19.5y Younger Biological Age: My Best Data Yet (31 Tests Since 2018) 

What's most astonishing with this is how consistent you are.

Nice work and congrats!

Wonderful! I'm so happy for you!!

Congrats Mike. Wonderful results. Looking forward to see how you surpassed and achieved your highest ever albumin score of 5.1.

Great work! You are crushing it 💪

Excellent work and great appreciation for you be the explorer/scout out ahead and reporting back to us.

I hope this motivates people to be able to adjust their life style.

Congrats for these results!

Really your hardwork got you the best score! Next eagerly looking for causation i.e foods and supplements to get this score. Thanks! 🎉

I bet you were very excited with these new results! I look forward to your next few videos

So outstanding results we can't wait too long to find out what were the factors behind that.

The biggest study on globulin I know is Fulks et al 2014, Serum Globulin Predicts All-Cause Mortality for Life Insurance Applicants. Its a minimally adjusted report, but indicates 3 is problematic as you mentioned.

Hi Michael! Nice outcome, congrats! Will it be possible to make a video on MCV and your correlations with foods? So far I was not able to lower it and it is on the high end 92 fl, thanks!

Thanks

impressive results. Very good, sincere congrats! following your approach now since almost 2y, and observing your interventions, and given the fact that you already have been in the target area, I particularly would attribute that improvement to 3 changes: reduction of fructose, increase of HDL, and lifting NAD. It took a while until the changes precipitated, as the body has to renew and find the equilibrium. I would expect that the next result is even better, as it is spring season :) Are you also doing psychometrics, such as reaction tests, standardized memory tests an the like? They have been show to be good early indicators. Such, establishing a baseline now could be pretty valuable later.

thanks the Levine spreadsheet , i calculate my phenoage 49 years my chrono 62, nice to knw, i am on TRT btw

Nice! 👍🏻 I have a question about grains. Maybe not the right video, but let's ask anyway. What is your opinion on eating organic rye or wheat bread? Of course the ones with high fiber content. And maybe even sourdough. Any comments on those? Thanks so much!

I can't wait to be here in 20 years when i'll read in the comments "Wow! This guy is doing nice for being 71!" I have a question though, Michael i'm reading your book and i've seen you present many tests about your oral microbiome but not the gut one.. which is arguably more important given your focus on nutrition. You're doing very good measuring input maybe seeing how the output is behaving like different food taken at different times or before or after others (since that too has an effect).. synergistic effects! i believe this would give you the cutting edge advantage. At that point you would exactly know how much you really absorbed of the food you ate and what is your body regenerating from.

Wow i want to follow in your footsteps

At 19.5-years you maybe reaching the limit of what can “naturally” be achieved. A fantastic result. I applaud the notion that running up LDL a little might have overall positive effects on other bio markers. The only area I question is holding hsCRP below 0.3, while holding down inflammation must be a good thing, having some can stimulate angiogenesis which should be a good thing. I have no idea where the ideal hsCRP should be but I’m doubtful 0 is the ideal.

I find the topic fascinating and your videos very informative! What I am wondering though is what the ultimate point is if we are still judged based on our chronological age rather than our actual biological age and are subjected to various stereotypes. Perhaps you have a good answer to that question. Thanks!

After correction for multiple testing, nothing was significant in the last video. There is zero reason to raise LDL. The Mendelian randomization studies clearly show that LDL is harmful at any age and level.

"How healthy is Dr. Lustgarten?" "Yes."

Hi, a question about the excel file for calculating biological age, I don't understand how it works, should I replace my biomarkers ​​with yours in the first paragraph? and then how do I do the calculation? Thank you

Very interesting as always. I've found that my creatinine level will be lower if I suspend my creatine supplement and gym workouts for 3 - 4 days prior to taking the blood test. you may want to try this for your next test. thanks

Amazing results. Be interesting to find a way to determine whether changing these biomarkers to more youthful levels has a noticeable impact on quality of life and if they maintain their correlation with various conditions - ie, does rolling back the biomarker also reduce the incidence and degree of various geriatric conditions. Probably need a long time and a larger sample size to know for sure, but happy to have an anecdote. One note - the creatinine. Don't know if you're supplementing with creatine or not, but that along with age and muscle mass (or injury to muscle tissue) can drastically change what is "normal." Same for EGFR based on creatinine. If you supplement with creatine, a % spontaneously converts to creatinine, and the blood panels go on lots of assumptions including NOT supplementing creatine. So, if your creatinine and EGFR (cr) numbers look bad in the future, just check against other markers of kidney function, and if they're fine, your creatinine and EGFR (based on cr) is fine, too. When you have real kidney damage, all the markers move together. In fact, if you're over 60 and/or have real kidney damage, a Cystatin C test (more common in the EU) and EGFR (cyc) based on Cystatin C will give you a much better idea of the damage as it correlates better unless you're taking specific medications like corticosteroids that can interfere with it.

Congratulations on your best score yet. How did RDW 11.6 compare to previous tests that seems to be significant.

What is your response to the recent niacin study release??

I have played around with this calculator and I think it sucks. First, by including age, that makes it a complete cheat. And second, the functions chosen for each are wimpy. They are not configured to reflect all cause mortality or anything else. You can enter values that would make someone dead, and it happily gives ridiculously low age. If this was robust and logical, any value extreme that would be harmful should be reflected as harmful and shortened life. Third. It can completely miss significantly harmful health values, and exaggerate the importance of others. Maybe you can say I am biased because I have high RDW, but how do I die of high RDW? I had my red blood cells checked in other ways and they appear to work fine. Iron/TIBC saturation is fine, Ferritin is fine, iron is fine, Total iron Binding Capacity is fine (400 where normal is 245-450). Hematocrit is pretty close to the middle at 46.3 Hemoglobin is near the middle at 15.1 The only reason they have RDW-CV is to identify anemia, some blood disorders like sickle cell and leukemia. I don't have any of these, as can easily be verified by other blood markers and my DNA. I checked for sickle cell even though I am 99.8% north-western European, and highly unlikely to have inherited it, and I checked for thalassemia, and again no SNIPs for that. Any test that includes age and heavily weights it, is going to correlate well with it. I think it is folly to be trying to change all your biomarkers to try to get a lower score on this test. Especially when it rewards extreme and obviously unhealthy values. And I don't think results are at all useful, regardless of any correlations. Try these funky values: Al 19.9, Cr 0.01, Glu 1, CRP 0.01, Lym 100, MCV 0.1, RDW 0.01, Al Pho 0.01, WBC 0.01, Age 0.01 I'll leave it to you to generate the cool value. If you are serious, you need something else. Looking at individual values' all cause mortality curves, and age average curves as you have done on many videos is much better, even if less satisfying than an overall age output. It sure would be nice if we had blood work of centenarians (especially 105+) from when they were 20. Maybe if we cloned 500 of them, then measured them every year to at least 20? Waiting around the other direction would be hopless. Would have to be done in secret or in a country where that would be legal. Yes, they would be eating modern food and such, but I suspect the results would still strongly contrast with results from 500 average 20-year-olds in meaningful ways eating similar foods. I think the rules against cloning and gene-line genetic modification are a disaster born of irrational and unestablished imaginary harms born of mythology from science fiction.

Great scores! I’d like to get my creatinine down to get a better score.. I’m taking creatine 2.5g per day now. How long should I stop creatine before blood test to get a good score?

cool

Great results 👍👍 Do you check if there could be a U-shaped curve, correlation between niacin supplementation and the aging marker you tested? For example what impact has 200mg niacin on aging and NAD instead of 600mg.. Another really interesting point would be niacinamide supplementation or a combination of both niacin and nicotinamide. Niacinamide has no effect on LDL afaik Also regarding the negative effect of niacin: you maybe missed methylation as an super important factor concerning high dose b3 Niacin is a big methyl thief and high dose b3 leads to significant undermethylation (if you are a normal or undermethylator) B3 should always be combined with the same amount of TMG betaine as a methyl donor (Chris Masterjohn phd)

I'm surprised to hear you say can I hold at 19.5 years instead of saying can I beat it? Do you believe you can't get any lower?

I keep hearing that cystatin C is a better kidney test than creatinine or eGFR, although I can't get my doctor to recommend it. The thing is, Creatine is widely reputed to have beneficial effects, but there's no question that it raise creatinine and/or lowers eGFR. It does in me anyway, and I've stopped it. But I've been advised by random youtube commenters to test my cystatin C instead, which shouldn't been affected by Creatine intake.

With extremely low LDL, do you get erections and can you have sex three times a day? Serious qurstion

I'd like to see what hydrogen water and Nitric Oxide do...