...four days of New Orleans cured me...I got on the plane a nonsmoker for the rest of my life. I jokingly call it the N'Awlins cure. I am very thankful for Tretinoin...my skin is wonderful. I had some acne scars not deep, I had crows feet, my pores were enlarged but I now have very fine smooth skin on my face and neck and even backs of hands the age spots were gone in 6mos. I used to avoid upper eyelids, neck, above and underlip areas but worked into those as fine lines appeared by using moisturizer followed by every other night use slowly, gradually working up to every night following Dr. DRAYS advice!

@Represent252 Год назад

Good for you Sybil. I’m trying to quit now and it’s so hard😢

@madaleinemulrey8545 2 года назад

Thank you for clarifying this subject. As a veteran I receive my health care from the VA, and would never trust their doctors, or the results of any research they conduct. VA: Tretinoin causes cancer. Also VA: “It has never been shown that PTSD is relevant to the mission of the Veteran’s Administration” ( VA response to the PTSD study proposal submitted by Dr. Bessel Van Der Kolk MD. ) Dr. Van Der Kolk left the VA after his proposal was rejected, then went on to work for Harvard University’s Massachusetts Mental Health Center, and become a leading trauma expert. The VA still hasn’t gotten the memo. Enough said.

@jr-pr9lw 2 года назад

Thank you for your service.

@bradc304 2 года назад

I did not know that about Bessel. He is the world's leading trauma researcher. His book has been on the New York Times best seller list for many years.

@vetsai8199 2 года назад

My nephew was a combat medic in Afghanistan, and suffered a coma and PTSD as the result of being the sole survivor of an attack on the Humvee he was riding in. The VA is not at all doing a decent job of treating his headaches and PTSD. However, most psychologist/psychiatrist will NOT accept insurance, and their rates range from $300-500/hr! Who but a multi-millionaire can afford that?? The VA has my nephew drugged within an inch of his life!

@madaleinemulrey8545 2 года назад

@@silvereight6054 I’m happy to see that you are satisfied with the care your family members have received at the VA Healthcare System. That said, please understand that many veterans do not share this experience, which is why the *reported* veteran suicide rate is #22ADay. ( The reported rate is based on data provided by only 21 states, which do not include California, Illinois, New York, or Texas. The actual veteran suicide rate is estimated to be more than 60 per day.) My point being that in 1978 the VA was fortunate to have the doctor who would later become one of the leading trauma experts on the planet working for their agency, but as is typically the case with the best, and brightest doctors, the VA bureaucracy met his dedication with contempt. Even now, the VA bureaucracy refuses to implement Dr. Van Der Kolk’s treatment protocol, along with other options which are proven to be effective, to the detriment of many veterans suffering from PTSD. This is shameful, unacceptable, and a national disgrace. As Dr. Van Der Kolk stated on his website: “I currently treat only a few veterans and I am not intimately familiar with what is happening at the Veterans Administration. The VA is a pretty closed system-people who work at the VA rarely attend my workshops or lectures, or those of my close colleagues. I hear that their main focus is on cognitive behavioral treatments, and on desensitizing people to their memories. These treatments, research shows, are not particularly effective. That is not surprising, given that being traumatized is not an issue of faulty cognition-the problems emanate from parts of the brain that have little to do with cognition.”

@Damselfly54315 2 года назад

The VA has gotten a LOT wrong, we do not use the VA facilities, we have other Dr's, my brother in law does use the VA and they miss a LOT in his health, I had to tell him to get them to biopsy several spots on him that DID turn out to be skin cancers...but a retired Dermatologist also got one spot on me wrong too, I told her that this one spot bked a lot, she said I was just too rough on my skin, told her I really wasn't, finally went to a plastic surgeon who removed the spot on my face that ny gut told me was a problem, it came back to be cancerous, so can't say it's just the VA in things...some Dr's just assume too much and DO NOT listen to the patient...and that seems to be getting worse across the board even more so recently...I've use Retin-A a long time, and even though I do smoke its not had any bad affect with me, granted I don't smoke a lot, but its still never affected me, my lungs are very good...I dont drink, or take a ton of prescription drugs and I think they over look the 2 combined factors that smoking AND drinking have greater incidents of lung cancer, or smoking and opioid uses also seem to be more causation in lung cancers...smoking is NOT good for ur lungs but its not the main cause of lung cancers in my age group of 60+ to 75 years old group, I've paid attention to ppl who DID get lung cancer and in that group of ppl it was smoking plus alcohol use at a very high rate... I dont trust VA studies, I know of one person who was in some sort of trials thru the military of experiments that has become psychotic, hes young and the tests caused him to be mentally ill, he thinks the military/government is bugging his phone, his walls have cameras in them, but it was only after he was in an experiment group of late 20's ppl who now have mental illnesses due to that study...my favorite family Dr was retired military, so its not the Drs per say just the more link of the Dr's NOW not truly listening to patients concerns...

@kelleycranny3972 2 года назад

I've been using Retin -A since the age of 13. I'm now 53. So glad I've continued using it all these years. Definitely has kept my skin looking young! But of course I have always been an avid sunscreen user which also has helped!

@algernon2005 2 года назад

Wow, lucky you. I can imagine your skin looks amazing.

@Roll587 2 года назад

I WISH I were in the same boat!

@kelleycranny3972 2 года назад

I only stopped use during my pregnancies. It's never too late to start! My daughter is 30 and just started to use tretinoin through Curology.

@lukasdevries 2 года назад

wish i could do the same but my dermatologist doesn’t want to prescribe it to me :(

@saymabinteali5772 2 года назад

@kelley cranny, when did you stop using it? And when did you start to reuse it again? I am really curious about this topic but I don’t know anyone who has done it. I have started using it for a month and if everything is fine then I will continue it. One thing that concerns me is how will I use it after getting married/pregnant. When will I stop using it before getting pregnant and when will I be able to reuse it again?😥🧡

@MT-yx5cu 2 года назад

I am a veteran. The VA healthcare system been under scrutiny for years. They are being extra careful and proactive now to restore veteran's trust so I would definitely take these findings seriously.

@gabrielleg.1347 Год назад

They have been under scrutiny for years now for what? Can you please explain your comment more? I believe this study was done in 2009.

@kaede7876 2 года назад

I feel so comforted watching your videos Dr. I am not able to book a check-up with my dermatologist all that often because she is always so booked and the US is just like that... so whenever I have concerns I know you have made a video on it. Your videos empower me to be able to explain skincare to my friends/ family that don't see the purpose of it or understand it. Thank you so much for being such a source of knowledge!

@waljoal 2 года назад

Could you please do a video on the correlation between Retin A/retinoid/retinol use and meibomian gland dysfunction. Studies have shown that it damages those glands which are crucial for providing the lipid layer of our tears. (Studies have also shown that Accutane damages not only the meibomian glands but also negatively affects the mucin layer, tear osmolarity, as well as the ocular surface. This damage often shows up years after having discontinued it’s use.) Thanks!

@rebecastevens8892 2 года назад

My skin loves Tretinoin. I’ve been using almost a year, and my skin is so much smoother and with less sun damage. It’s even slightly less oily; it’s a game changer. Once you go Tretinoin you don’t go back! It’s truly a great drug.

@cheekymonkeygirl3378 2 года назад

Same here. My skin is glowing. 🐭

@jkdecalcomania1079 2 года назад

Does it work for the appearance of pores?

@princessamal5959 2 года назад

Am using a month now my acne is almost gone but at night am feeling burning and my pores look visible

@vevera3876 2 года назад

@@princessamal5959 hang in there and keep going

@megandavis7357 2 года назад

Same for me! I have very sensitive skin so it was very slow going for me at first. Took almost three months to be able to use it nightly without redness and peeling skin. Since then it’s been great and my skin looks amazing! Well worth the painful/ slow beginning. :))

@lorim521 2 года назад

This ties into my recent question for you, Dr. Dray! “The absorption through the skin is negligible”, so why is it so controversial in pregnancy and nursing? I know that it’s not been studied but some research has shown it is not harmful during pregnancy. I wish there was more discussion about this for women that are struggling with acne

@DomesticHausWitch 2 года назад

Many women use bio oil for stretch marks during pregnancy but it has retinol in it

@tristantries9211 2 года назад

Yes I stopped using all differin or vit A during pregnancy because it's cited as being dangerous and now idk about breastfeeding

@Opalescenttreeshark 2 года назад

It’s because it’s a class c drug: no animal studies have shown harm to a fetus however there haven’t been any well-controlled studies actually done on pregnant women to prove it’s for sure safe. Typically class c drugs are given to pregnant women if the benefit outweighs the risk. I suppose in this case they don’t assume controlling acne is enough of a benefit to justify the potential risk.

@bitterangels4001 2 года назад

@@tristantries9211 I firmly believe breastfeeding is *alot* more healthy than any formulas

@heybearnation 2 года назад

I literally just asked this lol I can't help but believe it's just super extra precautions that are unnecessary Lots of things are considered dangerous when pregnant yet women do them for months because they don't even know they're pregnant or know that they're unsafe and the babies end up perfectly fine Imo, it's like helicopter parenting but for pregnancy

@virginiavidacak5475 2 года назад

As an esthetician, content like this is so beneficial for those of us seeking continuing education. Thank you.

@SunnyCarnivore 2 года назад

I am a veteran and lost my job during the 2008 economic crash so i lost my health care benefits and had to go to the VA for the first time, i was in my fifties. After 8 months of being enrolled i had 2 upper respiratory infections that they refused to give me antibiotics for even though i went back several times, each time until i was so sick that both times they told me to go to the ER; makes no sense. At this point they took me off of all medications that i had been on for decades cold turkey which caused so many other issues; i became very ill and ended up in the ER several times with high blood pressure stroke alerts. They also thought i had reproductive cancer so i had a surgery to take it all out but there was not a thing wrong and than they refused all hormone treatment except estrogen only which is dangerous. So i would not take anything the VA has to say seriously; they do not like to give medications and i feel come up with "studies" they have done with ridiculous results to back themselves up because every time i challenged them that is exactly what they did, recite some ridiculous study that they did that makes no sense at all. I had to go to a civilian doctor and pay out of pocket to get proper care. I have been on retin a for over 30 years and i am just fine. Do not take the VA seriously; they do not know what they are doing from my experience with them.

@praguhbis 2 года назад

I started using Tretinoin 0.25 for acne in 2009. However, these days, I am nearing 50 now. I get red splotches on my face. So I don't use it anymore. I use Olay and other creams. I had a pretty smooth forehead despite a high-tension job. After Mom passed away in 2020, forehead lines started appearing pretty fast - almost overnight, and even my hair started growing white and losing hair. I am still mourning her.

@Minty.cat. Год назад

Sorry for your loss! I know how hard it is to bury your loved ones. It's something that changes you completely.

@dariovariodinx Год назад

Very aorry

@anitapiotrowski7513 Год назад

Loosing a parent is hard sorry for your loss

@dunndiddeli2067 Год назад

❤

@anitapiotrowski7513 Год назад

Sorry for your loss. My mom passed 2019 brother 2020. It’s tough !

@gloriamartinez2535 2 года назад

Dr. Dray. I have been taken Beta-Carotene since I was a teenager. No problems. Very very healthy I have been using retinA for over 20 years now. No problem. I have very nice complexion. I keep getting compliments on my skin. I am a person. Never have smoked. So I will continue to do what I have been doing. Thank you for a great very informative video.

@AmeliaLidstrom 2 года назад

lol I love how you go "I am a person." full sentence as if we may need to be concerned you are something else

@MFreedoom 2 года назад

I'm glad you are a person haha.

@gloriamartinez2535 2 года назад

@@AmeliaLidstrom Sorry. YES I am a person and as such make mistakes especially when typing. Glad you are so especial. You are not a person I assume. What are you? I am a person that view others as persons.

@gypsya1915 2 года назад

You are weird Gloria floria

@AmeliaLidstrom 2 года назад

@@gloriamartinez2535 it wasn't a hate comment it was something for us to enjoy, a smile or a laugh. I thought you might find it funny too. because it was great

@SueRosalie 2 года назад

Yep tretinoin has a ton of solid data for safety and efficacy for anti-ageing. Dermatologist Dr Natalia Spierings' mother has been using it nightly for 40 years and has fantastic skin. She got onto it on the advice of her husband who is a neurologist.

@maryastark8075 2 года назад

Due to the advanced ages of the study participants it brings to mind "agent orange". There is a severe form of adult acne that so many of our veterans were stricken with. Along with lung cancer and damage to many other body systems. I cannot fathom why veterans in this age group would be chosen for a tretinoin study. Seems rather strange.

@codiannsmith Год назад

That's a really good point! hmm...

@monicasharma8160 Год назад

I developed severe hip and lower back pain this month. Been using medik8 retinal. By chance happened to come across a video where many developed these symptoms including head aches. I immediately stopped the cream and my hip and back pain have almost gone now !! Wow. So lucky I found this out !!

@elenbrandt290 2 года назад

As always...you are the reality check and fountain of information! THANKS!

@ginnygeiken2625 2 года назад

I have been using Retin A 0.1% every day for 25 years, and I’m in perfect health!

@MT-yx5cu 2 года назад

Check your liver enzymes

@d.n.8919 7 месяцев назад

@@MT-yx5cuif it’s been 25 years I’d be seriously surprised if she’s had an issue with that that went unnoticed

@dinahweisberg750 2 года назад

Thank you for this amazingly educational video! I've been using Retin-A since I was 18 due to acne. I'm now 58. It is the most effective anti-wrinkle and anti-rosacea treatment I could possibly use, according to my Derm. My skin looks like that of a 35 year old. I won't stop until/unless I absolutely have to.

@joannaw1164 2 года назад

Thank you for informing me Retina A is anti rosacia, since I'm having a flare-up after many years of not!

@tomasgarcia7499 2 года назад

Ok it’s cool to see someone else mention Retin-A helps with Rosacea because I swear it’s making my redness slowly going away.

@aaliyahkhilchi8886 11 месяцев назад

I have very bad skin condition so thinking to using retinol but how long should I spouse what should I do during pregnancy time

@user-fg1vp3se8f 7 месяцев назад

How did you managed during pregnancy then??

@gemmarium4337 2 года назад

I love you Dr. Dray! You’re the only person online I listen to about skin care!

@DrDrayzday 2 года назад

Thanks!

@matthewirwin1112 2 года назад

I love these type of videos a lot. Breaking down the literature and bringing nuance to otherwise scary information.

@stephanienewton6618 Год назад

I tolerated tretinoin in my 20s and 30s. But now in my 40s I get severe body aches every time I use even a small amount. I may try a retinol one day but I’m kind of scared to. I don’t smoke.

@SueRosalie Год назад

it's not causing your body aches - go see a doctor

@stephanienewton6618 Год назад

@@SueRosalie every time I quit using it I’m back to feeling normal. I don’t need a doc to tell me to stop using it 🤣

@beyond50skin 2 года назад

I love these quick clarification videos regarding one off studies and their implications

@riariaria 2 года назад

I’ve read that smoking, lung cancer and vitamin C (another antioxidant) has unexpectedly also been shown in SOME studies to worsen outcomes for lung cancer patients. These studies sometimes conflict and I wonder if generally the role of antioxidant’s in potentially exasperating lung cancers is something that we have yet to fully understand.

@JEESSZZOO1 2 года назад

& I have heard the opposite--of the BENEFITS of C on lung ca

@riariaria 2 года назад

@@JEESSZZOO1 According to a Cochrane Review “Vitamin C likely results in little to no difference in lung cancer incidence (RR 1.29, 95% CI 0.67 to 2.49; 2 RCTs, 14953 participants; moderate-certainty evidence). In women, vitamin C increases the risk of lung cancer incidence (RR 1.84, 95% CI 1.14 to 2.95; 1 RCT, 7627 participants; high-certainty evidence). In men, vitamin C results in little to no difference in mortality for lung cancer (RR 0.81, 95% CI 0.53 to 1.23; 1 RCT, 7326 participants; high-certainty evidence).” The specifics can be found on PubMed

@JEESSZZOO1 2 года назад

@@riariaria while I used to hold SACRED The Cochrane Collaboration, ever since Gates' "donation" of $1,000,000 & the firing of their initial founders in order to rec' a favorable review of his HPV vax (which was later refuted by a Cochrane orig) I do not hold them in the same esteem I once did. Same for most of the very biased clinical trials who pay other dr friends for favorable review. It's become a very difficult job to wade thru & find ANY clinical studies (esp as it pertains to the current vax being shoved down our throats/bodies). that are honest. But TY for the f/u

@XYZOxyz 2 года назад

I've heard that but C in very large doses literally cures cancer

@aliasrose 2 года назад

I heard of the study that said vitamin E increases risk of lung cancer in smokers. The possible theory to explain this was that smoking damages cells and their dna over the years, and damaged cells are often programed to die, apoptosis. The antioxidants may repair the damage just enough to prevent apoptosis, but the DNA is still damaged and a those damaged cell have a higher chance of developing into cancer. Basically, antioxidants may save a cell that should've died. That is a logical possibility. With regard to current cancer patients getting chemo, antioxidants may interfere with the ability of the ability of the chemo, a poison, to kill the cancer cells. It may rescue them from death in a similar way.

@mom4life513 2 года назад

Thank you for all this free advice You are helping millions. You've helped me save so much money. Your the only honest Dermatologist out there. Thank you for your time. Your the best

@barbarabraue4087 2 года назад

Thank God, because I have been using it for a few years now. I’m not a smoker. Thank you Dr Dray for bringing this to our attention.

@chaseypoo17 2 года назад

I recently started putting tretinoin on my neck and am lucky to have had no side effects or irritation 😎

@jaywellington6504 2 года назад

Great detective and research work. This is what makes this channel extraordinary.

@I_am_Musiq94 2 года назад

I started tretinoin at 23 because my face was horrible and benzoyl peroxide/salicylic acid did nothing for my skin except burn it…did the tretinoin and sulphur soap with aczone up until 28 and dumb me thought “I’ve been on this stuff for years, I should start weening myself off of it, maybe I’m out of the acne phase”…WRONG WRONG WRONG. Within 2 months my face started breaking out again, like everyday 3 new pimples popped up, I got back on those meds so fast..it’s been 4 months since I stopped and started again and my skin has finally started easing up on breaking out. My skin had to basically start over getting use to the meds. To the point my skin hurt and was really dry… I may eventually stop using aczone but I will never stop using tretinoin

@TheRaveyBabyy Год назад

Same my skin is terrible worst than before

@melissabaez5300 2 года назад

I’m just curious. You mentioned the absorption from retinA into the body is negligible. How come this is then not taken into account when pregnant? I know of the studies that show birth defects with medication of Accutane. But if the absorption is so minimum that it doesn’t matter, then why can’t pregnant females use topical tretinoin.

@newt702 2 года назад

I would love to know the answer to this

@db-gb5xi 2 года назад

From what I've read it's strictly due to being cautious.

@Jojorocks23 2 года назад

Studies are avoided on pregnant woman. Too risky during the 1-2 trimester. Surprises me pregnant woman took the jab. Minimal absorption but didn’t mention cumulative effect? As well, there was a study that mentioned IBS and Crohn’s Disease were worsen with Retin A decades ago which is hard to find. More study is needed. When we like something we tend to ignore any debate on it.😢

@piedpiper1201 2 года назад

just because you become pregnant stopping for a few months doesnt mean you havnt already stored from the years using it, they dont allow anything when pregnant as they dont want to get sued for a million possible things that can go wrong

@euphrasiepolly5575 2 года назад

bc not a lot of pregnant people would volunteer for an experiment which could lead the fetus to be deformed or miscarried. It may be completely safe to use tret while pregnant but you just wouldn't know for sure bc there are no experiments/ researches for it. That's why physicians just play it safe bc the benefits of avoiding it outweighs the risks.

@47bigcadillac 9 месяцев назад

Here is a tip from someone who has been using RetinA 0.05% for the last 40 years on his face ..wear nitrile gloves when you apply and massage the creme ! because the skin on your finger tip absorbs about as much as the skin on your face, so you waste 50% of that precious tube into your finger..also reduces overall systemic absorption. Buy nitrile gloves one size larger and you can re-use the same glove many times.

@bellebb8673 2 года назад

This was so informative. Even beyond the specific topic, I just really enjoy hearing a clear scientific discussion of research. I enjoyed science in school but have not used it much in my career, except for some statistics. It's interesting to hear this kind of methodical analysis. P.S. I have been using Retin A for five years now, and my skin looks younger than when I STARTED. Honestly, at my age pushing 70, I don't think I'd stop even if there was a proven slight risk of earlier death. Emphasis on the "slight", but still....

@rebeccatrono3376 2 года назад

The question of liver impact has kept me from using it. That, and the fact that pregnant women are advised against using it. The liver issue isn't spoken about, so I'm excited to have it addressed, because I would like to use it myself.

@bogarttamboritik6213 2 года назад

Tretinoin is the generic name of vitamin A...and you used it topically, therefore i should say it is safe and effective even if let us just say the skin absorbed it...after all we do need vitamin A...

@jessicamiller6145 2 года назад

I used this and loved it, until it sent my liver enzymes up. I don't drink. I stopped using the cream and my liver enzymes went down immediately.

@martying94 Год назад

does anyone know more about it? I have some liver issues, although I don't drink and have a healthy lifestyle, but I'd like to know more about it

@byzantineladybug9471 2 года назад

Veterans are exposed to conditions that are unique to veterans and these conditions often increase veterans health risks (ie burn pits, agent orange, chemicals etc.). Add to that tremendous stress, sleep disruption, questionable food quality--all of these factors increase the health risks to veterans.

@mystictitaness 2 года назад

💯 this

@skincarelover9568 2 года назад

Thank you Dr Dray!! I got scared at first I have been using retin a for 15 years 🙌🏼🙌🏼

@exoticspeedefy7916 2 месяца назад

Doctor here. Some, people have reported altered liver enzyme levels outside normal range due to long term Tretinoin use though, and we know Vitamin A is toxic in high dosage. I am still not convinced it is good to use long term or as an anti-aging alternative.

@melissasaal8577 2 года назад

Dr Dray! Can you do a video on different Stimulant medications and hair loss (ritalin,adderall, medikinet etc ). Seems to be a rare side effect that is not uaually reported and or brushed away even though some people are experiencing this. It isnt talked of enough and there are only few case studies on this

@marylawman8603 2 года назад

I knew you'd set the record straight on this. Thank you so much for the information and for always giving us the actual facts. You're the best! Happy Tuesday, Dr Dray!! I hope you have a beautiful evening. 💚

@KimberleySanchez 2 года назад

Thank you for always presenting such valuable info - you rock!

@Hello_Pri 2 года назад

Thanks for always providing such great information on skincare/dermatology. Your channel is a wonderful resource. I watch often!

@bettycesky4947 2 года назад

You are The Best! Thank you so much. You are ALWAYS informative.

@booksarediamonds Год назад

Say what you want tret can be scary I got a weird feeling in my lungs whenever I woke up.

@SueRosalie Год назад

that's in your head

@jennrangi 2 года назад

Hi Dr Dray! like others, i’ve also heard that tret can cause dry eyes and would also like if you could talk about that as well and the studies behind it

@meganNefarious 2 года назад

She has talked about this many times....She says yes, tret too close to the eyes can potentially cause dry eye...but I use it on my eyes with no problems.. If you can tolerate it, it's fine...but if not, just don't bring it up too close to your eyes..

@cynthiah1298 2 года назад

I would like to see her address MGD eye dry eyes and effects of retin A

@jennrangi 2 года назад

@@meganNefarious do you know if there’s a video where she talks in-depth about it?

@meganNefarious 2 года назад

@@jennrangi If you go to her page and type tretinoin dry eyes into her search bar a coupe videos pop up...She has mentioned it in a ton of videos but hopefully one of those two will answer some of your questions..

@db-gb5xi 2 года назад

I'd check eye channels for this as well since some of them have videos covering this, Dr. Rupa Wong, Eye School with Dr. D, Eye Channel by Eye Surgeon Dr Audrey Tai, The Eye Surgeon, etc.

@debrakirkley4590 2 года назад

As always a very informative video. The beginning of the video really had me scared. You're so appreciated. Thanks, Love ♥️

@zaykiaabdul6825 2 года назад

This is what cleared my skin it sauced my life

@Ohkeh640 Год назад

What % how often are you using it? What cleanser and moisturiser

@KB-sz9lu 10 месяцев назад

I used tretinoin after i got severe acne on my shoulder after Dermatologist prescription and I never used it on my face even after 3 months of use I didnt see any improvement and I stopped using after the Dermatologist recommendation and after 7 months I got diagnosed with severe Ulcerative Colitis without family history or and early symptoms and my Gastroentologist confirmed me that Tretioin caused the UC ! What a terrible mistake just one cream made life upside down !

@WiseFamin 2 года назад

Thanks for doing this informative video! It was definitely something I was wondering about. As always, appreciate the bibliography. Until now though, I hadn't realized the VA study was more than 10 years old!

@bonnetbasketful9362 2 года назад

Wow, Dr Gray's skin is flawless and glowing like never before.😍

@ledzungkennedy3022 2 года назад

Thank you Dr Dray. You’re a great person. I’m wishing all the best .

@silogreen3367 10 месяцев назад

I am 21 years old and I started using tretinoin for about a month and a half. During that month, I began noticing chest pain, heart pains, stomach pains, difficulty breathing as I tied to fall asleep and an increase in anxiety. These side effects are REAL and no one talks about them. If you simply look up Tretinoin next to any of these conditions you will find article after article stating that it is in fact true, but these dermatologists never talk about these possible issues. Please do your research before starting tretinoin, I have completely stopped using it for three days and the pain that I was feeling daily is completely gone now. Do your research!

@Happy67986 7 месяцев назад

Your Right.. yesterday I used tretinoin cream I couldn't sleep whole night and chest pain

@Happy67986 7 месяцев назад

After that did you continue tretinoin cream ?

@Happy67986 7 месяцев назад

Please reply

@ruyabaraz 7 месяцев назад

If you look closely, all those articles are talking about oral versions of tretinoin. Not topical. And only about 1-2% is absorbed into the body when you use it topically.

@theresahenderson3534 7 месяцев назад

@@ruyabaraz Your skin is an organ and absorbs chemicals easily if it's topical.

@HeatherAnne Год назад

If the mean age was 71, those are Vietnam vets who were most likely exposed to agent orange. My dad died at sixty-four because of long-term issues with agent orange exposure. My sister and I have health issues because we are agent orange kids. Any study on Vietnam vets has to take that into consideration. A lot of them also smoked back then.

@messianic_scam Год назад

what is agent orange?!

@HeatherAnne Год назад

@messianic scam It was an herbicide used during the Vietnam War to kill the plants in the jungle because the Viet Cong hid there. It was extremely toxic and many if not most Vietnam veterans were exposed to it. Vietnam vets are in their 70s now but for decades many of them and their kids (like me) have suffered chronic illness due to Agent Orange. They're getting weird cancers and a long list of other issues. My dad died at 64 from his long term injuries all the way back to the Vietnam War. He suffered for a long time. The government fully admits this and offers them medical care but it's not enough.

@HighPriestess_Archive 2 месяца назад

@@HeatherAnnewow I’ve never heard of that either but it makes complete sense. Prayers & Love to you and your Family ❤️❤️🙏

@HeatherAnne 2 месяца назад

@@HighPriestess_Archive thank you

@Duchess-of-Camelot 4 месяца назад

I don't know about death but I can attest to it bringing on a Lupus flare every time I use it.

@margieryne6220 2 года назад

Thank you for the information that you give us, you’re very knowledgeable! TFS!🥰

@RM-ud9tf 2 года назад

Thank you, Dr. Dray! Very informative, and fascinating topic today! We all appreciate what you do for your skin care community followers. See you tomorrow !

@sonosource4811 2 года назад

I’ve been using Retin A for 20 years, twice a week, .1%. Started out at .05% and gradually worked my way up to .1%. At 62 years of age now, no wrinkles. This has been my fountain of youth. You MUST wear sunscreen. I always get remarks about my skin, and I tell everyone “Retin A and sunscreen, and if you can swing it also wear a SPF hat”. UV is your enemy.

@Damselfly54315 2 года назад

A lot of sun damage happens in childhood thru young adult years that comes out later in life, its also vital to sunscreen KIDS! TEACH them early to not get sunburn after sunburn

@jinanzeidan3271 2 года назад

@@Sh-bb7tp at first yes, but make sure not to place it close to your eyes. Always on the bone around your eyes not closer. And use the Eye drops, that would help a lot. Its been almost 10 months since I started using tretinoin, I faced this. Just,keep it away from your eyes/ use eye drops and you will be fine 🙂

@aqilahtaufik5922 2 года назад

how badly i want to see your face right now, i wish it could motivate me to stay consistent with tret. and im the one who always to avoid sunscreen. my laziness is urgh. anyway, thanks for your review, it really motivate me to wear sunscreen now

@mayitbe6606 2 года назад

wow, you didn't have wrinkles at 40? I had wrinkles at my late twenties.

@aqilahtaufik5922 2 года назад

@@mayitbe6606 ITS A SIGN YOU SHOULD START UR TRET :) SENDING ALL THE FAITH AND LOVE TO YOU

@francescafrancesca9872 2 года назад

Thank you for this information. You are amazingly informative and you don't cherry pick studies to try to prove yourself or constantly sell something with your studies and points you prove.. Straight education...you're awesome. ❤💯

@user-EinsteinSarge 2 года назад

Thank you Dr. Dray - have a great day!

@rimelzargouni 2 года назад

Excited to watch! Have a great day☀️💗

@DrDrayzday 2 года назад

Thanks for watching

@lunarctiica1696 2 года назад

I‘d love to hear your opinion on the cancer increasing sunscreen studies too!

@SueRosalie Год назад

those are false too, I think she does have a video on that

@shelahansuriza9463 2 года назад

Hi, your very informative and thorough. You brought up some key points regarding long term use which is pertinent. I especially enjoyed your walk through the park vlog. Beautiful park it looked so pristine. I believe our skin benefits greatly from trees, flowers and fauna. We share breath with Forested environments. Thank you Dr. Dray

@catpoofy 2 года назад

What is your thoughts on titanium dioxide? It is currently an ingredient that has skittles in a nasty lawsuit because its links to cancer. It is an ingredient in many skincare and makeup products. Even some of my high end products have it listed in ingredient lists.

@kittycat8222 2 года назад

It’s on all children’s temporary tattoos too. 😩

@fro3tbite_cactusv273 Год назад

Everything must be logical but my personal experience , everytime I use retinol or tretionoini get horrible uti then i stop using it and uti disappears.i use it once every four days

@PT-tw6kg 2 года назад

I've been using retin a for 40 yrs from 28yrs old until now at 68 yrs old.

@AmeliaLidstrom 2 года назад

did you experience the "retinol uglies" or did you get your skin used to it over time by starting with a lower concentration, then going to higher? how much time do you spend outdoors, and has it ever been an issue even with SPF? I'm going to start tretinoin soon (age 30) and I'm an outdoors lover, and recently I got a retinol burn even while wearing sunscreen and I'm just nervous!!!

@Lizzytrixx 2 года назад

I’m so glad this video popped up on my feed 😃 Thanks for sharing!

@DrDrayzday 2 года назад

You are so welcome!

@PamperedWife 2 года назад

Geez. I had never heard about the study but you can probably find a correlation between anything and death!

@Sunnysideup01 Год назад

I had the worst experience!!! 2 weeks in of starting it .05 % I developed the worst panic disorder, insomnia , breathing problems etc …very scary !!!!

@elenora67 10 месяцев назад

Hi , did it get better when you stopped?

@a.e2385 9 месяцев назад

Dr Dray wont say a negative thing about Retin A it seems because she love this stuff too much, i cant take her seriously anymore i have read alot of negative experiences witg retin a but he will never adress them.

@Deb888-8 2 года назад

Thank you Andrea for your info ,I ve been using Stevie A 0.05 for about 3.5 yrs now.Was using it daily but I cut back to a couple of times a week as I had a beautician tell me I should nt be using it for so long and thats why my skin was so bad.I m nearly 59 and most of my life I lived in the sun,tanning etc with no sunscrean, as it was nt talked about back in the day.However I was always told how good my skin was.An my 50 s I started peri menapause and also 54 I had a major trauma to which I suffer PTSDand a lot of anger and anxiety to which I was constantly waking most of the night to severe nightmares,it was then I noticed my skin getting worse, since starting to use retin A I noticed my skin looking better and neither using retin A or the incident has killed me yet 🙂🙂

@laarniecuizon8287 2 года назад

Very informative Dr Dray! Thank you for this. Really appreciate it. ❤️❤️❤️

@phuonglam3246 2 года назад

Dr Dray is a Godsend ! Thank you Dr Dray !

@taylorlinnan 2 года назад

I’ve lost a lot of trust in the dermatology and aesthetics industry and I’ve started not trusting her as well. When she endorsed fillers as being a safe solution to specific problems that’s when I started suspecting she may not be as informed as I thought. Fillers never fully dissolve btw and can cause major issues.

@Shqipegrl 2 года назад

My guess is she meant fillers are safer than going under the knife? Lesser of two evils kind of thing.

@GetWellSoonR.E.M. Год назад

Fillers ARE SAFE if injected correctly. They do carry a risk if injected incorrectly. Please don’t spread misinformation and fear monger.

@SueRosalie Год назад

they are safe and you should also follow Dr Natalia Spierings as well as Dr Dray

@nickyb932 Год назад

if you’re gonna make a ridiculous claim like that you should probably leave your credentials in the comments.

@farahnafiz3019 2 года назад

Wonderful content Dr. Dray! Thank you for making time to create such educational content ❤️. I have a request though, could you make a video on pregnant women with psoriatic arthritis? I recently got pregnant, I live in Bangladesh where medical help is not that advanced. I am panicking :( . Will I be okay?

@lienemeid 2 года назад

Thank you so much!! I asked about this the other day, very grateful!

@cooperwoodard 2 года назад

Thank you for breaking this down!! Your advice has completely changed my skin x

@maribon6740 2 года назад

Hi Dr Dray! Thank you for all your useful information. I had a question re: sunscreen. Does using blotting paper to control oiliness after chemical sunscreen application reduce the effectiveness of chemical sunscreens? I am really struggling to find an affordable yet cosmetically appealing sunscreen in Europe. Thank you! 😊

@Nadia-wb3zu 2 года назад

Summary : Tretinoin is safe and won’t kill you. You’re welcome

@lanaalshehri9032 2 года назад

Thank you!

@alinasheikh8804 11 месяцев назад

Please reply can it cause skin cancer and lung cancer because I want to use it for life time but after reading the article I am scared please reply

@alinasheikh8804 11 месяцев назад

Long term of 0.1 is safe for life time I have milia all over my face I use it for milia and White head

@taishasharee4433 10 месяцев назад

❤

@sevothtartesama18 2 года назад

Thank you so much for reading comments and doing this video! ❤️

@haylee_xx 2 года назад

i recently saw a tiktok from a derm that said that tretinoin can cause premature aging if used everyday because of constant skin inflammation, is that true?

@saraaaa466 2 года назад

...no wth😭. that is simply incorrect BECAUSE it doesn't cause skin inflammation everyday. Only for the first couple weeks or so. if you use it correctly, it'll cause miracles.

@NicePerson58 2 года назад

Check the background of the derm. Perhaps they have skincare lines.

@haylee_xx 2 года назад

@@NicePerson58 ur a genius, she has a skincare line

@PedroHenrique-ev9ol 2 года назад

If your skin can't acclamate to it, it can be true. inflammation of any kind is pro aging. So a believe using too much of a strength is not for everyone. Studies says that 0.025 have same benefits than higher concentrations without as much inflammation.

@hi-ve1cw 2 года назад

You shouldn't use tretinoin every day anyway, it's too harsh. I started with once a week, built up to twice a week, and now do every other day and am keeping it at that

@susanvee1 2 года назад

Well I'm not a smoker but I've used Tret .10% for 28 years. I guess I'll see what happens! I'm not going to stop using it now.

@newt702 2 года назад

Reading that u used it for 28 yrs I immediately looked at your profile picture. As expected, your skin looks amazing!

@susanvee1 2 года назад

@@newt702 thank you very much!

@KEIHFR 2 года назад

I've been using tretinoin for more than 5 years. I knew that something couldn't be right with that study.

@danielegagnon7920 2 года назад

Thank you for sharing this information with us! Always interesting to know the scientific studies about skin products!

@kathleenhannon7068 2 года назад

Thank you Dr Dray. I love your channel!! Very professional & informative.

@lordmoy666 2 года назад

Can you do a video on how to properly read trusted studies? We are not taught on how to properly analyze studies so the media or companies just throw the word "studies " around and cite poorly conducted studies, and we become easily fooled. What should we look for in studies and what are some red flags in deeply biased studies

@nhisnewemailful 2 года назад

Sample size, how recent the study was, how inclusive or exclusive the process was of picking participants, deviation of changes in control groups 🤔

@nhisnewemailful 2 года назад

I would love her input on this, you're spot on that it would be helpful.

@yogagirl2807 2 года назад

Helpful also to find out who sponsored (paid for) any study.

@db-gb5xi 2 года назад

@@silvereight6054 Lab Muffin mentioned something like that on one of her platforms. She said it's very frustrating when studies get misinterpreted/misrepresented to the public whether it's by the media or folks who have an axe to grind and then you have to swim up stream to try and undo the damage, see EWG.

@SueRosalie 2 года назад

go and do 3 years of statistics and research methods at university. You can't teach yourself that overnight. And then you need to understand why peer review is necessary. Everything is science is a specialization. The main concern is studies conducted by Big Skincare themselves twist and conflate the results with marketing spin in order to promote their products. And they use a small number of subjects and rely a lot of self reports; and subjective opinions not things like biopsies done in a clinic. They are doing the research not in order to inform science but in order to market their product and mislead the public.

@glgl1472 2 года назад

I've been using tretinoin 0.1 mg for 40 years I'm 64 the oldest anyone has ever guessed me at is 50 and that's only recently. I've done a lot of other treatments over the years and I believe that retin a and Botox are the best anti-aging treatments. I've always wondered if Botox will rear his head as some other cancer-causing or other onto word cuz so many people use it.

@SueRosalie Год назад

the safety of botox has also been established

@kurtmarais1576 2 года назад

I appreciate your content so so much Dr Dray. Thank you so much from beautiful South Africa 🌷🌷

@Lisa-yn5du Год назад

I took tretinoin 2 times, a few months in between and for just 1 week. Shortly after, I got a high fever and bad flu symptoms. Even nausea came up. Is this my liver not being able to handle it? It happened both times for me.

@lifestyle_kd1238 Год назад

Can you also talk about its impact on menstrual cycle? Ever since I started using Tret, I have seen that my period is irregular (which was never the case before using it)

@SueRosalie Год назад

not linked. There is no biological mechanism by which it can disrupt your cycle. People need to stop conflating things that are not related.

@sallyolbrys8633 2 года назад

Dr Drey. I've been following you for a while a few years ago my neck started aging prematurely.. I started using retinol nightly and after 2 months I was able to reverse the aging,, however recently I had to have eye surgery, for a retinal tear and during my research for a proper recovery I found that retinols can cause problems with your tear ducts, I was wondering if you could do a video and educate people on what would be a good alternative if you're predisposition to eye disease to use for sun damage skin other than retinol. Thank you for educating us on skin care.

@madaleinemulrey8545 2 года назад

I had no idea that this is a potential side effect of retinol. Thank you for sharing this information!

@sallyolbrys8633 2 года назад

@@madaleinemulrey8545 ,, unfortunately I disease runs in my family I really didn't pay much attention to it until it happened to me.. but yes it's good information to know and I no longer use any retinols

@moideenfawaz5754 5 месяцев назад

Hey what eye surgery? I didn’t reallt get you . I have done lasik and i use tretioin on my face not on eyes but on dark circles area so your saying tretioin affect eyes??? Kindly replyyy i beg you

@AbbeyYung 2 года назад

Awesome video! Thanks as always for keeping things calm & logical Dr Dray 😊

@DrDrayzday 2 года назад

Thanks for watching!

@Autumn567 2 года назад

Thank you dr dray🙏🏻 would love to get an explanation about tretnoin and retinal percentages equivalence

@SueRosalie Год назад

there are no retinol equivalents to retinoic acid - don't waste your money on cosmetics

@lanasnow7787 2 года назад

Ok so the question is we know that medication gets absorbed through the skin ... will prolonged use of tretinoids cause liver damage ?

@Kelly-pp1et 3 месяца назад

Duh. Of course don’t expect from dermatologists to hear the truth

@cheryltucker1123 2 года назад

I have tried using retina A several times over the years and always after a couple of weeks using it as recommended I become very depressed. About a week after stopping it goes away. I don’t know if there is a relationship but I have read it could be a side effect. Have you heard of this? Thank you!

@Tof235 2 года назад

During which phase of your cycle do you use it, have you noticed? Or is it throughout the month? Also, do you take any other medication it might interact with?

@SueRosalie Год назад

it's not linked to mood swings

@julienigh5992 2 года назад

Thank you Dr Dray! I can always count on you for informative fun content! please never stop!