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This test measures the levels of SHBG in your blood. SHBG stands for sex hormone binding globulin. It's a protein made by the liver and attaches itself to sex hormones found in both men and women. These hormones are:
Testosterone, the main sex hormone in men
Dihydrotestosterone (DHT), another male sex hormone
Estradiol, a form of estrogen, the main sex hormone in women
SHBG controls how much of these hormones are delivered to the body's tissues. Although SHBG attaches to all three of these hormones, an SHBG test is mostly used to look at testosterone. SHBG levels can show if there is too much or too little testosterone being used by the body.
An SHBG test is most often used to find out how much testosterone is going to the body's tissues. Testosterone levels can be measured in a separate test called total testosterone. This test shows how much testosterone is in the body, but not how much is being used by the body.
Measurement of SHBG is useful in the evaluation of mild disorders of androgen metabolism and enables identification of those women with hirsutism who are more likely to respond to estrogen therapy. Testosterone: SHBG ratios correlate well with both measured and calculated values of free testosterone and help to discriminate subjects with excessive androgen activity from normal individuals.
A primary reason for SHBG levels to increase is from high cortisol levels. High cortisol levels occur from both a short term and long term stress response of any type (physical or emotional). The connection between SHBG and cortisol is a primary reason stress takes such a toll on hormone balance.
The first thing to remember about SHBG is that it is a binding protein so it is designed to transport inactive things either to a target tissue, or out of the body. Anything that is bound to it cannot unbind very easily at all- consider it stuck and unavailable for use. Testosterone is the primary hormone that sticks to SHBG. So, when there is a lot of SHBG in the blood, there is a lot of testosterone stuck to it and inaccessible.
SHBG and testosterone are inversely related. This means when SHBG is low, testosterone is likely high. This is often seen in women with PCOS, hypothyroid, and other issues where testosterone levels are too high (compared to estrogen levels). In men, SHBG is often high when testosterone levels are low. Low SHBG in men can be an indicator, especially in conventional medical settings, of underlying chronic disease states that are emerging. Low or high SHBG should never be ignored. Anytime hormone levels are checked, SHBG should be checked as well and interpreted by a practitioner who understands how this protein is affected by, and effects both testosterone and estrogen levels.
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Dr. Jawad is a Board Certified Chiropractic Neurologist and Acupuncturist. In addition, a Diplomat for the American Chiropractic Neurology Board, Fellow of the American College of Functional Neurology as well as Fellow of the International Academy of Medical Acupuncture. He is a Certified Functional Medicine Practitioner.
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15 сен 2024
