17.5y Younger Biological Age (Blood Test #4 In 2024, Full Lab Test Analysis)

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11 июн 2024

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Комментарии : 71

@barrie888 28 дней назад

tks for the Excel link for the Levine test,very useful

@rasheemmcdowell4144 27 дней назад

Thank you

@DavidPodolsky Месяц назад

Excellent results, Mike, congrats.

@conqueragingordietrying1797 29 дней назад

Thanks David!

@spoudaois4535 Месяц назад

I'm a Urologist . The testosterone levels are excellent and healthy. Remember there is variability of testosterone sensitivity which is why the normal range is wide.

@stefan-cosmin.ionescu807 23 дня назад

Mike, can you check for bilirubin correlations with other biomarkers or epigenetic age in a future video? I recently stumbled across some articles which suggest that higher or at least slightly higher than average bilirubin levels are associated with antioxidant and anti-inflammatory effects which protect against a wide variety of diseases, despite bilirubin being infamously known as a toxic by-product which underlies jaundice.

@conqueragingordietrying1797 23 дня назад

Hi @stefan-cosmin.ionescu807, there might be some truth to that data-I see the same pattern in centenarians, but I think potentially protective bilirubin elevations are late-life or disease specific. Bilirubin is lower in youth, so that's my current target...

@berdi4berdi4 26 дней назад

Excellent Michael, why do you think it got worse in 2023?

@conqueragingordietrying1797 26 дней назад

Thanks @berdi4berdi4. There's an outlier in 2023's data which pushed the average higher, which was likely driven by tryptophan supplementation-induced gut dysbiosis, as I had uncharacteristic GI symptoms on the morning of that test.

@jamesgilmore8192 Месяц назад

Mike -- Have you seen this preprint? Biological aging of different blood cell types 2024, Marttila et al. From what I can tell the processing of the blood spots for the epigenetic tests DunedinPACE, Horvath, etc use only peripheral blood mononuclear cells and don't include RBCs as they degrade. This papers indicates that different pbmcs have different ages even within the same person. And I'm left wondering if the ratio of the pbmc's are important (e.g. for DunedinPACE more B cells and monocytes relative to T cells gives an older age). If you have a line to trudiagnostic it might be worth asking them about the processing of cell numbers. You can get lymphocyte counts via flow cytometry, which might help you resolve things, but pricy though.

@conqueragingordietrying1797 Месяц назад

Thanks James-I hadn't. They provide lymphocyte counts, and I also have same-day counts. But I'm not sure how I'd use that data...

@jamesgilmore8192 Месяц назад

@@conqueragingordietrying1797 Exploratory analysis. For DunedinPACE and DNAmPhenoage you could regress the ratio (monocytes+B)/(NK+CD4+CD8) (clustered effects based on the marttila paper) and see if there is any relationship. Or the approximation ignoring b cells monocytes/lymphocytes. For TL its (monocytes+B+NK)/(CD4+CD8). For hannum (monocytes+B+NK+CD4)/(CD8). Maybe you can try monocytes/lymphocytes for TL and hannum debatable. No obvious ratio for horvath. Hopefully these come out null because if they don't the epi tests are just reporting pbmc ratios. If they do report the sub-types, cd4/cd8 declines with aging, I'm not sure if you've covered it.

@edwhite2255 29 дней назад

I have seen studies that indicate lower WBC can be indicative of lower inflammation

@conqueragingordietrying1797 29 дней назад

Yes, thanks Ed, but too low can be a problem, especially for lymphocytes. The goal is to get them back to youthful levels, ~2000

@barrie888 28 дней назад

btw you have amazing total testosterone and your free t is great too , thats a fasted am peak level correct . anyway i am going to be interested to see what you decide to do with that sbhg

@conqueragingordietrying1797 28 дней назад

Thanks @barrie888. No plan to change SHBG, for now

@Nof1LongevityQuest Месяц назад

How often do you check TSH? Excellent on the cholesterol!

@conqueragingordietrying1797 Месяц назад

Thanks Gail. Every test going forward...

@LVArturs Месяц назад

At what point do you plan using more supplements, what's the time frame and biomarker sets that'd warrant that?

@conqueragingordietrying1797 Месяц назад

Only when all aspects of diet are exhausted. For example, I'm not consistently using low-dose nicotinic acid for NAD.

@davidflorez1196 Месяц назад

@@conqueragingordietrying1797 how frequently are you taking Nicotinic acid?

@prismgems 29 дней назад

I think you should put all the data you've accumulated into a machine learning model and see if it can tease out some patterns for you. A lot of work, though, exhaustively entering all that data, inputs and outputs, for only the possibility it might recognize patterns you've missed.

@conqueragingordietrying1797 29 дней назад

I'd be happy to do that, but have 0 coding experience...

@prismgems 29 дней назад

@@conqueragingordietrying1797 Maybe some kind expert will read this and do it as a challenge. 🙂

@jamesgilmore8192 29 дней назад

@@conqueragingordietrying1797 Mike -- I could of course try, but unfortunately, I don't think there is not enough data to make ML useful. Usually you need 100 or so measurements for those methods to be useful beyond traditional approaches. Developing a collection of linear models and using a hierarchal optimisation that allows some extrapolation may work. I don't think it would replace your approach, just supplement it with more information.

@eruiluvatar236 28 дней назад

@@conqueragingordietrying1797 I could easily do it but as James said, it likely won't work well. Even 100 data points would be way too few if what the model needs to learn is difficult and we have good reasons to think it is. Then we would need to know what do we want out of the model. I believe that a neural network that given a set of blood test values tries to predict the foods, exercise, sleep and other factors that caused them may be of some interest. If you have the data in a spreadsheet (I believe you do at least for the food), it woul be real easy to do. Of course I fully expect it to not work that well unless you happen to have thousands of data points and even if it did work well, it is not easy to see how it does arrive to conclussions or to know at what point the predictions become unreliable when the input data deviates from what it did see during training (ie putting the ideal numbers of something you are far from ideal and hoping that what it says will do it). Non neural network approaches like k-nn or svm may also be interesting as they tend to be more explainable and to need less data even if they are ultimatelly less powerfull when there is plenty of data. Anyway, if you want me to, I would be happy to try.

@Blurns 27 дней назад

I don't really think you need an AI for it. It's a Design of Experiments thing that could probably be done just as easily in Excel.

@OneDougUnderPar 29 дней назад

I've heard that Brazil nuts can vary quite a lot in their selenium content for various reasons. Are you able to confirm the content of yours? Would you consider supplementing briefly instead of eating the nuts to test their content?

@conqueragingordietrying1797 29 дней назад

I'd prefer to get it via food-I'm considering measuring plasma selenium levels, which could indicate if the Brazil nuts are low in selenium, or if they're unable to raise plasma levels.

@OneDougUnderPar 29 дней назад

@@conqueragingordietrying1797 I'm 100% with you on sourcing from food as a priority, my thinking was that supplementing gives you a credible reference point from which you can then translate to food. Testing plasma levels sounds cool though. Do you chew the nuts or are they blended? If peanuts/peanut butter research is any indication, particle size would make a difference in nutrient uptake.

@rickw4023 23 дня назад

Are you mixing up biological (epigenetic/DNAm) age such as PhenoAge with phenotypic age? One can have vastly different phenotypic age and PhenoAge. Have you measured PhenoAge or GrimAge?

@conqueragingordietrying1797 23 дня назад

Hi @rickw4023, nope, I'm not mixing it up. I haven't measured DNAmPhenoAge or GrimAge, but instead Horvath and DunedinPACE.

@whatthefunction9140 29 дней назад

Do you have a video on your exersise routine?

@conqueragingordietrying1797 29 дней назад

There's a 20-minute portion in the "Fitness" playlist from 2y ago-everything in that is currently the same Movements in the full 90-minute workout are listed in a Patreon post

@whatthefunction9140 29 дней назад

@@conqueragingordietrying1797 wondering how a change there might affect your bloodwork.

@conqueragingordietrying1797 29 дней назад

@@whatthefunction9140 The routine is standardized in terms of frequency, intensity, duration, movements, sets, reps for the past 4+ years...

@conqueragingordietrying1797 29 дней назад

@@whatthefunction9140 The big change over the past 3y is calorie restriction, ~20 lb (mostly fat) loss.

@halinallet652 29 дней назад

Have you considered that youthful results might not be the best for maximum life expectancy. Could it be that when you are young, a person is like a raging campfire that burns out its vitality faster than a fading campfire burning with a small flame.

@mihailopra2313 Месяц назад

No comments on Eusinophiles mark ?

@conqueragingordietrying1797 29 дней назад

Eosinophils were below-average (71) for this test, which is good news

@justsaying7065 Месяц назад

Are you still losing weight or is your weight constant now?

@conqueragingordietrying1797 Месяц назад

Constant at 140-141 lbs

@jamesgilmore8192 Месяц назад

Maybe methionine or creatine would assist with homocysteine? I wonder what the BCAA's did to other markers through mTOR as they didn't seem to hurt here much.

@conqueragingordietrying1797 Месяц назад

Creatine is a definite possibility for homocysteine Next up, though, might be revisiting the methyl-folate and B12, B6 stack where I saw my best homocysteine data (7.3) Blood glucose was close to my highest ever-I'm not sure if it was the BCAAs or total fat moving past 93g/d. I don't yet have corresponding epigenetic or metabolomic data for that test, so there will be more insight...

@jamesgilmore8192 29 дней назад

@@conqueragingordietrying1797 Good point on glucose, may well be both as there are known mechanisms: bcaa's->mtor->higher glucose and fat->more dags->higher glucose. You could probably average a triple finger stick in the morning everyday or cgm to resolve that fairly quickly. I do wonder if you'll eventually need more zone 2 training if glucose keeps going up.

@Nof1LongevityQuest 19 дней назад

@@conqueragingordietrying1797 Interestingly, I just did blood work and got two different numbers for glucose: 87 and 92. The reason? I had one last InsideTracker test to use up, but since they don't include ALP (which I wanted so that I could calculate PhenoAge), my doctor ordered a CMP. Therefore, I had double scores on 5-6 markers. Most were very close or spot-on, but I consider this a fairly large variance. Do you think the lab somehow handled them differently, or that my blood actually varied that much?

@frankfeather8548 29 дней назад

Curious if you've ever checked fasting insulin since lower levels can increase SHBG. Also, do you know yourA1c level?

@conqueragingordietrying1797 29 дней назад

Yep, for a 5 tests in 2022: average insulin was relatively low, 3.2 mIU/mL 5.1 for HbA1c in Oct 2023: ru-vid.com/video/%D0%B2%D0%B8%D0%B4%D0%B5%D0%BE-vzWc00nn3yA.html

@ladagspa2008 Месяц назад

First of all, great numbers. Your difference in BioAge - Levine phenoage is more than mine. I have many thoughts on this report of yours, since I also have Hashimoto's and do caloric restriction as well as track testosterone/shbg. 1. As I commented last time, T3 will be increased by going to maintenance/surplus, and especially if carbs are added. Adding iron/selenium/iron/zinc only helps if you are deficient which you are not. Your T3 is low due to energy deficit. Low carb diets depress T3 further compared to moderate carbs diets, even if calorie intake is same. 2. Your high SHBG is problematic. Its too high. It is independently linked to erectile dysfunction in at least one Chinese study. (Ming Liao et al 2012). SHBG is raised by caloric restriction, low carb diets, low insulin secretion, high cortisol. Or during liver disease. I predict that your fasting insulin is low (due to higher fat diet, insulin sensitivity and exercise), cortisol is highish causing the high SHBG. Eating more calories from carbs should ameliorate this issue. This type of thing is common in keto/carnivore blood numbers (one of the reasons Paul Saladino added back fruits). SHBG is also lowered by TRT. 3. Your fasting glucose at 98 is problematic. I think this again is due to high stress due to diet, caloric restriction and exercise raising cortisol. High cortisol, low insulin = higher glucose. Tldr - i think constant caloric restriction is showing its effect. Probably will do well with a break.

@conqueragingordietrying1797 Месяц назад

We'll see about T3, there may be other ways besides calories or carbs that can impact it SHBG is not an issue, I have no issue with erectile dysfunction, and covered the dichotomy in the video. If SHBG being high is bad for health, then CR is bad for human health, which is unlikely I agree about glucose, I've course corrected, we'll see if it returns to lower values for the next test I disagree about a CR break, a lot more biomarkers are going in the right direction vs wrong in its presence. I did increase calorie intake for the 1st time in 3y (by a small amount), though, for this test.

@ladagspa2008 Месяц назад

@@conqueragingordietrying1797 I acknowledge the disagreement, but do note that Bryan Johnson explicitly does TRT to counter the lowering effect of CR on free testosterone. While CR may be good overall, there's no reason why there cant be breaks to allow for hormones to recalibrate to normal levels. I don't think lower Free Test is linked to longevity.

@conqueragingordietrying1797 Месяц назад

@@ladagspa2008 If free T was an issue, I'd expect non-youthful values for RBCs and hemoglobin, as found in older adults (free T declines during aging). However, both are youthful in my case, which suggests no limitation of free T on erythropoiesis

@ladagspa2008 Месяц назад

@@conqueragingordietrying1797 Yes, the red blood cell and haematocrit numbers are fine, but these are not the only gauge to check whether lowish free T and high SHBG are a problem. The lab range of 10-50 for SHBG is there for a reason. I frequent testosterone forums, and read tons of T and SHBG related papers and your 143 (almost 3x upper limit) SHBG is the highest I have seen so far (for a male). Definitely worth deep diving into. For example, shbg is very high in Anorexia (do read this literature).

@jamesgilmore8192 Месяц назад

@@ladagspa2008 I think BJ stopped TRT and increased calories by ~10%. CR without TRT is possible. It's a fair question how much CR is needed, especially with a large supplement stack.