My sister recommended your podcast to me. I'm a die hard F1 fan. When I heard you guys in the introduction saying you were going to discuss Formula 1, I thought "surely they don't mean racing, but maybe there's some dietary drink they are gonna discuss that coincidentally is called 'Formula 1'" Loved to hear you talking about iRacing and the Mercedes W12. It's my favorite class to race in. Needless to say you are now my favorite podcaster. Maybe I'll see you out on the track :)
Peter, have you looked at the "China Study" by T. Colin Campbell? It would be great to see how you compare and contrast your view on nutrition and longevity.
Absolutely love this episode!!! I have always been a fan of all forms of speed and racing, so the discussion on F1 was highly entertaining and appreciated!!!
You've mentioned before that you don't expect to live past 100. If you think that you can basically eliminate atherosclerosis by lowering apoB, and Gi cancers by proper screening, do you expect to die from some other type of cancer?
Huge thanks to Peter for yet another outstanding and rigorous, science-based approach to healthspan. I'm happy to be proved wrong, but he is shooting down 2 approaches that had gained a lot of traction among enthusiasts: 1) Time-Restricted Feeding (TRF): He's unconvinced that it has benefits beyond caloric reduction (minute 44). "...the answer today is no". So, one might ask: if you aren't obese and/or have insulin intolerance, why go hungry by pursuing this? 2) NAD-Precursors: He's unconvinced on the basis of sound research to date that this has any real merits. "I remain incredibly un-optimistic".."incredibly uninspiring data so far" (1:06). So much for the recent holy grail (despite assertions to the contrary by other luminaries such as David SInclair of Harvard).
Because Peter changes his positions based on new information, I follow him and always find him helpful. My wife has cancer and I've found the medical system to be absolutely broken in America. I can't understand how 1 radiation oncologist & 2 medical oncologists deny the Warburg Effect. They also deny that insulin is also a growth hormone, etc. One medical oncologist thought Lew Cantley was a "naturopath with a website". The other couldn't tell us WHY the MammaPrint test said she was high risk; "They need to make a profit so they have to keep that private". Neither answered me when I asked about chemo's absolute risk vs relative risk, just sidestepped it. I wish Peter would do more on cancer very soon. The waters are muddy at best.
There's much contradictory info re sufficient protein consumption. Longevity-focused scientists make the case for lower protein intake, citing the average amounts ingested by the longest-lived population, the Okinawans, among other evidence; whereas there's also the view that more protein should be consumed, say after 60, to help prevent sarcopenia. I would love to know which way to go on this.
No kidding. Here we have one longevity expert with almost a total opposite view of David Sinclair, who advocates OMAD and plant based/low protein. I have no idea what to do anymore.
When you get older your digestive system gets less efficient. You will need more protein to absorb the same amount. On the other hand, cancers must learn a series of tricks to keep growing when everything in your body is ready to stop them. Before a cancer learns how to fake the signals that make your body feed it first, it will tend to starve when there isn't enough protein available, but when there's lots of surplus protein ready for it to grow with, it can live and grow and learn how to grow better. So it's plausible that too much protein much of the time, will benefit cancer growth. When the time comes that we can easily monitor how much protein you eat and how much you need and how fast it gets used up, then it will make sense to try to get just the right amount.
How about a podcast on “doing the deep work”. When talking about using psilocybin, you spoke of people doing the work. Lots of people talk about doing the deep work. But no one ever explains what that work is…
I'm wondering about grip strength being an index of strength - That the longevity is about overall strength. If so training grip strength would not affect longevity.
So I live with ApoB of 160 plus AlLP 17 uric acid 4.7 CAC zero at 55 and BP 115/70 average. TG to HDL is 1.2, it is usually under 1. Should I let the ApoB be?
There are toxicities with immunotherapy. I had Opdivo and Yervoy for mucosal melanoma and have been NED since the margin surgery. I had 1 dose neoadjuvantly, and 2 adjuvantly. I developed colitis that was severe enough that I stopped treatment. I lost a lot of weight while using steroids to stop the colitis. I dropped from 122 lbs to 108. That said it appears to have worked well on the cancer and I am not receiving further treatment at this time. Note mucosal melanoma is rare and has a low mutation rate.
Hey great info. I am looking for clarification on the "dexter test"..you'll said it was not that expensive $200 in US. I can't find reference to it in Canada so I may not have the correct term? thanKS
Oh noooo...I selfishly REALLY wanted you to read the audiobook! But given you'll hate it so much, I'll just buy the physical book instead and imagine your voice 🥰.
I think the 15% estimate for F1 interest is way low. Can we get some kind of study on this? I did get interested in F1 through the Netflix series. That is a crazy sport with super interesting team dynamics
loved the whole podcast with the f1 sum up. Amazing admiration to you for being so open to modify your belief, and your statements regarding trf and fasting. Huge appreciation also for al your info, currently i am trying to persuade my parents into exercising and healthy lifestyle using your view points and analogies, specially the one saying exercise is 5x more potent that anything else on improving health and longevity!
Great update team - for me a step back and review my longevity strategy - I'd love to hear the latest research on TRF for "skinny people" lean phenotypes - how to optimise benefits and risks to watch/avoid.
Disagree on TRE, I work out everyday. Bad advice on TRE in my opinion. Eating causes hunger and leads to overeating. Major problem in the country is no metabolic flexibility. I have it
Peter, you definitely have the privilege of being more persuasive with medical professionals due to your status. I've requested cancer screenings from Kaiser and they tell me they don't offer cancer screenings to anyone below 30. I have a family history of cancer so I'm a bit concerned but the current state of the medical establishment is preventing me from using some of your advice here
I’ve watched F1 for the last 20 years. The problem I have with it is still it’s to dependant on having the best car. I’m honestly trying to do other stuff when it’s on and just watch the highlights. Also the Uk commentators are normally quite knowledgeable but amazing bias.
@@singhgrewaal283 Yeah, especially if you already have a low fat percentage perhaps? I bet that if you're obese, loosing muscle isn't as big of a concern, as long as you're eating a fair amount during your eating window. I'm doing Keto + 19/5 hour fasting/eating window, with two meals. I don't count macros but I'm eating until I feel full. Hardly any carbs.
@@viperracing2889 how low is low? body fat, I have 27 % total body fat and FFMI of 14.8, I cant miss out on weight training with my TRF which is the only way I can restrict my calories
@@singhgrewaal283 Good question. I guess it's a gradual slope. A friend told me that you can cut 70 calories from your calorie intake, for every kg of body fat that you have, without loosing muscle mass. This means that if you have 20 kg of body fat then you can cut 1,400 calories without loosing muscle mass.
A while back, I thought I heard Peter say he liked Pelaton, and that he was an investor? Did something change? Other than trazodone, is diphenhydramine (the active ingredient in most sleep aids / allergy medicine) as bad as benzodiazepine? My problem is with sleep maintenance.. I can fall asleep fine, but wide-awake after just a few hours. Would the use of these pills be less harmful if taken after a few hours of "normal" sleep? Regarding how 30 percent of all U.S. cancers (170k/600k) are in the GI (between the mouth to anus). are there any other early GI cancer screenings other than colon? Regarding how one should eat a gram of protein per pound of body weight.. any concern on uric acid? Does the *RATIO* between APOB and APOA yield any better insight that APOB alone? For example, my ApoB100/ApoA is 0.7... TG/HDL
I am a physician who regularly uses trazodone as a sleep aid. Among my colleagues it is commonly used. I would say at this point trazodone is main stream use for insomnia
I still do it with no goal of weight loss because I feel better, sleep better. I eat in an 8 hour window with stable weight. I weight lift and eat plenty of protein.
The argument is that the only disadvantage of getting too much protein is that your kidneys might fail. But maybe if there are a whole lot of amino acids available to use, pre-cancer cells might grow easier. That's one less adaptation they need to become cancerous. So MAYBE getting too much protein too much of the time might have other problems.
Hope you reconsider doing the audiobook. I'm too a poor reader along with chronic headaches that makes reading a nightmare. Without podcasts and audiobooks I learn very little, and wont learn from your book. F1... Thank you I got into it a few years ago.
First of all, thank a lot for sharing your knowledge. Attia is amazing! My only critique is this. You taught me that a proxy is not the real deal, it is just a proxy. And focused efforts for modifying that single proxy without finding the root cause are a bit useless. It is funny to hear that part of your training is designed and focused to improve specifically grip strength. But that is just a proxy! And does not makes sense to train for that specifically. I mean, we can measure it as a response to a general training, but training specifically for improving grip strength makes no sense. I mean, if you become a super gripper due to that focused training, that may not say anything about your longevity chances.
After 200 episodes it doesn't seem like we have much more than what Jack La Lanne was preaching 50 years ago. He lived to 96 so there you go. Oh well I will still listen if for nothing else the Peloton bashing cracks me up!
I'm over 60 and have a hip issue. The only choice I'm being given is a hip replacement. You had a labrum repair. Would you have ever considered a replacement? Are replacements of joint a mistake.
Hope to hear a changed opinion. Rather hear a person who enjoys reading it but if you can enjoy it somehow it would be better to hear from you Peter. I think most are familiar with your voice and meanings. Goodluck!
As a T2 diabetic I have been practicing time restricted eating for about 1 ½ years. I have lost close to 50lbs during that time. The last several weeks I have been going through exactly the symptoms that Peter describes in this podcast. I wear a CGM and observed a dramatic increase in my blood glucose over night reaching an alarming peak of over 200 in the early morning. I did not understand what was happening to me until I listened to this podcast. I was afraid I would soon have to go back on insulin. I increased my protein intake dramatically and observed a 40% lowering of my overnight and morning blood glucose levels. I have also decreased the length of fast particularly on days when I workout hard. It appears to be working. This info came just at the right time for me and was extremely helpful. Thank you Peter!!
Gabapentin is so good for sleep but you have to keep taking more so inpractical for true insomniacs. But if anyone is really suffering and just needs a few weeks of good sleep go for it
Someone send this note to Peter: Episode with an excellent candidate to discuss and combat Negative Self Talk. With a deep weight on reversing Peter's dislike of reading aloud and dislike of writing the source material and making it EXCITING in the way it's written. Perhaps a mentor-level writer, War of Art comes to mind (Pressfield), perhaps a CBT specialist, perhaps Yuval Harari. Perhaps 2 of these. Get the excitement back in peters narrative, adventurousness, this will promote more excitement in READING his work! Peter with Pressfield + Harari (both experts in human psychology of story and narrative) would be a mind-blowing show. Make it happen. Be positive!
