Updates in Primary Myelofibrosis with Dr. Ayalew Tefferi

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In this episode, we discuss updates in primary myelofibrosis with Dr. Ayalew Tefferi from the Mayo Clinic. Here are the key studies we discussed:
1. GIPSS: Genetically inspired prognostic scoring system that is exclusively based on genetic markers.
www.nature.com...
2. MIPSS70+ Version 2.0: Mutation and Karyotype-Enhanced International Prognostic Scoring System for Primary Myelofibrosis
ascopubs.org/d...
3. TRANSFORM-1: A Randomized, Double-Blind, Placebo-Controlled, Multicenter, International Phase 3 Study of Navitoclax in Combination with Ruxolitinib Versus Ruxolitinib Plus Placebo in Patients with Untreated Myelofibrosis
ashpublication...
4. MANIFEST-2: Pelabresib in Combination with Ruxolitinib for Janus Kinase Inhibitor Treatment-Naïve Patients with Myelofibrosis: Results of the MANIFEST-2 Randomized, Double-Blind, Phase 3 Study
ashpublication...
5. XPORT-MF-034: Selinexor Plus Ruxolitinib in JAK Inhibitor (JAKi)-Naïve Patients with Myelofibrosis: Long Term Follow up from XPORT-MF-034 Suggestive of Disease Modification

Опубликовано:

4 окт 2024

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Комментарии : 3

@heysza9905 4 месяца назад

Great interview!

@clemqueens1943 3 месяца назад

Dr Tefferi!!! This podcast should be required for all in the Hematology realm. Dr Tefferi, I want to thank you for your excellent work specifically as it pertains to Myelofibrosis. I do have a wonderful MPN Specialist who saw that my symptoms were warranting an updated BMB which showed MF 2-3. I’m a 62 female who’s been battling an MPN for over 30 years and begging to get a Stem Cell Transplant because my PV caused difficult life altering symptoms. So once the results were back, my wonderful doctor said the soonest we could do it is 3 months and I said “I’M IN!” I may be the only person on the planet who’s excited to get a transplant. Obviously there’s risk but I’d much rather have a chance of being cured than a crappy 1-3 years. Thank you for making this available. I appreciate you all.