CoQ10 gets shuttled around on LDL along with fat soluble vitamins, cholesterol, triglycerides, and phospholipids. Lipoproteins are too big to cross the BBB. From my understanding because of this limitation the brain cells produce their own cholesterol and CoQ10
BBB is not just about the osmotic molecular sizing as you point out; so bbb i. Hydophobic (keeps RBCs out) ii. the brain probably produces its own CoQ10 and say Seratonin.. Depending on your preference caffeine and alchohol cross BBB quite easily. personally i visualize the BBB as a protein mesh ( a kin to the mucosa in the gut ) . Hence it is subject to attack by things like glucose. Perhaps it is this loss of back pressure that promotes alzheimers and the like. Of course the mileage on your myelin sheath various with age and general health (and genetics ApoE-2 according to Ali Nadir et al)
My cholesterol is fine. I eat healthy, not overweight, never smoked yet my doctors rang me to suggest( coherse) me into taking, statins. I am 78. I was appalled. It was simply a push to earn more money. They can barely show interest if you are ill. This is in the UK.
Your brain makes it's own cholesterol. Statins including all of them, quickly or slowly stops brain functions. Leading to dementia but not if your taking it once per week or less. Sweden study from September 2023. 300,000 plus people were involved.
@@steelzmb4262 Ken Berry is hardly a reliable source of information. To the contrary, a study "Statin use and risk of dementia or Alzheimer’s disease: a systematic review and meta-analysis of observational studies" found that "In the pooled analyses, statins were associated with a decreased risk of dementia [36 studies, OR 0.80 (CI 0.75-0.86)] and of AD [21 studies, OR 0.68 (CI 0.56-0.81)]."
Vitamin D is made in the body by the action of sunlight on the skin. The UV rays convert cholesterol into Vitamin D. So if statins deplete cholesterol, and there is no Vitamin D supplementation, it follows that naturally produced Vitamin D will also be depleted.
Thank you. It's interesting that the studies did not consider that, or perhaps they simply didn't look deeply enough or set up the right conditions for collecting data on the topic.
The liver makes cholesterol not the brain. Dr. Nadir Ali a cardiologist just did a video on cholesterol and the effects of statins and he says coq10 supplements don’t cross the blood brain barrier.
From John's Hopkins: "But in fact, the brain makes its own cholesterol. It doesn’t depend on the cholesterol in the blood." (www.hopkinsmedicine.org/health/conditions-and-diseases/high-cholesterol/3-myths-about-cholesterol-lowering-statin-drugs) However, I don't know how much to trust this article on other matters. The author makes the leap from the above assertion to claiming that therefore statins don't cause memory problems, which to me doesn't follow.
The real question is: Who funded the study? Was the study observational or clinical? Who funded the so-called peer group? What was the purpose of the study in the first place?
Statins actually delete a part of the biological pathways to the production of cholesterol, and Q10 is affected because something begets something begets Q10 begets something begets cholesterol, where there may be 1 or more in between begets. This means that it's not an absorption issue with Q10. One thing that puzzles me though is that proponents statins (manufacturers and doctors, not influencers) suggest that cholesterol can be produced by any cell that needs it, not just in the liver where the statins I guess do there work, so why do statins only work in the liver? There needs to be more research on this to clarify what the issues are.
I agree about how CoQ10 is reduced. My point about absorption was really about why supplements are not shown to be as effective as we'd think they should be when someone is on statins. I wouldn't think statins would affect CoQ10 supplements, that is exogenous CoQ10.
Millions of people take statins in our society. Has cardiovascular disease actually been wiped out? Or significantly reduced? Are people on average living longer now? Has cardiovascular disease been solved?
I point out in an earlier video that there are 93 MILLION patients prescribed statins in the US alone; that's a quarter of the population. Yet CVD has not been wiped out. The medical community's response is to increase statin use rather than more selectively prescribe statins to the very few who might actually benefit. That's my main issue with statins - that they are prescribed indiscriminately and actually called a "wonder-drug" by the pushers. It's the shotgun approach to medicine - give drugs to everyone and hope something good happens. There's clearly a fundamental problem with the approach. And while I know your questions are presented rhetorically, the answers are: No, no, no, and no.
@mystatinfreelife I am 71, I have been a vegan since 1980 and I don't smoke. Yet still I got blocked arteries and required a quadruple bypass operation, and was put on statins and baby aspirin. I had high blood pressure. So I was also put on a tablet to reduce blood pressure, which I am happy to take into the future. But I stopped taking the statins maybe 6 weeks ago, and I stopped taking the baby aspirin and I feel much better already. I think my heart disease is caused by stress. Now that I am retired the stress is significantly reduced. I never had a heart attack, but I got symptoms, like shortness of breath and mild nausea which were warning signs, enough to get me to visit a cardiologist and then have an angiogram at the Victorian Heart Hospital, here in Melbourne. My stress was likely caused by my lengthy daily commute through heavy traffic and the fact that I had a stressful job, which is now behind me. I live in Australia and got my bypass done at a very good public hospital. The angiogram guys said they were not letting me go home and admitted me immediately to the hospital, and I had the operation within a few days at no $cost, thanks to our wonderful free health system. An Australian journalist named Maryanne Demasi did 2 great short documentaries about 10 years ago. The first was about cholesterol mythology and superstition and lies. The second was about statin mythology, superstition and lies. Maryanne Demasi ended up losing her job at ABC television because of this, though they did an extensive investigation into her documentaries and found no factual errors.
Yes I agree. The fraction blood test eas stated by the author to show type A” I was asking which of the specific blood test dictates that conclusion? I have the MNR results and my cardiologist will not explain them to me because I refused to go on a pcsk9 inhibitor for ldl . I don’t believe he is being honest with me 🤷🏼♂️
4:09 4:17 😅😮😢🎉 4:42 ❤🎉🎉nnnnnnoooooooe can tell you, or WILL TELL YOU what is your soft plaque severity. Calcium score will NOT SHOW HOW MUCH SOFT PLAQUE there is.
You are correct. That takes a CIMT. In that discussion I was talking about stabilization of soft plaque that turns into hard plaque, which the CAC does pick up. That is the controversial issue that some doctors claim to be the case.
