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Vilhelm (Will) Bohr: DNA Damage and Repair, Brain Aging, and Alzheimer’s Disease 

BRAIN PONDERINGS podcast with Mark Mattson
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DNA damage, most often caused by oxygen free radicals, can result in mutations in proliferative cells that transform them into cancer cells. Impaired DNA repair is implicated in aging and neurodegenerative disorders. In this episode Professor Will Bohr talks about his research on the molecular mechanisms by which cells repair their nuclear and mitochondrial DNA, the involvement of impaired DNA repair in neurons in premature aging syndromes and Alzheimer’s disease, and the potential of NAD+ supplementation to sustain DNA repair and prevent neuronal degeneration.
LINKS:
Professor Bohr’s lab page: icmm.ku.dk/english/research-g...
Review articles:
www.ncbi.nlm.nih.gov/pmc/arti...
www.ncbi.nlm.nih.gov/pmc/arti...
www.ncbi.nlm.nih.gov/pmc/arti...

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23 ноя 2023

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Комментарии : 6   
@gloriamitchell4005
@gloriamitchell4005 8 месяцев назад
Little more on NMN please
@adamlikhan
@adamlikhan 8 месяцев назад
I just watched your interview on The Truth About Alzheimer's. You mentioned glutamate as your favorite neurotransmitter, and it occurred to me that umami, which is the fifth taste (after sweet, salty, bitter, and sour) is a receptor for glutamate. That is, glutamate is umami. I thought it was interesting that such an important protein has its own receptor. Obviously it was important evolutionarily.
@brainponderingswithmarkmat648
@brainponderingswithmarkmat648 8 месяцев назад
Thanks for your comment. Yes, it is indeed interesting that glutamate has its own (G protein-coulpled) receptor on taste bud cells. In retrospect I wish I would have included this in my book Sculptor and Destroyer: mitpress.mit.edu/9780262048187/sculptor-and-destroyer/
@adamlikhan
@adamlikhan 8 месяцев назад
Well, maybe when you publish a revised edition, you can add that in. I'm a big fan of your work. I've been following you for decades. Yours was the first study I ever saw on fasting. This was back in the 1990s. My wife used to fast occasionally, and at the time, I was sure it had to be bad for her, so I was desperately trying to find a scientific study on fasting to prove it to her so she would stop fasting, and at the time, I couldn't find any. I read many books on fasting, but they were written by people who had worked at fasting clinics and told lots of miraculous stories about the amazing things fasting did to people, but there were no references to any scientific studies. None. I thought it had to be a bunch of horsepucky. How could any one thing have that many positive effects anyway? But one day my brother sent me a study by you on fasting mice. It was the beginning of me changing my mind about fasting. Anyway, I really appreciate the work you've been doing all these years. You've definitely changed my life. And my wife's too. @@brainponderingswithmarkmat648
@marzymarrz5172
@marzymarrz5172 8 месяцев назад
The name Bohr rings a bell... I dont know about vigorous exercise as you get older. Maybe you can do it but an easy walk for 1-2 miles works for me. Of course you are not 73 yrs old.
@brainponderingswithmarkmat648
@brainponderingswithmarkmat648 8 месяцев назад
You are certainly correct that in general the intensity of the exercise that is possible declines with age. I am 66 and I have noticed this although I am still able to get my heart rate up and sweat on a bicycle. Walking is certainly good for your health - keep it up!!!
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