Conversations with scientists at the forefront of brain research.
Here are a few of the major questions that BRAIN PONDERINGS guests will tackle:
How have brains evolved to enable success in diverse environments? How does the brain develop in the womb and in early life? What are the mechanisms responsible for learning and memory, language, and emotions? How does the brain respond to life’s challenges? In what ways does the brain influence the body and vice-versa? What is known about the causes of psychiatric, neurodegenerative, and other brain disorders? What new technologies are being developed to treat neurological disorders? How do naturally occurring and man-made chemicals affect the brain? Where are the boundaries between ethical and unethical neuroscience research? How can gene therapy, cell regeneration, and brain stimulation be used for brain disorders?
Please Dr Bandy! We need you to dissect Project 2025 and the men who crafted it and Trump who is claiming he knows nothing about it. Please get on the national news again!
It is fascinating to see there are so many different kinds of connection in the pathology of all kinds of diseases and their characteristics and shift of pathways. Interesting!!!
Misogyny is alive and well in the professions - even the professions traditionally female dominated - and it seems to be getting worse since the dangerous Donald fanned the flames.
Growing hungrier when we haven't slept makes sense from an evolutionary standpoint where it would have been an advantage to put on weight during the summer months when days were long and food was abundant.
2nd listen - BTW the Interment Fasting Klotho study was done in lab of Sandrine Thuret (French) and published in 2021 in Molecular Psychiatry "Intermittent fasting enhances long-term memory consolidation adult hippocampal neurogenesis, and expression of longevity gene Klotho" Open access. Every other day fasting in mice. Would like to know about TRE in humans.
I have the duty to warn that Dr Bandy is an unethical n irresponsible doctor. Im glad shes being fired for violating professional ethics n thinking shes above ethical practice. Dr Bandy, you are very dangerous n we hope you will never get to work in this field again You need to be banned permanently for being a pathological liar
The glutamate = total understanding of neuronal pathology * all brain cell... no data analytics or algorithms required for parsing information for adaptive functions, this is the FUNDAMENTAL theory of consciousness and brain neurology, don't say otherwise ;)
Afraid the level of discussion is above my pay grade - is there a two sentence summary as a practical take away? Should I be chelating iron, if so, how does one do so?
Regarding how the kidneys produce Klotho, yet it doesn't cross the Blood-Brain-Barrier.. aside from Platelet-Factor-4 what other pathway is thought to be mediating the neuron helmet? Would love to see a urine/blood test to measure klotho activity by the kidneys.. for brain and early CKD detection.
Are you aware of any trials in the use of TMS with pediatric patients (16 years old) with brain damage post ADEM? Damage includes: cognitive, right side weakness (functional & sensory) & right-side visual cut (occipital lobe damage to left side). 17:31 / 51:26 Alvaro Pascual-Leone
Hi Mark P. Mattson, your podcast videos are very well. But your video has no Thumbnail. Thumbnail is very important for a RU-vid Video. I've created a thumbnail for you and already sent you.
Davidson steals the 2,500 year knowledge of contemplative practices and tries to put a venner of ‘scientific study’ to make it pass for his own knowledge …Not very Honest or Scientific!
I think an underrated source of polyphenols are regeneratively raised ruminants. They become more bioavailable with the processing of the animal and accumulate
Both participants are intellectually corrupt imho. If not that then not equipped with enough real understanding of psychology / projection / the shadow for this.
Fascinating concerning TRE, and Exercise making up for nutritional quality to a surprising extent. BUT what about the impacts of poor sleep/chronic insomnia. And how can I cure my own challenges with this latter issue?
Exercise and TRE can help sleep as well as reading before you go to sleep and having a completely dark room when you sleep. You can try taking melatonin about an hour before bedtime. If you are still experiencing insomnia then I suggest seeing a doctor at a sleep clinic.
Also really curious about dopamine's affect in reinforcement learning and how SPWs maybe actually lead to action. A huge problem in ML right now is how to make agents "creative" with reasoning capability. This is seen as sort of the next step in AI. I just took a break from this video to go get a burrito, which is about 5 miles away. At some point, my brain decided that the learned reward from a burrito would be higher than continuing to watch the video, and something drove my body to get up, get my keys, get in the car, and go to the burrito place. I surely have the path mapped out in my place cells, since I've been to this burrito place hundreds of times and I likely have a high reward associated with that place. Surely SPWs fired rapidly to pre-plan the trip, but what drove the brain to fire the SPW complex in the first place? Was it the learned reward? How does reinforcement learning relate to this? Did my physical hunger trigger my brain to fabricate the highest probability sequence in my mind that would lead to satiation? Surely there are hundreds of food options I'm aware of, but maybe the probability of planning out this particular burrito place was higher because I had thought about it a few times earlier in the day.
Loving this. I studied SPWs over 10 years ago as an undergrad and I have a newfound interest in them because of the parallels to ML. SPWs are sort of the OG backpropagation and sleep is the training cycle that is required for information synthesis. Messing with SPWs during sleep can render a rat memoryless, as if the training never happened. Everything is just sequences all the way down, so curious how the computer scientists stumbled on LLMs which are sequential learning models.
Hello you two. My Mother, maternal Grandmother AND myself had our final periods at 41, 39, and 40 respectively. Not sure about GM, but Mother and I had Zero post-menopausal symptoms. Personally I had extreme dark moods one+ days before period, and terrible night-sweats, etc., in perimenopause. And Lots of insomnia since undergrad years, through today (age 65 yrs). THANK YOU to Marija for inspiring even this sharing of mine, of female aspects of brain/body health.
Great conversation between two of my favorite neuroscientists, Dr. Mattson and Dr. Picard. Lots of learning moments including that we are warm-blooded due to mitochondria, free intact mitochondria are in the saliva and blood, and glia are most affected by psychosocial experiences. Profound that mitochondria might have been the reason lungs and cardiovascular systems evolved to bring oxygen to them. Thank you both! 🧠
I kove Dr.Lee. I turned off this interview because I simply couldn't take this person interrupting Dr. Lee and listening to his "slug like" speaking style. I bought her book and have watched other interviews where Dr.Lee did not have a rude slug for a host.
As expected from this podcast, some great insights. Valuable info for much of society. Public Health officials and politicians need to listen to this. Interesting cross-over learnings between TBI and Neuro-degenerative disease.
Very interesting! I am a long-distance runner interested in learning and practising how exercise and intermittent fasting greatly benefit health. Thank you Mark for inviting so many great scientists to this podcast. Very inspiring !! From my simple association, the MHI is a bit like the VO2Max, an index that shows people's fitness levels.
