WAY More than a Powerhouse: The Incredible Roles Mitochondria Play

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We all know Mitochondria are the powerhouse of the cell.
But is that ALL they do?
This video provides a really broad introduction to the incredibly mutlifacted roles mitochondria play in everyday cell life. A review video like this will gloss over lots of important details though. Corrections, clarifications and sources are here: bit.ly/clockworkep5
Fact checking for this episode was generously donated by the BRILLIANT @Astroboi on discord
(check out his lecture channel here: bit.ly/astrolecture)
Sources are cited in this ever-growing twitter thread: (wait, I need to publish first)
This channel is created with the support of all our patrons on Patreon: / clockworkshow
Support the channel directly with a one time donation: www.paypal.me/clockworkshow
This channel is dedicated to sparking your curiosity about biochemistry, not to being a definitive resource. To help you continue you biochem journey, I'm really excited to partner with Biocord , a Discord server dedicated to bringing together biologists from around the globe! Join the conversation with thousands of life sciences professionals and enthusiasts here:- / discord
All music is by Jeremy Blake( / redmeansrecording , released on the RU-vid Audio Library.
Intro music: Let's Go Home (bit.ly/rmrlgh)
Outro music: Lost and Found (bit.ly/rmrlnf)
The style of this video was largely developed based on tutorials by Ben Marriot: (bit.ly/posterizethis)

Опубликовано:

26 июн 2024

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Комментарии : 77

@PowerhouseCell 3 года назад

Citric Acid Cycle gang ✊ This was amazing! This was probably the best mitochondrion video I've ever seen- your videos just keep getting better!

@Clockworkbio 3 года назад

Woah--Citric Acid? Really? This is valuable data. People keep blowing my mind with the labels they use. Thanks so much due--can't wait for your next one!

@russellmitchell9438 Месяц назад

Commenting on a 3yr old video here, but... I definitely prefer the more in-depth and detailed style of videos over the fast and loose ones... can get that anywhere. The detailed treatment of the clockwork mechanisms are what I'm here for and would like to see more of.

@thorr18BEM Месяц назад

Quality > quantity

@twerktospec 28 дней назад

Blah blah blah 💤💤 🎶cry me a river🎶

@Dr.Kraig_Ren 5 дней назад

@@thorr18BEMyes

@anshitsingh1979 3 года назад

Mitochondria are the Trojan Horses of the cell!

@Clockworkbio 3 года назад

shhhh you're going to give too much away too soon. The people aren't ready.

@Gelatinocyte2 Месяц назад

Mitochondria are the workhorses of the cell?

@nirmalbabu9570 26 дней назад

but the good kind XD

@Blahajlover3079 Месяц назад

"Are the power-house of the cell!" We all say in unison.

@fightocondria Месяц назад

Seriously, it took the algorithm 4 years for me to find you?

@graemelaubach3106 Год назад

I would love to watch hour long explanations of specific biochemical pathways with this beautiful animation. You're killin it.

@elcherry 3 года назад

Fun fact: if you mix the voice of Sheldon Copper with John Green's, you get the narrator for this video.

@Clockworkbio 3 года назад

Oh my gosh this comment cracked the code and now I can't get those two voices out of my head.

@MarmaladeINFP Месяц назад

There is another topic related to mitochondrial functioning and cellular health. You could consider doing a video or series of videos on the role of sunlight, melanin, molecular oxygen, molecular hydrogen, electrons, redox potential, deuterium, metabolic water, exclusion zone water, and DHA. These are sometimes discussed in terms of quantum biology, as quantum physics is involved (entanglement, tunneling, etc). But that can be ignored so as to offer a simpler mechanistic explanation without needing to the larger complexity of the body as a dynamic system of energy, light, and information. The relevant point being not only that, as explained in this video, that the mitochondria do a lot of things but also that many things affect the mitochondria. Impressively, mitochondria play a pivotal role interconnecting so many factors, processes, and systems.

@torak456 Месяц назад

@4:43 “At a macro level, you already know the two methods we have for getting rid of waste products in your body”. I’m going to go with exhaling, to expel waste CO2, and expectorating, to get rid of mucous and such. They both have ‘ex’ right there in the name!

@pimbel8830 Месяц назад

I wanted to leave dumb comment about two other kinds of waste but it was too dumb

@mishoidenis 3 года назад

A little mention about mitochondria's role in apoptosis and this would be the perfect introductory video on the subject! Big thumbs up!

@MikuMikuCheetah 25 дней назад

I’ve watched about 6 of your videos and omg I want more! I want specifics and more processes! I almost failed biology in high school cause it was taught badly but this channel has opened an entire world for me about how cool bio chem is! I’m so fascinated! And as a visual learner, the moving diagrams work wonders!

@Th3OneWhoWaits 21 день назад

He said in other videos and community post that season two is coming soon!

@RBmusic2000 2 года назад

Good work with your channel. I like long videos, but having a quicker version to introduce us to the basics of the content helps simplify the information. The topics can be jammed stuffed with information, so having two versions of the same video helps people who are slow learners, or learning these topics for the first time break it all down

@facultyofbioengineeringand45 3 года назад

Nice video! Though at 2:53 you have a little typo: adenine is depicted as pyrimidine, while cytosine as purine. Oh, and standard color coding for atom types is gone at the heme part.

@Clockworkbio 3 года назад

Yea that's a really embarrassing gap in my fact checking process. I have no idea how I reversed that during animation when had it noted right in the script. Adding in a correction for a future blog post and I'll keep trying to figure out a more robust fact-checking process. Thank you so much for pointing this out!

@franciscobohm1699 3 года назад

Hey I REALLY hope you can keep these videos up, Ive seen a couple of them and I really like your style. Thanks for doing this!!!

@Clockworkbio 3 года назад

Hey that means a lot! I'm working real hard to figure out a balance between putting these out quickly and doing them well. Every video I try something new and try to get better. I've got 12 more scripts in the pipe--and I'm starting to reach out to researchers to come on a podcast style show where we tackle these topics with even more depth. We'll keep growing this for sure!

@franciscobohm1699 3 года назад

@@Clockworkbio TBH the quality and frecuency of your videos kinda worries me a little, it must be a very hard work and i just hope you dont burn out too quick specially if it's only yourself doing it

@Th3OneWhoWaits 21 день назад

Very insightful. I actually went back to the source papers and made a map of most of the functions. It spanned over a page lol.

@narrativeless404 25 дней назад

5:33 That thing even looks like what's it's gonna come out of

@andrewfedorowicz4965 3 года назад

Your videos are fantastic. For future videos, I might suggest how insulin resistance affects cellular metabolism, how antibiotics work on a cellular level, and the chemical process of cholesterol production. (If it’s too “medical biology” for your channel, I get it, but I think those topics would work nicely with your biochemical process descriptions/explanations.)

@Wutata 3 года назад

This channel will blow up soon. The quality is through the roof and extremely interesting! Subscribed.

@Me-ld8bt Месяц назад

This channel requires more subs.

@Clockworkbio Месяц назад

Subs basically doubled in the last week. We’re on the right track!

@SayanurRahaman 3 года назад

This video is amazing. It is great that you guys are doing sci-comm videos on somewhat advanced topics. Hold tight, I see a very nice future for this channel

@mrsmlthomas99 3 года назад

Your videos are incredible, well done

@Th3OneWhoWaits 21 день назад

Topics from this video that could be part of season 2: - Heme synthesis - Hydrogen Sulfide degradation - Fatty Acid breakdown - Urea Cycle

@MrCore2Man 3 года назад

Awesome videos, mate!

@tyapca7 Месяц назад

Very nice! A big thank you! Keep on, please. Thumbs up!

@newphonebrasil8664 Год назад

Awesome! Keep up the good work!

@satiremuch2643 10 месяцев назад

Very interesting, well done and thank you.

@colorizedenhanced-silentmo6247 3 года назад

Hi, This Glorious Clockwork. it's a surprisingly enjoyable video. thanks. :)

@bioZone101 3 года назад

great video

@Sphaerocarpaceae Месяц назад

Algorithm brought me here and I’m glad it did.

@DJR000 Месяц назад

The channel is too good to not be famous. But he stopped uploading

@Gelatinocyte2 Месяц назад

I've read one of his recent comments in another video that he's been working on a big project for all these years now.

@MostlyPennyCat Месяц назад

ATP Synthase is cool though, an electric proton conducting motor that either charges a proton pool or a chemical pool depending on which way round it's turning.

@popescucristian8978 Месяц назад

weight loss the mitochondria is the only organelle capable of beta oxidizing fatty acids thus it enables the human body ( or any other animal body ) to generate energy from its adipose tissue

@pelegshalev7359 7 дней назад

please come back!

@cobalius Месяц назад

calling them procariotic nuggis is really something

@LuisAldamiz Месяц назад

The first cells must have been all about membranes and proton gradients, right?

@Gelatinocyte2 Месяц назад

Yup. Even to this day, prokaryotes specialize in membrane embedded metabolic pathways for the sake of proton gradients.

@Redrum420CF 3 года назад

Hi Jessie gender asked during her livestream for us to subscribe but I also liked the video. I’m subscribed to a bunch of other science RU-vid channels like sci show, smarter everyday, vsauce and sci guys.

@mh6276 Месяц назад

I still prefer the rough ER. It's my favorite organelle.

@Gelatinocyte2 Месяц назад

Just a specific part of the ER, not the whole organelle?

@eaudesolero5631 Месяц назад

so how do the mitochondria and the ATP cycle relate to the concept of tiredness and exhaustion? how's it related to depression? diabetes? why is it that something like feeling dread at the concept of approaching a difficult challenging experience can drain all of your energy?

@Gelatinocyte2 Месяц назад

I think most of these questions are best answered by Neurology. As for exhaustion: muscle activity demands a lot of ATP.

@JaneXemylixa 3 года назад

1:54 Is this what became of the Mitochondria Republic flag from r/vexillology? :P

@Clockworkbio 3 года назад

It's actually exactly a minute later at 2:54. God I love this goofy crossover and I'm so happy the folks from r/vexillology are filtering in here. Really hope I can figure out a way to make people have feelings about chemicals the way Roman Mars makes people have feelings about flags.

@JaneXemylixa 3 года назад

@@Clockworkbio I subbed to your channel before I found that subreddit. Hope others may be experiencing it in the other direction :)

@thatpaulschofield Месяц назад

Have heard the story of Darth Plagueis the Wise?

@farzanaalaman3655 Год назад

The [word that was said at the period of 0:09 to 0:11] is the POWERHOUSE OF THE CELL

@dond668 Месяц назад

Could mitochondria be responsible for all the chronic fatigue being experienced following the Covid lock down? How do we heal our sick mitochondria?

@Youtuber69428 Месяц назад

My brother in Christ. How did you come to the assumption of sick mitochondria. A facebook page?

@dond668 Месяц назад

@@RU-vidr69428 are you implying that mitochondria is not affected by poor nutrition or complete lack of exercise?

@Youtuber69428 Месяц назад

@@dond668 I misread, I thought you said COVID causes sick mitochondria, which isn't really a thing either.

@pimbel8830 Месяц назад

This video isn't in any playlist :)

@rayansattarkhan6807 Месяц назад

So like little Livers in the cells.

@PewDiePie777 Месяц назад

Mitochondria is you.

@bluelagoony Год назад

Power nuggets😅

@josephbaker5810 27 дней назад

I enjoy your videos. However, when I look at biology I see deliberatenees rather than randomness even given billions of years of mutations...

@ExiledGypsy Месяц назад

I think I have finally managed to become part of the majority that should make feel better but maybe I have been manipulated to join in by watching too many videos on RU-vid trying not get caught in any echo chamber. But I keep getting outraged every time I watch a video like this, even though I might agree with the content because it is just not interesting. The fact that everyone talks about the energy production function of Mitochondria is not because no one knows about its other functions but because it is proving impossible to improve this specific function that is believed to be the cause of so many ailments and suffering. Anyone trying to do so will only find a bunch of inconclusive research papers or worse, a large crowd of snake oil salesmen. So, as Kubrick told Jack Nicholson when he turned up for the Shining having prepared by spending a long time researching; what you say might be right but just not interesting enough to listen to.

@Gelatinocyte2 Месяц назад

Can I have some of that stuff you're on right now?

@ExiledGypsy 29 дней назад

@@Gelatinocyte2 Just keep watching youtube, It is subliminal.