[FREE GUIDE] The Vitamins That Cured My Chronic Fatigue: www.felixharder.net/vitaminlist Full Program & Practitioner List: www.felixharder.net/program - Related Videos - Walsh Protocol: ru-vid.com/video/%D0%B2%D0%B8%D0%B4%D0%B5%D0%BE-Y-ptpm3wpeo.html Methylation Explained: ru-vid.com/video/%D0%B2%D0%B8%D0%B4%D0%B5%D0%BE-QzEckF_g4tE.html - Timestamps - 00:00 Introduction 00:29 Folate Explained 01:36 Methylfolate & Methylation 02:36 Why You Get Side Effects From Methylfolate 04:42 Folate For Overmethylators
I just found your channel. I would really like to hear your opinion on my nutritional situation. You've talked about something that NONE of my doctors or surgeons have told me. I'll try to make the story short, but it started in 2002 after I had roux-n-y gastric bypass surgery. I have a horrible reaction after eating. My heart races, body aches, flu-like symptoms, nausea, and I feel like crap for about 45 minutes. I've been told that it's called "dumping syndrome." But absolutely no one can tell me its mechanism and how to counteract this reaction. Now, after all these years, I have nutritional deficiencies, malabsorbsion, and osteoporosis (among a few other diagnoses). In 2009, I started in pain management and went on opiods for pain. That choice ruined my life because of developing a dependency on the meds. It was a nightmare trying to get off of them, so I went on suboxone. Well, the wonderful organization online, bupe.me, that prescribes suboxone is also conducting clinical tests to prove that those poisonous opiods actually create methalization of the neurotransmitters and cause damage to the DNA. You are the only person that I've seen to discuss methalization and its issues. Do you have any advice on how 1) I can get relief from the effects of eating (I've developed an aversion to food because I don't like being sick afterwards. I got down to 99 lbs, and the Dr wanted me to get a feeding tube!) 2) What do you think about the clinical study regarding methalization and opiods? Thank you for the very informative video.
Yeah I’ve become more and more convinced that what we need is to supplement ALL the essential vitamins and minerals. Focusing too much on one or the other might help somewhat but then lead to problems down the line. Buying powder form in bulk is how one can afford to do so.
Seems as if you are splitting. Common. My use of methylated folate and methylated cobalamin stopped my bloating and my reflux esophagitis of 30 years. Your scant discussion regarding COMT and Mthfr genetic alterations was pathetic. You, likely obtained some income from your critical discussion, however, you made things more likely more confusing for sufferers. I am not about censorship. I am about folks that know about this subject challenging you.
If minerals and their balance is confusing than topic of B vitamins is confusion on steroids.. We basically have no idea what B vitamins, what doses and form we should or shouldn't take.. Even if we feel good or better on some B vitamins that could be some drug like effect that creates some imbalance down the road.. I take them mainly B1 as benfotiamin, some B2, some B5, biotin. But I don't take them daily so my body has chance to balance itself IF I am creating some imbalance with them.. What B vitamins are you taking Felix?
I used to be very sensitive to getting anxiety from B vitamins. There's a B Complex called B minus from seeking health that has most of the active forms, but without B12 and folate, it's working pretty well for me. Going from 1/10 to 1/5 of a capsule did make my startle sensitivity come back, but that has subsided for the most part after 2 months. I'm able to take 200mcg methylfolate now without anxiety, I used to get anxiety from just 40mcg. Disclaimer that improved diet probably helped with this as well.
I feel you! The topic of methylation and b vitamins is a huge rabbit hole. I talk about why it's sometimes better to focus on other things first in this video: ru-vid.com/video/%D0%B2%D0%B8%D0%B4%D0%B5%D0%BE-QzEckF_g4tE.html
I respect this perspective.. in my opinion since this is the case I believe if someone wishes to incorporate supplementation, it should be of a naturally derived supplement or vitamin. To mitigate any harmful side effects at the least.. me personally my body requires supplemental b vitamins.
You say Methylfolate causes neurotransmitter reuptake, and at 4:42 You say overmethylation causes too much neurotransmitters, and say to take folic/folinic acid for reducing neurotransmitters but not take methylfolate for reducing neurotransmitters? If someone has MTHFR mutation does that imply they can't be an overmethylator?
That Dr. Ben Lynch says not to take folic acid as it is not a natural compound and can make things worse. I’m not sure about that but felt I should let you know to dig deeper before taking it. Lynch also says that while too MTHFR gene variants receive the most attention, there are many variants that can change the way your methylation works. This, in conjunction with other genes like compt is likely why treating illness this way is extremely specific to the person and complicated. That being said, it’s more precise, lasting, and lacking in side effects than pharmaceuticals because we are using natural compounds that our bodies were designed for. I’m just struggling to know what to do as even the really smart people who teach in this field are not in agreement, and I can’t even afford your average local naturopathic practitioner.
Thank you for this video, I got tested for the MTHFR, gene mutation, and I do have it. I started taking a multivitamin with methyl folate and methyl B12 and felt better as you said, but then felt that I needed to taper off I now take the vitamin approximately twice a week and I do really well. My main issue was digestive, and when I take the vitamins with the methyl folate and methyl B12 am absolutely well.
@@865style Have you tried taking hydroxocobalamin or adenosylcobalamin instead of methylcobalamin? Depending on which gene you have, different forms work better (so I've read).
WOW, it is absolutely wild how timely this video is for me! I have been taking 400 mcg of (6S)-5-MTHF for about 3 months in preparation for pregnancy since I learned it is more bioavailable than folic acid. Mainly I was feeling fine, however, over the past few weeks, I noticed a sudden sharp increase in anxiety, OCD thought patterns, and intrusive thoughts. It came out of nowhere and felt very strange - I didn't feel like myself. Yesterday I woke up early after not sleeping well with a racing mind and heart. I knew something was off, and I had read about potential side effects with MTHF, so I went down a rabbit hole of research and realized this must be what it was. Long story short, I stopped taking it yesterday and woke up this morning feeling SO much better - not quite back to normal, but with so much more mental clarity, and a less chaotic out-of-control feeling in my mind. So validating seeing this video today! Thank you for sharing! I really appreciate your work. I haven't done any testing regarding my methylation status but I'm guessing this experience is hinting that I might be an undermethylator? I'm curious - what is your opinion on preconception/pregnancy regarding folate for people like this? At this point I'm leaning towards just focusing on food sources.
I was doing same as pregnancy prep. I know I'm an undermethylator. I had instant bad mood on the 5 methyl folate. My naturopath told me to take folinic acid with it, something to do with another pathway, I'm not sure if it helped as I kind of gave up. But you could try that
I am with you. 10 days supplementing left me with severe anxiety, intrusive thoughts and terrible sleep. How did you recover? I. 10 days out since stopping and still not there.
Take calcium magnesium boron a little vitamin d k2, b6, zinc, and maybe a little vitamin c copper and manganese. But really you should get a hair test done to see if you are a fast or slow oxidizer. You might need all the b vitamins if you are a slow oxidizer. I am not sure where felix learned everything besides from experience, but I can be pretty sure he learned a lot from Dr wilson nutritional balancing. On that program you eat a lot of cooked vegetables. If you take a break and just eat some meat and cooked vegetables that will bring you back in line tell you figure out what supplements you need for sure. You won't find a better diet, because most people have horrible digestion and cooking the vegetables is basically taking liquid supplements with balanced nutrients. Get an instant pot and you are set.
My healthcare provider says to not stop folate supplementation and rely on diet as you need 10x as much folate during pregnancy. Can you not test folic acid (instead of methyl folate) to see if that is better? I hope you find what works best for you and you have a good pregnancy.
Aww now this. I can never get the same answers from different channels, everything I bought for nothing now. So gonna just do what I want we all have to die anyway.
I have taken a lot of methylfolate with my B12 injections and have zero problems with it. I am super sensitive to supplements, and several make me hyper but methylfolate is NOT one of them. TMG, glycine different story. Your video is very interesting though and it is new info for me.
Twice the amount of vit B12 to methylfolate and enough b2 and b3 resolve the issue, the guy in the video doesn't understand anything. This video explains it so much better and in detail
So then would 200 mcg a day of methylfolate be reasonable for anyone not getting much folate from diet and also low in neurotransmitters and mthfr activity? Basically, getting enough to avoid deficiency but avoiding the side effects of excessive dosage.
Make sure you test it and if you feel the side effects through time, lower the dose. Listen to your body. (Not medical advice entertainment purposes only.)
I took 1000 methylgolate for 10 days and it has broken me. Everything from palpitations, pins and needles, stomach pain, and a deep confusion. I am 10 days out and gradually getting back to normal. Any advice for what people in my case should do to a) recover and b) supplement going forward. TiA
I think it’s a case of if you want to take the supplements and you start to feel better just do a cycle of them and see how your body feels, if you feel your body has responded well, get yourself, checked to see where your levels are at if all is well, and everything seems to be in balance then I would suggest just supplementing with food, then down the road if you can feel your body is lacking a little bit then do another cycle whether that’s one week or two weeks don’t go crazy
I got severly ill lately and I think it's sudden onsef of B12 deficiency. I've been injectimg both hydroxocobalamin for 2 weeks every other day, and now switchded to injections wirh 15mg mekobalamin. And every time I've tried adding any form of folate I have suffered new and worse neurpathies. First I tried folic acid, then methyl folate and lastly folinic acid. At doses of 800mcg I can tell it will set off worse neuropathies and severe tinnutus. Don't know whats going on. Havent done any gene testing yet. Maybe the batch of hydroxo had gone bad... >.< It does however lower homocystaine. So it does something at least.
I'm not sure if I missed something or you were incredibly vague in displaying this information. Did you mean to say chronic methylfolate increases expression of SERT, NET, DAT or improves their Vmax? If yes can you cite your sources, I was unable to find any studies showing these results.
Undermethylators whose main problem is low serotonin usually do best to avoid all types of folate supplements. Other undermethylators might benefit for low to normal doses :)
After doing a lot of research and knowing a good amount about things I believe people are prescribing too much methylfolate and methyl b12. I cannot tolerate b12 supplements. But, the supplements I took are really high in b12. 1000mcg-5000mcg. In my opinion people like myself who are homozygous for c677t mutation cannot tolerate methylfolate or b12 because we are extremely deficient in the vitamins. For instance I'm about to be 37 and I've obviously had this issue my whole life. So my body is not use to high doses of b12. So what may be normal or ok for others to take is not ok for my body because its always been depleted badly. So i got methyl b12 gummies with only 12mcg per gummy. I'm curious on where i will start to get negative side effects from it. Or I'm thinking if i slowly build up b12 levels my body will get used to it more and more. People like myself with severe mthfr deficiency cannot expect to react the same as people who are heterozygous for c677t or have 1298 mutation or compound. But getting 50mcg of methyl b12 is better than getting zero because you cant tolerate 5000mcg. Yes 50mcg is a lot less but it's a lot better than nothing. Then you can add in supplements to take the stress off of your body's methylation needs. By taking creatine and phosphatidylcholine, betaine. Then add in L-carnitine. I've always got a lot of good energy from L-carnitine. L-carnitine requires methylation as well.
@@krownzera yea but if you dont have enough methylation it wont matter much. Without folate, b12, b6 serotonin norepinephrine and dopamine wont get produced as they're supposed to.
So what can an undermethylator do then!? What type of folate whould be useful, if any, or what type of B vitamins in general? Is a methylated B complex not a good idea!? 🤷🏻♂️🤷🏻♂️🤷🏻♂️ Thank you!
Tolerance to folates depends on the person. Some undermethylators do fine on low dose methylfolate, while others have to avoid supplements completely. If you want to take it, I'd start with low doses and monitor your mood over the next few months :)
The only methylated supplement that fks me up is B12. I switched to Adenosylcobalamin and have no issues what so ever. I also do fine with B9 and B6 or anything else methylated. I guess we all have different needs.
If you're an undermethylator, wouldn't DMG & TMG supplementation help? I would think if you know you're undermethylating, this would already be in your regimen.
5-MTHF isn't by itself the problem, however it isn't a solution either, it is just the natural version of folate (B9). Just as Methylcobalamin is the natural form of B12, if you take a low dose supplement of B9, (say 400mcg) and are not deficient in other B group vitamins / major minerals it by itself isn't likely to cause problems. The issue generally is when people mega dose and don't realise that mega dosing in 1 vitamin can affect the amount of other vitamins / minerals needed by the body as many vitamins and minerals are used together by the body so mega dosing in 1 can lead to deficiencies in others. What most people will not tell you is that most supplements are mega doses designed to treat chronic conditions so always try to find the lowest does possible unless recommended by a doctor to treat a specific condition. Re depression best solution I am aware of is 10-25mg p5p (natural form of B6) + 200mg elemental magnesium from Mag Glycinate, if you suddenly develop depression it can be a symptom of a deficiency of B6 or magnesium caused by mega dosing in other vitamins (B6 is a tricky one I do not recommend taking more than 10-15mg folic acid [synthetic form] per day or 30mg p5p [natural form], in high doses this causes nerve damage / rashes, ironically some vitamin suppliers include doses of ALA to detox high levels of B6 in the same supplements they issue with the excessive B6).
Please please please make a video on pregnancy supplements. I am a veterinary student, I spent a long time researching peer reviewed journal articles, and studies. Most of this research proved useless, I believe because a lot of it is American, and funded by the FDA. I'm told by most health practitioners that folate is a must during pregnancy, no one speaks about this re-uptake phenomenon.
I have homozygous c677t mutation. When i take vitamin b12 it makes my brain extremely active. I cannot tolerate it. I suffer from depression, anxiety, insomnia, low energy, fatigue, sore muscles. I know its because im a really bad methylator. Im gonna give methylfolate a shot but i suspect i will get a negative response just like i do from b12. Would you recommend creatine to reduce the load on my body's methylation system?? Im thinking id benefit from sam-e as well for my mental problems. Im sure im extremely depleted in it because i cannot methylate well. Im thinking of a combination of sam-e, creatine and betaine. Whats your opinion? Thanks.
How are you doing now? To my knowledge you shouldn’t take b12 methycalbalamin or methylfolate alone… but together. Otherwise youll be unbalanced. Btw, check your vitamin D levels.
Try folinic acid form of folate. It is the step after the methylated form, that your body would normally make at that point in the process if it methylated normally.
Try eat stake, red meat have all balanced in it for your brain and dont be agraif od cholesterol, you need your cholesterol in your brain as isolator. I was removed carbs from my diet and eat meat and 7 days after i was new person.
@@deberebor I unfortunately cannot tolerate tons of things. Folinic acid causes a reaction along with tons of other things. Turns our it's a histamine issue. Folic acid and b12 cause cells to release histamine along with tons of other things. So I have to get my histamine under control to fix my methylation. Otherwise it will just cause serious reactions.
So, not that safe? Everytime i try to supplement with any b vitamin.. science can't decide, i can't decide, and my body can't decide. Back to square one 😢
What are the concrete symptoms of the delayed wffects with methyl folate? What should I be on guard against? I started taking Methyl Folate 6 weeks ago. And what should I take instead, if anything? I am sure I am a "poor methylater".
Hello, I've been experiencing bad be headaches fatigue and some fever and cold/flu like symptoms. I'm not sure if it's sinc starting to take methyl multi vitamin or I'm sick. But I'm rarely ever sick and the dates when I started taking the supplements lines up with when symptoms began. Keen to hear your thoughts thanks
Yes, glycine is very important and will help.. glycine absorbs additional methyl groups.. and if it works successfully for you, is the best solution.. However glycine is excreted if you have too many methyl groups, like an outlet valve; so can lead to glycine deficiency (which is probably one of the reasons it causes problems for people after several months)..
Since taking methylated B complex and TMG I have almost no joint pain, more energy, better skin, better sleep, and way less anxiety! I’m a total believer. It’s awesome!
So glad I found your videos. Finally someone says what’s happening with to me. Have MTHFR and COMT supplemented with methyl and felt the worst I ever felt. So your saying try Folinic acid if that Happens ?
All types of folates increase neurotransmitter reuptake. So please get a whole blood histamine test to see if you need them in the first place. Basing your methylation status on genetic testing doesn't give you the whole picture. More on this here: ru-vid.com/video/%D0%B2%D0%B8%D0%B4%D0%B5%D0%BE-QzEckF_g4tE.html
@felix-harder In the end you mentioned other methylators. Would you make a video about it more in depth with some examples please. I crash my head to find out any explanation about my double B6 (not supplementing but having 2xMTHFR). I don’t believe in B6 toxicity and think that in the tissue it’s a deficiency which fools the researchers to consider toxicity. In the light of what you mentioned in the end let’s analyse this and brainstorm together?
@@jirihutecka9020 Indeed, my doctor prescribed me magnesium for my high blood pressure, 4% magnesium to be precise. I prescribed myself magnesium orotate.
Does anyone know if you should add the folonic acid to the methyl folate or just take folinic acid instead ? Have MTHFR and took methyl and felt absolutely horrible
@@descai10 thank you for the reply but I was told that by another video and then was just told if have a reaction from folic acid or methyl folate then you can’t take folinic acid either idk
Sorry, who is this person? what background does it have? holistic? what about all the generic docs and scientists that DO explain properly the process and how it contributes...............this hurts more than it helps in my opinion as I have the mutation, worked with doctors and is one of the things that make the system work, the issue is how much you take, hence is why you need to start very slow and go up until you find your sweet spot............................plus there are natural ways to help the person that has taken to much, with Glycine (way better or Naicin
"I'LL" see you in the next one. Germans seem to find it hard to say "I'll" but if you don't it makes no sense. You can't see me in the next one unless you are looking into a crystal ball.😂
